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6NUI
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BU of 6nui by Molmil
Human Guanylate Kinase
Descriptor: Guanylate kinase
Authors:Sabo, T.M, Khan, N, Ban, D, Trigo-Mourino, P, Carneiro, M.G, Trent, J.O, Konrad, M, Lee, D.
Deposit date:2019-02-01
Release date:2019-06-26
Last modified:2019-08-14
Method:SOLUTION NMR
Cite:Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer.
J.Biol.Chem., 294, 2019
3TMK
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BU of 3tmk by Molmil
CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION
Descriptor: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, THYMIDYLATE KINASE
Authors:Lavie, A, Schlichting, I, Konrad, M, Goody, R.S, Brundiers, R, Reinstein, J.
Deposit date:1998-01-26
Release date:1999-02-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.
Biochemistry, 37, 1998
1KGD
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Crystal Structure of the Guanylate Kinase-like Domain of Human CASK
Descriptor: FORMIC ACID, PERIPHERAL PLASMA MEMBRANE CASK
Authors:Li, Y, Spangenberg, O, Paarmann, I, Konrad, M, Lavie, A.
Deposit date:2001-11-26
Release date:2001-12-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.314 Å)
Cite:Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains.
J.Biol.Chem., 277, 2002
1LVG
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Crystal structure of mouse guanylate kinase in complex with GMP and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-MONOPHOSPHATE, Guanylate kinase, ...
Authors:Sekulic, N, Shuvalova, L, Spangenberg, O, Konrad, M, Lavie, A.
Deposit date:2002-05-28
Release date:2002-12-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural characterization of the closed conformation of mouse guanylate kinase.
J.Biol.Chem., 277, 2002
1TEV
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Crystal structure of the human UMP/CMP kinase in open conformation
Descriptor: SULFATE ION, UMP-CMP kinase
Authors:Segura-Pena, D, Sekulic, N, Ort, S, Konrad, M, Lavie, A.
Deposit date:2004-05-25
Release date:2004-06-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Substrate-induced Conformational Changes in Human UMP/CMP Kinase.
J.Biol.Chem., 279, 2004
1E9A
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Human thymidylate kinase complexed with the bisubstrate inhibitor AZTP5A
Descriptor: MAGNESIUM ION, P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE, THYMIDYLATE KINASE
Authors:Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9C
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Mutant human thymidylate kinase complexed with TMP and APPNP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-11
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9E
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Mutant human thymidylate kinase (F105Y) complexed with dTMP and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
Authors:Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
Deposit date:2000-10-11
Release date:2001-10-11
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E99
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Human thymidylate kinase complexed with AZTMP and ADP
Descriptor: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reinstein, J, Goody, R.S, Konrad, M, Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9D
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Mutant human thymidylate kinase (F105Y) complexed with AZTMP and ADP
Descriptor: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-11
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9F
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Mutant human thymidylate kinase complexed with TMP and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
Authors:Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reinstein, J, Goody, R.S, Konrad, M, Schlichting, I.
Deposit date:2000-10-11
Release date:2001-10-11
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E98
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Wild type human thymidylate kinase complexed with AZTMP and ADP
Descriptor: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
1E9B
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BU of 1e9b by Molmil
Human thymidylate kinase complexed with AZTMP and APPNP
Descriptor: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N, Lavie, A, Padiyar, S, Brundiers, R, Veit, T, Reintein, J, Goody, R.S, Konrad, M, Schlichting, I.
Deposit date:2000-10-10
Release date:2001-10-05
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Potentiating Azt Activation: Structures of Wildtype and Mutant Human Thymidylate Kinase Suggest Reasons for the Mutants' Improved Kinetics with the HIV Prodrug Metabolite Aztmp
J.Mol.Biol., 304, 2000
2A30
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BU of 2a30 by Molmil
Crystal structure of human deoxycytidine kinase in complex with deoxycytidine
Descriptor: 2'-DEOXYCYTIDINE, CALCIUM ION, Deoxycytidine kinase
Authors:Godsey, M.H, Ort, S, Sabini, E, Konrad, M, Lavie, A.
Deposit date:2005-06-23
Release date:2006-01-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.
Biochemistry, 45, 2006
2A2Z
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Crystal Structure of human deoxycytidine kinase in complex with deoxycytidine and uridine diphosphate
Descriptor: 2'-DEOXYCYTIDINE, CALCIUM ION, Deoxycytidine kinase, ...
Authors:Godsey, M.H, Ort, S, Sabini, E, Konrad, M, Lavie, A.
Deposit date:2005-06-23
Release date:2006-01-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Structural basis for the preference of UTP over ATP in human deoxycytidine kinase: illuminating the role of main-chain reorganization.
Biochemistry, 45, 2006
1NN5
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BU of 1nn5 by Molmil
Crystal structure of human thymidylate kinase with d4TMP + AppNHp
Descriptor: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN0
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Crystal structure of human thymidylate kinase with ddTMP and ADP
Descriptor: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NMZ
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Crystal structure of human thymidylate kinase with NH2TMP and AppNHp
Descriptor: 3'-DEOXY-3'-AMINOTHYMIDINE MONOPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NMY
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Crystal structure of human thymidylate kinase with FLTMP and AppNHp
Descriptor: 3'-FLUORO-3'-DEOXYTHYMIDINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN3
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Crystal structure of human thymidylate kinase with d4TMP + ADP
Descriptor: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NMX
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Crystal structure of human thymidylate kinase with FLTMP and ADP
Descriptor: 3'-FLUORO-3'-DEOXYTHYMIDINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1NN1
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Crystal structure of human thymidylate kinase with ddTMP and AppNHp
Descriptor: 3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ostermann, N, Segura-Pena, D, Meier, C, Veit, T, Monnerjahn, M, Konrad, M, Lavie, A.
Deposit date:2003-01-12
Release date:2003-03-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds
Biochemistry, 42, 2003
1E2F
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Human thymidylate kinase complexed with thymidine monophosphate, adenosine diphosphate and a magnesium-ion
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A.
Deposit date:2000-05-22
Release date:2001-05-17
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1E2Q
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Human thymidylate kinase complexed with TP5A and a magnesium-ion
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, THYMIDINE-5'-PHOSPHATE, ...
Authors:Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A.
Deposit date:2000-05-23
Release date:2001-05-17
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000
1E2E
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Human thymidylate kinase complexed with thymidine monophosphate, adenosine diphosphate,a magnesium-ion and ALf3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, MAGNESIUM ION, ...
Authors:Ostermann, N, Schlichting, I, Brundiers, R, Konrad, M, Reinstein, J, Veit, T, Goody, R.S, Lavie, A.
Deposit date:2000-05-22
Release date:2001-05-17
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8, 2000

 

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