Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2BKL
DownloadVisualize
BU of 2bkl by Molmil
Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Inter-Domain Dynamics in Catalysis and Specificity
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-[(BENZYLOXY)CARBONYL]-L-ALANYL-L-PROLINE, PROLYL ENDOPEPTIDASE, ...
Authors:Khosla, C, Shan, L, Mathews, I.I.
Deposit date:2005-02-16
Release date:2005-03-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Interdomain Dynamics in Catalysis and Specificity
Proc.Natl.Acad.Sci.USA, 102, 2005
2QO3
DownloadVisualize
BU of 2qo3 by Molmil
Crystal Structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase
Descriptor: (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, ACETATE ION, ...
Authors:Khosla, C, Cane, E.D, Tang, Y, Chen, Y.A, Kim, C.Y.
Deposit date:2007-07-19
Release date:2007-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase
Chem.Biol., 14, 2007
2NM0
DownloadVisualize
BU of 2nm0 by Molmil
Crystal Structure of SCO1815: a Beta-Ketoacyl-Acyl Carrier Protein Reductase from Streptomyces coelicolor A3(2)
Descriptor: Probable 3-oxacyl-(Acyl-carrier-protein) reductase
Authors:Khosla, C, Tang, Y, Lee, H.Y, Tang, Y, Kim, C.Y, Mathews, I.I.
Deposit date:2006-10-20
Release date:2007-01-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2).
Biochemistry, 45, 2006
3RGI
DownloadVisualize
BU of 3rgi by Molmil
Trans-acting transferase from Disorazole synthase
Descriptor: DisD protein
Authors:Khosla, C, Mathews, I.I, Wong, F.T, Jin, X.
Deposit date:2011-04-08
Release date:2011-07-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Structure and Mechanism of the trans-Acting Acyltransferase from the Disorazole Synthase.
Biochemistry, 50, 2011
3SBM
DownloadVisualize
BU of 3sbm by Molmil
Trans-acting transferase from Disorazole synthase in complex with Acetate
Descriptor: ACETATE ION, DisD protein, HEXAETHYLENE GLYCOL
Authors:Khosla, C, Mathews, I.I, Wong, F.T, Jin, X.
Deposit date:2011-06-06
Release date:2011-07-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure and Mechanism of the trans-Acting Acyltransferase from the Disorazole Synthase.
Biochemistry, 50, 2011
7SQL
DownloadVisualize
BU of 7sql by Molmil
Crystal structure of human uridine-cytidine kinase 2 complexed with a weak small molecule inhibitor
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, N-(4-bromophenyl)-2-{[1-(4-fluorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}acetamide, ...
Authors:Mashayekh, S, Stunkard, L.M, Kienle, M, Mathews, I.I, Khosla, C.
Deposit date:2021-11-05
Release date:2022-10-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2).
Biochemistry, 61, 2022
8EE0
DownloadVisualize
BU of 8ee0 by Molmil
KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment 1B2
Descriptor: 1B2 antibody heavy chain, 1B2 antibody light chain, 6-deoxyerythronolide B synthase
Authors:Cogan, D.P, Brodsky, K.L, Guzman, K.M, Mathews, I.I, Khosla, C.
Deposit date:2022-09-06
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.
Biochemistry, 62, 2023
8EE1
DownloadVisualize
BU of 8ee1 by Molmil
KS-AT didomain from module 2 of the 6-deoxyerythronolide B synthase in complex with antibody fragment AA5
Descriptor: 6-deoxyerythronolide B synthase, AA5 antibody heavy chain, AA5 antibody light chain
Authors:Cogan, D.P, Brodsky, K.L, Guzman, K.M, Mathews, I.I, Khosla, C.
Deposit date:2022-09-06
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.
Biochemistry, 62, 2023
1YR2
DownloadVisualize
BU of 1yr2 by Molmil
Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Inter-Domain Dynamics in Catalysis and Specificity
Descriptor: GLYCEROL, prolyl oligopeptidase
Authors:Shan, L, Mathews, I.I, Khosla, C.
Deposit date:2005-02-02
Release date:2005-03-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Interdomain Dynamics in Catalysis and Specificity
Proc.Natl.Acad.Sci.USA, 102, 2005
6C9U
DownloadVisualize
BU of 6c9u by Molmil
Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab)
Descriptor: 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Heavy chain of Fab 1B2, ...
Authors:Deis, L.N, Li, X, Mathews, I.I, Khosla, C.
Deposit date:2018-01-28
Release date:2018-05-23
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.
J. Am. Chem. Soc., 140, 2018
6MLK
DownloadVisualize
BU of 6mlk by Molmil
Structure of Thioesterase from DEBS with a thioesterase-specific antibody
Descriptor: 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6, CHLORIDE ION, ...
Authors:Mathews, I.I, Li, X, Khosla, C.
Deposit date:2018-09-27
Release date:2018-10-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase.
Biochemistry, 57, 2018
6W7S
DownloadVisualize
BU of 6w7s by Molmil
Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 2G10
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2G10 (Fab heavy chain), 2G10 (Fab light chain), ...
Authors:Cogan, D.P, Mathews, I.I, Khosla, C.
Deposit date:2020-03-19
Release date:2020-09-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction.
J.Am.Chem.Soc., 142, 2020
6WH9
DownloadVisualize
BU of 6wh9 by Molmil
Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 1D10
Descriptor: 1D10 (Fab heavy chain), 1D10 (Fab light chain), KR1, ...
Authors:Cogan, D.P, Mathews, I.I, Khosla, C.
Deposit date:2020-04-07
Release date:2020-09-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction.
J.Am.Chem.Soc., 142, 2020
2HG4
DownloadVisualize
BU of 2hg4 by Molmil
Structure of the ketosynthase-acyltransferase didomain of module 5 from DEBS.
Descriptor: 6-Deoxyerythronolide B Synthase, ACETATE ION, CHLORIDE ION, ...
Authors:Tang, Y, Kim, C.Y, Mathews, I.I, Cane, D.E, Khosla, C.
Deposit date:2006-06-26
Release date:2006-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:The 2.7-A crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2Q3Z
DownloadVisualize
BU of 2q3z by Molmil
Transglutaminase 2 undergoes large conformational change upon activation
Descriptor: Polypeptide, SULFATE ION, Transglutaminase 2
Authors:Strop, P, Pinkas, D.M, Brunger, A.T, Khosla, C.
Deposit date:2007-05-30
Release date:2007-10-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Transglutaminase 2 undergoes a large conformational change upon activation
Plos Biol., 5, 2007
1MNA
DownloadVisualize
BU of 1mna by Molmil
Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.0
Descriptor: polyketide synthase IV
Authors:Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MNQ
DownloadVisualize
BU of 1mnq by Molmil
Thioesterase Domain of Picromycin Polyketide Synthase (PICS TE), pH 8.4
Descriptor: polyketide synthase IV
Authors:Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MO2
DownloadVisualize
BU of 1mo2 by Molmil
Thioesterase Domain from 6-Deoxyerythronolide Synthase (DEBS TE), pH 8.5
Descriptor: Erythronolide synthase, modules 5 and 6
Authors:Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MN6
DownloadVisualize
BU of 1mn6 by Molmil
Thioesterase Domain from Picromycin Polyketide Synthase, pH 7.6
Descriptor: polyketide synthase IV
Authors:Tsai, S.-C, Lu, H, Cane, D.E, Khosla, C, Stroud, R.M.
Deposit date:2002-09-05
Release date:2003-02-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
7M7H
DownloadVisualize
BU of 7m7h by Molmil
6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1'
Descriptor: 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ...
Authors:Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
Deposit date:2021-03-28
Release date:2021-11-17
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7F
DownloadVisualize
BU of 7m7f by Molmil
6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 1
Descriptor: 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ...
Authors:Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
Deposit date:2021-03-28
Release date:2021-11-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7I
DownloadVisualize
BU of 7m7i by Molmil
6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2 (TE-free)
Descriptor: 1B2 (heavy chain), 1B2 (light chain), EryAI, ...
Authors:Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
Deposit date:2021-03-28
Release date:2021-11-17
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7G
DownloadVisualize
BU of 7m7g by Molmil
6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: State 2
Descriptor: 1B2 (heavy chain), 1B2 (light chain), EryAI,6-deoxyerythronolide-B synthase EryA3, ...
Authors:Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
Deposit date:2021-03-28
Release date:2021-11-17
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7E
DownloadVisualize
BU of 7m7e by Molmil
6-Deoxyerythronolide B synthase (DEBS) hybrid module (M3/1) in complex with antibody fragment 1B2
Descriptor: 1B2 (heavy chain), 1B2 (light chain), 6-deoxyerythronolide-B synthase EryA2, ...
Authors:Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
Deposit date:2021-03-28
Release date:2021-11-17
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021
7M7J
DownloadVisualize
BU of 7m7j by Molmil
6-Deoxyerythronolide B synthase (DEBS) module 1 in complex with antibody fragment 1B2: "turnstile closed" state (TE-free)
Descriptor: 1B2 (heavy chain), 1B2 (light chain), EryAI
Authors:Cogan, D.P, Zhang, K, Chiu, W, Khosla, C.
Deposit date:2021-03-28
Release date:2021-11-17
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Mapping the catalytic conformations of an assembly-line polyketide synthase module.
Science, 374, 2021

 

12>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon