Author results

3KIN
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KINESIN (DIMERIC) FROM RATTUS NORVEGICUS
Descriptor:KINESIN HEAVY CHAIN, ADENOSINE-5'-DIPHOSPHATE
Authors:Kozielski, F., Sack, S., Marx, A., Thormahlen, M., Schonbrunn, E., Biou, V., Thompson, A., Mandelkow, E.-M., Mandelkow, E.
Deposit date:1997-08-25
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
Cell(Cambridge,Mass.), 91, 1997
1T5C
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CRYSTAL STRUCTURE OF THE MOTOR DOMAIN OF HUMAN KINETOCHORE PROTEIN CENP-E
Descriptor:Centromeric protein E, MAGNESIUM ION, NITRATE ION, ...
Authors:Garcia-Saez, I., Yen, T., Wade, R.H., Kozielski, F., Structural Proteomics in Europe (SPINE)
Deposit date:2004-05-04
Release date:2005-05-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the motor domain of the human kinetochore protein CENP-E.
J.Mol.Biol., 340, 2004
2E9S
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HUMAN NEURONAL RAB6B IN THREE INTERMEDIATE FORMS
Descriptor:Ras-related protein Rab-6B, NITRATE ION, MAGNESIUM ION, ...
Authors:Vellieux, F.M., Tcherniuk, S., Garcia-Saez, I., Kozielski, F.
Deposit date:2007-01-26
Release date:2008-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:3D structure of human neuronal Rab6B in three intermediate forms
To be Published
6G6Z
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EG5-INHIBITOR COMPLEX
Descriptor:Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Talapatra, S.K., Kozielski, F., Tham, C.L.
Deposit date:2018-04-04
Release date:2018-08-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors.
Eur J Med Chem, 156, 2018
2X2R
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((4-CHLOROPHENYL)DIPHENYLMETHYLTHIO)PROPANOIC ACID
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, (2R)-2-AMINO-3-[(2R)-2-METHYL-1,1-DIPHENYL-BUTYL]SULFANYL-PROPANOIC ACID, ...
Authors:Kaan, H.Y.K., Weiss, J., Menger, D., Ulaganathan, V., Laggner, C., Popowycz, F., Joseph, B., Kozielski, F.
Deposit date:2010-01-15
Release date:2011-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54, 2011
2XAE
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-2-AMINO-3-((S)-2-METHYL-1,1-DIPHENYLBUTYLTHIO)PROPANOIC ACID
Descriptor:KINESIN-LIKE PROTEIN KIF11, (2R)-2-AMINO-3-[(4-CHLOROPHENYL)-DIPHENYL-METHYL]SULFANYL-PROPANOIC ACID, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Weiss, J., Menger, D., Ulaganathan, V., Tkocz, K., Laggner, C., Popowycz, F., Joseph, B., Kozielski, F.
Deposit date:2010-03-31
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Activity Relationship and Multidrug Resistance Study of New S-Trityl-L-Cysteine Derivatives as Inhibitors of Eg5.
J.Med.Chem., 54, 2011
2FE4
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THE CRYSTAL STRUCTURE OF HUMAN NEURONAL RAB6B IN ITS INACTIVE GDP-BOUND FORM
Descriptor:Ras-related protein Rab-6B, MAGNESIUM ION, NITRATE ION, ...
Authors:Garcia-Saez, I., Tcherniuk, F., Kozielski, F.
Deposit date:2005-12-15
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of human neuronal Rab6B in the active and inactive form.
Acta Crystallogr.,Sect.D, 62, 2006
2IEH
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-MON97, A NEW MONASTROL-BASED INHIBITOR THAT BINDS AS (R)-ENANTIOMER
Descriptor:Kinesin-like protein KIF11, MAGNESIUM ION, POTASSIUM ION, ...
Authors:Garcia-Saez, I., Kozielski, F.
Deposit date:2006-09-19
Release date:2007-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.
J.Biol.Chem., 282, 2007
4A50
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH 2-AMINO-5-(3-METHYLPHENYL)-5,5-DIPHENYLPENTANOIC ACID
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Kozielski, F.
Deposit date:2011-10-24
Release date:2012-10-31
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.
J.Med.Chem., 55, 2012
4A51
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH 1-(3-(((2-AMINOETHYL)THIO)DIPHENYLMETHYL)PHENYL)ETHANONE HYDROCHLORIDE
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Kozielski, F.
Deposit date:2011-10-24
Release date:2012-10-31
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.
J.Med.Chem., 55, 2012
4BBG
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH 3-(((2-AMINOETHYL)SULFANYL)(3-ETHYLPHENYL) PHENYLMETHYL)PHENOL
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Kozielski, F.
Deposit date:2012-09-22
Release date:2013-05-15
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Optimized S-Trityl-L-Cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models.
J.Med.Chem., 56, 2013
6H80
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DENGUE-RDRP3-INHIBITOR COMPLEX CO-CRYSTALLISATION
Descriptor:Genome polyprotein, 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, ZINC ION, ...
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2018-07-31
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases.
Biol Open, 8, 2019
6H9R
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DENGUE-RDRP3-INHIBITOR COMPLEX SOAKING
Descriptor:Genome polyprotein, 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, ZINC ION, ...
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2018-08-05
Release date:2019-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases.
Biol Open, 8, 2019
6HKX
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EG5-INHIBITOR COMPLEX
Descriptor:Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, (2~{S})-2-(3-azanylpropyl)-5-[2,5-bis(fluoranyl)phenyl]-~{N}-methoxy-~{N}-methyl-2-phenyl-1,3,4-thiadiazole-3-carboxamide, ...
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2018-09-09
Release date:2019-09-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Is the fate of clinical candidate Arry-520 already sealed? Predicting resistance in Eg5-inhibitor complexes.
Mol.Cancer Ther., 2019
6HKY
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EG5-INHIBITOR COMPLEX
Descriptor:Kinesin-like protein KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Talapatra, S.K., Kozielski, F.
Deposit date:2018-09-09
Release date:2019-09-25
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Is the fate of clinical candidate Arry-520 already sealed? Predicting resistance in Eg5-inhibitor complexes.
Mol.Cancer Ther., 2019
2FFQ
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THE CRYSTAL STRUCTURE OF HUMAN NEURONAL RAB6B IN ITS ACTIVE GTPGS-BOUND FORM
Descriptor:Ras-related protein Rab-6B, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Garcia-Saez, I., Tcherniuk, S., Kozielski, F.
Deposit date:2005-12-20
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:The structure of human neuronal Rab6B in the active and inactive form.
Acta Crystallogr.,Sect.D, 62, 2006
2KIN
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KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS
Descriptor:KINESIN, SULFATE ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Sack, S., Muller, J., Kozielski, F., Marx, A., Thormahlen, M., Biou, V., Mandelkow, E.-M., Brady, S.T., Mandelkow, E.
Deposit date:1997-04-28
Release date:1998-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure of motor and neck domains from rat brain kinesin.
Biochemistry, 36, 1997
2WOG
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INTERMEDIATE AND FINAL STATES OF HUMAN KINESIN EG5 IN COMPLEX WITH S-TRITYL-L-CYSTEINE
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Hackney, D.D., Kozielski, F.
Deposit date:2009-07-23
Release date:2010-08-04
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:An Allosteric Transition Trapped in an Intermediate State of a New Kinesin-Inhibitor Complex.
Biochem.J., 425, 2010
2X7C
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-ENASTRON
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2X7D
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (S)-DIMETHYLENASTRON
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2X7E
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CRYSTAL STRUCTURE OF HUMAN KINESIN EG5 IN COMPLEX WITH (R)-FLUORASTROL
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kaan, H.Y.K., Ulaganathan, V., Rath, O., Laggner, C., Prokopcova, H., Dallinger, D., Kappe, C.O., Kozielski, F.
Deposit date:2010-02-26
Release date:2010-07-14
Last modified:2011-09-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol.
J.Med.Chem., 53, 2010
2XT3
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HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING
Descriptor:KINESIN-LIKE PROTEIN KIF7, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Klejnot, M., Kozielski, F.
Deposit date:2010-10-04
Release date:2011-12-14
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (1.882 Å)
Cite:Structural Insights Into Human Kif7, a Kinesin Involved in Hedgehog Signalling.
Acta Crystallogr.,Sect.D, 68, 2012
2Y5W
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CRYSTAL STRUCTURE OF DROSOPHILA MELANOGASTER KINESIN-1 MOTOR DOMAIN DIMER
Descriptor:KINESIN HEAVY CHAIN, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Kaan, H.Y.K., Hackney, D.D., Kozielski, F.
Deposit date:2011-01-18
Release date:2011-08-24
Last modified:2011-08-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition.
Science, 333, 2011
2Y65
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CRYSTAL STRUCTURE OF DROSOPHILA MELANOGASTER KINESIN-1 MOTOR DOMAIN DIMER-TAIL COMPLEX
Descriptor:KINESIN HEAVY CHAIN, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Kaan, H.Y.K., Hackney, D.D., Kozielski, F.
Deposit date:2011-01-19
Release date:2011-08-24
Last modified:2015-09-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structure of the Kinesin-1 Motor-Tail Complex Reveals the Mechanism of Autoinhibition.
Science, 333, 2011
3ZCW
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EG5 - NEW ALLOSTERIC BINDING SITE
Descriptor:KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ulaganathan, V., Talapatra, S.K., Kozielski, F., Pannifer, A.D.
Deposit date:2012-11-23
Release date:2013-01-23
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.691 Å)
Cite:Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein.
J.Am.Chem.Soc., 135, 2013
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