Author results

1B06
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SUPEROXIDE DISMUTASE FROM SULFOLOBUS ACIDOCALDARIUS
Descriptor:PROTEIN (SUPEROXIDE DISMUTASE), FE (III) ION
Authors:Knapp, S., Kardinahl, S., Niklas, H., Tibbelin, G., Schafer, G., Ladenstein, R.
Deposit date:1998-11-16
Release date:1999-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Refined crystal structure of a superoxide dismutase from the hyperthermophilic archaeon Sulfolobus acidocaldarius at 2.2 A resolution.
J.Mol.Biol., 285, 1999
1B26
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GLUTAMATE DEHYDROGENASE
Descriptor:GLUTAMATE DEHYDROGENASE
Authors:Knapp, S., Devos, W.M., Rice, D., Ladenstein, R.
Deposit date:1998-12-04
Release date:1999-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of glutamate dehydrogenase from the hyperthermophilic eubacterium Thermotoga maritima at 3.0 A resolution.
J.Mol.Biol., 267, 1997
1XWS
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CRYSTAL STRUCTURE OF THE HUMAN PIM1 KINASE DOMAIN
Descriptor:Proto-oncogene serine/threonine-protein kinase Pim-1, SULFATE ION, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Authors:Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
Deposit date:2004-11-02
Release date:2004-11-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human PIM1 kinase domain
To be Published
2BIK
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HUMAN PIM1 PHOSPHORYLATED ON SER261
Descriptor:PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, CHLORIDE ION
Authors:Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
Deposit date:2005-01-22
Release date:2005-02-07
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human Pim1 Phosphorylated on Ser261
To be Published
2BIL
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THE HUMAN PROTEIN KINASE PIM1 IN COMPLEX WITH ITS CONSENSUS PEPTIDE PIMTIDE
Descriptor:CONSENSUS PIM1 PEPTIDE PIMTIDE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Authors:Knapp, S., Debreczeni, J., Bullock, A., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Guo, K.
Deposit date:2005-01-22
Release date:2005-02-07
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The Human Protein Kinase Pim1 in Complex with its Consensus Peptide Pimtide
To be Published
1B3B
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THERMOTOGA MARITIMA GLUTAMATE DEHYDROGENASE MUTANT N97D, G376K
Descriptor:PROTEIN (GLUTAMATE DEHYDROGENASE)
Authors:Knapp, S., Lebbink, J.H.G., Van Der Oost, J., Devos, W.M., Rice, D., Ladenstein, R.
Deposit date:1998-12-07
Release date:1999-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. I. Introduction of a six-residue ion-pair network in the hinge region.
J.Mol.Biol., 280, 1998
2TMG
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THERMOTOGA MARITIMA GLUTAMATE DEHYDROGENASE MUTANT S128R, T158E, N117R, S160E
Descriptor:PROTEIN (GLUTAMATE DEHYDROGENASE)
Authors:Knapp, S., Lebbink, J.H.G., van der Oost, J., de Vos, W.M., Rice, D., Ladenstein, R.
Deposit date:1998-12-04
Release date:1999-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. II: construction of a 16-residue ion-pair network at the subunit interface.
J.Mol.Biol., 289, 1999
6QXK
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HUMAN PIM1 BOUND TO OX0999
Descriptor:Serine/threonine-protein kinase pim-1, Pimtide, 2-[(1-methylpiperidin-4-yl)methylamino]-5-[[2-[4-(trifluoromethyloxy)phenyl]-1,3-thiazol-4-yl]methyl]-1,3-thiazol-4-one
Authors:Alexander, L.T., Elkins, J.M., Russell, A., Bountra, C., Edwards, A.M., Knapp, S.
Deposit date:2019-03-07
Release date:2019-04-24
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:PIM1 bound to OX0999
To Be Published
4C57
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STRUCTURE OF GAK KINASE IN COMPLEX WITH A NANOBODY
Descriptor:Cyclin-G-associated kinase, NANOBODY, SULFATE ION, ...
Authors:Chaikuad, A., Keates, T., Krojer, T., Allerston, C.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S.
Deposit date:2013-09-10
Release date:2013-10-09
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of Cyclin G-Associated Kinase (Gak) Trapped in Different Conformations Using Nanobodies.
Biochem.J., 459, 2014
4C58
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STRUCTURE OF GAK KINASE IN COMPLEX WITH NANOBODY (NBGAK_4)
Descriptor:Cyclin-G-associated kinase, nanobody, 1,2-ETHANEDIOL, ...
Authors:Chaikuad, A., Keates, T., Allerston, C.K., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S.
Deposit date:2013-09-10
Release date:2013-10-09
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.
Biochem. J., 459, 2014
4C59
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STRUCTURE OF GAK KINASE IN COMPLEX WITH NANOBODY (NBGAK_4)
Descriptor:Cyclin-G-associated kinase, NANOBODY, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
Authors:Chaikuad, A., Keates, T., Allerston, C.K., Gileadi, O., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S.
Deposit date:2013-09-10
Release date:2013-10-09
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.
Biochem. J., 459, 2014
1BBX
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NON-SPECIFIC PROTEIN-DNA INTERACTIONS IN THE SSO7D-DNA COMPLEX, NMR, 1 STRUCTURE
Descriptor:DNA (5'-D(*CP*TP*AP*GP*CP*GP*CP*GP*CP*TP*AP*G)-3'), DNA-BINDING PROTEIN 7D
Authors:Agback, P., Baumann, H., Knapp, S., Ladenstein, R., Hard, T.
Deposit date:1998-04-24
Release date:1998-10-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Architecture of Nonspecific Protein-DNA Interactions in the Sso7D-DNA Complex
Nat.Struct.Biol., 5, 1998
1JAK
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STREPTOMYCES PLICATUS BETA-N-ACETYLHEXOSAMINIDASE IN COMPLEX WITH (2R,3R,4S,5R)-2-ACETAMIDO-3,4-DIHYDROXY-5-HYDROXYMETHYL-PIPERIDINIUM CHLORIDE (IFG)
Descriptor:Beta-N-acetylhexosaminidase, SULFATE ION, CHLORIDE ION, ...
Authors:Mark, B.L., Vocadlo, D.J., Zhao, D., Knapp, S., Withers, S.G., James, M.N.
Deposit date:2001-05-30
Release date:2001-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Biochemical and structural assessment of the 1-N-azasugar GalNAc-isofagomine as a potent family 20 beta-N-acetylhexosaminidase inhibitor.
J.Biol.Chem., 276, 2001
2YAK
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STRUCTURE OF DEATH-ASSOCIATED PROTEIN KINASE 1 (DAPK1) IN COMPLEX WITH A RUTHENIUM OCTASPORINE LIGAND (OSV)
Descriptor:DEATH-ASSOCIATED PROTEIN KINASE 1, RUTHENIUM OCTASPORINE 4
Authors:Feng, L., Geisselbrecht, Y., Blanck, S., Wilbuer, A., Atilla-Gokcumen, G.E., Filippakopoulos, P., Kraeling, K., Celik, M.A., Harms, K., Maksimoska, J., Marmorstein, R., Frenking, G., Knapp, S., Essen, L.-O., Meggers, E.
Deposit date:2011-02-23
Release date:2011-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors.
J.Am.Chem.Soc., 133, 2011
3PUP
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STRUCTURE OF GLYCOGEN SYNTHASE KINASE 3 BETA (GSK3B) IN COMPLEX WITH A RUTHENIUM OCTASPORINE LIGAND (OS1)
Descriptor:Glycogen synthase kinase-3 beta, Ruthenium octasporine
Authors:Filippakopoulos, P., Kraling, K., Essen, L.O., Meggers, E., Knapp, S.
Deposit date:2010-12-06
Release date:2010-12-22
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors.
J.Am.Chem.Soc., 133, 2011
1SSO
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SOLUTION STRUCTURE AND DNA-BINDING PROPERTIES OF A THERMOSTABLE PROTEIN FROM THE ARCHAEON SULFOLOBUS SOLFATARICUS
Descriptor:SSO7D
Authors:Baumann, H., Knapp, S., Lundback, T., Ladenstein, R., Hard, T.
Deposit date:1995-03-31
Release date:1995-05-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus.
Nat.Struct.Biol., 1, 1994
1Z57
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CRYSTAL STRUCTURE OF HUMAN CLK1 IN COMPLEX WITH 10Z-HYMENIALDISINE
Descriptor:Dual specificity protein kinase CLK1, DEBROMOHYMENIALDISINE
Authors:Debreczeni, J., Das, S., Knapp, S., Bullock, A., Guo, K., Amos, A., Fedorov, O., Edwards, A., Sundstrom, M., von Delft, F., Niesen, F.H., Ball, L., Sobott, F., Arrowsmith, C., Structural Genomics Consortium (SGC)
Deposit date:2005-03-17
Release date:2005-04-12
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
2EU9
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CRYSTAL STRUCTURE OF CLK3
Descriptor:Dual specificity protein kinase CLK3, 1,2-ETHANEDIOL
Authors:Papagrigoriou, E., Rellos, P., Das, S., Ugochukwu, E., Turnbull, A., von Delft, F., Bunkoczi, G., Sobott, F., Bullock, A., Fedorov, O., Gileadi, C., Savitsky, P., Edwards, A., Aerrowsmith, C., Weigelt, J., Sundstrom, M., Knapp, S.
Deposit date:2005-10-28
Release date:2005-11-08
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation.
Structure, 17, 2009
2IVX
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CRYSTAL STRUCTURE OF HUMAN CYCLIN T2 AT 1.8 A RESOLUTION
Descriptor:CYCLIN-T2, 1,2-ETHANEDIOL
Authors:Debreczeni, J.E., Bullock, A.N., Fedorov, O., Savitsky, P., Berridge, G., Das, S., Pike, A.C.W., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Gorrec, F., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., von Delft, F., Knapp, S.
Deposit date:2006-06-21
Release date:2006-07-19
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
EMBO J., 27, 2008
2JAV
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HUMAN KINASE WITH PYRROLE-INDOLINONE LIGAND
Descriptor:SERINE/THREONINE-PROTEIN KINASE NEK2, 5-[(Z)-(5-CHLORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]-N-(DIETHYLAMINO)ETHYL]-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE
Authors:Pike, A.C.W., Rellos, P., Das, S., Fedorov, O., Papagrigoriou, E., Debreczeni, J.E., Turnbull, A.P., Gorrec, F., Bray, J., Sundstrom, M., Arrowsmith, C.H., Edwards, A., Weigelt, J., von Delft, F., Knapp, S.
Deposit date:2006-11-30
Release date:2006-12-04
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and Regulation of the Human Nek2 Centrosomal Kinase
J.Biol.Chem., 282, 2007
2QEP
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CRYSTAL STRUCTURE OF THE D1 DOMAIN OF PTPRN2 (IA2BETA)
Descriptor:Receptor-type tyrosine-protein phosphatase N2, CHLORIDE ION
Authors:Ugochukwu, E., Barr, A., Alfano, I., Berridge, G., Burgess-Brown, N., Das, S., Fedorov, O., King, O., Niesen, F., Watt, S., Savitsky, P., Salah, E., Pike, A.C.W., Bunkoczi, G., von Delft, F., Sundstrom, M., Edwards, A., Arrowsmith, C.H., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-06-26
Release date:2007-07-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell(Cambridge,Mass.), 136, 2009
3D7C
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN GCN5, THE GENERAL CONTROL OF AMINO-ACID SYNTHESIS PROTEIN 5-LIKE 2
Descriptor:General control of amino acid synthesis protein 5-like 2
Authors:Filippakopoulos, P., Eswaran, J., Picaud, S., Fedorov, O., Murray, J., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-05-21
Release date:2008-07-15
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3DAI
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF THE HUMAN ATAD2
Descriptor:ATPase family AAA domain-containing protein 2, SULFATE ION, CHLORIDE ION
Authors:Filippakopoulos, P., Keates, T., Picaud, S., Fedorov, O., Roos, A.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-05-29
Release date:2008-09-09
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3DWY
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN CREBBP
Descriptor:CREB-binding protein, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Picaud, S., Fedorov, O., Karim, R., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Wickstroem, M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2008-07-23
Release date:2008-08-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
3GG3
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CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN PCAF
Descriptor:Histone acetyltransferase PCAF, CHLORIDE ION
Authors:Filippakopoulos, P., Keates, T., Picaud, S., Rehana, K., Fedorov, O., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2009-02-27
Release date:2009-03-17
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012