Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1FKN
DownloadVisualize
BU of 1fkn by Molmil
Structure of Beta-Secretase Complexed with Inhibitor
Descriptor: MEMAPSIN 2, inhibitor
Authors:Hong, L, Koelsch, G, Lin, X, Wu, S, Terzyan, S, Ghosh, A, Zhang, X.C, Tang, J.
Deposit date:2000-08-09
Release date:2000-10-09
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor.
Science, 290, 2000
3PSG
DownloadVisualize
BU of 3psg by Molmil
THE HIGH RESOLUTION CRYSTAL STRUCTURE OF PORCINE PEPSINOGEN
Descriptor: PEPSINOGEN
Authors:Hartsuck, J.A, Koelsch, G, Remington, S.J.
Deposit date:1991-09-03
Release date:1993-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The high-resolution crystal structure of porcine pepsinogen.
Proteins, 13, 1992
1M4H
DownloadVisualize
BU of 1m4h by Molmil
Crystal Structure of Beta-secretase complexed with Inhibitor OM00-3
Descriptor: Inhibitor OM00-3, beta-Secretase
Authors:Hong, L, Turner, R.T, Koelsch, G, Ghosh, A.K, Tang, J.
Deposit date:2002-07-02
Release date:2002-08-28
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Memapsin 2 (beta-Secretase) in Complex with Inhibitor OM00-3
Biochemistry, 41, 2002
1XS7
DownloadVisualize
BU of 1xs7 by Molmil
Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).
Descriptor: Beta-secretase 1, N-[(4S,5S,7R)-8-({(S)-1-[(BENZYLAMINO)OXOMETHYL]-2-METHYLPROPYL}AMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXO-OCT-4-YL]-(4S,7S)-4 -ISOPROPYL-2,5,9-TRIOXO-1-OXA-3,6,10-TRIAZACYCLOHEXADECANE-7-CARBOXAMIDE
Authors:Ghosh, A, Devasamudram, T, Hong, L, DeZutter, C, Xu, X, Weerasena, V, Koelsch, G, Bilcer, G, Tang, J.
Deposit date:2004-10-18
Release date:2004-12-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).
Bioorg.Med.Chem.Lett., 15, 2005
1XN2
DownloadVisualize
BU of 1xn2 by Molmil
New substrate binding pockets for beta-secretase.
Descriptor: Beta-secretase 1, OM03-4
Authors:Turner III, R.T, Hong, L, Koelsch, G, Ghosh, A.K, Tang, J.
Deposit date:2004-10-04
Release date:2005-03-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).
Biochemistry, 44, 2005
1XN3
DownloadVisualize
BU of 1xn3 by Molmil
Crystal structure of Beta-secretase bound to a long inhibitor with additional upstream residues.
Descriptor: Beta-secretase 1, Peptidic inhibitor
Authors:Turner III, R.T, Hong, L, Koelsch, G, Ghosh, A.K, Tang, J.
Deposit date:2004-10-04
Release date:2005-03-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase).
Biochemistry, 44, 2005
2P4J
DownloadVisualize
BU of 2p4j by Molmil
Crystal structure of beta-secretase bond to an inhibitor with Isophthalamide Derivatives at P2-P3
Descriptor: Beta-secretase 1, N-[(1S,2S,4R)-2-HYDROXY-1-ISOBUTYL-5-({(1S)-1-[(ISOPROPYLAMINO)CARBONYL]-2-METHYLPROPYL}AMINO)-4-METHYL-5-OXOPENTYL]-5-[METHYL(METHYLSULFONYL)AMINO]-N'-[(1R)-1-PHENYLETHYL]ISOPHTHALAMIDE
Authors:Hong, L, Ghosh, A.K, Tang, J.
Deposit date:2007-03-12
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
J.Med.Chem., 50, 2007
1PY1
DownloadVisualize
BU of 1py1 by Molmil
Complex of GGA1-VHS domain and beta-secretase C-terminal phosphopeptide
Descriptor: ADP-ribosylation factor binding protein GGA1, Beta-secretase
Authors:Zhu, G, Zhang, X.C.
Deposit date:2003-07-07
Release date:2003-11-04
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.
Biochemistry, 42, 2003
2G94
DownloadVisualize
BU of 2g94 by Molmil
Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.
Descriptor: Beta-secretase 1, N~2~-[(2R,4S,5S)-5-{[N-{[(3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHOXY]CARBONYL}-3-(METHYLSULFONYL)-L-ALANYL]AMINO}-4-HYDROXY-2,7-DIMETHYLOCTANOYL]-N-ISOBUTYL-L-VALINAMIDE
Authors:Hong, L, Ghosh, A, Tang, J.
Deposit date:2006-03-05
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.
J.Am.Chem.Soc., 128, 2006
2VKM
DownloadVisualize
BU of 2vkm by Molmil
Crystal structure of GRL-8234 bound to BACE (Beta-secretase)
Descriptor: BETA-SECRETASE 1, N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide
Authors:Hong, L, Tang, J, Ghosh, A.K.
Deposit date:2007-12-04
Release date:2008-12-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Potent Memapsin 2 (Beta-Secretase) Inhibitors: Design, Synthesis, Protein-Ligand X-Ray Structure, and in Vivo Evaluation.
Bioorg.Med.Chem.Lett., 18, 2008

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon