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3LBD
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BU of 3lbd by Molmil
LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO 9-CIS RETINOIC ACID
Descriptor: (9cis)-retinoic acid, RETINOIC ACID RECEPTOR GAMMA
Authors:Klaholz, B.P, Renaud, J.-P, Mitschler, A, Moras, D, Structural Proteomics in Europe (SPINE)
Deposit date:1998-02-04
Release date:1999-03-02
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational adaptation of agonists to the human nuclear receptor RAR gamma.
Nat.Struct.Biol., 5, 1998
1ML5
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BU of 1ml5 by Molmil
Structure of the E. coli ribosomal termination complex with release factor 2
Descriptor: 30S 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ...
Authors:Klaholz, B.P, Pape, T, Zavialov, A.V, Myasnikov, A.G, Orlova, E.V, Vestergaard, B, Ehrenberg, M, van Heel, M.
Deposit date:2002-08-30
Release date:2003-01-14
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Structure of the Escherichia coli ribosomal termination complex with release factor 2
Nature, 421, 2003
1EXA
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BU of 1exa by Molmil
ENANTIOMER DISCRIMINATION ILLUSTRATED BY CRYSTAL STRUCTURES OF THE HUMAN RETINOIC ACID RECEPTOR HRARGAMMA LIGAND BINDING DOMAIN: THE COMPLEX WITH THE ACTIVE R-ENANTIOMER BMS270394.
Descriptor: DODECYL-ALPHA-D-MALTOSIDE, R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID, RETINOIC ACID RECEPTOR GAMMA-2
Authors:Klaholz, B.P, Mitschler, A, Belema, M, Zusi, C, Moras, D, Structural Proteomics in Europe (SPINE)
Deposit date:2000-05-02
Release date:2000-06-09
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma.
Proc.Natl.Acad.Sci.USA, 97, 2000
1EXX
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ENANTIOMER DISCRIMINATION ILLUSTRATED BY CRYSTAL STRUCTURES OF THE HUMAN RETINOIC ACID RECEPTOR HRARGAMMA LIGAND BINDING DOMAIN: THE COMPLEX WITH THE INACTIVE S-ENANTIOMER BMS270395.
Descriptor: 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID, DODECYL-ALPHA-D-MALTOSIDE, RETINOIC ACID RECEPTOR GAMMA-2
Authors:Klaholz, B.P, Mitschler, A, Belema, M, Zusi, C, Moras, D, Structural Proteomics in Europe (SPINE)
Deposit date:2000-05-05
Release date:2000-06-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FCY
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BU of 1fcy by Molmil
ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARBETA/GAMMA-SELECTIVE RETINOID CD564
Descriptor: 6-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID, DODECYL-ALPHA-D-MALTOSIDE, RETINOIC ACID RECEPTOR GAMMA-1
Authors:Klaholz, B.P, Mitschler, A, Moras, D, Structural Proteomics in Europe (SPINE)
Deposit date:2000-07-19
Release date:2000-09-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural basis for isotype selectivity of the human retinoic acid nuclear receptor.
J.Mol.Biol., 302, 2000
1FCZ
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ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE PANAGONIST RETINOID BMS181156
Descriptor: 4-[3-OXO-3-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-PROPENYL]-BENZOIC ACID, DODECYL-ALPHA-D-MALTOSIDE, RETINOIC ACID RECEPTOR GAMMA-1
Authors:Klaholz, B.P, Mitschler, A, Moras, D, Structural Proteomics in Europe (SPINE)
Deposit date:2000-07-19
Release date:2000-09-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Structural basis for isotype selectivity of the human retinoic acid nuclear receptor.
J.Mol.Biol., 302, 2000
1FCX
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ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID BMS184394
Descriptor: 6-[HYDROXY-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALEN-2-YL)-METHYL]-NAPHTALENE-2-CARBOXYLIC ACID, DODECYL-ALPHA-D-MALTOSIDE, RETINOIC ACID RECEPTOR GAMMA-1
Authors:Klaholz, B.P, Mitschler, A, Moras, D, Structural Proteomics in Europe (SPINE)
Deposit date:2000-07-19
Release date:2000-09-11
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural basis for isotype selectivity of the human retinoic acid nuclear receptor.
J.Mol.Biol., 302, 2000
4LBD
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BU of 4lbd by Molmil
LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961
Descriptor: 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID, RETINOIC ACID RECEPTOR GAMMA
Authors:Klaholz, B.P, Renaud, J.-P, Mitschler, A, Moras, D, Structural Proteomics in Europe (SPINE)
Deposit date:1998-02-04
Release date:1999-03-02
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conformational adaptation of agonists to the human nuclear receptor RAR gamma.
Nat.Struct.Biol., 5, 1998
1FD0
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BU of 1fd0 by Molmil
ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID SR11254
Descriptor: 6-[HYDROXYIMINO-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALEN-2-YL)-METHYL]-NAPHTALENE-2-CARBOXYLIC ACID, DODECYL-ALPHA-D-MALTOSIDE, RETINOIC ACID RECEPTOR GAMMA-1
Authors:Klaholz, B.P, Moras, D, Structural Proteomics in Europe (SPINE)
Deposit date:2000-07-19
Release date:2002-09-27
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:C-H...O hydrogen bonds in the nuclear receptor RARgamma--a potential tool for drug selectivity.
Structure, 10, 2002
5LKS
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BU of 5lks by Molmil
Structure-function insights reveal the human ribosome as a cancer target for antibiotics
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
Authors:Myasnikov, A.G, Natchiar, S.K, Nebout, M, Hazemann, I, Imbert, V, Khatter, H, Peyron, J.-F, Klaholz, B.P.
Deposit date:2016-07-23
Release date:2017-04-26
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Nat Commun, 7, 2016
8CEF
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BU of 8cef by Molmil
Asymmetric Dimerization in a Transcription Factor Superfamily is Promoted by Allosteric Interactions with DNA
Descriptor: DNA (26-MER), Nuclear receptor DNA binding domain, ZINC ION
Authors:Patel, A.K.M, Shaik, T.B, McEwen, A.G, Moras, D, Klaholz, B.P, Billas, I.M.L.
Deposit date:2023-02-01
Release date:2023-08-09
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.486 Å)
Cite:Asymmetric dimerization in a transcription factor superfamily is promoted by allosteric interactions with DNA.
Nucleic Acids Res., 51, 2023
6YWW
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BU of 6yww by Molmil
MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion
Descriptor: DNA (5'-D(*AP*TP*AP*TP*AP*AP*TP*TP*GP*TP*GP*TP*GP*TP*GP*TP*GP*CP*AP*G)-3'), DNA/RNA (5'-D(*TP*CP*TP*GP*CP*AP*CP*A)-R(P*(5HC))-D(P*AP*CP*AP*CP*AP*AP*TP*TP*AP*TP*A)-3'), Truncated methyl CpG binding protein 2 transcript 1
Authors:Ibrahim, A, Papin, C, Mohideen-Abdul, K, Gras, S.L, Stoll, I, Bronner, C, Dimitrov, S, Klaholz, B.P, Hamiche, A.
Deposit date:2020-04-30
Release date:2021-06-16
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:MeCP2 is a microsatellite binding protein that protects CA repeats from nucleosome invasion.
Science, 372, 2021
4WKR
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BU of 4wkr by Molmil
LaRP7 wrapping up the 3' hairpin of 7SK non-coding RNA (302-332)
Descriptor: 7SK GGHP4 (300-332), La-related protein 7
Authors:Uchikawa, E, Natchiar, K.S, Han, X, Proux, F, Roblin, P, Zhang, E, Durand, A, Klaholz, B.P, Dock-Bregeon, A.-C.
Deposit date:2014-10-03
Release date:2015-03-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7.
Nucleic Acids Res., 43, 2015
2VAZ
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BU of 2vaz by Molmil
Model of the S15-mRNA complex fitted into the cryo-EM map of the 70S entrapment complex.
Descriptor: 30S RIBOSOMAL PROTEIN S15, RPSO MRNA OPERATOR
Authors:Marzi, S, Myasnikov, A.G, Serganov, A, Ehresmann, C, Romby, P, Yusupov, M, Klaholz, B.P.
Deposit date:2007-09-05
Release date:2007-10-02
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structured Mrnas Regulate Translation Initiation by Binding to the Platform of the Ribosome.
Cell(Cambridge,Mass.), 130, 2007
6QZP
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BU of 6qzp by Molmil
High-resolution cryo-EM structure of the human 80S ribosome
Descriptor: (3beta)-O~3~-[(2R)-2,6-dihydroxy-2-(2-methoxy-2-oxoethyl)-6-methylheptanoyl]cephalotaxine, 18S rRNA (1740-MER), 28S rRNA (3773-MER), ...
Authors:Natchiar, S.K, Myasnikov, A.G, Kratzat, H, Hazemann, I, Klaholz, B.P.
Deposit date:2019-03-12
Release date:2019-04-24
Last modified:2021-08-04
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Visualization of chemical modifications in the human 80S ribosome structure.
Nature, 551, 2017
3J4J
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BU of 3j4j by Molmil
Model of full-length T. thermophilus Translation Initiation Factor 2 refined against its cryo-EM density from a 30S Initiation Complex map
Descriptor: Translation initiation factor IF-2
Authors:Simonetti, A, Marzi, S, Billas, I.M.L, Tsai, A, Fabbretti, A, Myasnikov, A, Roblin, P, Vaiana, A.C, Hazemann, I, Eiler, D, Steitz, T.A, Puglisi, J.D, Gualerzi, C.O, Klaholz, B.P.
Deposit date:2013-08-26
Release date:2013-09-25
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.
Proc.Natl.Acad.Sci.USA, 110, 2013
5FOJ
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BU of 5foj by Molmil
Cryo electron microscopy structure of Grapevine Fanleaf Virus complex with Nanobody
Descriptor: Nanobody, RNA2 polyprotein
Authors:Orlov, I, Hemmer, C, Ackerer, L, Lorber, B, Ghannam, A, Poignavent, V, Hleibieh, K, Sauter, C, Schmitt-Keichinger, C, Belval, L, Hily, J.M, Marmonier, A, Komar, V, Gersch, S, Schellenberger, P, Bron, P, Vigne, E, Muyldermans, S, Lemaire, O, Demangeat, G, Ritzenthaler, C, Klaholz, B.P.
Deposit date:2015-11-22
Release date:2016-01-20
Last modified:2021-08-11
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis of nanobody recognition of grapevine fanleaf virus and of virus resistance loss.
Proc.Natl.Acad.Sci.USA, 2020
4UMM
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BU of 4umm by Molmil
The Cryo-EM structure of the palindromic DNA-bound USP-EcR nuclear receptor reveals an asymmetric organization with allosteric domain positioning
Descriptor: 2,3,14,20,22-PENTAHYDROXYCHOLEST-7-EN-6-ONE, 5'-D(*CP*AP*AP*GP*GP*GP*TP*TP*CP*AP*AP*TP*GP*CP *AP*CP*TP*TP*GP*TP)-3', 5'-D(*DGP*AP*CP*AP*AP*GP*TP*GP*CP*AP*TP*TP*GP*DAP *AP*CP*CP*CP*TP*T)-3', ...
Authors:Maletta, M, Orlov, I, Moras, D, Billas, I.M.L, Klaholz, B.P.
Deposit date:2014-05-19
Release date:2014-06-25
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (11.6 Å)
Cite:The Palindromic DNA-Bound Usp-Ecr Nuclear Receptor Adopts an Asymmetric Organization with Allosteric Domain Positioning.
Nat.Commun., 5, 2014
6Y57
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BU of 6y57 by Molmil
Structure of human ribosome in hybrid-PRE state
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A.
Deposit date:2020-02-25
Release date:2020-04-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes.
Cell Rep, 31, 2020
6Y0G
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BU of 6y0g by Molmil
Structure of human ribosome in classical-PRE state
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
Authors:Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A.
Deposit date:2020-02-07
Release date:2020-04-15
Last modified:2020-04-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes.
Cell Rep, 31, 2020
6Y2L
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BU of 6y2l by Molmil
Structure of human ribosome in POST state
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
Authors:Bhaskar, V, Schenk, A.D, Cavadini, S, von Loeffelholz, O, Natchiar, S.K, Klaholz, B.P, Chao, J.A.
Deposit date:2020-02-16
Release date:2020-04-15
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes.
Cell Rep, 31, 2020
4UG0
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BU of 4ug0 by Molmil
STRUCTURE OF THE HUMAN 80S RIBOSOME
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S RIBOSOMAL PROTEIN, ...
Authors:Khatter, H, Myasnikov, A.G, Natchiar, S.K, Klaholz, B.P.
Deposit date:2015-03-20
Release date:2015-06-10
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of the human 80S ribosome
NATURE, 520, 2015
4V3P
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BU of 4v3p by Molmil
The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes
Descriptor: 18S ribosomal RNA, 26S ribosomal RNA, 40S WHEAT GERM RIBOSOME protein 4, ...
Authors:Myasnikov, A.G, Afonina, Z.A, Menetret, J.F, Shirokov, V.A, Spirin, A.S, Klaholz, B.P.
Deposit date:2014-10-20
Release date:2015-04-22
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (34 Å)
Cite:The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes.
Nat Commun, 5, 2014
4B3X
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BU of 4b3x by Molmil
Bacterial translation initiation factor IF2 (1-363), apo form
Descriptor: GLYCEROL, TRANSLATION INITIATION FACTOR IF-2
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-26
Release date:2013-05-29
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
4B43
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Bacterial translation initiation factor IF2 (1-363), apo form, double mutant K86L H130A
Descriptor: GLYCEROL, IODIDE ION, MAGNESIUM ION, ...
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-09-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.937 Å)
Cite:Molecular Basis of GTP Hydrolysis by Bacterial Translation Initiation Factor If2
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