Author results

3ONW
  • Download 3onw
  • View 3onw
Molmil generated image of 3onw
STRUCTURE OF A G-ALPHA-I1 MUTANT WITH ENHANCED AFFINITY FOR THE RGS14 GOLOCO MOTIF.
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D., Kimple, A.J., Sammond, D.W., Miley, M.J., Machius, M., Kuhlman, B., Willard, F.S., Siderovski, D.P.
Deposit date:2010-08-30
Release date:2010-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein {alpha} Subunit Mutants.
J.Biol.Chem., 286, 2011
3QI2
  • Download 3qi2
  • View 3qi2
Molmil generated image of 3qi2
A GALPHA P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE: G42R BOUND TO RGS14 GOLOCO
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Regulator of G-protein signaling 14, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
Deposit date:2011-01-26
Release date:2012-02-01
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
3UMS
  • Download 3ums
  • View 3ums
Molmil generated image of 3ums
CRYSTAL STRUCTURE OF THE G202A MUTANT OF HUMAN G-ALPHA-I1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Lambert, N.A., Johnston, C.A., Cappell, S.D., Kuravi, S., Kimple, A.J., Willard, F.S., Siderovski, D.P.
Deposit date:2011-11-14
Release date:2012-02-08
Method:X-RAY DIFFRACTION (2.343 Å)
Cite:Correction for Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity
Proc.Natl.Acad.Sci.USA, 2012
4GOU
  • Download 4gou
  • View 4gou
Molmil generated image of 4gou
CRYSTAL STRUCTURE OF AN RGS-RHOGEF FROM ENTAMOEBA HISTOLYTICA
Descriptor:EhRGS-RhoGEF
Authors:Bosch, D.E., Kimple, A.J., Muller, R.E., Willard, F.S., Machius, M., Siderovski, D.P.
Deposit date:2012-08-20
Release date:2013-01-09
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Determinants of RGS-RhoGEF Signaling Critical to Entamoeba histolytica Pathogenesis.
Structure, 21, 2013
3QE0
  • Download 3qe0
  • View 3qe0
Molmil generated image of 3qe0
A GALPHA-I1 P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, MAGNESIUM ION, ...
Authors:Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
Deposit date:2011-01-19
Release date:2012-01-25
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
4FID
  • Download 4fid
  • View 4fid
Molmil generated image of 4fid
CRYSTAL STRUCTURE OF A HETEROTRIMERIC G-PROTEIN SUBUNIT FROM ENTAMOEBA HISTOLYTICA, EHG-ALPHA-1
Descriptor:G protein alpha subunit, GUANOSINE-5'-DIPHOSPHATE
Authors:Bosch, D.E., Kimple, A.J., Muller, R.E., Gigure, P.M., Willard, F.S., Machius, M., Temple, B.R., Siderovski, D.P.
Deposit date:2012-06-08
Release date:2012-11-28
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Heterotrimeric G-protein Signaling Is Critical to Pathogenic Processes in Entamoeba histolytica.
Plos Pathog., 8, 2012
2V4Z
  • Download 2v4z
  • View 2v4z
Molmil generated image of 2v4z
THE CRYSTAL STRUCTURE OF THE HUMAN G-PROTEIN SUBUNIT ALPHA (GNAI3) IN COMPLEX WITH AN ENGINEERED REGULATOR OF G-PROTEIN SIGNALING TYPE 2 DOMAIN (RGS2)
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN G(K) SUBUNIT ALPHA, REGULATOR OF G-PROTEIN SIGNALING 2, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Roos, A.K., Soundararajan, M., Pike, A.C.W., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Knapp, S.
Deposit date:2008-09-30
Release date:2008-11-04
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Determinants of G-Protein Alpha Subunit Selectivity by Regulator of G-Protein Signaling 2(Rgs2).
J.Biol.Chem., 284, 2009
1ZV4
  • Download 1zv4
  • View 1zv4
Molmil generated image of 1zv4
STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING 17 (RGSZ2)
Descriptor:Regulator of G-protein signaling 17
Authors:Schoch, G.A., Jansson, A., Elkins, J.M., Haroniti, A., Niesen, F.H., Bunkoczi, G., Lee, W.H., Turnbull, A.P., Yang, X., Sundstrom, M., Arrowsmith, C., Edwards, A., Marsden, B., Gileadi, O., Ball, L., von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-06-01
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2A72
  • Download 2a72
  • View 2a72
Molmil generated image of 2a72
STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING DOMAIN OF RGS7
Descriptor:Regulator of G-protein signalling 7, CHLORIDE ION
Authors:Schoch, G.A., Johansson, C., Phillips, C., Debreczeni, J., Smee, C., Elkins, J.M., Sundstrom, M., Edwards, A., Arrowsmith, C., von Delft, F., Gileadi, O., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-07-04
Release date:2005-07-12
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2AF0
  • Download 2af0
  • View 2af0
Molmil generated image of 2af0
STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING DOMAIN OF RGS2
Descriptor:Regulator of G-protein signaling 2
Authors:Papagrigoriou, E., Johannson, C., Phillips, C., Smee, C., Elkins, J.M., Weigelt, J., Arrowsmith, C., Edwards, A., Sundstrom, M., Von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-07-25
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2BT2
  • Download 2bt2
  • View 2bt2
Molmil generated image of 2bt2
STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING 16
Descriptor:REGULATOR OF G-PROTEIN SIGNALING 16
Authors:Bunkoczi, G., Haroniti, A., Longman, E., Niesen, F., Soundararajan, M., Ball, L.J., von Delft, F., Doyle, D.A., Arrowsmith, C., Edwards, A., Sundstrom, M.
Deposit date:2005-05-25
Release date:2005-06-03
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Diversity in the Rgs Domain and its Interaction with Heterotrimeric G Protein Alpha- Subunits.
Proc.Natl.Acad.Sci.USA, 105, 2008
2BV1
  • Download 2bv1
  • View 2bv1
Molmil generated image of 2bv1
REGULATOR OF G-PROTEIN SIGNALLING 1 (HUMAN)
Descriptor:REGULATOR OF G-PROTEIN SIGNALLING 1
Authors:Elkins, J.M., Yang, X., Soundararajan, M., Schoch, G.A., Haroniti, A., Sundstrom, M., Edwards, A., Arrowsmith, C., Doyle, D.A.
Deposit date:2005-06-20
Release date:2005-06-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc. Natl. Acad. Sci. U.S.A., 105, 2008
2ES0
  • Download 2es0
  • View 2es0
Molmil generated image of 2es0
STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING DOMAIN OF RGS6
Descriptor:regulator of G-protein signalling 6
Authors:Schoch, G.A., Phillips, C., Turnbull, A., Niesen, F., Johansson, C., Elkins, J.M., Longman, E., Gilealdi, C., Sobott, F., Ball, L., Sundstrom, M., Edwards, A., Arrowsmith, C., von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-10-25
Release date:2005-11-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2GTP
  • Download 2gtp
  • View 2gtp
Molmil generated image of 2gtp
CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF HUMAN RGS1 AND ACTIVATED GI ALPHA 1
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, Regulator of G-protein signaling 1, ...
Authors:Soundararajan, M., Turnbull, A.P., Ugochukwu, E., Gorrec, F., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-04-28
Release date:2006-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2I59
  • Download 2i59
  • View 2i59
Molmil generated image of 2i59
SOLUTION STRUCTURE OF RGS10
Descriptor:Regulator of G-protein signaling 10
Authors:Fedorov, O., Higman, V.A., Diehl, A., Leidert, M., Lemak, A., Schmieder, P., Oschkinat, H., Elkins, J., Soundarajan, M., Doyle, D.A., Arrowsmith, C., Sundstrom, M., Weigelt, J., Edwards, A., Ball, L.J., Structural Genomics Consortium (SGC)
Deposit date:2006-08-24
Release date:2006-10-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2IHB
  • Download 2ihb
  • View 2ihb
Molmil generated image of 2ihb
CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF HUMAN RGS10 AND ACTIVATED GI ALPHA 3
Descriptor:Guanine nucleotide-binding protein G(k) subunit alpha, Regulator of G-protein signalling 10, TETRAFLUOROALUMINATE ION, ...
Authors:Soundararajan, M., Turnbull, A.P., Papagrigoriou, E., Pike, A.C.W., Bunkoczi, G., Ugochukwu, E., Gorrec, F., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-09-26
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2IHD
  • Download 2ihd
  • View 2ihd
Molmil generated image of 2ihd
CRYSTAL STRUCTURE OF HUMAN REGULATOR OF G-PROTEIN SIGNALING 8, RGS8
Descriptor:Regulator of G-protein signaling 8, CHLORIDE ION
Authors:Turnbull, A.P., Papagrigoriou, E., Ugochukwu, E., Salah, E., Gileadi, C., Burgess, N., Bhatia, C., Gileadi, O., Bray, J., Elkins, J., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-09-26
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2IK8
  • Download 2ik8
  • View 2ik8
Molmil generated image of 2ik8
CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF HUMAN RGS16 AND ACTIVATED GI ALPHA 1
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, Regulator of G-protein signaling 16, ...
Authors:Soundararajan, M., Turnbull, A.P., Papagrigoriou, E., Debreczeni, J., Gorrec, F., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-10-02
Release date:2006-11-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2JM5
  • Download 2jm5
  • View 2jm5
Molmil generated image of 2jm5
SOLUTION STRUCTURE OF THE RGS DOMAIN FROM HUMAN RGS18
Descriptor:Regulator of G-protein signaling 18
Authors:Higman, V.A., Leidert, M., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G., Yang, X., Brockmann, C., Schmieder, P., Diehl, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
Deposit date:2006-10-11
Release date:2006-10-24
Last modified:2012-08-15
Method:SOLUTION NMR
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2JNU
  • Download 2jnu
  • View 2jnu
Molmil generated image of 2jnu
SOLUTION STRUCTURE OF THE RGS DOMAIN OF HUMAN RGS14
Descriptor:Regulator of G-protein signaling 14
Authors:Dowler, E.F., Diehl, A., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G.A., Yang, X., Brockmann, C., Leidert, M., Rehbein, K., Schmieder, P., Kuhne, R., Higman, V.A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
Deposit date:2007-02-02
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2ODE
  • Download 2ode
  • View 2ode
Molmil generated image of 2ode
CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF HUMAN RGS8 AND ACTIVATED GI ALPHA 3
Descriptor:Guanine nucleotide-binding protein G(k) subunit alpha, Regulator of G-protein signaling 8, TETRAFLUOROALUMINATE ION, ...
Authors:Gileadi, C., Soundararajan, M., Turnbull, A.P., Elkins, J.M., Papagrigoriou, E., Pike, A.C.W., Bunkoczi, G., Gorrec, F., Umeano, C., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C.H., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-12-22
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2OWI
  • Download 2owi
  • View 2owi
Molmil generated image of 2owi
SOLUTION STRUCTURE OF THE RGS DOMAIN FROM HUMAN RGS18
Descriptor:Regulator of G-protein signaling 18
Authors:Higman, V.A., Leidert, M., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G., Yang, X., Brockmann, C., Schmieder, P., Diehl, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
Deposit date:2007-02-16
Release date:2007-02-27
Last modified:2012-08-15
Method:SOLUTION NMR
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3D7M
  • Download 3d7m
  • View 3d7m
Molmil generated image of 3d7m
CRYSTAL STRUCTURE OF THE G PROTEIN FAST-EXCHANGE DOUBLE MUTANT I56C/Q333C
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, MAGNESIUM ION, ...
Authors:Funk, M.A., Preininger, A.M., Oldham, W.M., Meier, S.M., Hamm, H.E., Iverson, T.M.
Deposit date:2008-05-21
Release date:2009-03-03
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.
Biochemistry, 48, 2009
2XTZ
  • Download 2xtz
  • View 2xtz
Molmil generated image of 2xtz
CRYSTAL STRUCTURE OF THE G ALPHA PROTEIN ATGPA1 FROM ARABIDOPSIS THALIANA
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
Authors:Jones, J.C., Duffy, J.W., Machius, M., Temple, B.R.S., Dohlman, H.G., Jones, A.M.
Deposit date:2010-10-13
Release date:2011-02-16
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:The Crystal Structure of a Self-Activating G Protein Alpha Subunit Reveals its Distinct Mechanism of Signal Initiation
Sci.Signal., 159, 2011