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2QO3
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CRYSTAL STRUCTURE OF [KS3][AT3] DIDOMAIN FROM MODULE 3 OF 6-DEOXYERTHRONOLIDE B SYNTHASE
分子名称:EryAII Erythromycin polyketide synthase modules 3 and 4, ACETATE ION, CHLORIDE ION, ...
著者Khosla, C., Cane, E.D., Tang, Y., Chen, Y.A., Kim, C.Y.
登録日2007-07-19
公開日2007-09-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.59 Å)
主引用文献Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase
Chem.Biol., 14, 2007
2BKL
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STRUCTURAL AND MECHANISTIC ANALYSIS OF TWO PROLYL ENDOPEPTIDASES: ROLE OF INTER-DOMAIN DYNAMICS IN CATALYSIS AND SPECIFICITY
分子名称:PROLYL ENDOPEPTIDASE, N-[(BENZYLOXY)CARBONYL]-L-ALANYL-L-PROLINE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Khosla, C., Shan, L., Mathews, I.I.
登録日2005-02-16
公開日2005-03-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Interdomain Dynamics in Catalysis and Specificity
Proc.Natl.Acad.Sci.USA, 102, 2005
2NM0
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CRYSTAL STRUCTURE OF SCO1815: A BETA-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE FROM STREPTOMYCES COELICOLOR A3(2)
分子名称:Probable 3-oxacyl-(Acyl-carrier-protein) reductase
著者Khosla, C., Tang, Y., Lee, H.Y., Tang, Y., Kim, C.Y., Mathews, I.I.
登録日2006-10-20
公開日2007-01-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2).
Biochemistry, 45, 2006
3RGI
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TRANS-ACTING TRANSFERASE FROM DISORAZOLE SYNTHASE
分子名称:DisD protein
著者Khosla, C., Mathews, I.I., Wong, F.T., Jin, X.
登録日2011-04-08
公開日2011-07-13
最終更新日2011-08-10
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Structure and Mechanism of the trans-Acting Acyltransferase from the Disorazole Synthase.
Biochemistry, 50, 2011
3SBM
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TRANS-ACTING TRANSFERASE FROM DISORAZOLE SYNTHASE IN COMPLEX WITH ACETATE
分子名称:DisD protein, ACETATE ION, HEXAETHYLENE GLYCOL
著者Khosla, C., Mathews, I.I., Wong, F.T., Jin, X.
登録日2011-06-06
公開日2011-07-13
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structure and Mechanism of the trans-Acting Acyltransferase from the Disorazole Synthase.
Biochemistry, 50, 2011
1YR2
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STRUCTURAL AND MECHANISTIC ANALYSIS OF TWO PROLYL ENDOPEPTIDASES: ROLE OF INTER-DOMAIN DYNAMICS IN CATALYSIS AND SPECIFICITY
分子名称:prolyl oligopeptidase, GLYCEROL
著者Shan, L., Mathews, I.I., Khosla, C.
登録日2005-02-02
公開日2005-03-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Interdomain Dynamics in Catalysis and Specificity
Proc.Natl.Acad.Sci.USA, 102, 2005
2HG4
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STRUCTURE OF THE KETOSYNTHASE-ACYLTRANSFERASE DIDOMAIN OF MODULE 5 FROM DEBS.
分子名称:6-Deoxyerythronolide B Synthase, ACETATE ION, SULFATE ION, ...
著者Tang, Y., Kim, C.Y., Mathews, I.I., Cane, D.E., Khosla, C.
登録日2006-06-26
公開日2006-07-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献The 2.7-A crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
1KEZ
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CRYSTAL STRUCTURE OF THE MACROCYCLE-FORMING THIOESTERASE DOMAIN OF ERYTHROMYCIN POLYKETIDE SYNTHASE (DEBS TE)
分子名称:ERYTHRONOLIDE SYNTHASE
著者Tsai, S.-C., Miercke, L.J.W., Krucinski, J., Gokhale, R., Chen, J.C.-H., Foster, P.G., Cane, D.E., Khosla, C., Stroud, R.M.
登録日2001-11-19
公開日2002-01-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.
Proc.Natl.Acad.Sci.USA, 98, 2001
1MN6
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THIOESTERASE DOMAIN FROM PICROMYCIN POLYKETIDE SYNTHASE, PH 7.6
分子名称:polyketide synthase IV
著者Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
登録日2002-09-05
公開日2003-02-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MNA
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THIOESTERASE DOMAIN OF PICROMYCIN POLYKETIDE SYNTHASE (PICS TE), PH 8.0
分子名称:polyketide synthase IV
著者Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
登録日2002-09-05
公開日2003-02-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MNQ
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THIOESTERASE DOMAIN OF PICROMYCIN POLYKETIDE SYNTHASE (PICS TE), PH 8.4
分子名称:polyketide synthase IV
著者Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
登録日2002-09-05
公開日2003-02-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MO2
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THIOESTERASE DOMAIN FROM 6-DEOXYERYTHRONOLIDE SYNTHASE (DEBS TE), PH 8.5
分子名称:Erythronolide synthase, modules 5 and 6
著者Tsai, S.-C., Lu, H., Cane, D.E., Khosla, C., Stroud, R.M.
登録日2002-09-05
公開日2003-02-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases
Biochemistry, 41, 2002
1MZJ
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CRYSTAL STRUCTURE OF THE PRIMING BETA-KETOSYNTHASE FROM THE R1128 POLYKETIDE BIOSYNTHETIC PATHWAY
分子名称:Beta-ketoacylsynthase III, COENZYME A, ACETYL GROUP
著者Pan, H., Tsai, S.C., Meadows, E.S., Miercke, L.J.W., Keatinge-Clay, A., O'Connell, J., Khosla, C., Stroud, R.M.
登録日2002-10-08
公開日2002-12-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway
Structure, 10
1NM2
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MALONYL-COA:ACP TRANSACYLASE
分子名称:malonyl CoA:acyl carrier protein malonyltransferase, NICKEL (II) ION, ACETIC ACID
著者Keatinge-Clay, A.T., Shelat, A.A., Savage, D.F., Tsai, S., Miercke, L.J.W., O'Connell III, J.D., Khosla, C., Stroud, R.M.
登録日2003-01-08
公開日2003-01-21
最終更新日2018-09-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Catalysis, Specificity, and ACP Docking Site of Streptomyces coelicolor Malonyl-CoA:ACP Transacylase
Structure, 11, 2003
1OR5
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SOLUTION STRUCTURE OF THE HOLO-FORM OF THE FRENOLICIN ACYL CARRIER PROTEIN, MINIMIZED MEAN STRUCTURE
分子名称:acyl carrier protein
著者Li, Q., Khosla, C., Puglisi, J., Liu, C.W.
登録日2003-03-11
公開日2003-07-01
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution Structure and Backbone Dynamics of the Holo Form of the Frenolicin Acyl Carrier Protein
Biochemistry, 42, 2003
1R2J
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FKBI FOR BIOSYNTHESIS OF METHOXYMALONYL EXTENDER UNIT OF FK520 POLYKETIDE IMMUNOSUPPRESANT
分子名称:protein FkbI, FLAVIN-ADENINE DINUCLEOTIDE
著者Watanabe, K., Khosla, C., Stroud, R.M., Tsai, S.-C.
登録日2003-09-28
公開日2003-11-25
最終更新日2018-04-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of an Acyl-ACP Dehydrogenase from the FK520 Polyketide Biosynthetic Pathway: Insights into Extender Unit Biosynthesis
J.Mol.Biol., 334, 2003
1S9V
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CRYSTAL STRUCTURE OF HLA-DQ2 COMPLEXED WITH DEAMIDATED GLIADIN PEPTIDE
分子名称:HLA class II histocompatibility antigen, DQ(3) alpha chain, DQ(1) beta chain, ...
著者Kim, C.-Y., Quarsten, H., Bergseng, E., Khosla, C., Sollid, L.M.
登録日2004-02-05
公開日2004-03-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease
Proc.Natl.Acad.Sci.USA, 101, 2004
1TQY
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THE ACTINORHODIN KETOSYNTHASE/CHAIN LENGTH FACTOR
分子名称:Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, MAGNESIUM ION, ...
著者Keatinge-Clay, A.T., Maltby, D.A., Medzihradszky, K.F., Khosla, C., Stroud, R.M.
登録日2004-06-18
公開日2004-07-27
最終更新日2018-06-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An antibiotic factory caught in action.
Nat.Struct.Mol.Biol., 11, 2004
1XNV
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ACYL-COA CARBOXYLASE BETA SUBUNIT FROM S. COELICOLOR (PCCB), APO FORM #1
分子名称:propionyl-CoA carboxylase complex B subunit
著者Diacovich, L., Mitchell, D.L., Pham, H., Gago, G., Melgar, M.M., Khosla, C., Gramajo, H., Tsai, S.-C.
登録日2004-10-05
公開日2004-11-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
1XNW
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ACYL-COA CARBOXYLASE BETA SUBUNIT FROM S. COELICOLOR (PCCB), APO FORM #2, MUTANT D422I
分子名称:propionyl-CoA carboxylase complex B subunit
著者Diacovich, L., Mitchell, D.L., Pham, H., Gago, G., Melgar, M.M., Khosla, C., Gramajo, H., Tsai, S.-C.
登録日2004-10-05
公開日2004-11-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
1XNY
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BIOTIN AND PROPIONYL-COA BOUND TO ACYL-COA CARBOXYLASE BETA SUBUNIT FROM S. COELICOLOR (PCCB)
分子名称:propionyl-CoA carboxylase complex B subunit, propionyl Coenzyme A, BIOTIN
著者Diacovich, L., Mitchell, D.L., Pham, H., Gago, G., Melgar, M.M., Khosla, C., Gramajo, H., Tsai, S.-C.
登録日2004-10-05
公開日2004-11-09
最終更新日2015-09-30
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
1XO6
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ACYL-COA CARBOXYLASE BETA SUBUNIT FROM S. COELICOLOR (PCCB), APO FORM #3
分子名称:propionyl-CoA carboxylase complex B subunit
著者Diacovich, L., Mitchell, D.L., Pham, H., Gago, G., Melgar, M.M., Khosla, C., Gramajo, H., Tsai, S.-C.
登録日2004-10-05
公開日2004-11-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity
Biochemistry, 43, 2004
2FO5
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CRYSTAL STRUCTURE OF RECOMBINANT BARLEY CYSTEINE ENDOPROTEASE B ISOFORM 2 (EP-B2) IN COMPLEX WITH LEUPEPTIN
分子名称:Cysteine proteinase EP-B 2, ACE-LEU-LEU-argininal (leupeptin), SULFATE ION
著者Bethune, M.T., Strop, P., Brunger, A.T., Khosla, C.
登録日2006-01-12
公開日2006-07-18
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Heterologous Expression, Purification, Refolding, and Structural-Functional Characterization of EP-B2, a Self-Activating Barley Cysteine Endoprotease.
Chem.Biol., 13, 2006
2JU1
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SOLUTION STRUCTURE OF ACYL CARRIER PROTEIN DOMAIN FROM MODULE 2 OF 6-DEOXYERYTHRONOLIDE B SYNTHASE (DEBS)
分子名称:Erythronolide synthase
著者Alekseyev, V.Y., Liu, C.W., Puglisi, J.D., Khosla, C.
登録日2007-08-12
公開日2007-10-02
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase.
Protein Sci., 16, 2007
2JU2
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MINIMIZED MEAN SOLUTION STRUCTURE OF THE ACYL CARRIER PROTEIN DOMAIN FROM MODULE 2 OF 6-DEOXYERYTHRONOLIDE B SYNTHASE (DEBS)
分子名称:Erythronolide synthase
著者Alekseyev, V.Y., Liu, C.W., Puglisi, J.D., Khosla, C.
登録日2007-08-12
公開日2007-10-02
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase.
Protein Sci., 16, 2007
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