6H7W
 
 | | Model of retromer-Vps5 complex assembled on membrane. | | Descriptor: | Putative vacuolar protein sorting-associated protein, Vacuolar protein sorting-associated protein 26-like protein, Vacuolar protein sorting-associated protein 29, ... | | Authors: | Kovtun, O, Leneva, N, Ariotti, N, Rohan, T.S, Owen, D.J, Briggs, J.A.G, Collins, B.M. | | Deposit date: | 2018-07-31 | | Release date: | 2018-09-26 | | Last modified: | 2018-10-10 | | Method: | ELECTRON MICROSCOPY (11.4 Å) | | Cite: | Structure of the membrane-assembled retromer coat determined by cryo-electron tomography.
Nature, 561, 2018
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6YAF
 | | AP2 on a membrane containing tyrosine-based cargo peptide | | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Kovtun, O, Kane Dickson, V, Kelly, B.T, Owen, D, Briggs, J.A.G. | | Deposit date: | 2020-03-12 | | Release date: | 2020-07-29 | | Last modified: | 2020-08-19 | | Method: | ELECTRON MICROSCOPY (9.1 Å) | | Cite: | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles.
Sci Adv, 6, 2020
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6YAI
 | | Clathrin with bound beta2 appendage of AP2 | | Descriptor: | AP-2 complex subunit beta, Clathrin heavy chain, Clathrin light chain | | Authors: | Kovtun, O, Kane Dickson, V, Kelly, B.T, Owen, D, Briggs, J.A.G. | | Deposit date: | 2020-03-12 | | Release date: | 2020-07-29 | | Last modified: | 2020-08-19 | | Method: | ELECTRON MICROSCOPY (9.2 Å) | | Cite: | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles.
Sci Adv, 6, 2020
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6YAH
 | | AP2 in clathrin coats assembled on a membrane containing dileucine- and tyrosine-based cargo peptides | | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Kovtun, O, Kane Dickson, V, Kelly, B.T, Owen, D, Briggs, J.A.G. | | Deposit date: | 2020-03-12 | | Release date: | 2020-07-29 | | Last modified: | 2020-08-19 | | Method: | ELECTRON MICROSCOPY (10.2 Å) | | Cite: | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles.
Sci Adv, 6, 2020
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4QKV
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4QKW
 | | Crystal structure of the zebrafish cavin4a HR1 domain | | Descriptor: | CHLORIDE ION, Muscle-related coiled-coil protein | | Authors: | Kovtun, O, Tillu, V, Parton, R.G, Collins, B.M. | | Deposit date: | 2014-06-10 | | Release date: | 2015-03-18 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural insights into the organization of the cavin membrane coat complex
Dev.Cell, 31, 2014
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6YAE
 | | AP2 core in physiological buffer | | Descriptor: | AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Kane Dickson, V, Kovtun, O, Kelly, B.T, Owen, D.J, Briggs, J.A.G. | | Deposit date: | 2020-03-12 | | Release date: | 2020-07-29 | | Last modified: | 2020-08-19 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Architecture of the AP2/clathrin coat on the membranes of clathrin-coated vesicles.
Sci Adv, 6, 2020
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3OGO
 | | Structure of the GFP:GFP-nanobody complex at 2.8 A resolution in spacegroup P21212 | | Descriptor: | GFP-nanobody, Green fluorescent protein, ISOPROPYL ALCOHOL | | Authors: | Kubala, M.H, Kovtun, O, Alexandrov, K, Collins, B.M. | | Deposit date: | 2010-08-17 | | Release date: | 2010-08-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural and thermodynamic analysis of the GFP:GFP-nanobody complex.
Protein Sci., 19, 2010
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7BL1
 | | human complex II-BATS bound to membrane-attached Rab5a-GTP | | Descriptor: | Beclin-1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Tremel, S, Morado, D.R, Kovtun, O, Williams, R.L, Briggs, J.A.G, Munro, S, Ohashi, Y, Bertram, J, Perisic, O. | | Deposit date: | 2021-01-17 | | Release date: | 2021-03-03 | | Last modified: | 2021-03-24 | | Method: | ELECTRON MICROSCOPY (9.8 Å) | | Cite: | Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.
Nat Commun, 12, 2021
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7BLN
 | | VPS35/VPS29 arch of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins | | Descriptor: | Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | | Authors: | Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J. | | Deposit date: | 2021-01-18 | | Release date: | 2021-02-10 | | Last modified: | 2021-04-07 | | Method: | ELECTRON MICROSCOPY (8.9 Å) | | Cite: | Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.
Sci Adv, 7, 2021
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7BLR
 | | Vps35/Vps29 arch of fungal membrane-assembled retromer:Vps5 (SNX-BAR) complex. | | Descriptor: | Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | | Authors: | Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J. | | Deposit date: | 2021-01-18 | | Release date: | 2021-02-10 | | Last modified: | 2021-04-07 | | Method: | ELECTRON MICROSCOPY (9.3 Å) | | Cite: | Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.
Sci Adv, 7, 2021
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7BLP
 | | Vps35/Vps29 arch of fungal membrane-assembled retromer:Grd19 complex | | Descriptor: | Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | | Authors: | Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J. | | Deposit date: | 2021-01-18 | | Release date: | 2021-02-10 | | Last modified: | 2021-04-07 | | Method: | ELECTRON MICROSCOPY (9.5 Å) | | Cite: | Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.
Sci Adv, 7, 2021
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7BLO
 | | VPS26 dimer region of metazoan membrane-assembled retromer:SNX3 complex modelled with human proteins | | Descriptor: | 2-(BUTANOYLOXY)-1-{[(HYDROXY{[2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL BUTANOATE, C-term (residues 493-54) of Wls (fitted sequence corresponds to hDMT1-II), Sorting nexin-3, ... | | Authors: | Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J. | | Deposit date: | 2021-01-18 | | Release date: | 2021-03-03 | | Last modified: | 2021-04-07 | | Method: | ELECTRON MICROSCOPY (9.5 Å) | | Cite: | Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.
Sci Adv, 7, 2021
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7BLQ
 | | Vps26 dimer region of the fungal membrane-assembled retromer:Grd19 complex. | | Descriptor: | 2-(BUTANOYLOXY)-1-{[(HYDROXY{[2,3,4,6-TETRAHYDROXY-5-(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL)OXY]METHYL}ETHYL BUTANOATE, Sorting nexin-3, The C-terminal portion of Kex2 cargo, ... | | Authors: | Leneva, N, Kovtun, O, Morado, D.R, Briggs, J.A.G, Owen, D.J. | | Deposit date: | 2021-01-18 | | Release date: | 2021-03-03 | | Last modified: | 2021-04-07 | | Method: | ELECTRON MICROSCOPY (9.2 Å) | | Cite: | Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly.
Sci Adv, 7, 2021
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4PQP
 | | Crystal structure of human SNX14 PX domain in space group P43212 | | Descriptor: | GLYCEROL, Sorting nexin-14 | | Authors: | Mas, C, Norwood, S, Bugarcic, A, Kinna, G, Leneva, N, Kovtun, O, Teasdale, R, Collins, B. | | Deposit date: | 2014-03-03 | | Release date: | 2014-09-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural Basis for Different Phosphoinositide Specificities of the PX Domains of Sorting Nexins Regulating G-protein Signaling.
J.Biol.Chem., 289, 2014
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4PQO
 | | Structure of the human SNX14 PX domain in space group I41 | | Descriptor: | Sorting nexin-14 | | Authors: | Mas, C, Norwood, S, Bugarcic, A, Kinna, G, Leneva, N, Kovtun, O, Teasdale, R, Collins, B. | | Deposit date: | 2014-03-03 | | Release date: | 2014-09-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structural Basis for Different Phosphoinositide Specificities of the PX Domains of Sorting Nexins Regulating G-protein Signaling.
J.Biol.Chem., 289, 2014
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5W8M
 | | Crystal structure of Chaetomium thermophilum Vps29 | | Descriptor: | GLYCEROL, TRIETHYLENE GLYCOL, Vacuolar protein sorting-associated protein 29 | | Authors: | Collins, B.M, Leneva, N. | | Deposit date: | 2017-06-21 | | Release date: | 2018-06-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Structure of the membrane-assembled retromer coat determined by cryo-electron tomography.
Nature, 561, 2018
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7Z5C
 | | Chimera of AP2 with FCHO2 linker domain as a fusion on Cmu2 subunit | | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Kane Dickson, V, Qu, K, Owen, D.J, Briggs, J.A, Zaccai, N.R. | | Deposit date: | 2022-03-09 | | Release date: | 2022-05-11 | | Method: | ELECTRON MICROSCOPY (4.16 Å) | | Cite: | FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
Sci Adv, 8, 2022
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4LFT
 | | Structure of alpha-elapitoxin-Dpp2d isolated from Black Mamba (Dendroaspis polylepis) venom | | Descriptor: | Alpha-elapitoxin-Dpp2a | | Authors: | Wang, C.I.A, Reeks, T, Lewis, R.J, Alewood, P.F, Durek, T. | | Deposit date: | 2013-06-27 | | Release date: | 2014-06-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Isolation and Structural and Pharmacological Characterization of alpha-Elapitoxin-Dpp2d, an Amidated Three Finger Toxin from Black Mamba Venom.
Biochemistry, 53, 2014
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4P2I
 | | Crystal structure of the mouse SNX19 PX domain | | Descriptor: | MKIAA0254 protein | | Authors: | Collins, B.M. | | Deposit date: | 2014-03-04 | | Release date: | 2014-09-03 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Basis for Different Phosphoinositide Specificities of the PX Domains of Sorting Nexins Regulating G-protein Signaling.
J.Biol.Chem., 289, 2014
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4P2J
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7OIT
 | | Crystal structure of AP2 Mu2 in complex with FCHO2 WxxPhi motif (P3221 crystal form) | | Descriptor: | AP-2 complex subunit mu, F-BAR domain only protein 2, GLYCEROL | | Authors: | Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J. | | Deposit date: | 2021-05-12 | | Release date: | 2022-06-01 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
Sci Adv, 8, 2022
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7OHI
 | | FCHO1-peptide-AP2 alpha ear complex | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, AP-2 complex subunit alpha-2, F-BAR domain only protein 1, ... | | Authors: | Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J. | | Deposit date: | 2021-05-11 | | Release date: | 2022-06-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.41 Å) | | Cite: | FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
Sci Adv, 8, 2022
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7OG1
 | | AP2 clathrin adaptor core in complex with cargo peptide and FCHO2 | | Descriptor: | AP-2 complex subunit alpha-2, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J. | | Deposit date: | 2021-05-05 | | Release date: | 2022-06-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
Sci Adv, 8, 2022
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7OHZ
 | | Crystal structure of AP2 Mu2 - FCHO2 chimera (His6-tagged) | | Descriptor: | AP-2 complex subunit mu,F-BAR domain only protein 2 | | Authors: | Zaccai, N.R, Kelly, B.T, Evans, P.R, Owen, D.J. | | Deposit date: | 2021-05-11 | | Release date: | 2022-06-01 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
Sci Adv, 8, 2022
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