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1LB7
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BU of 1lb7 by Molmil
IGF-F1-1, A PEPTIDE ANTAGONIST OF IGF-1
Descriptor: IGF-1 ANTAGONIST F1-1
Authors:Deshayes, K, Schaffer, M.L, Skelton, N.J, Nakamura, G.R, Kadkhodayan, S, Sidhu, S.S.
Deposit date:2002-04-02
Release date:2002-06-19
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Rapid identification of small binding motifs with high-throughput phage display: discovery of peptidic antagonists of IGF-1 function.
Chem.Biol., 9, 2002
1TW6
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BU of 1tw6 by Molmil
Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing protein 7, ...
Authors:Franklin, M.C, Vucic, D, Wallweber, H.J.A, Das, K, Shin, H, Elliott, L.O, Kadkhodayan, S, Deshayes, K, Salvesen, G.S, Fairbrother, W.J.
Deposit date:2004-06-30
Release date:2004-11-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.713 Å)
Cite:Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP
Biochem.J., 385, 2005
1OY7
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BU of 1oy7 by Molmil
Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, AEVVAVKSE peptide, Baculoviral IAP repeat-containing protein 7, ...
Authors:Franklin, M.C, Kadkhodayan, S, Ackerly, H, Alexandru, D, Distefano, M.D, Elliott, L.O, Flygare, J.A, Vucic, D, Deshayes, K, Fairbrother, W.J.
Deposit date:2003-04-03
Release date:2003-08-26
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Biochemistry, 42, 2003
1OXN
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BU of 1oxn by Molmil
Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, AEAVPWKSE peptide, Baculoviral IAP repeat-containing protein 7, ...
Authors:Franklin, M.C, Kadkhodayan, S, Ackerly, H, Alexandru, D, Distefano, M.D, Elliott, L.O, Flygare, J.A, Vucic, D, Deshayes, K, Fairbrother, W.J.
Deposit date:2003-04-03
Release date:2003-08-26
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Biochemistry, 42, 2003
1OXQ
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Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, AVPIAQKSE (Smac) peptide, Baculoviral IAP repeat-containing protein 7, ...
Authors:Franklin, M.C, Kadkhodayan, S, Ackerly, H, Alexandru, D, Distefano, M.D, Elliott, L.O, Flygare, J.A, Vucic, D, Deshayes, K, Fairbrother, W.J.
Deposit date:2003-04-03
Release date:2003-08-26
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Function Analysis of Peptide Antagonists of Melanoma Inhibitor of Apoptosis (ML-IAP)
Biochemistry, 42, 2003
1YGC
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BU of 1ygc by Molmil
Short Factor VIIa with a small molecule inhibitor
Descriptor: (R)-4-[2-(3-AMINO-BENZENESULFONYLAMINO)-1-(3,5-DIETHOXY-2-FLUOROPHENYL)-2-OXO-ETHYLAMINO]-2-HYDROXY-BENZAMIDINE, CALCIUM ION, Coagulation factor VII, ...
Authors:Olivero, A.G, Eigenbrot, C, Goldsmith, R, Robarge, K, Artis, D.R, Flygare, J, Rawson, T, Refino, C, Bunting, S, Kirchhofer, D.
Deposit date:2005-01-04
Release date:2005-01-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo.
J.Biol.Chem., 280, 2005
3GT9
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BU of 3gt9 by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Descriptor: Baculoviral IAP repeat-containing 7, N-{(1S)-1-cyclohexyl-2-[(2S)-2-(4-naphthalen-1-yl-1,3-thiazol-2-yl)pyrrolidin-1-yl]-2-oxoethyl}-N~2~-methyl-L-alaninamide, ZINC ION
Authors:Franklin, M.C, Fairbrother, W.J, Cohen, F.
Deposit date:2009-03-27
Release date:2010-03-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.
Bioorg.Med.Chem.Lett., 20, 2010
3GTA
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BU of 3gta by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing 7, ...
Authors:Franklin, M.C, Fairbrother, W.J, Cohen, F.
Deposit date:2009-03-27
Release date:2010-03-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.
Bioorg.Med.Chem.Lett., 20, 2010
3F7I
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BU of 3f7i by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing protein 7, ...
Authors:Franklin, M.C, Fairbrother, W.J, Cohen, F.
Deposit date:2008-11-09
Release date:2009-03-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
J.Med.Chem., 52, 2009
3F7H
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BU of 3f7h by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing protein 7, ...
Authors:Franklin, M.C, Fairbrother, W.J, Cohen, F.
Deposit date:2008-11-09
Release date:2009-03-17
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
J.Med.Chem., 52, 2009
3F7G
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BU of 3f7g by Molmil
Structure of the BIR domain from ML-IAP bound to a peptidomimetic
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Baculoviral IAP repeat-containing protein 7, L-alanyl-L-valyl-N-(2,2-diphenylethyl)-L-prolinamide, ...
Authors:Franklin, M.C, Fairbrother, W.J, Cohen, F.
Deposit date:2008-11-09
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
J.Med.Chem., 52, 2009
1PMX
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BU of 1pmx by Molmil
INSULIN-LIKE GROWTH FACTOR-I BOUND TO A PHAGE-DERIVED PEPTIDE
Descriptor: IGF-1 ANTAGONIST F1-1, Insulin-like growth factor IB
Authors:Skelton, N.J.
Deposit date:2003-06-11
Release date:2003-10-21
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Complex with a Phage Display-Derived Peptide Provides Insight into the Function of Insulin-like Growth Factor I
Biochemistry, 42, 2003
2I3H
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BU of 2i3h by Molmil
Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW)
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AVPW peptide, ...
Authors:Fairbrother, W.J, Franklin, M.C.
Deposit date:2006-08-18
Release date:2006-09-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
Acs Chem.Biol., 1, 2006
2I3I
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BU of 2i3i by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Descriptor: (3R,6R,9AR)-2,2-DIMETHYL-6-[(N-METHYL-L-ALANYL)AMINO]-N-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)-5-OXO-2,3,5,6,9,9A-HEXAHYDRO[1,3]THIAZOLO[3,2-A]AZEPINE-3-CARBOXAMIDE, 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Fairbrother, W.J, Franklin, M.C.
Deposit date:2006-08-18
Release date:2006-09-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
Acs Chem.Biol., 1, 2006

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