Author results

2QEL
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CRYSTAL STRUCTURE OF THE HIGHLY AMYLOIDOGENIC TRANSTHYRETIN MUTANT TTR G53S/E54D/L55S- HEATED PROTEIN
Descriptor:Transthyretin
Authors:Karlsson, A., Sauer-Eriksson, A.E.
Deposit date:2007-06-26
Release date:2007-09-04
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Heating of proteins as a means of improving crystallization: a successful case study on a highly amyloidogenic triple mutant of human transthyretin
Acta Crystallogr.,Sect.F, 63, 2007
1KRH
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X-RAY STRUCTURE OF BENZOATE DIOXYGENASE REDUCTASE
Descriptor:Benzoate 1,2-Dioxygenase Reductase, SULFATE ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Karlsson, A., Beharry, Z.M., Eby, D.M., Coulter, E.D., Niedle, E.L., Kurtz Jr., D.M., Eklund, H., Ramaswamy, S.
Deposit date:2002-01-09
Release date:2002-05-15
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:X-ray crystal structure of benzoate 1,2-dioxygenase reductase from Acinetobacter sp. strain ADP1.
J.Mol.Biol., 318, 2002
1O7G
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NAPHTHALENE 1,2-DIOXYGENASE WITH NAPHTHALENE BOUND IN THE ACTIVE SITE.
Descriptor:NAPHTHALENE 1,2-DIOXYGENASE ALPHA SUBUNIT, NAPHTHALENE 1,2-DIOXYGENASE BETA SUBUNIT, 1,2-ETHANEDIOL, ...
Authors:Karlsson, A., Parales, J.V., Parales, R.E., Gibson, D.T., Eklund, H., Ramaswamy, S.
Deposit date:2002-11-05
Release date:2003-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of Naphthalene Dioxygenase: Side-on Binding of Dioxygen to Iron
Science, 299, 2003
1O7H
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NAPHTHALENE 1,2-DIOXYGENASE WITH OXIDIZED RIESKE IRON SULPHUR CENTER SITE.
Descriptor:NAPHTHALENE 1,2-DIOXYGENASE ALPHA SUBUNIT, NAPHTHALENE 1,2-DIOXYGENASE BETA SUBUNIT, 1,2-ETHANEDIOL, ...
Authors:Karlsson, A., Parales, J.V., Parales, R.E., Gibson, D.T., Eklund, H., Ramaswamy, S.
Deposit date:2002-11-05
Release date:2003-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Naphthalene Dioxygenase: Side-on Binding of Dioxygen to Iron
Science, 299, 2003
1O7M
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NAPHTHALENE 1,2-DIOXYGENASE, BINARY COMPLEX WITH DIOXYGEN
Descriptor:NAPHTHALENE 1,2-DIOXYGENASE ALPHA SUBUNIT, NAPHTHALENE 1,2-DIOXYGENASE BETA SUBUNIT, 1,2-ETHANEDIOL, ...
Authors:Karlsson, A., Parales, J.V., Parales, R.E., Gibson, D.T., Eklund, H., Ramaswamy, S.
Deposit date:2002-11-11
Release date:2003-02-20
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of Naphthalene Dioxygenase: Side-on Binding of Dioxygen to Iron
Science, 299, 2003
1O7N
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NAPHTHALENE 1,2-DIOXYGENASE, TERNARY COMPLEX WITH DIOXYGEN AND INDOLE
Descriptor:NAPHTHALENE 1,2-DIOXYGENASE ALPHA SUBUNIT, NAPHTHALENE 1,2-DIOXYGENASE BETA SUBUNIT, 1,2-ETHANEDIOL, ...
Authors:Karlsson, A., Parales, J.V., Parales, R.E., Gibson, D.T., Eklund, H., Ramaswamy, S.
Deposit date:2002-11-11
Release date:2003-02-20
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal Structure of Naphthalene Dioxygenase: Side-on Binding of Dioxygen to Iron
Science, 299, 2003
1O7P
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NAPHTHALENE 1,2-DIOXYGENASE, PRODUCT COMPLEX
Descriptor:NAPHTHALENE 1,2-DIOXYGENASE ALPHA SUBUNIT, NAPHTHALENE 1,2-DIOXYGENASE BETA SUBUNIT, 1,2-ETHANEDIOL, ...
Authors:Karlsson, A., Parales, J.V., Parales, R.E., Gibson, D.T., Eklund, H., Ramaswamy, S.
Deposit date:2002-11-11
Release date:2003-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of Naphthalene Dioxygenase: Side-on Binding of Dioxygen to Iron
Science, 299, 2003
1O7W
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NAPHTHALENE 1,2-DIOXYGENASE, FULLY REDUCED FORM
Descriptor:NAPHTHALENE 1,2-DIOXYGENASE ALPHA SUBUNIT, NAPHTHALENE 1,2-DIOXYGENASE BETA SUBUNIT, 1,2-ETHANEDIOL, ...
Authors:Karlsson, A., Parales, J.V., Parales, R.E., Gibson, D.T., Eklund, H., Ramaswamy, S.
Deposit date:2002-11-14
Release date:2003-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Naphthalene Dioxygenase: Side-on Binding of Dioxygen to Iron
Science, 299, 2003
1UUV
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NAPHTHALENE 1,2-DIOXYGENASE WITH NITRIC OXIDE AND INDOLE BOUND IN THE ACTIVE SITE.
Descriptor:NAPHTHALENE 1,2-DIOXYGENASE ALPHA SUBUNIT, NAPHTHALENE 1,2-DIOXYGENASE BETA SUBUNIT, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Karlsson, A., Parales, J.V., Parales, R.E., Gibson, D.T., Eklund, H., Ramaswamy, S.
Deposit date:2004-01-11
Release date:2005-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:No Binding to Naphthalene Dioxygenase.
J.Biol.Inorg.Chem., 10, 2005
1UUW
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NAPHTHALENE 1,2-DIOXYGENASE WITH NITRIC OXIDE BOUND IN THE ACTIVE SITE.
Descriptor:NAPHTHALENE 1,2-DIOXYGENASE ALPHA SUBUNIT, NAPHTHALENE 1,2-DIOXYGENASE BETA SUBUNIT, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Karlsson, A., Parales, J.V., Parales, R.E., Gibson, D.T., Eklund, H., Ramaswamy, S.
Deposit date:2004-01-11
Release date:2005-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:No Binding to Naphthalene Dioxygenase.
J.Biol.Inorg.Chem., 10, 2005
1IJN
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CRYSTAL STRUCTURE OF THE TRANSTHYRETIN MUTANT TTR C10A/Y114C
Descriptor:TRANSTHYRETIN, BETA-MERCAPTOETHANOL
Authors:Eneqvist, T., Karlsson, A., Olofsson, A., Sauer-Eriksson, A.E.
Deposit date:2001-04-27
Release date:2003-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Cys114-linked dimers of transthyretin are compatible with amyloid formation
Biochemistry, 44, 2005
4AJW
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DISCOVERY AND OPTIMIZATION OF NEW BENZIMIDAZOLE- AND BENZOXAZOLE-PYRIMIDONE SELECTIVE PI3KBETA INHIBITORS FOR THE TREATMENT OF PHOSPHATASE AND TENSIN HOMOLOGUE (PTEN)-DEFICIENT CANCERS
Descriptor:PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM, 2-[(1-methyl-1H-benzimidazol-2-yl)methyl]-6-morpholin-4-ylpyrimidin-4(3H)-one
Authors:Certal, V., Halley, F., Virone-Oddos, A., Delorme, C., Karlsson, A., Rak, A., Thompson, F., Filoche-Romme, B., El-Ahmad, Y., Carry, J.C., Abecassis, P.Y., Lejeune, P., Bonnevaux, H., Nicolas, J.P., Bertrand, T., Marquette, J.P., Michot, N., Benard, T., Below, P., Vade, I., Chatreaux, F., Lebourg, G., Pilorge, F., Angouillant-Boniface, O., Louboutin, A., Lengauer, C., Schio, L.
Deposit date:2012-02-20
Release date:2012-05-16
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers.
J.Med.Chem., 55, 2012
4BFR
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DISCOVERY AND OPTIMIZATION OF PYRIMIDONE INDOLINE AMIDE PI3KBETA INHIBITORS FOR THE TREATMENT OF PHOSPHATASE AND TENSIN HOMOLOGUE (PTEN)-DEFICIENT CANCERS
Descriptor:PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC S SUBUNIT BETA ISOFORM, 2-[2-(2-METHYL-2,3-DIHYDRO-INDOL-1-YL)-2-OXO-ETHYL]-6-MORPHOLIN-4-YL-3H-PYRIMIDIN-4-ONE
Authors:Certal, V., Carry, J.C., Halley, F., Virone-Oddos, A., Thompson, F., Filoche-Romme, B., El-Ahmad, Y., Karlsson, A., Charrier, V., Delorme, C., Rak, A., Abecassis, P.Y., Amara, C., Vincent, L., Bonnevaux, H., Nicolas, J.P., Mathieu, M., Bertrand, T., Marquette, J.P., Michot, N., Benard, T., Perrin, M.A., Perron, S., Monget, S., Gruss-Leleu, F., Doerflinger, G., Guizani, H., Brollo, M., Delbarre, L., Bertin, L., Richepin, P., Loyau, V., Garcia-Echeverria, C., Lengauer, C., Schio, L.
Deposit date:2013-03-22
Release date:2014-01-15
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery and Optimization of Pyrimidone Indoline Amide Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers.
J.Med.Chem., 57, 2014
1EHW
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HUMAN NUCLEOSIDE DIPHOSPHATE KINASE 4
Descriptor:NUCLEOSIDE DIPHOSPHATE KINASE, SULFATE ION
Authors:Milon, L., Meyer, P., Chiadmi, M., Munier, A., Johansson, M., Karlsson, A., Lascu, I., Capeau, J., Janin, J., Lacombe, M.-L.
Deposit date:2000-02-23
Release date:2000-05-17
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase.
J.Biol.Chem., 275, 2000
1GUY
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STRUCTURAL BASIS FOR THERMOPHILIC PROTEIN STABILITY: STRUCTURES OF THERMOPHILIC AND MESOPHILIC MALATE DEHYDROGENASES
Descriptor:MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, CADMIUM ION
Authors:Dalhus, B., Sarinen, M., Sauer, U.H., Eklund, P., Johansson, K., Karlsson, A., Ramaswamy, S., Bjork, A., Synstad, B., Naterstad, K., Sirevag, R., Eklund, H.
Deposit date:2002-02-04
Release date:2002-02-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
J.Mol.Biol., 318, 2002
1GUZ
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STRUCTURAL BASIS FOR THERMOPHILIC PROTEIN STABILITY: STRUCTURES OF THERMOPHILIC AND MESOPHILIC MALATE DEHYDROGENASES
Descriptor:MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Dalhus, B., Sarinen, M., Sauer, U.H., Eklund, P., Johansson, K., Karlsson, A., Ramaswamy, S., Bjork, A., Synstad, B., Naterstad, K., Sirevag, R., Eklund, H.
Deposit date:2002-02-04
Release date:2002-02-21
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
J.Mol.Biol., 318, 2002
1GV0
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STRUCTURAL BASIS FOR THERMOPHILIC PROTEIN STABILITY: STRUCTURES OF THERMOPHILIC AND MESOPHILIC MALATE DEHYDROGENASES
Descriptor:MALATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Dalhus, B., Sarinen, M., Sauer, U.H., Eklund, P., Johansson, K., Karlsson, A., Ramaswamy, S., Bjork, A., Synstad, B., Naterstad, K., Sirevag, R., Eklund, H.
Deposit date:2002-02-04
Release date:2002-02-15
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
J.Mol.Biol., 318, 2002
1GV1
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STRUCTURAL BASIS FOR THERMOPHILIC PROTEIN STABILITY: STRUCTURES OF THERMOPHILIC AND MESOPHILIC MALATE DEHYDROGENASES
Descriptor:MALATE DEHYDROGENASE
Authors:Dalhus, B., Sarinen, M., Sauer, U.H., Eklund, P., Johansson, K., Karlsson, A., Ramaswamy, S., Bjork, A., Synstad, B., Naterstad, K., Sirevag, R., Eklund, H.
Deposit date:2002-02-04
Release date:2002-02-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Thermophilic Protein Stability: Structures of Thermophilic and Mesophilic Malate Dehydrogenases
J.Mol.Biol., 318, 2002
1EG9
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NAPHTHALENE 1,2-DIOXYGENASE WITH INDOLE BOUND IN THE ACTIVE SITE.
Descriptor:PROTEIN (NAPHTHALENE 1,2-DIOXYGENASE ALPHA SUBUNIT), PROTEIN (NAPHTHALENE 1,2-DIOXYGENASE BETA SUBUNIT), SULFATE ION, ...
Authors:Carredano, E., Karlsson, A., Kauppi, B., Choudhury, D., Parales, R.E., Parales, J.V., Lee, K., Gibson, D.T., Eklund, H., Ramaswamy, S.
Deposit date:2000-02-15
Release date:2000-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Substrate binding site of naphthalene 1,2-dioxygenase: functional implications of indole binding.
J.Mol.Biol., 296, 2000
1OE0
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CRYSTAL STRUCTURE OF DROSOPHILA DEOXYRIBONUCLEOSIDE KINASE IN COMPLEX WITH DTTP
Descriptor:DEOXYRIBONUCLEOSIDE KINASE, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Mikkelsen, N.E., Johansson, K., Karlsson, A., Knecht, W., Andersen, G., Piskur, J., Munch-Petersen, B., Eklund, H.
Deposit date:2003-03-17
Release date:2003-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for Feedback Inhibition of the Deoxyribonucleoside Salvage Pathway:Studies of the Drosophila Deoxyribonucleoside Kinase
Biochemistry, 42, 2003
1OT3
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CRYSTAL STRUCTURE OF DROSOPHILA DEOXYRIBONUCLEOTIDE KINASE COMPLEXED WITH THE SUBSTRATE DEOXYTHYMIDINE
Descriptor:Deoxyribonucleoside Kinase, SULFATE ION, THYMIDINE
Authors:Mikkelsen, N.E., Johansson, K., Karlsson, A., Knecht, W., Andersen, G., Piskur, J., Munch-Petersen, B., Eklund, H.
Deposit date:2003-03-21
Release date:2003-05-27
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Feedback Inhibition of the Deoxyribonucleoside Salvage Pathway: Studies of the Drosophila Deoxyribonucleoside Kinase.
Biochemistry, 42, 2003
1SN0
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CRYSTAL STRUCTURE OF SEA BREAM TRANSTHYRETIN IN COMPLEX WITH THYROXINE AT 1.9A RESOLUTION
Descriptor:transthyretin, SULFATE ION, 3,5,3',5'-TETRAIODO-L-THYRONINE
Authors:Eneqvist, T., Lundberg, E., Karlsson, A., Huang, S., Santos, C.R., Power, D.M., Sauer-Eriksson, A.E.
Deposit date:2004-03-10
Release date:2004-08-03
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine.
J.Biol.Chem., 279, 2004
1SN2
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CRYSTAL STRUCTURE OF SEA BREAM TRANSTHYRETIN AT 1.90A RESOLUTION
Descriptor:transthyretin, SULFATE ION
Authors:Eneqvist, T., Lundberg, E., Karlsson, A., Huang, S., Cantos, C.R., Power, D.M., Sauer-Eriksson, A.E.
Deposit date:2004-03-10
Release date:2004-08-03
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine.
J.Biol.Chem., 279, 2004
1SN5
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CRYSTAL STRUCTURE OF SEA BREAM TRANSTHYRETIN IN COMPLEX WITH TRIIODOTHYRONINE AT 1.90A RESOLUTION
Descriptor:transthyretin, SULFATE ION, 3,5,3'TRIIODOTHYRONINE
Authors:Eneqvist, T., Lundberg, E., Karlsson, A., Huang, S., Cantos, C.R., Power, D.M., Sauer-Eriksson, A.E.
Deposit date:2004-03-10
Release date:2004-08-03
Last modified:2014-04-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine.
J.Biol.Chem., 279, 2004
2J87
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STRUCTURE OF VACCINIA VIRUS THYMIDINE KINASE IN COMPLEX WITH DTTP: INSIGHTS FOR DRUG DESIGN
Descriptor:THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ZINC ION, ...
Authors:El Omari, K., Solaroli, N., Karlsson, A., Balzarini, J., Stammers, D.K.
Deposit date:2006-10-23
Release date:2006-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of Vaccinia Virus Thymidine Kinase in Complex with Dttp: Insights for Drug Design.
Bmc Struct.Biol., 6, 2006
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