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5E0I
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CRYSTAL STRUCTURE OF THE HBV CAPSID Y132A MUTANT (VCID 8772) IN COMPLEX WITH NVR10-001E2 AT 1.95A RESOLUTION
Descriptor:Capsid protein, methyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)pyrimidine-5-carboxylate
Authors:Lukacs, C.M., Abendroth, J., Klumpp, K.
Deposit date:2015-09-28
Release date:2015-12-09
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.
Proc.Natl.Acad.Sci.USA, 112, 2015
1Y1U
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STRUCTURE OF UNPHOSPHORYLATED STAT5A
Descriptor:Signal transducer and activator of transcription 5A
Authors:Neculai, D., Neculai, A.M., Verrier, S., Straub, K., Klumpp, K., Pfitzner, E., Becker, S.
Deposit date:2004-11-19
Release date:2005-10-04
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Structure of the unphosphorylated STAT5a dimer
J.Biol.Chem., 280, 2005
2GIQ
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HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE NS5B WITH NNI-2 INHIBITOR
Descriptor:RNA-directed RNA polymerase, 1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE
Authors:Harris, S.F.
Deposit date:2006-03-29
Release date:2007-04-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus.
J.Virol., 80, 2006
2GIR
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HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE NS5B WITH NNI-1 INHIBITOR
Descriptor:RNA-directed RNA polymerase, 3-{ISOPROPYL[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]AMINO}-5-PHENYLTHIOPHENE-2-CARBOXYLIC ACID
Authors:Harris, S.F.
Deposit date:2006-03-29
Release date:2007-04-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus.
J.Virol., 80, 2006
3DI6
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HIV-1 RT WITH PYRIDAZINONE NON-NUCLEOSIDE INHIBITOR
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, 6-(4-chloro-2-fluoro-3-phenoxybenzyl)pyridazin-3(2H)-one
Authors:Harris, S.F., Villasenor, A., Dunten, P.
Deposit date:2008-06-19
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg.Med.Chem.Lett., 18, 2008
3DYA
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HIV-1 RT WITH NON-NUCLEOSIDE INHIBITOR ANNULATED PYRAZOLE 1
Descriptor:REVERSE TRANSCRIPTASE/RIBONUCLEASE H, p51 RT, 3-[6-bromo-2-fluoro-3-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-chlorobenzonitrile
Authors:Harris, S.F., Villasenor, A.
Deposit date:2008-07-25
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase
J.Med.Chem., 51, 2008
3E01
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HIV-RT WITH NON-NUCLEOSIDE INHIBITOR ANNULATED PYRAZOLE 2
Descriptor:Gag-Pol polyprotein, 3-[2-bromo-4-(1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl)phenoxy]-5-methylbenzonitrile
Authors:Harris, S.F., Villasenor, A.
Deposit date:2008-07-30
Release date:2008-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase
J.Med.Chem., 51, 2008
3FQK
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HEPATITIS C VIRUS POLYMERASE NS5B (BK 1-570) WITH HCV-796 INHIBITOR
Descriptor:RNA-directed RNA polymerase, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide
Authors:Harris, S.F., Wong, A.
Deposit date:2009-01-07
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus.
J.Biol.Chem., 284, 2009
3FQL
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HEPATITIS C VIRUS POLYMERASE NS5B (CON1 1-570) WITH HCV-796 INHIBITOR
Descriptor:RNA-directed RNA polymerase, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide, GLYCEROL
Authors:Harris, S.F., Wong, A.
Deposit date:2009-01-07
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus.
J.Biol.Chem., 284, 2009
3M8P
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HIV-1 RT WITH NNRTI TMC-125
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, 4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE
Authors:Harris, S.F., Villasenor, A.
Deposit date:2010-03-18
Release date:2010-05-19
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.
Bioorg.Med.Chem.Lett., 20, 2010
3M8Q
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HIV-1 RT WITH AMINOPYRIMIDINE NNRTI
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, 3,5-dimethyl-4-{[2-({1-[4-(methylsulfonyl)benzyl]piperidin-4-yl}amino)pyrimidin-4-yl]oxy}benzonitrile
Authors:Harris, S.F., Villasenor, A.
Deposit date:2010-03-18
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.
Bioorg.Med.Chem.Lett., 20, 2010
3NBP
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HIV-1 REVERSE TRANSCRIPTASE WITH AMINOPYRIMIDINE INHIBITOR 2
Descriptor:Reverse transcriptase/ribonuclease H, p51 RT, MANGANESE (II) ION, ...
Authors:Harris, S.F., Villasenor, A.G.
Deposit date:2010-06-03
Release date:2010-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.
Bioorg.Med.Chem.Lett., 20, 2010
6EJG
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CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 4
Descriptor:CD81 antigen, SINGLE CHAIN FV FRAGMENT
Authors:Harris, S.F., Wong, A., Kuglstatter, A.
Deposit date:2017-09-21
Release date:2018-05-30
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.82 Å)
Cite:Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies.
J. Mol. Biol., 430, 2018
6EJM
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CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 5
Descriptor:CD81 antigen, SINGLE CHAIN FV FRAGMENT
Authors:Kuglstatter, A., Harris, S.F., Villasenor, A.
Deposit date:2017-09-22
Release date:2018-05-30
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies.
J. Mol. Biol., 430, 2018
6EK2
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CRYSTAL STRUCTURE OF HUMAN CD81 LARGE EXTRACELLULAR LOOP IN COMPLEX WITH SINGLE CHAIN FV FRAGMENT 10
Descriptor:CD81 antigen, SINGLE CHAIN FV FRAGMENT
Authors:Harris, S.F., Villasenor, A., Kuglstatter, A.
Deposit date:2017-09-25
Release date:2018-05-30
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies.
J. Mol. Biol., 430, 2018