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1KHO
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BU of 1kho by Molmil
Crystal Structure Analysis of Clostridium perfringens alpha-Toxin Isolated from Avian Strain SWCP
Descriptor: ZINC ION, alpha-toxin
Authors:Justin, N, Moss, D.S, Titball, R.W, Basak, A.K.
Deposit date:2001-11-30
Release date:2002-06-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The first strain of Clostridium perfringens isolated from an avian source has an alpha-toxin with divergent structural and kinetic properties.
Biochemistry, 41, 2002
5HYN
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BU of 5hyn by Molmil
Structure of Human Polycomb Repressive Complex 2 (PRC2) with oncogenic histone H3K27M peptide
Descriptor: H3K27M, Histone-lysine N-methyltransferase EZH2, JARID2 K116me3, ...
Authors:Zhang, Y, Justin, N, Wilson, J.R, Gamblin, S.J.
Deposit date:2016-02-01
Release date:2016-05-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Nat Commun, 7, 2016
4X3E
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BU of 4x3e by Molmil
Crystal structure of EED in complex with a trimethylated Jarid2 peptide
Descriptor: ALA-GLN-ARG-M3L-PHE-ALA-GLN-SER, Polycomb protein EED
Authors:Justin, N, Gamblin, S.J, Margueron, R.
Deposit date:2014-11-28
Release date:2015-01-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
Mol.Cell, 57, 2015
2WXT
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BU of 2wxt by Molmil
Clostridium perfringens alpha-toxin strain NCTC8237
Descriptor: CADMIUM ION, CALCIUM ION, PHOSPHOLIPASE C, ...
Authors:Justin, N, Naylor, C.E, Basak, A.K.
Deposit date:2009-11-10
Release date:2009-11-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comparison of a Nontoxic Variant of Clostridium Perfringens [Alpha]-Toxin with the Toxic Wild-Type Strain
Acta Crystallogr.,Sect.D, 66, 2010
3IIY
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BU of 3iiy by Molmil
Crystal structure of Eed in complex with a trimethylated histone H1K26 peptide
Descriptor: Histone H1K26 peptide, Polycomb protein EED
Authors:Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J.
Deposit date:2009-08-03
Release date:2009-09-15
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Role of the polycomb protein EED in the propagation of repressive histone marks.
Nature, 461, 2009
3IIW
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BU of 3iiw by Molmil
Crystal structure of Eed in complex with a trimethylated histone H3K27 peptide
Descriptor: Histone H3 peptide, Polycomb protein EED
Authors:Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J.
Deposit date:2009-08-03
Release date:2009-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Role of the polycomb protein EED in the propagation of repressive histone marks.
Nature, 461, 2009
3IJ0
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BU of 3ij0 by Molmil
Crystal structure of Eed in complex with a trimethylated histone H3K9 peptide
Descriptor: Histone H3K9 peptide, Polycomb protein EED
Authors:Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J.
Deposit date:2009-08-03
Release date:2009-09-15
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Role of the polycomb protein EED in the propagation of repressive histone marks.
Nature, 461, 2009
3IJC
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BU of 3ijc by Molmil
Crystal structure of Eed in complex with NDSB-195
Descriptor: ETHYL DIMETHYL AMMONIO PROPANE SULFONATE, Polycomb protein EED
Authors:Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J.
Deposit date:2009-08-04
Release date:2009-09-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of the polycomb protein EED in the propagation of repressive histone marks.
Nature, 461, 2009
3IJ1
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BU of 3ij1 by Molmil
Crystal structure of Eed in complex with a trimethylated histone H4K20 peptide
Descriptor: Histone H4K20 peptide, Polycomb protein EED
Authors:Justin, N, Sharpe, M.L, Martin, S, Taylor, W.R, De Marco, V, Gamblin, S.J.
Deposit date:2009-08-03
Release date:2009-09-15
Last modified:2021-10-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Role of the polycomb protein EED in the propagation of repressive histone marks.
Nature, 461, 2009
5LS6
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BU of 5ls6 by Molmil
Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor
Descriptor: 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide, Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Jarid2 K116me3, ...
Authors:Zhang, Y, Justin, N, Chen, S, Wilson, J, Gamblin, S.
Deposit date:2016-08-22
Release date:2017-02-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.47 Å)
Cite:Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016
1XQH
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BU of 1xqh by Molmil
Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
Descriptor: 9-mer peptide from tumor protein p53, Histone-lysine N-methyltransferase, H3 lysine-4 specific, ...
Authors:Chuikov, S, Kurash, J.K, Wilson, J.R, Xiao, B, Justin, N, Ivanov, G.S, McKinney, K, Tempst, P, Prives, C, Gamblin, S.J, Barlev, N.A, Reinberg, D.
Deposit date:2004-10-12
Release date:2004-11-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Regulation of p53 activity through lysine methylation
Nature, 432, 2004
5M5G
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BU of 5m5g by Molmil
Crystal structure of the Chaetomium Thermophilum polycomb repressive complex 2 (PRC2)
Descriptor: Fragment from molecular 2 (region containing putative polycomb protein Suz12), HISTONE H3 11-Mer peptide, Putative uncharacterized protein, ...
Authors:Zhang, Y, Justin, N, Wilson, J, Gamblin, S.
Deposit date:2016-10-21
Release date:2017-01-11
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354, 2016
1I4T
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BU of 1i4t by Molmil
CRYSTAL STRUCTURE ANALYSIS OF RAC1-GMPPNP IN COMPLEX WITH ARFAPTIN
Descriptor: ARFAPTIN 2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Tarricone, C, Xiao, B, Justin, N, Gamblin, S.J, Smerdon, S.J.
Deposit date:2001-02-23
Release date:2001-05-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
Nature, 411, 2001
1I4L
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BU of 1i4l by Molmil
CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP IN COMPLEX WITH ARFAPTIN (P41)
Descriptor: ARFAPTIN 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Tarricone, C, Xiao, B, Justin, N, Gamblin, S.J, Smerdon, S.J.
Deposit date:2001-02-22
Release date:2001-05-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
Nature, 411, 2001
1I4D
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BU of 1i4d by Molmil
CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP COMPLEXED WITH ARFAPTIN (P21)
Descriptor: ARFAPTIN 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Tarricone, C, Xiao, B, Justin, N, Gamblin, S.J, Smerdon, S.J.
Deposit date:2001-02-20
Release date:2001-05-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
Nature, 411, 2001
1I49
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BU of 1i49 by Molmil
CRYSTAL STRUCTURE ANALYSIS OF ARFAPTIN
Descriptor: ARFAPTIN 2
Authors:Tarricone, C, Xiao, B, Justin, N, Gamblin, S.J, Smerdon, S.J.
Deposit date:2001-02-20
Release date:2001-05-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.
Nature, 411, 2001
4AGH
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BU of 4agh by Molmil
Structural features of ssDNA binding protein MoSub1 from Magnaporthe oryzae
Descriptor: MOSUB1, TRANSCRIPTION COFACTOR
Authors:Huang, J, Zhao, Y, Huang, D, liu, J, Peng, Y.
Deposit date:2012-01-27
Release date:2012-08-29
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (1.787 Å)
Cite:Structural Features of the Single-Stranded DNA-Binding Protein Mosub1 from Magnaporthe Oryzae.
Acta Crystallogr.,Sect.D, 68, 2012
2WXU
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BU of 2wxu by Molmil
Clostridium perfringens alpha-toxin strain NCTC8237 mutant T74I
Descriptor: CADMIUM ION, CALCIUM ION, PHOSPHOLIPASE C, ...
Authors:Vachieri, S.G, Naylor, C.E, Basak, A.K.
Deposit date:2009-11-10
Release date:2009-11-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Comparison of a Nontoxic Variant of Clostridium Perfringens [Alpha]-Toxin with the Toxic Wild-Type Strain
Acta Crystallogr.,Sect.D, 66, 2010
2WY6
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BU of 2wy6 by Molmil
Clostridium perfringens alpha-toxin strain NCTC8237 mutant T74I
Descriptor: CADMIUM ION, CALCIUM ION, GLYCEROL, ...
Authors:Vachieri, S.G, Naylor, C.E, Basak, A.K.
Deposit date:2009-11-12
Release date:2009-11-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Comparison of a Nontoxic Variant of Clostridium Perfringens [Alpha]-Toxin with the Toxic Wild-Type Strain
Acta Crystallogr.,Sect.D, 66, 2011
1CA1
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BU of 1ca1 by Molmil
ALPHA-TOXIN FROM CLOSTRIDIUM PERFRINGENS
Descriptor: ALPHA-TOXIN, CADMIUM ION, ZINC ION
Authors:Naylor, C.E, Basak, A.K, Titball, R.W.
Deposit date:1998-04-22
Release date:1999-05-04
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the key toxin in gas gangrene.
Nat.Struct.Biol., 5, 1998
1OLP
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BU of 1olp by Molmil
Alpha Toxin from Clostridium Absonum
Descriptor: ALPHA-TOXIN, CALCIUM ION, ZINC ION
Authors:Briggs, D.C, Basak, A.K.
Deposit date:2003-08-11
Release date:2003-10-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Clostridium Absonum Alpha-Toxin: New Insights Into Clostridial Phospholipase C Substrate Binding and Specificity
J.Mol.Biol., 333, 2003
1QM6
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BU of 1qm6 by Molmil
Closed form of Clostridium perfringens alpha-toxin strain NCTC8237
Descriptor: PHOSPHOLIPASE C, ZINC ION
Authors:Naylor, C.E, Miller, J, Titball, R.W, Basak, A.K.
Deposit date:1999-09-21
Release date:1999-09-27
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Characterisation of the Calcium-Binding C-Terminal Domain of Clostridium Perfringens Alpha-Toxin
J.Mol.Biol., 294, 1999
1QMD
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BU of 1qmd by Molmil
calcium bound closed form alpha-toxin from Clostridium perfringens
Descriptor: CALCIUM ION, PHOSPHOLIPASE C, ZINC ION
Authors:Naylor, C.E, Miller, J, Titball, R.W, Basak, A.K.
Deposit date:1999-09-27
Release date:2000-02-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterisation of the Calcium-Binding C-Terminal Domain of Clostridium Perfringens Alpha-Toxin
J.Mol.Biol., 294, 1999

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