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1AFV
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BU of 1afv by Molmil
HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3
Descriptor: ANTIBODY FAB25.3 FRAGMENT (HEAVY CHAIN), ANTIBODY FAB25.3 FRAGMENT (LIGHT CHAIN), HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 CAPSID PROTEIN, ...
Authors:Momany, C, Kovari, L.C, Prongay, A.J, Keller, W, Gitti, R.K, Lee, B.M, Gorbalenya, A.E, Tong, L, Mcclure, J, Ehrlich, L.S, Summers, M.F, Carter, C, Rossmann, M.G.
Deposit date:1997-03-14
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal structure of dimeric HIV-1 capsid protein.
Nat.Struct.Biol., 3, 1996
6B6I
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BU of 6b6i by Molmil
2.4A resolution structure of human Norovirus GII.4 protease
Descriptor: 3C-like protease
Authors:Muzzarelli, K.M, Kuiper, B.D, Spellmon, N.S, Hackett, J, Brunzelle, J.S, Kovari, I.A, Amblard, F, Yang, Z, Schinazi, R.F, Kovari, L.C.
Deposit date:2017-10-02
Release date:2018-10-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structural and Antiviral Studies of the Human Norovirus GII.4 Protease.
Biochemistry, 58, 2019
4YOA
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BU of 4yoa by Molmil
Crsystal structure HIV-1 Protease MDR769 L33F Complexed with darunavir
Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, HIV-1 Protease
Authors:Kuiper, B.D, Keusch, B, Dewdney, T.G, Chordia, P, Brunzelle, J.S, Ross, K, Kovari, I.A, MacArthur, R, Salimnia, H, Kovari, L.C.
Deposit date:2015-03-11
Release date:2015-07-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.697 Å)
Cite:The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.
Biochem Biophys Rep, 2, 2015
4YOB
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BU of 4yob by Molmil
Crystal Structure of Apo HIV-1 Protease MDR769 L33F
Descriptor: HIV-1 Protease
Authors:Kuiper, B.D, Keusch, B, Dewdney, T.G, Chordia, P, Ross, K, Brunzelle, J.S, Kovari, I.A, MacArthur, R, Salimnia, H, Kovari, L.C.
Deposit date:2015-03-11
Release date:2015-07-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.504 Å)
Cite:The L33F darunavir resistance mutation acts as a molecular anchor reducing the flexibility of the HIV-1 protease 30s and 80s loops.
Biochem Biophys Rep, 2, 2015
3R0Y
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BU of 3r0y by Molmil
Crystal Structures of Multidrug-resistant HIV-1 Protease in Complex with Mechanism-Based Aspartyl Protease Inhibitors
Descriptor: Multidrug-resistant clinical isolate 769 HIV-1 Protease, N-[(2S)-1-{[(2S,3S)-3-hydroxy-5-oxo-5-{[(2R)-1-oxo-3-phenyl-1-(prop-2-yn-1-ylamino)propan-2-yl]amino}-1-phenylpentan-2-yl]amino}-3-methyl-1-oxobutan-2-yl]pyridine-2-carboxamide
Authors:Yedidi, R.S, Gupta, D, Liu, Z, Brunzelle, J, Kovari, I.A, Woster, P.M, Kovari, L.C.
Deposit date:2011-03-09
Release date:2012-04-04
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.
Biochem.Biophys.Res.Commun., 421, 2012
3SO9
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BU of 3so9 by Molmil
Darunavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, HIV-1 protease
Authors:Wang, Y, Liu, Z, Brunzelle, S.J, Kovari, L.C, Kovari, I.A.
Deposit date:2011-06-30
Release date:2011-10-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.
Biochem.Biophys.Res.Commun., 412, 2011
3SPK
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BU of 3spk by Molmil
Tipranavir in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
Descriptor: HIV-1 protease, N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE
Authors:Wang, Y, Liu, Z, Brunzelle, J.S, Kovari, I.A, Kovari, L.C.
Deposit date:2011-07-01
Release date:2011-10-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:The higher barrier of darunavir and tipranavir resistance for HIV-1 protease.
Biochem.Biophys.Res.Commun., 412, 2011
4NKK
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BU of 4nkk by Molmil
Crystal structure of a multi-drug resistant clinical isolate-769 HIV-1 protease variant that is resistant to the dimerization inhibitory activity of TLF-PafF
Descriptor: HIV-1 protease
Authors:Yedidi, R.S, Proteasa, G, Kovari, L.C.
Deposit date:2013-11-12
Release date:2014-07-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF.
J.Mol.Graph.Model., 53C, 2014
1TW7
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BU of 1tw7 by Molmil
Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target
Descriptor: SODIUM ION, protease
Authors:Martin, P, Vickrey, J.F, Proteasa, G, Jimenez, Y.L, Wawrzak, Z, Winters, M.A, Merigan, T.C, Kovari, L.C.
Deposit date:2004-06-30
Release date:2005-07-19
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Wide Open 1.3A Structure of a Multi-drug Resistant HIV-1 Protease Represents a Novel Drug Target
Structure, 13, 2005
4FAF
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BU of 4faf by Molmil
Substrate CA/p2 in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
Descriptor: HIV-1 protease, substrate CA/p2 peptide
Authors:Wang, Y, Dewdney, T.G, Liu, Z, Reiter, S.J, Brunzelle, J.S, Kovari, I.A, Kovari, L.C.
Deposit date:2012-05-22
Release date:2012-08-29
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease.
Biology (Basel), 1, 2012
4EYR
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BU of 4eyr by Molmil
Crystal structure of multidrug-resistant clinical isolate 769 HIV-1 protease in complex with ritonavir
Descriptor: HIV-1 PROTEASE, RITONAVIR
Authors:Liu, Z, Yedidi, R.S, Wang, Y, Brunzelle, J.S, Kovari, I.A, Kovari, L.C.
Deposit date:2012-05-01
Release date:2013-01-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex.
Biochem.Biophys.Res.Commun., 431, 2013
4FAE
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BU of 4fae by Molmil
Substrate p2/NC in Complex with a Human Immunodeficiency Virus Type 1 Protease Variant
Descriptor: HIV-1 protease, Substrate p2/NC peptide
Authors:Wang, Y, Dewdney, T.G, Liu, Z, Reiter, S.J, Brunzelle, J.S, Kovari, I.A, Kovari, L.C.
Deposit date:2012-05-22
Release date:2012-08-29
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease.
Biology (Basel), 1, 2012
4GYE
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BU of 4gye by Molmil
MDR 769 HIV-1 Protease in Complex with Reduced P1F
Descriptor: P1F peptide, Protease
Authors:Dewdney, T.G, Wang, Y, Brunzelle, J, Reiter, S.J, Kovari, I.A, Kovari, L.C.
Deposit date:2012-09-05
Release date:2013-10-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease.
Bioorg.Med.Chem., 21, 2013
4GZF
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BU of 4gzf by Molmil
Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide
Descriptor: LrF peptide, Protease
Authors:Dewdney, T.G, Wang, Y, Kovari, I.A, Brunzelle, J.S, Reiter, S.J, Kovari, L.C.
Deposit date:2012-09-06
Release date:2013-10-30
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease.
Bioorg.Med.Chem., 21, 2013
1RV7
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BU of 1rv7 by Molmil
Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity
Descriptor: N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, protease
Authors:Logsdon, B.C, Vickrey, J.F, Martin, P, Proteasa, G, Koepke, J.I, Terlecky, S.R, Wawrzak, Z, Winters, M.A, Merigan, T.C, Kovari, L.C.
Deposit date:2003-12-12
Release date:2004-12-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity.
J.Virol., 78, 2004
1RPI
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BU of 1rpi by Molmil
Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity
Descriptor: alpha-D-glucopyranose, protease
Authors:Logsdon, B.C, Vickrey, J.F, Martin, P, Proteasa, G, Koepke, J.I, Terlecky, S.R, Wawrzak, Z, Winters, M.A, Merigan, T.C, Kovari, L.C.
Deposit date:2003-12-03
Release date:2004-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity.
J.Virol., 78, 2004
1RQ9
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BU of 1rq9 by Molmil
Crystal structures of a Multidrug-Resistant HIV-1 Protease Reveal an Expanded Active Site Cavity
Descriptor: [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-1,3-BIS([(3-AMINO)PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)-2H-1,3-DIAZEPINONE, protease
Authors:Logsdon, B.C, Vickrey, J.F, Martin, P, Proteasa, G, Koepke, J.I, Terlecky, S.R, Wawrzak, Z, Winters, M.A, Merigan, T.C, Kovari, L.C.
Deposit date:2003-12-04
Release date:2004-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity.
J.Virol., 78, 2004
3OAI
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BU of 3oai by Molmil
Crystal structure of the extra-cellular domain of human myelin protein zero
Descriptor: Maltose-binding periplasmic protein, Myelin protein P0, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Sohi, J, Kamholz, J, Kovari, L.C.
Deposit date:2010-08-05
Release date:2011-12-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the extracellular domain of human myelin protein zero.
Proteins, 80, 2012
3OTS
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BU of 3ots by Molmil
MDR769 HIV-1 protease complexed with MA/CA hepta-peptide
Descriptor: MA/CA substrate peptide, Multi-drug resistant HIV-1 protease
Authors:Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C.
Deposit date:2010-09-13
Release date:2011-03-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
3OTY
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BU of 3oty by Molmil
MDR769 HIV-1 protease complexed with RT/RH hepta-peptide
Descriptor: MDR HIV-1 protease, RT/RH substrate peptide
Authors:Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C.
Deposit date:2010-09-14
Release date:2011-03-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
3OUA
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BU of 3oua by Molmil
MDR769 HIV-1 protease complexed with p1/p6 hepta-peptide
Descriptor: HIV-1 protease, p1/p6 substrate peptide
Authors:Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C.
Deposit date:2010-09-14
Release date:2011-03-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
3OU1
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BU of 3ou1 by Molmil
MDR769 HIV-1 protease complexed with RH/IN hepta-peptide
Descriptor: MDR HIV-1 protease, RH/IN substrate peptide
Authors:Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C.
Deposit date:2010-09-14
Release date:2011-03-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
3OU4
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BU of 3ou4 by Molmil
MDR769 HIV-1 protease complexed with TF/PR hepta-peptide
Descriptor: HIV-1 protease, TF/PR substrate peptide
Authors:Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C.
Deposit date:2010-09-14
Release date:2011-03-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
3OU3
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BU of 3ou3 by Molmil
MDR769 HIV-1 protease complexed with PR/RT hepta-peptide
Descriptor: HIV-1 protease, PR/RT substrate peptide
Authors:Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C.
Deposit date:2010-09-14
Release date:2011-03-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
3OUC
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BU of 3ouc by Molmil
MDR769 HIV-1 protease complexed with p2/NC hepta-peptide
Descriptor: MDR HIV-1 protease, p2/NC substrate peptide
Authors:Liu, Z, Wang, Y, Brunzelle, J, Kovari, I.A, Kovari, L.C.
Deposit date:2010-09-14
Release date:2011-03-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011

 

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