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4BTH
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THE LEUA146TRP,PHEB24TYR DOUBLE MUTANT OF THE QUORUM QUENCHING N-ACYL HOMOSERINE LACTONE ACYLASE PVDQ HAS AN ALTERED SUBSTRATE SPECIFICITY TOWARDS SMALL ACYL CHAINS
分子名称:ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT ALPHA, ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT BETA, GLYCEROL
著者Koch, G., Nadal-Jimenez, P., Reis, C.R., Muntendam, R., Bokhove, M., Melillo, E., Dijkstra, B.W., Cool, R.H., Quax, W.J.
登録日2013-06-18
公開日2014-01-22
最終更新日2014-02-12
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Reducing Virulence of the Human Pathogen Burkholderia by Altering the Substrate Specificity of the Quorum-Quenching Acylase Pvdq
Proc.Natl.Acad.Sci.USA, 111, 2014
4CGS
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE PA SUBUNIT OF DHORI VIRUS POLYMERASE
分子名称:POLYMERASE SUBUNIT PA, GLYCEROL
著者Guilligay, D., Kadlec, J., Crepin, T., Lunardi, T., Bouvier, D., Kochs, G., Ruigrok, R.W.H., Cusack, S.
登録日2013-11-26
公開日2014-02-05
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase CAP-Snatching Domains.
Plos One, 9, 2014
4CGX
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE PA SUBUNIT OF THOGOTO VIRUS POLYMERASE (FORM 1)
分子名称:POLYMERASE ACIDIC PROTEIN
著者Guilligay, D., Kadlec, J., Crepin, T., Lunardi, T., Bouvier, D., Kochs, G., Ruigrok, R.W.H., Cusack, S.
登録日2013-11-27
公開日2014-02-05
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase CAP-Snatching Domains.
Plos One, 9, 2014
4CHC
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF THE PA SUBUNIT OF THOGOTO VIRUS POLYMERASE (FORM 2)
分子名称:POLYMERASE ACIDIC PROTEIN
著者Guilligay, D., Kadlec, J., Crepin, T., Lunardi, T., Bouvier, D., Kochs, G., Ruigrok, R.W.H., Cusack, S.
登録日2013-12-01
公開日2014-02-05
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase CAP-Snatching Domains.
Plos One, 9, 2014
4CHD
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CRYSTAL STRUCTURE OF THE '627' DOMAIN OF THE PB2 SUBUNIT OF THOGOTO VIRUS POLYMERASE
分子名称:POLYMERASE ACIDIC PROTEIN
著者Guilligay, D., Kadlec, J., Crepin, T., Lunardi, T., Bouvier, D., Kochs, G., Ruigrok, R.W.H., Cusack, S.
登録日2013-12-01
公開日2014-02-05
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase CAP-Snatching Domains.
Plos One, 9, 2014
4CHE
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CRYSTAL STRUCTURE OF THE PUTATIVE CAP-BINDING DOMAIN OF THE PB2 SUBUNIT OF THOGOTO VIRUS POLYMERASE
分子名称:POLYMERASE BASIC PROTEIN 2
著者Guilligay, D., Kadlec, J., Crepin, T., Lunardi, T., Bouvier, D., Kochs, G., Ruigrok, R.W.H., Cusack, S.
登録日2013-12-01
公開日2014-02-05
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase CAP-Snatching Domains.
Plos One, 9, 2014
4CHF
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CRYSTAL STRUCTURE OF THE PUTATIVE CAP-BINDING DOMAIN OF THE PB2 SUBUNIT OF THOGOTO VIRUS POLYMERASE (FORM 2)
分子名称:POLYMERASE BASIC PROTEIN 2
著者Guilligay, D., Kadlec, J., Crepin, T., Lunardi, T., Bouvier, D., Kochs, G., Ruigrok, R.W.H., Cusack, S.
登録日2013-12-01
公開日2014-02-05
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Comparative Structural and Functional Analysis of Orthomyxovirus Polymerase CAP-Snatching Domains.
Plos One, 9, 2014
3KGA
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CRYSTAL STRUCTURE OF MAPKAP KINASE 2 (MK2) COMPLEXED WITH A POTENT 3-AMINOPYRAZOLE ATP SITE INHIBITOR
分子名称:MAP kinase-activated protein kinase 2, MAGNESIUM ION, 6-{3-amino-1-[3-(1H-indol-6-yl)phenyl]-1H-pyrazol-4-yl}-3,4-dihydroisoquinolin-1(2H)-one
著者Kroemer, M., Velcicky, J., Izaac, A., Be, C., Huppertz, C., Pflieger, D., Schlapbach, A., Scheufler, C.
登録日2009-10-28
公開日2010-01-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy.
Bioorg.Med.Chem.Lett., 20, 2010
3LJB
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STRUCTURAL BASIS OF OLIGOMERISATION IN THE MXA STALK
分子名称:Interferon-induced GTP-binding protein Mx1
著者Gao, S., Daumke, O.
登録日2010-01-26
公開日2010-05-05
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis of oligomerization in the stalk region of dynamin-like MxA.
Nature, 465, 2010
3M2W
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CRYSTAL STRUCTURE OF MAPKAK KINASE 2 (MK2) COMPLEXED WITH A SPIROAZETIDINE-TETRACYCLIC ATP SITE INHIBITOR
分子名称:MAP kinase-activated protein kinase 2, 2'-(2-fluorophenyl)-1-methyl-6',8',9',11'-tetrahydrospiro[azetidine-3,10'-pyrido[3',4':4,5]pyrrolo[2,3-f]isoquinolin]-7'(5'H)-one, MAGNESIUM ION
著者Kroemer, M., Revesz, L., Be, C., Izaac, A., Huppertz, C., Schlapbach, A., Scheufler, C.
登録日2010-03-08
公開日2010-07-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II.
Bioorg.Med.Chem.Lett., 20, 2010
3M42
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CRYSTAL STRUCTURE OF MAPKAP KINASE 2 (MK2) COMPLEXED WITH A TETRACYCLIC ATP SITE INHIBITOR
分子名称:MAP kinase-activated protein kinase 2, MAGNESIUM ION, 2-[5-(2-methoxyethoxy)pyridin-3-yl]-8,9,10,11-tetrahydro-7H-pyrido[3',4':4,5]pyrrolo[2,3-f]isoquinolin-7-one
著者Scheufler, C., Revesz, L., Be, C., Izaac, A., Huppertz, C., Schlapbach, A., Kroemer, M.
登録日2010-03-10
公開日2011-03-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Novel pyrrolo[2,3-f]isoquinoline based MAPKAP-K2 (MK2) inhibitors with potent in vitro and in vivo activity
To be Published
3SZR
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CRYSTAL STRUCTURE OF MODIFIED NUCLEOTIDE-FREE HUMAN MXA
分子名称:Interferon-induced GTP-binding protein Mx1
著者Gao, S., Daumke, O.
登録日2011-07-19
公開日2011-10-12
最終更新日2011-11-16
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.
Immunity, 35, 2011
5GTM
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MODIFIED HUMAN MXA, NUCLEOTIDE-FREE FORM
分子名称:Interferon-induced GTP-binding protein Mx1
著者Chen, Y., Gao, S.
登録日2016-08-22
公開日2017-05-31
最終更新日2017-06-21
実験手法X-RAY DIFFRACTION (2.896 Å)
主引用文献Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
Nat Commun, 8, 2017