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3EK9
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BU of 3ek9 by Molmil
SPRY Domain-containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding
Descriptor: GLYCEROL, SPRY domain-containing SOCS box protein 2
Authors:Kuang, Z, Yao, S, Xu, Y, Garrett, T.J.P, Norton, R.S.
Deposit date:2008-09-19
Release date:2009-02-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding.
J.Mol.Biol., 386, 2009
2H7T
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BU of 2h7t by Molmil
Solution Structure of the C-terminal Domain of Insulin-like Growth Factor Binding Protein 2 (IGFBP-2)
Descriptor: Insulin-like growth factor-binding protein 2
Authors:Kuang, Z.
Deposit date:2006-06-03
Release date:2007-04-24
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2)
J.Mol.Biol., 364, 2006
2LO9
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BU of 2lo9 by Molmil
NMR solution structure of Mu-contoxin BuIIIB
Descriptor: Mu-conotoxin BuIIIB
Authors:Kuang, Z.
Deposit date:2012-01-20
Release date:2013-01-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Mammalian neuronal sodium channel blocker mu-conotoxin BuIIIB has a structured N-terminus that influences potency.
Acs Chem.Biol., 8, 2013
2LOC
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BU of 2loc by Molmil
Conotoxin analogue [D-Ala2]BuIIIB
Descriptor: Mu-conotoxin BuIIIB
Authors:Kuang, Z.
Deposit date:2012-01-21
Release date:2013-01-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Mammalian neuronal sodium channel blocker mu-conotoxin BuIIIB has a structured N-terminus that influences potency.
Acs Chem.Biol., 8, 2013
7EWF
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BU of 7ewf by Molmil
Selenomethionine-substituted structure of S. cerevisiae Csn12 in complex with Thp3 and Sem1
Descriptor: 26S proteasome complex subunit SEM1, Cop9 signalosome complex subunit 12, Protein THP3
Authors:Kuang, Z, Niu, L.
Deposit date:2021-05-25
Release date:2022-09-07
Last modified:2023-04-05
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural assembly of the nucleic-acid-binding Thp3-Csn12-Sem1 complex functioning in mRNA splicing.
Nucleic Acids Res., 50, 2022
7EWM
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BU of 7ewm by Molmil
Native crystal structure of S. cerevisiae Csn12 in complex with Thp3 and Sem1
Descriptor: 26S proteasome complex subunit SEM1, Cop9 signalosome complex subunit 12, Protein THP3
Authors:Kuang, Z, Niu, L.
Deposit date:2021-05-25
Release date:2022-09-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural assembly of the nucleic-acid-binding Thp3-Csn12-Sem1 complex functioning in mRNA splicing.
Nucleic Acids Res., 50, 2022
8JAT
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BU of 8jat by Molmil
Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans
Descriptor: 3-ketodihydrosphingosine reductase TSC10, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zhao, P, Kuang, Z.
Deposit date:2023-05-07
Release date:2023-06-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the 3-ketodihydrosphingosine reductase TSC10 from Cryptococcus neoformans.
Biochem.Biophys.Res.Commun., 670, 2023
5XN3
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BU of 5xn3 by Molmil
Crystal structure of SPSB2 in complex with a rational designed RGD containing cyclic peptide inhibitor of SPSB2-iNOS interaction
Descriptor: SPRY domain-containing SOCS box protein 2, cR8 peptide from NOS2
Authors:You, T, Kuang, Z.
Deposit date:2017-05-17
Release date:2017-06-14
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Crystal structure of SPSB2 in complex with a rational designed RGD-containing cyclic peptide inhibitor of SPSB2-iNOS interaction.
Biochem. Biophys. Res. Commun., 489, 2017
6JKJ
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BU of 6jkj by Molmil
Crystal structure of human SPSB2 in the apo-state
Descriptor: SPRY domain-containing SOCS box protein 2
Authors:Luo, Y, Kuang, Z.
Deposit date:2019-03-01
Release date:2019-07-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the SPRY domain of human SPSB2 in the apo state.
Acta Crystallogr.,Sect.F, 75, 2019
6JWN
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BU of 6jwn by Molmil
Crystal structure of the SPRY domain of SPSB2 in complex with cR9, a cyclic peptide inhibitor of SPSB-iNOS interaction
Descriptor: Nitric oxide synthase, inducible, SPRY domain-containing SOCS box protein 2
Authors:Li, K, Kuang, Z.
Deposit date:2019-04-21
Release date:2020-04-22
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Crystal structure of SPSB2 in complex with cR9, a cyclic peptide inhibitor of SPSB-iNOS interaction
To Be Published
6JWM
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BU of 6jwm by Molmil
Crystal structure of the SPRY domain of SPSB2 in complex with cR7, a potent cyclic peptide inhibitor of SPSB2-iNOS interaction
Descriptor: Nitric oxide synthase, inducible, SPRY domain-containing SOCS box protein 2
Authors:Li, K, Kuang, Z.
Deposit date:2019-04-21
Release date:2020-04-22
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Crystal structure of SPSB2 in complex with cR7, a potent cyclic peptide inhibitor of SPSB2-iNOS interaction
To Be Published
6KEY
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BU of 6key by Molmil
Structural basis for the regulation of inducible nitric oxide synthase (iNOS) by the SPRY domain-containing SOCS box protein 2 (SPSB2)
Descriptor: Nitric oxide synthase, inducible, SPRY domain-containing SOCS box protein 2
Authors:Li, K, Kuang, Z.
Deposit date:2019-07-05
Release date:2020-07-01
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Structural basis for the regulation of inducible nitric oxide synthase by the SPRY domain-containing SOCS box protein SPSB2, an E3 ubiquitin ligase.
Nitric Oxide, 113-114, 2021
7CCB
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BU of 7ccb by Molmil
Crystal structure of the SPRY domain-containing protein 7 (SPRY7)
Descriptor: SPRY domain-containing protein 7
Authors:Yang, J, Kuang, Z.
Deposit date:2020-06-16
Release date:2020-10-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Crystal structure of the SPRY domain-containing protein 7 reveals unique structural features.
Biochem.Biophys.Res.Commun., 531, 2020
2V24
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BU of 2v24 by Molmil
Structure of the human SPRY domain-containing SOCS box protein SSB-4
Descriptor: NICKEL (II) ION, SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 4
Authors:Uppenberg, J, Bullock, A, Keates, T, Savitsky, P, Pike, A.C.W, Ugochukwu, E, Bunkoczi, G, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A, Sundstrom, M, Knapp, S.
Deposit date:2007-05-31
Release date:2007-07-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Par-4 Recognition by the Spry Domain-and Socs Box-Containing Proteins Spsb1, Spsb2, and Spsb4.
J.Mol.Biol., 401, 2010
6OM3
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BU of 6om3 by Molmil
Crystal structure of the Orc1 BAH domain in complex with a nucleosome core particle
Descriptor: DNA (146-MER), DNA (147-MER), Histone H2A, ...
Authors:De Ioannes, P.E, Wang, M, Armache, K.-J.
Deposit date:2019-04-18
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure and function of the Orc1 BAH-nucleosome complex.
Nat Commun, 10, 2019
3EMW
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BU of 3emw by Molmil
Crystal Structure of human splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2) in complex with a 20-residue VASA peptide
Descriptor: 1,2-ETHANEDIOL, Peptide (VASA), SPRY domain-containing SOCS box protein 2
Authors:Filippakopoulos, P, Sharpe, T, Keates, T, Murray, J.W, Savitsky, P, Roos, A.K, Pike, A.C.W, Von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2008-09-25
Release date:2008-10-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
J.Mol.Biol., 401, 2010
3F2O
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BU of 3f2o by Molmil
Crystal Structure of human splA/ryanodine receptor domain and SOCS box containing 1 (SPSB1) in complex with a 20-residue VASA peptide
Descriptor: 20-mer peptide from ATP-dependent RNA helicase vasa, SPRY domain-containing SOCS box protein 1
Authors:Filippakopoulos, P, Sharpe, T, Keates, T, Murray, J.W, Savitsky, P, Roos, A, Pike, A.C.W, Von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2008-10-30
Release date:2008-12-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.
J.Mol.Biol., 401, 2010
2JK9
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BU of 2jk9 by Molmil
The structure of splA-ryanodine receptor domain and SOCS box containing 1 in complex with a PAR-4 peptide
Descriptor: PRKC APOPTOSIS WT1 REGULATOR PROTEIN, SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 1
Authors:Filippakopoulos, P, Bullock, A, Keates, T, Savitsky, P, Murray, J.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Wickstroem, M, Bountra, C, Knapp, S.
Deposit date:2008-08-22
Release date:2008-09-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural Basis for Par-4 Recognition by the Spry Domain-and Socs Box-Containing Proteins Spsb1, Spsb2, and Spsb4.
J.Mol.Biol., 401, 2010
7FCQ
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BU of 7fcq by Molmil
Crystallographic structure of neutralizing antibody P14-44 in complex with SARS-CoV-2 spike receptor-binding Domain (RBD)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, P14-44 antibody Fab fragment heavy chain, ...
Authors:Zheng, P, Jin, T.
Deposit date:2021-07-15
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance.
J.Clin.Invest., 132, 2022
7FCP
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BU of 7fcp by Molmil
Crystallographic structure of two neutralizing antibodies in complex with SARS-CoV-2 spike receptor-binding Domain (RBD)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Zheng, P, Jin, T.
Deposit date:2021-07-15
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance.
J.Clin.Invest., 132, 2022
7DSJ
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BU of 7dsj by Molmil
Anthranilate phosphoribosyltransferase from Saccharomyces cerevisiae in complex with PRPP and Mg
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, Anthranilate phosphoribosyltransferase, MAGNESIUM ION
Authors:Wu, X.
Deposit date:2020-12-31
Release date:2021-03-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Crystal structures of anthranilate phosphoribosyltransferase from Saccharomyces cerevisiae.
Acta Crystallogr.,Sect.F, 77, 2021
7DSM
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BU of 7dsm by Molmil
Anthranilate phosphoribosyltransferase from Saccharomyces cerevisiae
Descriptor: Anthranilate phosphoribosyltransferase
Authors:Wu, X.
Deposit date:2020-12-31
Release date:2021-03-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Crystal structures of anthranilate phosphoribosyltransferase from Saccharomyces cerevisiae.
Acta Crystallogr.,Sect.F, 77, 2021
7DSR
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BU of 7dsr by Molmil
Anthranilate phosphoribosyltransferase variant Gly141Asn from Saccharomyces cerevisiae in complex with 4-fluoroanthranilate
Descriptor: 2-amino-4-fluorobenzoic acid, Anthranilate phosphoribosyltransferase
Authors:Wu, X.
Deposit date:2020-12-31
Release date:2021-03-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of anthranilate phosphoribosyltransferase from Saccharomyces cerevisiae.
Acta Crystallogr.,Sect.F, 77, 2021
7DSO
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BU of 7dso by Molmil
Anthranilate phosphoribosyltransferase from Saccharomyces cerevisiae in complex with 4-fluoroanthranilate
Descriptor: 2-amino-4-fluorobenzoic acid, Anthranilate phosphoribosyltransferase
Authors:Wu, X.
Deposit date:2020-12-31
Release date:2021-03-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystal structures of anthranilate phosphoribosyltransferase from Saccharomyces cerevisiae.
Acta Crystallogr.,Sect.F, 77, 2021
7DSP
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BU of 7dsp by Molmil
Anthranilate phosphoribosyltransferase variant Ser121Ala from Saccharomyces cerevisiae with Mg bound
Descriptor: Anthranilate phosphoribosyltransferase, MAGNESIUM ION
Authors:Wu, X.
Deposit date:2020-12-31
Release date:2021-03-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of anthranilate phosphoribosyltransferase from Saccharomyces cerevisiae.
Acta Crystallogr.,Sect.F, 77, 2021

 

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