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4NNN
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YCP IN COMPLEX WITH MG132
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-18
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NNW
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YCP IN COMPLEX WITH Z-LEU-LEU-LEU-KETOALDEHYDE
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-19
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NO1
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YCP IN COMPLEX WITH Z-LEU-LEU-LEU-B(OH)2
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-19
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NO6
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YCP IN COMPLEX WITH Z-LEU-LEU-LEU-VINYLSULFONE
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-19
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (3 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NO8
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YCP IN COMPLEX WITH Z-LEU-LEU-LEU-KETOAMIDE
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-19
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
4NO9
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YCP IN COMPLEX WITH Z-LEU-LEU-LEU-EPOXYKETONE
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Stein, M.L., Cui, H., Beck, P., Dubiella, C., Voss, C., Krueger, A., Schmidt, B., Groll, M.
Deposit date:2013-11-19
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Systematic Comparison of Peptidic Proteasome Inhibitors Highlights the alpha-Ketoamide Electrophile as an Auspicious Reversible Lead Motif.
Angew.Chem.Int.Ed.Engl., 53, 2014
4R17
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LIGAND-INDUCED AZIRIDINE-FORMATION AT SUBUNIT BETA5 OF THE YEAST 20S PROTEASOME
Descriptor:Proteasome subunit alpha type-2, Proteasome subunit alpha type-3, Proteasome subunit alpha type-4, ...
Authors:Dubiella, C., Cui, H., Gersch, M., Brouwer, A.J., Sieber, S.A., Krueger, A., Liskamp, R., Groll, M.
Deposit date:2014-08-04
Release date:2014-10-15
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Angew.Chem.Int.Ed.Engl., 53, 2014
4R18
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LIGAND-INDUCED LYS33-THR1 CROSSLINKING AT SUBUNIT BETA5 OF THE YEAST 20S PROTEASOME
Descriptor:PROTEASOME SUBUNIT ALPHA TYPE-2, PROTEASOME SUBUNIT ALPHA TYPE-3, PROTEASOME SUBUNIT ALPHA TYPE-4, ...
Authors:Dubiella, C., Cui, H., Gersch, M., Brouwer, A.J., Sieber, S.A., Krueger, A., Liskamp, R., Groll, M.
Deposit date:2014-08-04
Release date:2014-10-15
Last modified:2014-11-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Angew.Chem.Int.Ed.Engl., 53, 2014