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5JQI
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CRYSTAL STRUCTURE OF FIMH A62S FROM E. COLI UTI89 BOUND TO FIMG N-TERMINAL EXTENSION
Descriptor:FimG N-terminal extension, Type 1 fimbiral adhesin FimH, GLYCEROL
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2016-05-05
Release date:2017-02-22
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.962 Å)
Cite:Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
Sci Adv, 3, 2017
5JR4
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CRYSTAL STRUCTURE OF FIMH A27V/V163A FROM E. COLI UTI89 BOUND TO FIMG N-TERMINAL EXTENSION
Descriptor:Type 1 fimbiral adhesin FimH, FimG N-terminal extension, GLYCEROL, ...
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2016-05-05
Release date:2017-02-22
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.596 Å)
Cite:Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
Sci Adv, 3, 2017
6AOW
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CRYSTAL STRUCTURE OF LECTIN DOMAIN OF F9 PILUS ADHESIN FMLH FROM E. COLI UTI89
Descriptor:F9 pilus adhesin FmlH, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-16
Release date:2018-02-28
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of lectin domain of F9 pilus adhesin FmlH from E. coli UTI89
To Be Published
6AOX
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH TF ANTIGEN
Descriptor:Fml fimbrial adhesin FmlD, 2-(acetylamino)-2-deoxy-3-O-beta-D-galactopyranosyl-alpha-D-galactopyranose
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-16
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of lectin domain of F9 pilus adhesin FmlH from E. coli UTI89
To Be Published
6AOY
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH O-NITROPHENYL BETA-GALACTOSIDE (ONPG)
Descriptor:Fml fimbrial adhesin FmlD, SULFATE ION, 1-O-[O-NITROPHENYL]-BETA-D-GALACTOPYRANOSE
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-16
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of lectin domain of F9 pilus adhesin FmlH from E. coli UTI89 bound to o-nitrophenyl beta-galactoside (ONPG)
To Be Published
6ARM
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH O-NITROPHENYL BETA-GALACTOSIDE (ONPG)
Descriptor:F9 pilus adhesin FmlH, 1-O-[O-NITROPHENYL]-BETA-D-GALACTOPYRANOSE, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-22
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with o-nitrophenyl beta-galactoside (ONPG)
To Be Published
6ARN
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH O-METHOXYPHENYL BETA-GALACTOSIDE (OMPG)
Descriptor:Putative Fml fimbrial adhesin FmlD, 2-methoxyphenyl beta-D-galactopyranoside, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-22
Release date:2018-02-28
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with o-methoxyphenyl beta-galactoside (OMPG)
To Be Published
6ARO
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH 8-HYDROXYQUINOLINE BETA-GALACTOSIDE
Descriptor:F9 pilus adhesin FmlH, quinolin-8-yl beta-D-galactopyranoside, SULFATE ION
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-23
Release date:2018-02-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with 8-hydroxyquinoline beta-galactoside
To Be Published
6AS8
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F9 PILUS ADHESIN FMLH LECTIN DOMAIN FROM E. COLI UTI89 CO-CRYSTALLIZED WITH ORTHO-BIPHENYL-2'-CARBOXYL N-ACETYL-BETA-GALACTOSAMINOSIDE
Descriptor:Fml fimbrial adhesin FmlD, 2'-{[2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl]oxy}[1,1'-biphenyl]-3-carboxylic acid
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2017-08-23
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:F9 pilus adhesin FmlH lectin domain from E. coli UTI89 co-crystallized with ortho-biphenyl-2'-carboxyl N-acetyl-beta-galactosaminoside
To Be Published
3OFI
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CRYSTAL STRUCTURE OF HUMAN INSULIN-DEGRADING ENZYME IN COMPLEX WITH UBIQUITIN
Descriptor:Insulin-degrading enzyme, Ubiquitin, ZINC ION, ...
Authors:Kalas, V., Ralat, L.A., Tang, W.-J.
Deposit date:2010-08-15
Release date:2010-09-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Ubiquitin is a novel substrate for human insulin-degrading enzyme.
J.Mol.Biol., 406, 2011
5F2F
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CRYSTAL STRUCTURE OF PARA-BIPHENYL-2-METHYL-3', 5' DI-METHYL AMIDE MANNOSIDE BOUND TO FIMH LECTIN DOMAIN
Descriptor:Protein FimH, 5-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}1,~{N}3-dimethyl-benzene-1,3-dicarboxamide, GLYCEROL
Authors:Kalas, V., Hultgren, S.J.
Deposit date:2015-12-01
Release date:2016-05-04
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.665 Å)
Cite:Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.
Chemmedchem, 11, 2016
5LNE
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E. COLI F9 PILUS ADHESIN FMLH BOUND TO THE THOMSEN-FRIEDENREICH (TF) ANTIGEN
Descriptor:Putative Fml fimbrial adhesin FmlD, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE, BETA-D-GALACTOSE, ...
Authors:Ruer, S., Conover, M.S., Kalas, V., Taganna, J., De Greve, H., Pinkner, J.S., Dodson, K.W., Hultgren, S.J., Remaut, H.
Deposit date:2016-08-04
Release date:2016-10-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.
Cell Host Microbe, 20, 2016
5LNG
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LECTIN DOMAIN OF E. COLI F9 PILUS ADHESIN FMLH
Descriptor:Putative Fml fimbrial adhesin FmlD, SULFATE ION
Authors:Ruer, S., Conover, M.S., Kalas, V., Taganna, J., De Greve, H., Pinkner, J.S., Dodson, K.W., Hultgren, S.J., Remaut, H.
Deposit date:2016-08-04
Release date:2016-10-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.
Cell Host Microbe, 20, 2016
4IOF
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CRYSTAL STRUCTURE ANALYSIS OF FAB-BOUND HUMAN INSULIN DEGRADING ENZYME (IDE)
Descriptor:Insulin-degrading enzyme, Fab-bound IDE, heavy chain, ...
Authors:McCord, L.A., Liang, W.G., Hoey, R., Dowdell, E., Koide, A., Koide, S., Tang, W.J.
Deposit date:2013-01-07
Release date:2013-07-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.353 Å)
Cite:Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.
Proc.Natl.Acad.Sci.USA, 110, 2013
5F3F
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CRYSTAL STRUCTURE OF PARA-BIPHENYL-2-METHYL-3'-METHYL AMIDE MANNOSIDE BOUND TO FIMH LECTIN DOMAIN
Descriptor:Protein FimH, 3-[4-[(2~{R},3~{S},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-methyl-phenyl]-~{N}-methyl-benzamide
Authors:Klein, R.D., Hultgren, S.J.
Deposit date:2015-12-02
Release date:2016-12-07
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Antibiotic-sparing therapy against gram-negative UPEC bacteria: Potent anti-virulence activity of FimH C-mannoside antagonists
To Be Published