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2P8L
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CRYSTAL STRUCTURE OF THE HIV-1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELLELDKWASLWN
Descriptor:nmAb 2F5, light chain, heavy chain, ...
Authors:Julien, J.P., Bryson, S., Pai, E.F.
Deposit date:2007-03-22
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
2P8M
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CRYSTAL STRUCTURE OF THE HIV-1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ELLELDKWASLWN IN NEW CRYSTAL FORM
Descriptor:nmAb 2F5, light chain, heavy chain, ...
Authors:Julien, J.P., Bryson, S., Pai, E.F.
Deposit date:2007-03-22
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
3D0L
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CRYSTAL STRUCTURE OF THE HIV-1 BROADLY NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH THE GP41 FP-MPER HYB3K CONSTRUCT 514GIGALFLGFLGAAGS528KK-AHX-655KNEQELLELDKWASLWN671
Descriptor:2F5 heavy chain, 2F5 light chain, Hyb3k peptide construct, ...
Authors:Bryson, S., Julien, J.P., Pai, E.F.
Deposit date:2008-05-01
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
3D0V
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CRYSTAL STRUCTURE OF THE HIV-1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE LLELDKWASLW
Descriptor:2F5 Fab heavy chain, 2F5 Fab light chain, gp41 peptide LLELDKWASLW
Authors:Bryson, S., Julien, J.P., Pai, E.F.
Deposit date:2008-05-02
Release date:2008-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
3DRQ
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CRYSTAL STRUCTURE OF THE HIV-1 BROADLY NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH THE GP41 FP-MPER HYB3K CONSTRUCT 514GIGALFLGFLGAAGS528KK-AHX-655KNEQELLELDKWASLWN671 SOAKED IN PEG/2-PROPANOL SOLUTION
Descriptor:2F5 Fab' light chain, 2F5 Fab' heavy chain, gp41 peptide epitope, ...
Authors:Bryson, S., Julien, J.P., Pai, E.F.
Deposit date:2008-07-11
Release date:2008-10-07
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
3IDG
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CRYSTAL STRUCTURE OF THE HIV-1 CROSS NEUTRALIZING MONOCLONAL ANTIBODY 2F5 IN COMPLEX WITH GP41 PEPTIDE ALDKWD
Descriptor:2F5 Fab light chain, 2F5 Fab heavy chain, gp41 MPER peptide
Authors:Julien, J.P., Bryson, S., Pai, E.F.
Deposit date:2009-07-21
Release date:2010-03-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications.
J.Virol., 83, 2009
5IDL
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CRYSTAL STRUCTURE OF THE GERMLINE-TARGETING HIV-1 GP120 ENGINEERED OUTER DOMAIN, EOD-GT8
Descriptor:Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT8, N-ACETYL-D-GLUCOSAMINE
Authors:Julien, J.P., Ereno-Orbea, J., Jardine, J.G., Schief, W.R., Wilson, I.A.
Deposit date:2016-02-24
Release date:2016-10-05
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science, 351, 2016
5VKJ
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CRYSTAL STRUCTURE OF HUMAN CD22 IG DOMAINS 1-3
Descriptor:B-cell receptor CD22, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Julien, J.P., Ereno-Orbea, J., Sicard, T.
Deposit date:2017-04-21
Release date:2017-10-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Molecular basis of human CD22 function and therapeutic targeting.
Nat Commun, 8, 2017
5VKM
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CRYSTAL STRUCTURE OF HUMAN CD22 IG DOMAINS 1-3 IN COMPLEX WITH ALPHA 2-6 SIALYLLACTOSE
Descriptor:B-cell receptor CD22, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Julien, J.P., Ereno-Orbea, J., Sicard, T.
Deposit date:2017-04-21
Release date:2017-10-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis of human CD22 function and therapeutic targeting.
Nat Commun, 8, 2017
2F5A
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CRYSTAL STRUCTURE OF FAB' FROM THE HIV-1 NEUTRALIZING ANTIBODY 2F5
Descriptor:PROTEIN (ANTIBODY 2F5 (LIGHT CHAIN)), PROTEIN (ANTIBODY 2F5 (HEAVY CHAIN))
Authors:Bryson, S., Julien, J.P., Hynes, R.C., Pai, E.F.
Deposit date:1999-04-08
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications.
J.Virol., 83, 2009
2F5B
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CRYSTAL STRUCTURE OF FAB' FROM THE HIV-1 NEUTRALIZING ANTIBODY 2F5 IN COMPLEX WITH ITS GP41 EPITOPE
Descriptor:PROTEIN (ANTIBODY 2F5 (LIGHT CHAIN)), PROTEIN (ANTIBODY 2F5 (HEAVY CHAIN)), PROTEIN (GP41 EPITOPE)
Authors:Bryson, S., Julien, J.P., Hynes, R.C., Pai, E.F.
Deposit date:1999-04-09
Release date:2003-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic definition of the epitope promiscuity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5: vaccine design implications.
J.Virol., 83, 2009
3RFN
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EPITOPE BACKBONE GRAFTING BY COMPUTATIONAL DESIGN FOR IMPROVED PRESENTATION OF LINEAR EPITOPES ON SCAFFOLD PROTEINS
Descriptor:BB_1wnu_001, ZINC ION
Authors:Azoitei, M.L., Ban, Y.A., Julien, J.P., Bryson, S., Schroeter, A., Kalyuzhniy, O., Porter, J.R., Adachi, Y., Baker, D., Szabo, E., Pai, E.F., Schief, W.R.
Deposit date:2011-04-06
Release date:2011-11-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
3RHU
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EPITOPE BACKBONE GRAFTING BY COMPUTATIONAL DESIGN FOR IMPROVED PRESENTATION OF LINEAR EPITOPES ON SCAFFOLD PROTEINS
Descriptor:SC_1wnu
Authors:Azoitei, M.L., Ban, Y.A., Julien, J.P., Bryson, S., Schroeter, A., Kalyuzhniy, O., Porter, J.R., Adachi, Y., Baker, D., Szabo, E., Pai, E.F., Schief, W.R.
Deposit date:2011-04-12
Release date:2011-11-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
3RI0
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EPITOPE BACKBONE GRAFTING BY COMPUTATIONAL DESIGN FOR IMPROVED PRESENTATION OF LINEAR EPITOPES ON SCAFFOLD PROTEINS
Descriptor:BB_2cx5_001, GLYCEROL, SULFATE ION
Authors:Azoitei, M.L., Ban, Y.A., Julien, J.P., Bryson, S., Schroeter, A., Kalyuzhniy, O., Porter, J.R., Adachi, Y., Baker, D., Szabo, E., Pai, E.F., Schief, W.R.
Deposit date:2011-04-12
Release date:2011-11-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
3RIJ
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EPITOPE BACKBONE GRAFTING BY COMPUTATIONAL DESIGN FOR IMPROVED PRESENTATION OF LINEAR EPITOPES ON SCAFFOLD PROTEINS
Descriptor:SC_2cx5, GLYCEROL
Authors:Azoitei, M.L., Ban, Y.A., Julien, J.P., Bryson, S., Schroeter, A., Kalyuzhniy, O., Porter, J.R., Adachi, Y., Baker, D., Szabo, E., Pai, E.F., Schief, W.R.
Deposit date:2011-04-13
Release date:2011-11-09
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
4YAQ
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CRYSTAL STRUCTURE OF A COMPUTATIONALLY OPTIMIZED PG9 MUTANT
Descriptor:PG9_N100FY Fab heavy chain, PG9_N100FY Light Chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Murrell, S., Julien, J.P., Wilson, I.A.
Deposit date:2015-02-17
Release date:2015-06-03
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.
J.Clin.Invest., 125, 2015
5BK0
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CRYSTAL STRUCTURE OF 663 FAB BOUND TO CIRCUMSPOROZOITE PROTEIN NANP 5-MER
Descriptor:663 Antibody, light chain, heavy chain, ...
Authors:Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P.
Deposit date:2017-09-12
Release date:2017-12-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Immunity, 47, 2017
5BK3
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CRYSTAL STRUCTURE OF THE NEUTRALIZING ANTI-CIRCUMSPOROZOITE PROTEIN 580 ANTIBODY
Descriptor:580 Antibody, light chain, heavy chain, ...
Authors:Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P.
Deposit date:2017-09-12
Release date:2017-12-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Immunity, 47, 2017
5BK5
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CRYSTAL STRUCTURE OF THE ANTI-CIRCUMSPOROZOITE PROTEIN 663 GERMLINE ANTIBODY
Descriptor:663 germline antibody, heavy chain, light chain, ...
Authors:Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P.
Deposit date:2017-09-12
Release date:2017-12-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Immunity, 47, 2017
5VKK
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CRYSTAL STRUCTURE OF FAB FRAGMENT OF ANTI-CD22 EPRATUZUMAB
Descriptor:Epratuzumab Fab Heavy Chain, Epratuzumab Fab Light Chain
Authors:Sicard, T., Ereno-Orbea, J., Julien, J.P.
Deposit date:2017-04-21
Release date:2017-10-04
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.014 Å)
Cite:Molecular basis of human CD22 function and therapeutic targeting.
Nat Commun, 8, 2017
5VL3
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CD22 D1-D3 IN COMPLEX WITH THERAPEUTIC FAB EPRATUZUMAB
Descriptor:B-cell receptor CD22, Epratuzumab Fab Heavy Chain, Epratuzumab Fab Light Chain, ...
Authors:Sicard, T., Ereno-Orbea, J., Julien, J.P.
Deposit date:2017-04-24
Release date:2017-10-11
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular basis of human CD22 function and therapeutic targeting.
Nat Commun, 8, 2017
6AZM
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CRYSTAL STRUCTURE OF THE 580 GERMLINE ANTIBODY BOUND TO CIRCUMSPOROZOITE PROTEIN NANP 5-MER
Descriptor:580 germline antibody, light chain, heavy chain, ...
Authors:Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P.
Deposit date:2017-09-11
Release date:2017-12-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Immunity, 47, 2017
6AZX
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CRYSTAL STRUCTURE OF THE NEUTRALIZING ANTI-CIRCUMSPOROZOITE PROTEIN 663 ANTIBODY
Descriptor:663 antibody, heavy chain, light chain
Authors:Scally, S.W., Bosch, A., Triller, G., Wardemann, H., Julien, J.P.
Deposit date:2017-09-13
Release date:2017-12-13
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Immunity, 47, 2017
6AZZ
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CRYSTAL STRUCTURE OF PFS25 IN COMPLEX WITH THE TRANSMISSION BLOCKING ANTIBODY 1190
Descriptor:1190 antibody, heavy chain, light chain, ...
Authors:Scally, S.W., McLeod, B., Bosch, A., King, C.R., Julien, J.P.
Deposit date:2017-09-13
Release date:2017-11-08
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017
6B08
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CRYSTAL STRUCTURE OF PFS25 IN COMPLEX WITH THE TRANSMISSION BLOCKING ANTIBODY 1276
Descriptor:1276 antibody, heavy chain, light chain, ...
Authors:Scally, S.W., McLeod, B., Bosch, A., King, C.R., Julien, J.P.
Deposit date:2017-09-14
Release date:2017-11-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.
Nat Commun, 8, 2017