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4C7A
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BU of 4c7a by Molmil
Crystal structure of the Smoothened CRD, selenomethionine-labeled
Descriptor: SMOOTHENED, SODIUM ION, ZINC ION
Authors:Nachtergaele, S, Whalen, D.M, Mydock, L.K, Zhao, Z, Malinauskas, T, Krishnan, K, Ingham, P.W, Covey, D.F, Rohatgi, R, Siebold, C.
Deposit date:2013-09-20
Release date:2013-11-06
Last modified:2013-11-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Function of the Smoothened Extracellular Domain in Vertebrate Hedgehog Signaling
Elife, 2, 2013
4C79
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BU of 4c79 by Molmil
Crystal structure of the Smoothened CRD, native
Descriptor: SMOOTHENED, SODIUM ION, ZINC ION
Authors:Nachtergaele, S, Whalen, D.M, Mydock, L.K, Zhao, Z, Malinauskas, T, Krishnan, K, Ingham, P.W, Covey, D.F, Rohatgi, R, Siebold, C.
Deposit date:2013-09-20
Release date:2013-11-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Structure and Function of the Smoothened Extracellular Domain in Vertebrate Hedgehog Signaling
Elife, 2, 2013
4Y14
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BU of 4y14 by Molmil
Structure of protein tyrosine phosphatase 1B complexed with inhibitor (PTP1B:CPT157633)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-bromo-4-[difluoro(phosphono)methyl]-N-methyl-Nalpha-(methylsulfonyl)-L-phenylalaninamide, CHLORIDE ION, ...
Authors:Choy, M.S, Connors, C, Page, R, Peti, W.
Deposit date:2015-02-06
Release date:2015-08-05
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.
J.Clin.Invest., 125, 2015
7ZI0
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BU of 7zi0 by Molmil
Structure of human Smoothened in complex with cholesterol and SAG
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide, CHOLESTEROL, ...
Authors:Byrne, E.F.X, Woolley, R.E, Ansell, B, Sansom, M.S.P, Newstead, S, Siebold, C.
Deposit date:2022-04-07
Release date:2022-06-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Sci Adv, 8, 2022

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PDB entries from 2024-03-27

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