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2CMO
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BU of 2cmo by Molmil
The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209
Descriptor: 2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC ACID, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ...
Authors:Kasper, C, Pickering, D.S, Mirza, O, Olsen, L, Kristensen, A.S, Greenwood, J.R, Liljefors, T, Schousboe, A, Watjen, F, Gajhede, M, Sigurskjold, B.W, Kastrup, J.S.
Deposit date:2006-05-11
Release date:2006-06-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The Structure of a Mixed Glur2 Ligand-Binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-Ns1209.
J.Mol.Biol., 357, 2006
5CC2
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BU of 5cc2 by Molmil
STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE IONOTROPIC GLUTAMATE RECEPTOR-LIKE GLUD2 IN COMPLEX WITH 7-CKA
Descriptor: 7-Chlorokynurenic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Naur, P, Gajhede, M, Kastrup, J.S.
Deposit date:2015-07-01
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.
Mol.Pharmacol., 89, 2016
8QEZ
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BU of 8qez by Molmil
Crystal structure of the AMPA receptor GluA2-L504Y-N775S ligand binding domain in complex with L-glutamate and positive allosteric modulator BPAM395 at 1.55A resolution
Descriptor: 6-chloranyl-4-cyclopropyl-2,3-dihydrothieno[3,2-e][1,2,4]thiadiazine 1,1-dioxide, ACETATE ION, CACODYLATE ION, ...
Authors:Dorosz, J, Laulumaa, S, Frydenvang, K, Kastrup, J.S.
Deposit date:2023-09-01
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators.
Eur.J.Med.Chem., 264, 2023
2WKY
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BU of 2wky by Molmil
Crystal structure of the ligand-binding core of GluR5 in complex with the agonist 4-AHCP
Descriptor: 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE, CHLORIDE ION, GLUTAMATE RECEPTOR, ...
Authors:Naur, P, Gajhede, M, Kastrup, J.S.
Deposit date:2009-06-18
Release date:2009-07-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Glutamate Receptor Glur5 Agonist (S)-2-Amino-3-(3-Hydroxy-7,8-Dihydro-6H-Cyclohepta[D]Isoxazol-4-Yl)Propionic Acid and the 8-Methyl Analogue: Synthesis, Molecular Pharmacology, and Biostructural Characterization
J.Med.Chem., 52, 2009
7PX1
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BU of 7px1 by Molmil
Conotoxin from Conus mucronatus
Descriptor: CADMIUM ION, Conus mucronatus, IODIDE ION
Authors:Mueller, E, Hackney, C.M, Ellgaard, L, Morth, J.P.
Deposit date:2021-10-07
Release date:2022-11-02
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3.
Plos Biol., 21, 2023
7PX2
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BU of 7px2 by Molmil
Conotoxin Mu8.1 from Conus mucronatus
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Conotoxin Mu8.1
Authors:Mueller, E, Hackney, C, Ellgaard, L, Morth, J.P.
Deposit date:2021-10-07
Release date:2022-11-16
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3.
Plos Biol., 21, 2023
8BSU
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BU of 8bsu by Molmil
Crystal structure of the kainate receptor GluK3-H523A ligand binding domain in complex with kainate and the positive allosteric modulator BPAM344 at 2.9A resolution
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ACETATE ION, ...
Authors:Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
Deposit date:2022-11-26
Release date:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Positive allosteric modulation of homomeric kainate receptors GluK1-3
To Be Published
8BST
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BU of 8bst by Molmil
Crystal structure of the kainate receptor GluK3-H523A ligand binding domain in complex with kainate at 2.7A resolution
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, ACETATE ION, CHLORIDE ION, ...
Authors:Venskutonyte, R, Frydenvang, K, Kastrup, J.S.
Deposit date:2022-11-26
Release date:2023-12-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.
Febs J., 2023
2V3T
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BU of 2v3t by Molmil
Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in the apo form
Descriptor: CALCIUM ION, GLUTAMATE RECEPTOR DELTA-2 SUBUNIT SYNONYM GLURDELTA2, GLUR DELTA-2
Authors:Naur, P, Vestergaard, B, Gajhede, M, Kastrup, J.S.
Deposit date:2007-06-22
Release date:2007-08-07
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine.
Proc.Natl.Acad.Sci.USA, 104, 2007
3ZRT
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BU of 3zrt by Molmil
Crystal structure of human PSD-95 PDZ1-2
Descriptor: DISKS LARGE HOMOLOG 4
Authors:Sorensen, P.L, Kastrup, J.S, Gajhede, M.
Deposit date:2011-06-19
Release date:2012-03-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.398 Å)
Cite:A High-Affinity, Dimeric Inhibitor of Psd-95 Bivalently Interacts with Pdz1-2 and Protects Against Ischemic Brain Damage.
Proc.Natl.Acad.Sci.USA, 109, 2012
2V3U
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BU of 2v3u by Molmil
Structure of the ligand-binding core of the ionotropic glutamate receptor-like GluRdelta2 in complex with D-serine
Descriptor: CHLORIDE ION, D-SERINE, GLUTAMATE RECEPTOR DELTA-2 SUBUNIT, ...
Authors:Naur, P, Vestergaard, B, Gajhede, M, Kastrup, J.S.
Deposit date:2007-06-22
Release date:2007-08-07
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Ionotropic Glutamate-Like Receptor {Delta}2 Binds D-Serine and Glycine.
Proc.Natl.Acad.Sci.USA, 104, 2007

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