7TW9
 
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7TW7
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7TW8
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8FRK
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8FRJ
 | | Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC0946 | | Descriptor: | 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Transcription factor ETV6,Guanine-N7 methyltransferase nsp14 chimera, ZINC ION | | Authors: | Kottur, J, Aggarwal, A.K. | | Deposit date: | 2023-01-07 | | Release date: | 2023-07-26 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
Plos Pathog., 19, 2023
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4Q43
 | | Polymerase-damaged DNA complex | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, DNA (5'-D(*T*CP*TP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA (5'-D(*TP*CP*TP*(RDG)P*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Kottur, J, Sharma, A, Nair, D.T. | | Deposit date: | 2014-04-13 | | Release date: | 2015-05-06 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic
Structure, 23, 2015
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4Q45
 | | DNA Polymerase- damaged DNA complex | | Descriptor: | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, DNA (5'-D(*TP*CP*TP*A*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA (5'-D(*TP*CP*TP*AP*GP*GP*(RDG)P*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), ... | | Authors: | Kottur, J, Sharma, A, Nair, D.T. | | Deposit date: | 2014-04-13 | | Release date: | 2015-05-06 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.176 Å) | | Cite: | Unique structural features in DNA polymerase IV enable efficient bypass of the N2 adduct induced by the nitrofurazone antibiotic
Structure, 23, 2015
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6IG1
 | | DNA polymerase IV - DNA ternary complex 10 | | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN3, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2018-09-21 | | Release date: | 2018-11-28 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.97 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction.
Nucleic Acids Res., 46, 2018
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5YUR
 | | DNA polymerase IV - DNA ternary complex 1 | | Descriptor: | DNA polymerase IV, DTN, SODIUM ION, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-08-29 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.035 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YUY
 | | DNA polymerase IV - DNA ternary complex 9 | | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-10-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YUT
 | | DNA polymerase IV - DNA ternary complex 3 | | Descriptor: | DNA polymerase IV, DTN, MAGNESIUM ION, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-09-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YUZ
 | | DNA polymerase IV - DNA ternary complex 11 | | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN1, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-11-14 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction.
Nucleic Acids Res., 46, 2018
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5YUW
 | | DNA polymerase IV - DNA ternary complex 6 | | Descriptor: | DNA polymerase IV, DTN1, DTN2C, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-11-07 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.124 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YYE
 | | DNA polymerase IV - ternary complex 16 | | Descriptor: | 5'-O-[hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]thymidine, DNA polymerase IV, DTN2, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-12-08 | | Release date: | 2018-09-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.325 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YV1
 | | DNA polymerase IV - DNA ternary complex 13 | | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN1, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-09-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YV3
 | | DNA polymerase IV - DNA ternary complex 7 | | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN1, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-11-07 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YV0
 | | DNA polymerase IV - DNA ternary complex 12 | | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN1, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-11-14 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction.
Nucleic Acids Res., 46, 2018
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5YUU
 | | DNA polymerase IV - DNA ternary complex 4 | | Descriptor: | DNA polymerase IV, DTN1, DTN2, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2019-01-02 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.892 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YUS
 | | DNA polymerase IV - DNA ternary complex 2 | | Descriptor: | DNA polymerase IV, DTN, MAGNESIUM ION, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-11-07 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YUX
 | | DNA polymerase IV - DNA ternary complex 8 | | Descriptor: | DIPHOSPHATE, DNA polymerase IV, DTN1, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-12-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.04 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YUV
 | | DNA polymerase IV - DNA ternary complex 5 | | Descriptor: | DNA polymerase IV, DTN1, DTN2, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-10-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YV2
 | | DNA polymerase IV - DNA ternary complex 14 | | Descriptor: | DNA polymerase IV, DTN1, DTN2, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-11-23 | | Release date: | 2018-09-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5YYD
 | | DNA polymerase IV - ternary complex 15 | | Descriptor: | 5'-O-[hydroxy{[hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]thymidine, DNA polymerase IV, DTN2, ... | | Authors: | Kottur, J, Nair, D.T. | | Deposit date: | 2017-12-08 | | Release date: | 2018-09-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction
Nucleic Acids Res., 46, 2018
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5ZLV
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7JTP
 | | Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | | Descriptor: | Elongin-B, Elongin-C, GLYCEROL, ... | | Authors: | Kottur, J, Jain, R, Aggarwal, A.K. | | Deposit date: | 2020-08-18 | | Release date: | 2021-10-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Sci Transl Med, 13, 2021
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