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6A93
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CRYSTAL STRUCTURE OF 5-HT2AR IN COMPLEX WITH RISPERIDONE
Descriptor:5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 3-[2-[4-(6-fluoranyl-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, CHOLESTEROL, ...
Authors:Kimura, T.K., Asada, H., Inoue, A., Kadji, F.M.N., Im, D., Mori, C., Arakawa, T., Hirata, K., Nomura, Y., Nomura, N., Aoki, J., Iwata, S., Shimamura, T.
Deposit date:2018-07-11
Release date:2019-02-13
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
Nat.Struct.Mol.Biol., 26, 2019
6A94
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CRYSTAL STRUCTURE OF 5-HT2AR IN COMPLEX WITH ZOTEPINE
Descriptor:5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 2-(3-chloranylbenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine, CHOLESTEROL, ...
Authors:Kimura, T.K., Asada, H., Inoue, A., Kadji, F.M.N., Im, D., Mori, C., Arakawa, T., Hirata, K., Nomura, Y., Nomura, N., Aoki, J., Iwata, S., Shimamura, T.
Deposit date:2018-07-11
Release date:2019-02-13
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine.
Nat.Struct.Mol.Biol., 26, 2019
6IGK
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CRYSTAL STRUCTURE OF HUMAN ETB RECEPTOR IN COMPLEX WITH ENDOTHELIN-3
Descriptor:Endothelin receptor type B,Endolysin,Endothelin receptor type B, Endothelin-3, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Shihoya, W., Izume, T., Inoue, A., Yamashita, K., Kadji, F.M.N., Hirata, K., Aoki, J., Nishizawa, T., Nureki, O.
Deposit date:2018-09-25
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.
Nat Commun, 9, 2018
6IGL
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CRYSTAL STRUCTURE OF HUMAN ETB RECEPTOR IN COMPLEX WITH IRL1620
Descriptor:Endothelin receptor type B,Endolysin,Endothelin receptor type B, IRL1620, CITRIC ACID, ...
Authors:Shihoya, W., Izume, T., Inoue, A., Yamashita, K., kadji, F.M.N., Hirata, K., Aoki, J., Nishizawa, T., Nureki, O.
Deposit date:2018-09-25
Release date:2018-11-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of human ETBreceptor provide mechanistic insight into receptor activation and partial activation.
Nat Commun, 9, 2018
5X93
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HUMAN ENDOTHELIN RECEPTOR TYPE-B IN COMPLEX WITH ANTAGONIST K-8794
Descriptor:Endothelin B receptor,Endolysin,Endothelin B receptor, 3-[6-[(4-tert-butylphenyl)sulfonylamino]-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]oxy-N-(2,6-dimethylphenyl)propanamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Shihoya, W., Nishizawa, T., Yamashita, K., Hirata, K., Okuta, A., Tani, K., Fujiyoshi, Y., Doi, T., Nureki, O.
Deposit date:2017-03-05
Release date:2017-08-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog
Nat. Struct. Mol. Biol., 24, 2017
5XPR
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HUMAN ENDOTHELIN RECEPTOR TYPE-B IN COMPLEX WITH ANTAGONIST BOSENTAN
Descriptor:Endothelin B receptor,Endolysin,Endothelin B receptor, 4-tert-butyl-N-[6-(2-hydroxyethyloxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]benzenesulfonamide, SULFATE ION
Authors:Shihoya, W., Nishizawa, T., Yamashita, K., Hirata, K., Okuta, A., Tani, K., Fujiyoshi, Y., Doi, T., Nureki, O.
Deposit date:2017-06-04
Release date:2017-08-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog
Nat. Struct. Mol. Biol., 24, 2017
6K1Q
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HUMAN ENDOTHELIN RECEPTOR TYPE-B IN COMPLEX WITH INVERSE AGONIST IRL2500
Descriptor:Endothelin B receptor,Endolysin,Endothelin B receptor, (2~{S})-2-[[(2~{R})-2-[(3,5-dimethylphenyl)carbonyl-methyl-amino]-3-(4-phenylphenyl)propanoyl]amino]-3-(1~{H}-indol-3-yl)propanoic acid, PHOSPHATE ION, ...
Authors:Nagiri, C., Shihoya, W., Nureki, O.
Deposit date:2019-05-11
Release date:2019-07-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human endothelin ETBreceptor in complex with peptide inverse agonist IRL2500.
Commun Biol, 2, 2019
6LPB
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CRYO-EM STRUCTURE OF THE HUMAN PAC1 RECEPTOR COUPLED TO AN ENGINEERED HETEROTRIMERIC G PROTEIN
Descriptor:Pituitary adenylate cyclase-activating polypeptide, Pituitary adenylate cyclase-activating polypeptide type I receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Kobayashi, K., Shihoya, W., Nishizawa, T., Nureki, O.
Deposit date:2020-01-09
Release date:2020-03-11
Last modified:2020-03-25
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein.
Nat.Struct.Mol.Biol., 27, 2020
6OS9
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HUMAN NEUROTENSIN RECEPTOR 1 (HNTSR1) - GI1 PROTEIN COMPLEX IN CANONICAL CONFORMATION (C STATE)
Descriptor:Neurotensin receptor type 1, JMV449, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Kato, H.E., Zhang, Y., Kobilka, B.K., Skiniotis, G.
Deposit date:2019-05-01
Release date:2019-07-10
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational transitions of a neurotensin receptor 1-Gi1complex.
Nature, 572, 2019
6OSA
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HUMAN NEUROTENSIN RECEPTOR 1 (HNTSR1) - GI1 PROTEIN COMPLEX IN NON-CANONICAL CONFORMATION (NC STATE)
Descriptor:Neurotensin receptor type 1, JMV449, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Kato, H.E., Zhang, Y., Kobilka, B.K., Skiniotis, G.
Deposit date:2019-05-01
Release date:2019-07-10
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Conformational transitions of a neurotensin receptor 1-Gi1complex.
Nature, 572, 2019
171916
数据于2020-12-02公开中