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1XHX
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BU of 1xhx by Molmil
Phi29 DNA Polymerase, orthorhombic crystal form
Descriptor: DNA polymerase, MAGNESIUM ION, SULFATE ION
Authors:Kamtekar, S, Berman, A.J, Wang, J, Lazaro, J.M, de Vega, M, Blanco, L, Salas, M, Steitz, T.A.
Deposit date:2004-09-21
Release date:2004-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage phi29
Mol.Cell, 16, 2004
1XHZ
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BU of 1xhz by Molmil
Phi29 DNA polymerase, orthorhombic crystal form, ssDNA complex
Descriptor: 5'-D(*TP*TP*TP*TP*T)-3', DNA polymerase
Authors:Kamtekar, S, Berman, A.J, Wang, J, Lazaro, J.M, de Vega, M, Blanco, L, Salas, M, Steitz, T.A.
Deposit date:2004-09-21
Release date:2004-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage phi29
Mol.Cell, 16, 2004
2EX3
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BU of 2ex3 by Molmil
Bacteriophage phi29 DNA polymerase bound to terminal protein
Descriptor: DNA polymerase, DNA terminal protein, LEAD (II) ION
Authors:Kamtekar, S, Berman, A.J, Wang, J, de Vega, M, Blanco, L, Salas, M, Steitz, T.A.
Deposit date:2005-11-07
Release date:2006-03-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition
Embo J., 25, 2006
2GM4
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BU of 2gm4 by Molmil
An activated, tetrameric gamma-delta resolvase: Hin chimaera bound to cleaved DNA
Descriptor: 5'-D(*CP*AP*GP*TP*GP*TP*CP*CP*GP*AP*TP*AP*AP*TP*TP*TP*AP*TP*AP*AP*A)-3', 5'-D(*TP*TP*AP*TP*CP*GP*GP*AP*CP*AP*CP*TP*G)-3', Transposon gamma-delta resolvase
Authors:Kamtekar, S, Ho, R.S, Li, W, Steitz, T.A.
Deposit date:2006-04-05
Release date:2006-06-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GM5
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BU of 2gm5 by Molmil
An activated, truncated gamma-delta resolvase tetramer
Descriptor: Transposon gamma-delta resolvase
Authors:Kamtekar, S, Ho, R.S, Li, W, Steitz, T.A.
Deposit date:2006-04-05
Release date:2006-06-27
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination.
Proc.Natl.Acad.Sci.Usa, 103, 2006
1NJ2
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BU of 1nj2 by Molmil
Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus
Descriptor: MAGNESIUM ION, Proline-tRNA Synthetase, ZINC ION
Authors:Kamtekar, S, Kennedy, W.D, Wang, J, Stathopoulos, C, Soll, D, Steitz, T.A.
Deposit date:2002-12-30
Release date:2003-03-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
Proc.Natl.Acad.Sci.USA, 100, 2003
1NJ5
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Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus bound to proline sulfamoyl adenylate
Descriptor: '5'-O-(N-(L-PROLYL)-SULFAMOYL)ADENOSINE, MAGNESIUM ION, Proline-tRNA Synthetase, ...
Authors:Kamtekar, S, Kennedy, W.D, Wang, J, Stathopoulos, C, Soll, D, Steitz, T.A.
Deposit date:2002-12-30
Release date:2003-03-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
Proc.Natl.Acad.Sci.USA, 100, 2003
1NJ1
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Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus bound to cysteine sulfamoyl adenylate
Descriptor: 5'-O-(N-(L-CYSTEINYL)-SULFAMOYL)ADENOSINE, MAGNESIUM ION, Proline-tRNA Synthetase, ...
Authors:Kamtekar, S, Kennedy, W.D, Wang, J, Stathopoulos, C, Soll, D, Steitz, T.A.
Deposit date:2002-12-30
Release date:2003-03-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
Proc.Natl.Acad.Sci.USA, 100, 2003
1NJ8
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Crystal Structure of Prolyl-tRNA Synthetase from Methanocaldococcus janaschii
Descriptor: Proline-tRNA Synthetase
Authors:Kamtekar, S, Kennedy, W.D, Wang, J, Stathopoulos, C, Soll, D, Steitz, T.A.
Deposit date:2002-12-30
Release date:2003-03-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
Proc.Natl.Acad.Sci.USA, 100, 2003
1NJ6
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BU of 1nj6 by Molmil
Crystal structure of Prolyl-tRNA Synthetase from Methanothermobacter thermautotrophicus bound to alanine sulfamoyl adenylate
Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, MAGNESIUM ION, Proline-tRNA Synthetase, ...
Authors:Kamtekar, S, Kennedy, W.D, Wang, J, Stathopoulos, C, Soll, D, Steitz, T.A.
Deposit date:2002-12-30
Release date:2003-03-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The structural basis of cysteine aminoacylation of tRNAPro by prolyl-tRNA synthetases
Proc.Natl.Acad.Sci.USA, 100, 2003
2XR9
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BU of 2xr9 by Molmil
Crystal structure of Autotaxin (ENPP2)
Descriptor: CALCIUM ION, ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE FAMILY MEMBER 2, IODIDE ION, ...
Authors:Kamtekar, S, Hausmann, J, Day, J.E, Christodoulou, E, Perrakis, A.
Deposit date:2010-09-13
Release date:2011-01-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis of substrate discrimination and integrin binding by autotaxin.
Nat. Struct. Mol. Biol., 18, 2011
1XI1
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BU of 1xi1 by Molmil
Phi29 DNA polymerase ssDNA complex, monoclinic crystal form
Descriptor: 5'-D(P*TP*TP*TP*TP*T)-3', DNA polymerase, MAGNESIUM ION
Authors:Kamtekar, S, Berman, A.J, Wang, J, Lazaro, J.M, de Vega, M, Blanco, L, Salas, M, Steitz, T.A.
Deposit date:2004-09-21
Release date:2004-12-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Correction of X-ray intensities from single crystals containing lattice-translocation defects
Acta Crystallogr.,Sect.D, 61, 2005
3LCD
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BU of 3lcd by Molmil
Inhibitor Bound to A DFG-In structure of the Kinase Domain of CSF-1R
Descriptor: Macrophage colony-stimulating factor 1 receptor, N~3~-(2,6-dichlorobenzyl)-5-(4-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}phenyl)pyrazine-2,3-diamine, SULFATE ION
Authors:Kamtekar, S, Day, J.E, Reitz, B.A, Mathis, K.J, Meyers, M.J.
Deposit date:2010-01-10
Release date:2010-03-02
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode
Bioorg.Med.Chem.Lett., 20, 2010
3LCO
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Inhibitor Bound to A DFG-Out structure of the Kinase Domain of CSF-1R
Descriptor: 3-({4-methoxy-5-[(4-methoxybenzyl)oxy]pyridin-2-yl}methoxy)-5-(1-methyl-1H-pyrazol-4-yl)pyrazin-2-amine, Macrophage colony-stimulating factor 1 receptor
Authors:Kamtekar, S, Day, J.E, Reitz, B.A, Mathis, K.J, Meyers, M.J.
Deposit date:2010-01-11
Release date:2010-09-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure-based drug design enables conversion of a DFG-in binding CSF-1R kinase inhibitor to a DFG-out binding mode.
Bioorg.Med.Chem.Lett., 20, 2010
2ODR
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BU of 2odr by Molmil
Methanococcus Maripaludis Phosphoseryl-tRNA synthetase
Descriptor: phosphoseryl-tRNA synthetase
Authors:Steitz, T.A, Kamtekar, S.
Deposit date:2006-12-26
Release date:2007-02-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.228 Å)
Cite:Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase.
Proc.Natl.Acad.Sci.Usa, 104, 2007
3KJF
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BU of 3kjf by Molmil
Caspase 3 Bound to a covalent inhibitor
Descriptor: (3S)-3-({[(5S,10aS)-2-{(2S)-4-carboxy-2-[(phenylacetyl)amino]butyl}-1,3-dioxo-2,3,5,7,8,9,10,10a-octahydro-1H-[1,2,4]triazolo[1,2-a]cinnolin-5-yl]carbonyl}amino)-4-oxopentanoic acid, Caspase-3
Authors:Kamtekar, S, Watt, W, Finzel, B.C, Harris, M.S, Blinn, J, Wang, Z, Tomasselli, A.G.
Deposit date:2009-11-03
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
3KJN
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BU of 3kjn by Molmil
Caspase 8 bound to a covalent inhibitor
Descriptor: (3S)-3-({[(5S)-2-{2-[(1H-benzimidazol-5-ylcarbonyl)amino]ethyl}-7-(cyclohexylmethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Caspase-8
Authors:Kamtekar, S, Watt, W, Finzel, B.C, Harris, M.S, Blinn, J, Wang, Z, Tomasselli, A.G.
Deposit date:2009-11-03
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
3KJQ
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Caspase 8 with covalent inhibitor
Descriptor: (3S)-3-({[(5S,8R)-2-(3-carboxypropyl)-8-(2-{[(4-chlorophenyl)acetyl]amino}ethyl)-1,3-dioxo-2,3,5,8-tetrahydro-1H-[1,2,4]triazolo[1,2-a]pyridazin-5-yl]carbonyl}amino)-4-oxopentanoic acid, Caspase-8
Authors:Kamtekar, S, Watt, W, Finzel, B.C, Harris, M.S, Blinn, J, Wang, Z, Tomasselli, A.G.
Deposit date:2009-11-03
Release date:2010-08-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.
Biochim.Biophys.Acta, 1804, 2010
1HQY
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BU of 1hqy by Molmil
Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK LOCUS HSLU, HEAT SHOCK LOCUS HSLV
Authors:Wang, J, Song, J.J, Seong, I.S, Franklin, M.C, Kamtekar, S, Eom, S.H, Chung, C.H.
Deposit date:2000-12-20
Release date:2001-11-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU.
Structure, 9, 2001
1HT1
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BU of 1ht1 by Molmil
Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK LOCUS HSLU, HEAT SHOCK LOCUS HSLV
Authors:Wang, J, Song, J.J, Seong, I.S, Franklin, M.C, Kamtekar, S, Eom, S.H, Chung, C.H.
Deposit date:2000-12-27
Release date:2001-11-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU.
Structure, 9, 2001
1HT2
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BU of 1ht2 by Molmil
Nucleotide-Dependent Conformational Changes in a Protease-Associated ATPase HslU
Descriptor: ADENOSINE-5'-DIPHOSPHATE, HEAT SHOCK LOCUS HSLU, HEAT SHOCK LOCUS HSLV
Authors:Wang, J, Song, J.J, Seong, I.S, Franklin, M.C, Kamtekar, S, Eom, S.H, Chung, C.H.
Deposit date:2000-12-27
Release date:2001-11-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Nucleotide-dependent conformational changes in a protease-associated ATPase HsIU.
Structure, 9, 2001
3UJ3
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BU of 3uj3 by Molmil
Crystal Structure of the synaptic tetramer of the G-Segment Invertase (Gin)
Descriptor: DNA-invertase
Authors:Ritacco, C.J, Wang, J, Kamtekar, S, Steitz, T.A.
Deposit date:2011-11-07
Release date:2012-12-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.51 Å)
Cite:Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase.
Nucleic Acids Res., 41, 2013
1G4B
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CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM
Descriptor: ATP-DEPENDENT HSL PROTEASE ATP-BINDING SUBUNIT HSLU, ATP-DEPENDENT PROTEASE HSLV
Authors:Wang, J, Song, J.J, Franklin, M.C, Kamtekar, S, Im, Y.J, Rho, S.H, Seong, I.S, Lee, C.S, Chung, C.H, Eom, S.H.
Deposit date:2000-10-26
Release date:2001-02-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (7 Å)
Cite:Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism.
Structure, 9, 2001
1G4A
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BU of 1g4a by Molmil
CRYSTAL STRUCTURES OF THE HSLVU PEPTIDASE-ATPASE COMPLEX REVEAL AN ATP-DEPENDENT PROTEOLYSIS MECHANISM
Descriptor: 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, ATP-DEPENDENT HSL PROTEASE ATP-BINDING SUBUNIT HSLU, ATP-DEPENDENT PROTEASE HSLV
Authors:Wang, J, Song, J.J, Franklin, M.C, Kamtekar, S, Im, Y.J, Rho, S.H, Seong, I.S, Lee, C.S, Chung, C.H, Eom, S.H.
Deposit date:2000-10-26
Release date:2001-02-21
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism.
Structure, 9, 2001
2WAP
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BU of 2wap by Molmil
3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with the drug-like urea inhibitor PF-3845
Descriptor: 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid, CHLORIDE ION, FATTY-ACID AMIDE HYDROLASE 1, ...
Authors:Mileni, M, Kamtekar, S, Stevens, R.C.
Deposit date:2009-02-11
Release date:2009-05-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery and Characterization of a Highly Selective Faah Inhibitor that Reduces Inflammatory Pain.
Chem.Biol., 16, 2009

 

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