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5VP2
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH MADUMYCIN II AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Osterman, I.A., Khabibullina, N.F., Komarova, E.S., Kasatsky, P., Kartsev, V.G., Bogdanov, A.A., Dontsova, O.A., Konevega, A.L., Sergiev, P.V., Polikanov, Y.S.
Deposit date:2017-05-04
Release date:2017-06-28
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.
Nucleic Acids Res., 45, 2017
6OF1
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH DIRITHROMYCIN AND BOUND TO MRNA AND A-, P-, AND E-SITE TRNAS AT 2.80A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Khabibullina, N.F., Tereshchenkov, A.G., Komarova, E.S., Syroegin, E.A., Shiriaev, D.I., Paleskava, A., Kartsev, V.G., Bogdanov, A.A., Konevega, A.L., Dontsova, O.A., Sergiev, P.V., Osterman, I.A., Polikanov, Y.S.
Deposit date:2019-03-28
Release date:2019-04-17
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides.
Antimicrob.Agents Chemother., 63, 2019