Author results

1EXA
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ENANTIOMER DISCRIMINATION ILLUSTRATED BY CRYSTAL STRUCTURES OF THE HUMAN RETINOIC ACID RECEPTOR HRARGAMMA LIGAND BINDING DOMAIN: THE COMPLEX WITH THE ACTIVE R-ENANTIOMER BMS270394.
Descriptor:RETINOIC ACID RECEPTOR GAMMA-2, R-3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID, DODECYL-ALPHA-D-MALTOSIDE
Authors:Klaholz, B.P., Mitschler, A., Belema, M., Zusi, C., Moras, D., Structural Proteomics in Europe (SPINE)
Deposit date:2000-05-02
Release date:2000-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma.
Proc.Natl.Acad.Sci.USA, 97, 2000
1EXX
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ENANTIOMER DISCRIMINATION ILLUSTRATED BY CRYSTAL STRUCTURES OF THE HUMAN RETINOIC ACID RECEPTOR HRARGAMMA LIGAND BINDING DOMAIN: THE COMPLEX WITH THE INACTIVE S-ENANTIOMER BMS270395.
Descriptor:RETINOIC ACID RECEPTOR GAMMA-2, 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID, DODECYL-ALPHA-D-MALTOSIDE
Authors:Klaholz, B.P., Mitschler, A., Belema, M., Zusi, C., Moras, D., Structural Proteomics in Europe (SPINE)
Deposit date:2000-05-05
Release date:2000-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FCX
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ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID BMS184394
Descriptor:RETINOIC ACID RECEPTOR GAMMA-1, 6-[HYDROXY-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALEN-2-YL)-METHYL]-NAPHTALENE-2-CARBOXYLIC ACID, DODECYL-ALPHA-D-MALTOSIDE
Authors:Klaholz, B.P., Mitschler, A., Moras, D., Structural Proteomics in Europe (SPINE)
Deposit date:2000-07-19
Release date:2000-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural basis for isotype selectivity of the human retinoic acid nuclear receptor.
J.Mol.Biol., 302, 2000
1FCY
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ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARBETA/GAMMA-SELECTIVE RETINOID CD564
Descriptor:RETINOIC ACID RECEPTOR GAMMA-1, 6-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALENE-2-CARBONYL)-NAPHTALENE-2-CARBOXYLIC ACID, DODECYL-ALPHA-D-MALTOSIDE
Authors:Klaholz, B.P., Mitschler, A., Moras, D., Structural Proteomics in Europe (SPINE)
Deposit date:2000-07-19
Release date:2000-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural basis for isotype selectivity of the human retinoic acid nuclear receptor.
J.Mol.Biol., 302, 2000
1FCZ
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ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE PANAGONIST RETINOID BMS181156
Descriptor:RETINOIC ACID RECEPTOR GAMMA-1, 4-[3-OXO-3-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-PROPENYL]-BENZOIC ACID, DODECYL-ALPHA-D-MALTOSIDE
Authors:Klaholz, B.P., Mitschler, A., Moras, D., Structural Proteomics in Europe (SPINE)
Deposit date:2000-07-19
Release date:2000-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Structural basis for isotype selectivity of the human retinoic acid nuclear receptor.
J.Mol.Biol., 302, 2000
1ML5
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STRUCTURE OF THE E. COLI RIBOSOMAL TERMINATION COMPLEX WITH RELEASE FACTOR 2
Descriptor:30S 16S RIBOSOMAL RNA, T-RNA(PHE), A- AND P-SITE MESSENGER RNA CODONS, ...
Authors:Klaholz, B.P., Pape, T., Zavialov, A.V., Myasnikov, A.G., Orlova, E.V., Vestergaard, B., Ehrenberg, M., van Heel, M.
Deposit date:2002-08-30
Release date:2003-01-14
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (14 Å)
Cite:Structure of the Escherichia coli ribosomal termination complex with release factor 2
Nature, 421, 2003
3LBD
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LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO 9-CIS RETINOIC ACID
Descriptor:RETINOIC ACID RECEPTOR GAMMA, (9cis)-retinoic acid
Authors:Klaholz, B.P., Renaud, J.-P., Mitschler, A., Moras, D., Structural Proteomics in Europe (SPINE)
Deposit date:1998-02-04
Release date:1999-03-02
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformational adaptation of agonists to the human nuclear receptor RAR gamma.
Nat.Struct.Biol., 5, 1998
4LBD
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LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO THE SYNTHETIC AGONIST BMS961
Descriptor:RETINOIC ACID RECEPTOR GAMMA, 3-FLUORO-4-[2-HYDROXY-2-(5,5,8,8-TETRAMETHYL-5,6,7,8,-TETRAHYDRO-NAPHTALEN-2-YL)-ACETYLAMINO]-BENZOIC ACID
Authors:Klaholz, B.P., Renaud, J.-P., Mitschler, A., Moras, D., Structural Proteomics in Europe (SPINE)
Deposit date:1998-02-04
Release date:1999-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conformational adaptation of agonists to the human nuclear receptor RAR gamma.
Nat.Struct.Biol., 5, 1998
1FD0
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ISOTYPE SELECTIVITY OF THE HUMAN RETINOIC ACID NUCLEAR RECEPTOR HRAR: THE COMPLEX WITH THE RARGAMMA-SELECTIVE RETINOID SR11254
Descriptor:RETINOIC ACID RECEPTOR GAMMA-1, 6-[HYDROXYIMINO-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTALEN-2-YL)-METHYL]-NAPHTALENE-2-CARBOXYLIC ACID, DODECYL-ALPHA-D-MALTOSIDE
Authors:Klaholz, B.P., Moras, D., Structural Proteomics in Europe (SPINE)
Deposit date:2000-07-19
Release date:2002-09-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:C-H...O hydrogen bonds in the nuclear receptor RARgamma--a potential tool for drug selectivity.
Structure, 10, 2002
5LKS
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STRUCTURE-FUNCTION INSIGHTS REVEAL THE HUMAN RIBOSOME AS A CANCER TARGET FOR ANTIBIOTICS
Descriptor:28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Myasnikov, A.G., Natchiar, S.K., Nebout, M., Hazemann, I., Imbert, V., Khatter, H., Peyron, J.-F., Klaholz, B.P.
Deposit date:2016-07-23
Release date:2017-04-26
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure-function insights reveal the human ribosome as a cancer target for antibiotics.
Nat Commun, 7, 2016
2VAZ
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MODEL OF THE S15-MRNA COMPLEX FITTED INTO THE CRYO-EM MAP OF THE 70S ENTRAPMENT COMPLEX.
Descriptor:RPSO MRNA OPERATOR, 30S RIBOSOMAL PROTEIN S15
Authors:Marzi, S., Myasnikov, A.G., Serganov, A., Ehresmann, C., Romby, P., Yusupov, M., Klaholz, B.P.
Deposit date:2007-09-05
Release date:2007-10-02
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (10 Å)
Cite:Structured Mrnas Regulate Translation Initiation by Binding to the Platform of the Ribosome.
Cell(Cambridge,Mass.), 130, 2007
3J4J
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MODEL OF FULL-LENGTH T. THERMOPHILUS TRANSLATION INITIATION FACTOR 2 REFINED AGAINST ITS CRYO-EM DENSITY FROM A 30S INITIATION COMPLEX MAP
Descriptor:Translation initiation factor IF-2
Authors:Simonetti, A., Marzi, S., Billas, I.M.L., Tsai, A., Fabbretti, A., Myasnikov, A., Roblin, P., Vaiana, A.C., Hazemann, I., Eiler, D., Steitz, T.A., Puglisi, J.D., Gualerzi, C.O., Klaholz, B.P.
Deposit date:2013-08-26
Release date:2013-09-25
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.
Proc.Natl.Acad.Sci.USA, 110, 2013
4B3X
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BACTERIAL TRANSLATION INITIATION FACTOR IF2 (1-363), APO FORM
Descriptor:TRANSLATION INITIATION FACTOR IF-2, GLYCEROL
Authors:Simonetti, A., Urzhumtsev, A., Klaholz, B.P.
Deposit date:2012-07-26
Release date:2013-05-29
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
4B43
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BACTERIAL TRANSLATION INITIATION FACTOR IF2 (1-363), APO FORM, DOUBLE MUTANT K86L H130A
Descriptor:TRANSLATION INITIATION FACTOR IF-2, MAGNESIUM ION, GLYCEROL, ...
Authors:Simonetti, A., Urzhumtsev, A., Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-09-18
Method:X-RAY DIFFRACTION (1.937 Å)
Cite:Molecular Basis of GTP Hydrolysis by Bacterial Translation Initiation Factor If2
To be Published
4B44
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BACTERIAL TRANSLATION INITIATION FACTOR IF2 (1-363), COMPLEX WITH GDP AT PH8.0
Descriptor:TRANSLATION INITIATION FACTOR IF-2, GUANOSINE-5'-DIPHOSPHATE
Authors:Simonetti, A., Urzhumtsev, A., Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-09-18
Last modified:2015-02-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Basis of GTP Hydrolysis by Bacterial Translation Initiation Factor If2
To be Published
4B47
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BACTERIAL TRANSLATION INITIATION FACTOR IF2 (1-363), COMPLEX WITH GDP AT PH6.5
Descriptor:TRANSLATION INITIATION FACTOR IF-2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Simonetti, A., Urzhumtsev, A., Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-05-29
Last modified:2015-02-11
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
4B48
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BACTERIAL TRANSLATION INITIATION FACTOR IF2 (1-363), COMPLEX WITH GTP
Descriptor:TRANSLATION INITIATION FACTOR IF-2, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Simonetti, A., Urzhumtsev, A., Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-05-29
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
4L92
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STRUCTURE OF THE RBP FROM LACTOCOCCAL PHAGE 1358 IN COMPLEX WITH 2 GLCNAC MOLECULES
Descriptor:Receptor Binding Protein, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Farenc, C., Spinelli, S., Bebeacua, C., Tremblay, D., Orlov, I., Blangy, S., Klaholz, B.P., Moineau, S., Cambillau, C.
Deposit date:2013-06-18
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Virulent Siphophage CyoEM Structure and Host Recognition and Infection Mechanism
To be Published
4L97
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STRUCTURE OF THE RBP OF LACTOCOCCAL PHAGE 1358 IN COMPLEX WITH GLUCOSE-1-PHOSPHATE
Descriptor:Receptor Binding Protein, ALPHA-D-GLUCOSE-1-PHOSPHATE
Authors:Farenc, C., Spinelli, S., Bebeacua, C., Tremblay, D., Orlov, I., Blangy, S., Klaholz, B.P., Moineau, S., Cambillau, C.
Deposit date:2013-06-18
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:A Virulent Siphophage CyoEM Structure and Host Recognition and Infection Mechanism
To be Published
4L99
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STRUCTURE OF THE RBP FROM LACTOCOCCAL PHAGE 1358 IN COMPLEX WITH GLYCEROL
Descriptor:Receptor Binding Protein, GLYCEROL, ZINC ION
Authors:Farenc, C., Spinelli, S., Bebeacua, C., Tremblay, D., Orlov, I., Blangy, S., Klaholz, B.P., Moineau, S., Cambillau, C.
Deposit date:2013-06-18
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Virulent Siphophage CyoEM Structure and Host Recognition and Infection Mechanism
To be Published
4L9B
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STRUCTURE OF NATIVE RBP FROM LACTOCOCCAL PHAGE 1358 (CSI DERIVATIVE)
Descriptor:Receptor Binding Protein, CESIUM ION
Authors:Farenc, C., Spinelli, S., Bebeacua, C., Tremblay, D., Orlov, I., Blangy, S., Klaholz, B.P., Moineau, S., Cambillau, C.
Deposit date:2013-06-18
Release date:2014-04-30
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Virulent Siphophage CyoEM Structure and Host Recognition and Infection Mechanism
To be Published
4UG0
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STRUCTURE OF THE HUMAN 80S RIBOSOME
Descriptor:28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ...
Authors:Khatter, H., Myasnikov, A.G., Natchiar, S.K., Klaholz, B.P.
Deposit date:2015-03-20
Release date:2015-06-10
Last modified:2018-02-14
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of the human 80S ribosome
NATURE, 520, 2015
4UMM
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THE CRYO-EM STRUCTURE OF THE PALINDROMIC DNA-BOUND USP-ECR NUCLEAR RECEPTOR REVEALS AN ASYMMETRIC ORGANIZATION WITH ALLOSTERIC DOMAIN POSITIONING
Descriptor:ECR-USP, 5'-D(*CP*AP*AP*GP*GP*GP*TP*TP*CP*AP*AP*TP*GP*CP *AP*CP*TP*TP*GP*TP)-3', 5'-D(*DGP*AP*CP*AP*AP*GP*TP*GP*CP*AP*TP*TP*GP*DAP *AP*CP*CP*CP*TP*T)-3', ...
Authors:Maletta, M., Orlov, I., Moras, D., Billas, I.M.L., Klaholz, B.P.
Deposit date:2014-05-19
Release date:2014-06-25
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (11.6 Å)
Cite:The Palindromic DNA-Bound Usp-Ecr Nuclear Receptor Adopts an Asymmetric Organization with Allosteric Domain Positioning.
Nat.Commun., 5, 2014
4V3P
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THE MOLECULAR STRUCTURE OF THE LEFT-HANDED SUPRA-MOLECULAR HELIX OF EUKARYOTIC POLYRIBOSOMES
Descriptor:G protein beta subunit, 40S ribosomal protein SA, Putative 40S ribosomal protein S3, ...
Authors:Myasnikov, A.G., Afonina, Z.A., Menetret, J.F., Shirokov, V.A., Spirin, A.S., Klaholz, B.P.
Deposit date:2014-10-20
Release date:2015-04-22
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (34 Å)
Cite:The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes.
Nat Commun, 5, 2014
4WKR
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LARP7 WRAPPING UP THE 3' HAIRPIN OF 7SK NON-CODING RNA (302-332)
Descriptor:La-related protein 7, 7SK GGHP4 (300-332)
Authors:Uchikawa, E., Natchiar, K.S., Han, X., Proux, F., Roblin, P., Zhang, E., Durand, A., Klaholz, B.P., Dock-Bregeon, A.-C.
Deposit date:2014-10-03
Release date:2015-03-18
Last modified:2015-04-15
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7.
Nucleic Acids Res., 43, 2015
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