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1LWR
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BU of 1lwr by Molmil
Solution structure of the NCAM fibronectin type III module 2
Descriptor: Neural Cell Adhesion Molecule 1, 140 kDa isoform
Authors:Kiselyov, V.V, Skladchikova, G, Hinsby, A.M, Jensen, P.H, Kulahin, N, Pedersen, N, Tsetlin, V, Poulsen, F.M, Berezin, V, Bock, E.
Deposit date:2002-06-03
Release date:2003-06-03
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP
Structure, 11, 2003
2CKN
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BU of 2ckn by Molmil
NMR Structure of the First Ig Module of mouse FGFR1
Descriptor: BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1
Authors:Kiselyov, V.V, Bock, E, Berezin, V, Poulsen, F.M.
Deposit date:2006-04-20
Release date:2006-05-31
Last modified:2020-01-15
Method:SOLUTION NMR
Cite:NMR Structure of the First Ig Module of Mouse Fgfr1.
Protein Sci., 15, 2006
1QZ1
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BU of 1qz1 by Molmil
Crystal Structure of the Ig 1-2-3 fragment of NCAM
Descriptor: Neural cell adhesion molecule 1, 140 kDa isoform
Authors:Soroka, V, Kolkova, K, Kastrup, J.S, Diederichs, K, Breed, J, Kiselyov, V.V, Poulsen, F.M, Larsen, I.K, Welte, W, Berezin, V, Bock, E, Kasper, C.
Deposit date:2003-09-15
Release date:2003-11-04
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion
Structure, 11, 2003
8DI2
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BU of 8di2 by Molmil
Site 2 insulin receptor binding peptide IM459N21
Descriptor: Site 2 binding peptide IM459N21
Authors:Lawrence, M.C, Hu, H, Martinez, F.J, Espinosa, J.F.
Deposit date:2022-06-28
Release date:2022-11-09
Method:SOLUTION NMR
Cite:Activation of the human insulin receptor by non-insulin-related peptides.
Nat Commun, 13, 2022
2WFU
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BU of 2wfu by Molmil
Crystal structure of DILP5 variant DB
Descriptor: PROBABLE INSULIN-LIKE PEPTIDE 5 A CHAIN, PROBABLE INSULIN-LIKE PEPTIDE 5 B CHAIN
Authors:Kulahin, N, Schluckebier, G, Sajid, W, De Meyts, P.
Deposit date:2009-04-15
Release date:2010-05-26
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Biological Properties of the Drosophila Insulin-Like Peptide 5 Show Evolutionary Conservation.
J.Biol.Chem., 286, 2011
2WFV
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Crystal structure of DILP5 variant C4
Descriptor: PROBABLE INSULIN-LIKE PEPTIDE 5 A CHAIN, PROBABLE INSULIN-LIKE PEPTIDE 5 B CHAIN
Authors:Kulahin, N, Schluckebier, G, Sajid, W, De Meyts, P.
Deposit date:2009-04-15
Release date:2010-05-26
Last modified:2012-04-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Biological Properties of the Drosophila Insulin-Like Peptide 5 Show Evolutionary Conservation.
J.Biol.Chem., 286, 2011
5U8Q
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BU of 5u8q by Molmil
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ...
Authors:Lawrence, M, Xu, Y.
Deposit date:2016-12-14
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2710402 Å)
Cite:How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018
5U8R
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BU of 5u8r by Molmil
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ...
Authors:Lawrence, M, Xu, Y.
Deposit date:2016-12-14
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.00001621 Å)
Cite:How ligand binds to the type 1 insulin-like growth factor receptor.
Nat Commun, 9, 2018
7U6E
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BU of 7u6e by Molmil
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM462
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IM462, ...
Authors:Kirk, N.S, Lawrence, M.C.
Deposit date:2022-03-03
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Activation of the human insulin receptor by non-insulin-related peptides
Nat Commun, 13, 2022
7U6D
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BU of 7u6d by Molmil
Head region of insulin receptor ectodomain (A-isoform) bound to the non-insulin agonist IM459
Descriptor: IM459, Isoform Short of Insulin receptor
Authors:Kirk, N.S, Lawrence, M.C.
Deposit date:2022-03-03
Release date:2022-10-05
Method:ELECTRON MICROSCOPY (5.03 Å)
Cite:Activation of the human insulin receptor by non-insulin-related peptides
Nat Commun, 13, 2022
4PFC
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BU of 4pfc by Molmil
Crystal structure of insulin degrading enzyme complexed with inhibitor
Descriptor: Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate
Authors:Wang, Y, Guo, S.
Deposit date:2014-04-28
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PF9
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BU of 4pf9 by Molmil
Crystal structure of insulin degrading enzyme complexed with inhibitor
Descriptor: Insulin-degrading enzyme, ZINC ION, methyl [(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}oxy)phenyl]-3-(quinolin-3-yl)propyl]carbamate
Authors:Wang, Y, Guo, S.
Deposit date:2014-04-28
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PF7
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BU of 4pf7 by Molmil
Crystal structure of insulin degrading enzyme complexed with inhibitor
Descriptor: (2S)-2-amino-N-{(1S)-1-cyclohexyl-2-[(4-methylphenyl)amino]-2-oxoethyl}-4-(methylselanyl)butanamide, Insulin-degrading enzyme, ZINC ION
Authors:Wang, Y, Guo, S.
Deposit date:2014-04-28
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.
J.Biol.Chem., 290, 2015
4PES
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BU of 4pes by Molmil
Crystal structure of insulin degrading enzyme complexed with inhibitor tert-butyl [(2S)-2-(2,5-difluorophenyl)-3-(quinolin-3-yl)propyl]carbamate
Descriptor: Ala-Ala-Ala, Insulin-degrading enzyme, ZINC ION, ...
Authors:Wang, Y, Guo, S.
Deposit date:2014-04-24
Release date:2015-06-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal structure of IDE complexed with an inhibitor
To Be Published
2NCM
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BU of 2ncm by Molmil
NEURAL CELL ADHESION MOLECULE, NMR, 20 STRUCTURES
Descriptor: NEURAL CELL ADHESION MOLECULE
Authors:Thomsen, N.K, Poulsen, F.M.
Deposit date:1996-12-16
Release date:1997-03-12
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:The three-dimensional structure of the first domain of neural cell adhesion molecule.
Nat.Struct.Biol., 3, 1996

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