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6XDC
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BU of 6xdc by Molmil
Cryo-EM structure of SARS-CoV-2 ORF3a
Descriptor: ORF3a protein
Authors:Kern, D.M, Hoel, C.M, Brohawn, S.G.
Deposit date:2020-06-10
Release date:2020-06-17
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
Nat.Struct.Mol.Biol., 28, 2021
7KJR
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BU of 7kjr by Molmil
Cryo-EM structure of SARS-CoV-2 ORF3a
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Apolipoprotein A-I, ORF3a protein
Authors:Kern, D.M, Hoel, C.M, Kotecha, A, Brohawn, S.G.
Deposit date:2020-10-26
Release date:2020-11-18
Last modified:2022-08-31
Method:ELECTRON MICROSCOPY (2.08 Å)
Cite:Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs.
Nat.Struct.Mol.Biol., 28, 2021
6NZZ
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BU of 6nzz by Molmil
LRRC8A-DCPIB in MSP1E3D1 nanodisc expanded state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Hite, R.K, Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
6O00
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BU of 6o00 by Molmil
apo-LRRC8A in MSP2N2 nanodisc constricted state
Descriptor: Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Hite, R.K, Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.18 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
6NZW
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BU of 6nzw by Molmil
LRRC8A-DCPIB in MSP1E3D1 nanodisc constricted state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Hite, R.K, Brohawn, S.G.
Deposit date:2019-02-14
Release date:2019-02-27
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
Elife, 8, 2019
8DRE
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BU of 8dre by Molmil
LRRC8A:C conformation 2 (oblong)
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-07-20
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.18 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8DRA
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BU of 8dra by Molmil
LRRC8A:C conformation 2 (oblong) LRR mask
Descriptor: Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-07-20
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.98 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8DS9
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BU of 8ds9 by Molmil
LRRC8A:C in MSPE3D1 nanodisc top focus
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-07-21
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8DR8
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BU of 8dr8 by Molmil
LRRC8A:C conformation 2 (oblong) top mask
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-07-20
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8DRK
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BU of 8drk by Molmil
LRRC8A:C conformation 1 (round) top focus
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-07-21
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8DSA
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BU of 8dsa by Molmil
LRRC8A:C in MSP1E3D1 nanodisc
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-07-21
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.48 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8DS3
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BU of 8ds3 by Molmil
LRRC8A:C conformation 1 (round)
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-07-21
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8DRN
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BU of 8drn by Molmil
LRRC8A:C conformation 1 (round) LRR focus 1
Descriptor: Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-07-21
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (4.12 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8DRQ
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BU of 8drq by Molmil
LRRC8A:C conformation 1 (round) LRR focus 3
Descriptor: Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-07-21
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (4.16 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8DRO
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BU of 8dro by Molmil
LRRC8A:C conformation 1 (round) LRR focus 2
Descriptor: Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-07-21
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (4.06 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8F7B
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BU of 8f7b by Molmil
LRRC8A(T48D):C conformation 2 top focus
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-11-18
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8F75
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BU of 8f75 by Molmil
LRRC8A(T48D):C conformation 2 LRR focus
Descriptor: Volume-regulated anion channel subunit LRRC8A, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-11-18
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8F7E
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BU of 8f7e by Molmil
LRRC8A(T48D):C conformation 2 top focus
Descriptor: Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-11-18
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (4.13 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8F77
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BU of 8f77 by Molmil
LRRC8A(T48D):C conformation 2 top focus
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-11-18
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8F7D
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BU of 8f7d by Molmil
LRRC8A(T48D):C conformation 2 top focus
Descriptor: Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-11-18
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8F74
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BU of 8f74 by Molmil
LRRC8A(T48D):C conformation 2 top focus
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-11-18
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8F79
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BU of 8f79 by Molmil
LRRC8A(T48D):C conformation 2 top focus
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-11-18
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
8F7J
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BU of 8f7j by Molmil
LRRC8A(T48D):C conformation 2 top focus
Descriptor: Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562
Authors:Kern, D.M, Brohawn, S.G.
Deposit date:2022-11-18
Release date:2023-03-08
Last modified:2023-07-05
Method:ELECTRON MICROSCOPY (4.32 Å)
Cite:Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels.
Nat.Struct.Mol.Biol., 30, 2023
7M19
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BU of 7m19 by Molmil
SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-2)
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Gerber, E.E, Brohawn, S.G.
Deposit date:2021-03-12
Release date:2021-03-24
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3.69 Å)
Cite:Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Nat Commun, 13, 2022
7M17
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BU of 7m17 by Molmil
SN-407-LRRC8A in MSP1E3D1 lipid nanodiscs (Pose-1)
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 7-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}heptanoic acid, Volume-regulated anion channel subunit LRRC8A
Authors:Kern, D.M, Gerber, E.E, Brohawn, S.G.
Deposit date:2021-03-12
Release date:2021-03-24
Last modified:2022-02-23
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Nat Commun, 13, 2022

 

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