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2JF5
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BU of 2jf5 by Molmil
crystal structure of Lys63-linked di-ubiquitin
Descriptor: CADMIUM ION, CHLORIDE ION, COBALT (II) ION, ...
Authors:Komander, D, Odenwaelder, P, Barford, D.
Deposit date:2007-01-26
Release date:2008-02-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Molecular Discrimination of Structurally Equivalent Lys 63-Linked and Linear Polyubiquitin Chains.
Embo Rep., 10, 2009
2BIY
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BU of 2biy by Molmil
Structure of PDK1-S241A mutant kinase domain
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ...
Authors:Komander, D, Kular, G.S, Deak, M, Alessi, D.R, van Aalten, D.M.F.
Deposit date:2005-01-26
Release date:2005-02-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.
J. Biol. Chem., 280, 2005
1OKY
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BU of 1oky by Molmil
Structure of human PDK1 kinase domain in complex with staurosporine
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, STAUROSPORINE, ...
Authors:Komander, D, Kular, G.S, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-08-01
Release date:2004-07-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Biochem.J., 375, 2003
1OKZ
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BU of 1okz by Molmil
Structure of human PDK1 kinase domain in complex with UCN-01
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, 7-HYDROXYSTAUROSPORINE, GLYCEROL, ...
Authors:Komander, D, Kular, G.S, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-08-01
Release date:2004-07-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Biochem.J., 375, 2003
1W1D
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BU of 1w1d by Molmil
Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to Inositol (1,3,4,5)-tetrakisphosphate
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, GOLD ION, ...
Authors:Komander, D, Deak, M, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2004-06-21
Release date:2004-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates
Embo J., 23, 2004
2VFJ
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BU of 2vfj by Molmil
Structure of the A20 Ovarian Tumour (OTU) domain
Descriptor: MAGNESIUM ION, SULFATE ION, TUMOR NECROSIS FACTOR
Authors:Komander, D, Barford, D.
Deposit date:2007-11-04
Release date:2007-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the A20 Otu Domain and Mechanistic Insights Into Deubiquitination
Biochem.J., 409, 2008
2V55
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BU of 2v55 by Molmil
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Komander, D, Garg, R, Wan, P.T.C, Ridley, A.J, Barford, D.
Deposit date:2008-10-01
Release date:2008-11-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.705 Å)
Cite:Mechanism of Multi-Site Phosphorylation from a Rock-I:Rhoe Complex Structure.
Embo J., 27, 2008
2VHF
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BU of 2vhf by Molmil
Structure of the CYLD USP domain
Descriptor: UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD, ZINC ION
Authors:Komander, D, Lord, C.J, Scheel, H, Swift, S, Hofmann, K, Ashworth, A, Barford, D.
Deposit date:2007-11-21
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module
Mol.Cell.Biol., 29, 2008
2VSZ
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BU of 2vsz by Molmil
Crystal Structure of the ELMO1 PH domain
Descriptor: ENGULFMENT AND CELL MOTILITY PROTEIN 1
Authors:Komander, D, Patel, M, Barford, D, Cote, J.-F.
Deposit date:2008-05-01
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:An Alpha-Helical Extension of the Elmo1 Pleckstrin Homology Domain Mediates Direct Interaction to Dock180 and is Critical in Rac Signaling.
Molecular Biology of the Cell, 19, 2008
2W9N
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BU of 2w9n by Molmil
crystal structure of linear di-ubiquitin
Descriptor: CHLORIDE ION, UBIQUITIN, ZINC ION
Authors:Komander, D, Reyes-Turcu, F, Wilkinson, K.D, Barford, D.
Deposit date:2009-01-27
Release date:2009-04-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Molecular Discrimination of Structurally Equivalent Lys 63-Linked and Linear Polyubiquitin Chains.
Embo Rep., 10, 2009
1UU8
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BU of 1uu8 by Molmil
Structure of human PDK1 kinase domain in complex with BIM-1
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, GLYCEROL, ...
Authors:Komander, D, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Garrido-Franco, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UVR
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BU of 1uvr by Molmil
Structure of human PDK1 kinase domain in complex with BIM-8
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, GLYCEROL, ...
Authors:Komander, D, Garrido-Franco, M, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2004-01-22
Release date:2004-03-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU7
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BU of 1uu7 by Molmil
Structure of human PDK1 kinase domain in complex with BIM-2
Descriptor: 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, ...
Authors:Komander, D, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Garrido-Franco, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU3
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BU of 1uu3 by Molmil
Structure of human PDK1 kinase domain in complex with LY333531
Descriptor: (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE, 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, ...
Authors:Komander, D, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Garrido-Franco, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-12-15
Release date:2004-03-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU9
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BU of 1uu9 by Molmil
Structure of human PDK1 kinase domain in complex with BIM-3
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, GLYCEROL, ...
Authors:Komander, D, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Garrido-Franco, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1W1G
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BU of 1w1g by Molmil
Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to DiC4-phosphatidylinositol (3,4,5)-trisphosphate
Descriptor: (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXYBUTOXY)PROPYL BUTYRATE, 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1
Authors:Komander, D, Deak, M, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2004-06-21
Release date:2004-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates
Embo J., 23, 2004
1W1H
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BU of 1w1h by Molmil
Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain
Descriptor: 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION
Authors:Komander, D, Deak, M, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2004-06-21
Release date:2004-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates
Embo J., 23, 2004
1E6N
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BU of 1e6n by Molmil
Chitinase B from Serratia marcescens inactive mutant E144Q in complex with N-acetylglucosamine-pentamer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHITINASE B, GLYCEROL, ...
Authors:Komander, D, Synstad, B, Eijsink, V.G.H, Van Aalten, D.M.F.
Deposit date:2000-08-21
Release date:2001-06-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Insights Into the Catalytic Mechanism of a Family 18 Exo-Chitinase
Proc.Natl.Acad.Sci.USA, 98, 2001
1E6R
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BU of 1e6r by Molmil
Chitinase B from Serratia marcescens wildtype in complex with inhibitor allosamidin
Descriptor: 2-acetamido-2-deoxy-beta-D-allopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-allopyranose, ALLOSAMIZOLINE, CHITINASE B, ...
Authors:Komander, D, Synstad, B, Eijsink, V.G.H, Van Aalten, D.M.F.
Deposit date:2000-08-22
Release date:2001-06-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Insights Into the Catalytic Mechanism of a Family 18 Exo-Chitinase
Proc.Natl.Acad.Sci.USA, 98, 2001
1E6Z
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BU of 1e6z by Molmil
CHITINASE B FROM SERRATIA MARCESCENS WILDTYPE IN COMPLEX WITH CATALYTIC INTERMEDIATE
Descriptor: 2-METHYL-4,5-DIHYDRO-(1,2-DIDEOXY-ALPHA-D-GLUCOPYRANOSO)[2,1-D]-1,3-OXAZOLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Komander, D, Synstad, B, Eijsink, V.G.H, Van Aalten, D.M.F.
Deposit date:2000-08-23
Release date:2001-06-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural Insights Into the Catalytic Mechanism of a Family 18 Exo-Chitinase
Proc.Natl.Acad.Sci.USA, 98, 2001
1E6P
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BU of 1e6p by Molmil
Chitinase B from Serratia marcescens inactive mutant E144Q
Descriptor: CHITINASE B, GLYCEROL, SULFATE ION
Authors:Komander, D, Synstad, B, Eijsink, V.G.H, Van Aalten, D.M.F.
Deposit date:2000-08-22
Release date:2001-06-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights Into the Catalytic Mechanism of a Family 18 Exo-Chitinase
Proc.Natl.Acad.Sci.USA, 98, 2001
1GPF
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BU of 1gpf by Molmil
CHITINASE B FROM SERRATIA MARCESCENS IN COMPLEX WITH INHIBITOR PSAMMAPLIN
Descriptor: CHITINASE B, SULFATE ION
Authors:Komander, D, Van Aalten, D.M.
Deposit date:2001-11-03
Release date:2002-10-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Psammaplin A, a Chitinase Inhibitor Isolated from the Fijian Marine Sponge Aplysinella Rhax
Bioorg.Med.Chem., 10, 2002
2UVM
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BU of 2uvm by Molmil
Structure of PKBalpha PH domain in complex with a novel inositol headgroup surrogate, benzene 1,2,3,4-tetrakisphosphate
Descriptor: BENZENE-1,2,3,4-TETRAYL TETRAKIS[DIHYDROGEN (PHOSPHATE)], RAC-ALPHA SERINE/THREONINE-PROTEIN KINASE, SODIUM ION
Authors:Komander, D, Mills, S.J, Trusselle, M.N, Safrany, S.T, van Aalten, D.M.F, Potter, B.V.L.
Deposit date:2007-03-12
Release date:2007-04-17
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Novel Inositol Phospholipid Headgroup Surrogate Crystallised in the Pleckstrin Homology Domain of Protein Kinase Balpha.
Acs Chem.Biol., 2, 2007
2VKI
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BU of 2vki by Molmil
Structure of the PDK1 PH domain K465E mutant
Descriptor: 3-PHOPSHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION
Authors:Komander, D, Bayascas, J.R, Deak, M, Alessi, D.R, van Aalten, D.M.F.
Deposit date:2007-12-19
Release date:2008-05-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mutation of the Pdk1 Ph Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance.
Mol.Cell.Biol., 28, 2008
5C9V
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BU of 5c9v by Molmil
Structure of human Parkin G319A
Descriptor: E3 ubiquitin-protein ligase parkin, GLYCEROL, SULFATE ION, ...
Authors:Wauer, T, Komander, D.
Deposit date:2015-06-29
Release date:2015-07-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Mechanism of phospho-ubiquitin-induced PARKIN activation.
Nature, 524, 2015

217705

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