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4B8T
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BU of 4b8t by Molmil
RNA BINDING PROTEIN Solution structure of the third KH domain of KSRP in complex with the G-rich target sequence.
Descriptor: 5'-R(*AP*GP*GP*GP*UP)-3', KH-TYPE SPLICING REGULATORY PROTEIN
Authors:Nicastro, G, Garcia-Mayoral, M.F, Hollingworth, D, Kelly, G, Martin, S.R, Briata, P, Gherzi, R, Ramos, A.
Deposit date:2012-08-30
Release date:2012-11-07
Last modified:2013-01-16
Method:SOLUTION NMR
Cite:Noncanonical G Recognition Mediates Ksrp Regulation of Let-7 Biogenesis
Nat.Struct.Mol.Biol., 19, 2012
1GM2
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BU of 1gm2 by Molmil
The independent structure of the antitryptic reactive site loop of Bowman-Birk inhibitor and sunflower trypsin inhibitor-1
Descriptor: BOWMAN-BIRK INHIBITOR DERIVED PEPTIDE
Authors:Brauer, A.B.E, Kelly, G, Matthews, S.J, Leatherbarrow, R.J.
Deposit date:2001-09-08
Release date:2002-08-29
Last modified:2020-07-29
Method:SOLUTION NMR
Cite:The (1)H-NMR solution structure of the antitryptic core peptide of Bowman-Birk inhibitor proteins: a minimal canonical loop.
J.Biomol.Struct.Dyn., 20, 2002
6I9B
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BU of 6i9b by Molmil
NMR structure of the La module from human LARP4A
Descriptor: La-related protein 4
Authors:Conte, M.R, Martino, L, Atkinson, R.A, Kelly, G, Cruz-Gallardo, I, De Tito, S, Trotta, R.
Deposit date:2018-11-22
Release date:2019-03-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:LARP4A recognizes polyA RNA via a novel binding mechanism mediated by disordered regions and involving the PAM2w motif, revealing interplay between PABP, LARP4A and mRNA.
Nucleic Acids Res., 47, 2019
6XU1
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BU of 6xu1 by Molmil
Crystal structure of tetrameric human H215A-SAMHD1 (residues 109-626) with GTP, dAMPNPP and Mg
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ...
Authors:Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A.
Deposit date:2020-01-17
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Nat Commun, 11, 2020
6YOM
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BU of 6yom by Molmil
Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dATP, dCMPNPP, Mn and Mg
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ...
Authors:Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A.
Deposit date:2020-04-14
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Nat Commun, 11, 2020
1L3G
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BU of 1l3g by Molmil
NMR Structure of the DNA-binding Domain of Cell Cycle Protein, Mbp1(2-124) from Saccharomyces cerevisiae
Descriptor: TRANSCRIPTION FACTOR Mbp1
Authors:Nair, M, McIntosh, P.B, Frenkiel, T.A, Kelly, G, Taylor, I.A, Smerdon, S.J, Lane, A.N.
Deposit date:2002-02-27
Release date:2003-02-18
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:NMR Structure of the DNA-Binding Domain of the Cell Cycle Protein Mbp1 from Saccharomyces cerevisiae
Biochemistry, 42, 2003
1LUD
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BU of 1lud by Molmil
SOLUTION STRUCTURE OF DIHYDROFOLATE REDUCTASE COMPLEXED WITH TRIMETHOPRIM AND NADPH, 24 STRUCTURES
Descriptor: 2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM, DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Polshakov, V.I, Smirnov, E.G, Birdsall, B, Kelly, G, Feeney, J.
Deposit date:2002-05-22
Release date:2002-12-18
Last modified:2016-12-28
Method:SOLUTION NMR
Cite:NMR-based solution structure of the complex of Lactobacillus casei dihydrofolate reductase with trimethoprim and NADPH
J.Biomol.Nmr, 24, 2002
1H8B
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BU of 1h8b by Molmil
EF-hands 3,4 from alpha-actinin / Z-repeat 7 from titin
Descriptor: ALPHA-ACTININ 2, SKELETAL MUSCLE ISOFORM, TITIN
Authors:Atkinson, R.A, Joseph, C, Kelly, G, Muskett, F.W, Frenkiel, T.A, Nietlispach, D, Pastore, A.
Deposit date:2001-02-01
Release date:2001-08-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Ca2+-Independent Binding of an EF-Hand Domain to a Novel Motif in the Alpha-Actinin-Titin Complex
Nat.Struct.Biol., 8, 2001
1O9S
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BU of 1o9s by Molmil
Crystal structure of a ternary complex of the human histone methyltransferase SET7/9
Descriptor: GENE FRAGMENT FOR HISTONE H3, HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-4 SPECIFIC, ...
Authors:Xiao, B, Jing, C, Wilson, J.R, Walker, P.A, Vasisht, N, Kelly, G, Howell, S, Taylor, I.A, Blackburn, G.M, Gamblin, S.J.
Deposit date:2002-12-18
Release date:2003-02-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structure and Catalytic Mechanism of the Human Histone Methyltransferase Set7/9
Nature, 421, 2003
1OWX
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BU of 1owx by Molmil
Solution structure of the C-terminal RRM of human La (La225-334)
Descriptor: Lupus La protein
Authors:Jacks, A, Babon, J, Kelly, G, Manolaridis, I, Cary, P.D, Curry, S, Conte, M.R.
Deposit date:2003-03-31
Release date:2003-07-29
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element
Structure, 11, 2003
5LSD
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BU of 5lsd by Molmil
recombinant mouse Nerve Growth Factor
Descriptor: Beta-nerve growth factor
Authors:Paoletti, F, de Chiara, C, Kelly, G, Lamba, D, Cattaneo, A, Pastore, A.
Deposit date:2016-08-25
Release date:2017-07-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor.
Front Mol Biosci, 3, 2016
1WA8
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BU of 1wa8 by Molmil
Solution Structure of the CFP-10.ESAT-6 Complex. Major Virulence Determinants of Pathogenic Mycobacteria
Descriptor: 6 KDA EARLY SECRETORY ANTIGENIC TARGET (ESAT-6), ESAT-6 LIKE PROTEIN ESXB
Authors:Renshaw, P.S, Lightbody, K.L, Veverka, V, Muskett, F.W, Kelly, G, Frenkiel, T.A, Gordon, S.V, Hewinson, R.G, Burke, B, Norman, J, Williamson, R.A, Carr, M.D, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-10-25
Release date:2005-06-27
Last modified:2019-08-21
Method:SOLUTION NMR
Cite:Structure and Function of the Complex Formed by the Tuberculosis Virulence Factors Cfp-10 and Esat-6
Embo J., 24, 2005
1A1D
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BU of 1a1d by Molmil
YEAST RNA POLYMERASE SUBUNIT RPB8, NMR, MINIMIZED AVERAGE STRUCTURE, ALPHA CARBONS ONLY
Descriptor: RNA POLYMERASE
Authors:Krapp, S, Kelly, G, Reischl, J, Weinzierl, R, Matthews, S.
Deposit date:1997-12-10
Release date:1999-03-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Eukaryotic RNA polymerase subunit RPB8 is a new relative of the OB family.
Nat.Struct.Biol., 5, 1998
1S7A
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BU of 1s7a by Molmil
NMR structure of the La motif of human La protein
Descriptor: Lupus La protein
Authors:Alfano, C, Sanfelice, D, Babon, J, Kelly, G, Jacks, A, Curry, S, Conte, M.R.
Deposit date:2004-01-29
Release date:2004-04-06
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.
Nat.Struct.Mol.Biol., 11, 2004
1S79
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BU of 1s79 by Molmil
Solution structure of the central RRM of human La protein
Descriptor: Lupus La protein
Authors:Alfano, C, Sanfelice, D, Babon, J, Kelly, G, Jacks, A, Curry, S, Conte, M.R.
Deposit date:2004-01-29
Release date:2004-04-06
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.
Nat.Struct.Mol.Biol., 11, 2004
6TXF
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BU of 6txf by Molmil
Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dAMPNPP and Mn
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ...
Authors:Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A.
Deposit date:2020-01-14
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Nat Commun, 11, 2020
1V06
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BU of 1v06 by Molmil
AXH domain of the transcription factor HBP1 from M.musculus
Descriptor: HMG BOX-CONTAINING PROTEIN 1
Authors:De Chiara, C, Kelly, G, Pastore, A.
Deposit date:2004-03-24
Release date:2005-04-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Axh Domain Adopts Alternative Folds the Solution Structure of Hbp1 Axh.
Structure, 13, 2005
6TX0
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BU of 6tx0 by Molmil
Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dAMPNPP and Mg
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ...
Authors:Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A.
Deposit date:2020-01-13
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Nat Commun, 11, 2020
6TXE
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BU of 6txe by Molmil
Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, dATP, dTMPNPP and Mg
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ...
Authors:Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A.G, Kelly, G, Taylor, I.A.
Deposit date:2020-01-14
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Nat Commun, 11, 2020
6TXC
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BU of 6txc by Molmil
Crystal structure of tetrameric human wt-SAMHD1 (residues 109-626) with GTP, dATP, dCMPNPP and Mg
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ...
Authors:Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A, Kelly, G, Taylor, I.A.
Deposit date:2020-01-14
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Nat Commun, 11, 2020
6TXA
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BU of 6txa by Molmil
Crystal structure of tetrameric human D137N-SAMHD1 (residues 109-626) with XTP, dGMPNPP and Mg
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ...
Authors:Morris, E.R, Kunzelmann, S, Caswell, S.J, Arnold, L.H, Purkiss, A, Kelly, G, Taylor, I.A.
Deposit date:2020-01-13
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.853 Å)
Cite:Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Nat Commun, 11, 2020
1HD9
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BU of 1hd9 by Molmil
The Bowman-Birk Inhibitor Reactive Site Loop Sequence Represents an Independent Structural Beta-Hairpin Motif
Descriptor: BOWMAN-BIRK INHIBITOR DERIVED PEPTIDE
Authors:Brauer, A.B.E, Kelly, G, McBride, J.D, Cooke, R.M, Matthews, S.J, Leatherbarrow, R.J.
Deposit date:2000-11-13
Release date:2001-03-29
Last modified:2023-11-15
Method:SOLUTION NMR
Cite:The Bowman-Birk Inhibitor Reactive Site Loop Sequence Represents an Independent Structural Beta-Hairpin Motif
J.Mol.Biol., 306, 2001
2BF0
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BU of 2bf0 by Molmil
crystal structure of the rpr of pcf11
Descriptor: CALCIUM ION, PCF11
Authors:Noble, C.G, Hollingworth, D, Martin, S.R, Adeniran, V.E, Smerdon, S.J, Kelly, G, Taylor, I.A, Ramos, A.
Deposit date:2004-12-02
Release date:2005-01-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Key Features of the Interaction between Pcf11 Cid and RNA Polymerase II Ctd.
Nat.Struct.Mol.Biol., 12, 2005
2BQZ
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BU of 2bqz by Molmil
Crystal structure of a ternary complex of the human histone methyltransferase Pr-SET7 (also known as SET8)
Descriptor: HISTONE H4, S-ADENOSYL-L-HOMOCYSTEINE, SET8 PROTEIN
Authors:Xiao, B, Jing, C, Kelly, G, Walker, P.A, Muskett, F.W, Frenkiel, T.A, Martin, S.R, Sarma, K, Reinberg, D, Gamblin, S.J, Wilson, J.R.
Deposit date:2005-04-28
Release date:2005-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Specificity and Mechanism of the Histone Methyltransferase Pr-Set7
Genes Dev., 19, 2005
2BKD
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BU of 2bkd by Molmil
Structure of the N-terminal domain of Fragile X Mental Retardation Protein
Descriptor: Fragile X messenger ribonucleoprotein 1
Authors:Ramos, A, Hollingworth, D, Adinolfi, S, Castets, M, Kelly, G, Frenkiel, T.A, Bardoni, B, Pastore, A.
Deposit date:2005-02-15
Release date:2006-01-18
Last modified:2023-02-01
Method:SOLUTION NMR
Cite:The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction.
Structure, 14, 2006

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