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1KEQ
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CRYSTAL STRUCTURE OF F65A/Y131C CARBONIC ANHYDRASE V, COVALENTLY MODIFIED WITH 4-CHLOROMETHYLIMIDAZOLE
Descriptor:F65A/Y131C-MI Carbonic Anhydrase V, POTASSIUM ION, ZINC ION, ...
Authors:Jude, K.M., Wright, S.K., Tu, C., Silverman, D.N., Viola, R.E., Christianson, D.W.
Deposit date:2001-11-16
Release date:2002-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Biochemistry, 41, 2002
2FOQ
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HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONG INHIBITORS
Descriptor:Carbonic anhydrase 2, ZINC ION, [2,2'-({4-[({2-[4-(AMINOSULFONYL)PHENYL]ETHYL}AMINO)CARBONYL]BENZYL}IMINO)DIACETATO(2-)-KAPPAO]COPPER, ...
Authors:Jude, K.M., Christianson, D.W.
Deposit date:2006-01-13
Release date:2006-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006
2FOS
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HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONG INHIBITORS
Descriptor:Carbonic Anhydrase II, ZINC ION, COPPER (II) ION, ...
Authors:Jude, K.M., Christianson, D.W.
Deposit date:2006-01-13
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006
2FOU
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HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONG INHIBITORS
Descriptor:Carbonic Anhydrase II, ZINC ION, COPPER (II) ION, ...
Authors:Jude, K.M., Christianson, D.W.
Deposit date:2006-01-14
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006
2FOV
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HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONG INHIBITORS
Descriptor:Carbonic Anhydrase II, ZINC ION, COPPER (II) ION, ...
Authors:Jude, K.M., Christianson, D.W.
Deposit date:2006-01-14
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006
2FOY
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HUMAN CARBONIC ANHYDRASE I COMPLEXED WITH A TWO-PRONG INHIBITOR
Descriptor:Carbonic anhydrase 1, ZINC ION, {2,2'-[(2-{[4-(AMINOSULFONYL)BENZOYL]AMINO}ETHYL)IMINO]DIACETATO(2-)-KAPPAO}COPPER
Authors:Jude, K.M., Banerjee, A.L., Haldar, M.K., Manokaran, S., Roy, B., Mallik, S., Srivastava, D.K., Christianson, D.W.
Deposit date:2006-01-14
Release date:2006-04-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity.
J.Am.Chem.Soc., 128, 2006
5UTZ
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HUMAN IL-2/FAB COMPLEX
Descriptor:Fab 5111 heavy chain, Fab 5111 light chain, Interleukin-2, ...
Authors:Jude, K.M., Garcia, K.C.
Deposit date:2017-02-15
Release date:2018-07-11
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (2.747 Å)
Cite:A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism.
Nat. Med., 24, 2018
5WB1
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LIGAND-FREE US28 WITH STABILIZING INTRACELLULAR NANOBODY
Descriptor:Envelope protein US28, nanobody 7 fusion protein
Authors:Jude, K.M., Burg, J.S., Garcia, K.C.
Deposit date:2017-06-27
Release date:2018-06-13
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.508 Å)
Cite:Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.
Elife, 7, 2018
5WB2
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US28 BOUND TO ENGINEERED CHEMOKINE CX3CL1.35 AND NANOBODIES
Descriptor:Envelope protein US28, nanobody 7 fusion protein, CX3CL1 protein, ...
Authors:Jude, K.M., Burg, J.S., Tsutsumi, N., Miles, T.F., Garcia, K.C.
Deposit date:2017-06-27
Release date:2018-06-13
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.
Elife, 7, 2018
6BJ2
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TCR589 IN COMPLEX WITH HIV(POL448-456)/HLA-B35
Descriptor:TCR 589 alpha chain, TCR 589 beta chain, HLA class I histocompatibility antigen, ...
Authors:Jude, K.M., Sibener, L.V., Garcia, K.C.
Deposit date:2017-11-03
Release date:2018-07-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell, 174, 2018
6BJ3
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TCR55 IN COMPLEX WITH HIV(POL448-456)/HLA-B35
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Jude, K.M., Sibener, L.V., Garcia, K.C.
Deposit date:2017-11-03
Release date:2018-07-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.898 Å)
Cite:Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell, 174, 2018
6BJ8
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TCR55 IN COMPLEX WITH PEP20/HLA-B35
Descriptor:HLA class I histocompatibility antigen, B-35 alpha chain, Beta-2-microglobulin, ...
Authors:Jude, K.M., Sibener, L.V., Yang, X., Garcia, K.C.
Deposit date:2017-11-05
Release date:2018-07-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding.
Cell, 174, 2018
6DG5
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STRUCTURE OF A DE NOVO DESIGNED INTERLEUKIN-2/INTERLEUKIN-15 MIMETIC COMPLEX WITH IL-2RB AND IL-2RG
Descriptor:Neoleukin-2/15, Interleukin-2 receptor subunit beta, Cytokine receptor common subunit gamma, ...
Authors:Jude, K.M., Silva, D.-A., Yu, S., Baker, D., Garcia, K.C.
Deposit date:2018-05-16
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (2.516 Å)
Cite:De novo design of potent and selective mimics of IL-2 and IL-15.
Nature, 565, 2019
6DG6
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STRUCTURE OF A DE NOVO DESIGNED INTERLEUKIN-2/INTERLEUKIN-15 MIMETIC
Descriptor:Neoleukin-2/15
Authors:Jude, K.M., Silva, D.-A., Yu, S., Baker, D., Garcia, K.C.
Deposit date:2018-05-16
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:De novo design of potent and selective mimics of IL-2 and IL-15.
Nature, 565, 2019
6E3K
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INTERFERON GAMMA SIGNALLING COMPLEX WITH IFNGR1 AND IFNGR2
Descriptor:Interferon gamma, Interferon gamma receptor 1, Interferon gamma receptor 2, ...
Authors:Jude, K.M., Mendoza, J.L., Garcia, K.C.
Deposit date:2018-07-14
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of the IFN gamma receptor complex guides design of biased agonists.
Nature, 567, 2019
6E3L
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INTERFERON GAMMA SIGNALLING COMPLEX WITH IFNGR1 AND IFNGR2
Descriptor:Interferon gamma, Interferon gamma receptor 1, Interferon gamma receptor 2, ...
Authors:Jude, K.M., Mendoza, J.L., Garcia, K.C.
Deposit date:2018-07-14
Release date:2019-02-27
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of the IFN gamma receptor complex guides design of biased agonists.
Nature, 567, 2019
6MOE
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MONOMERIC DARPIN E2 COMPLEX WITH EPOR
Descriptor:E2 DARPin, Erythropoietin receptor, PHOSPHATE ION, ...
Authors:Jude, K.M., Mohan, K., Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.091 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOF
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MONOMERIC DARPIN G2 COMPLEX WITH EPOR
Descriptor:G2 DARPin, Erythropoietin receptor, 1,2-ETHANEDIOL
Authors:Jude, K.M., Mohan, K., Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.894 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOG
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DIMERIC DARPIN C_R3
Descriptor:DARPin C_R3, 1,2-ETHANEDIOL, TRIETHYLENE GLYCOL
Authors:Jude, K.M., Mohan, K., Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOH
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DIMERIC DARPIN C_R3 COMPLEX WITH EPOR
Descriptor:Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ...
Authors:Jude, K.M., Mohan, K., Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOI
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DIMERIC DARPIN C_ANGLE_R5 COMPLEX WITH EPOR
Descriptor:Dimeric DARPing CCR5 (C_angle_R5), Erythropoietin receptor, SULFATE ION, ...
Authors:Jude, K.M., Mohan, K., Garcia, K.C., Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.065 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOJ
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DIMERIC DARPIN A_ANGLE_R5 COMPLEX WITH EPOR
Descriptor:Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, D(-)-TARTARIC ACID, ...
Authors:Jude, K.M., Mohan, K., Garcia, K.C.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (2.431 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOK
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DIMERIC DARPIN ANR7 COMPLEX WITH EPOR
Descriptor:Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor
Authors:Jude, K.M., Mohan, K., Garcia, K.C., Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (5.101 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
6MOL
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MONOEXTENDED DARPIN M_R12 COMPLEX WITH EPOR
Descriptor:Monoextended DARPin R12 (M_R12), Erythropoietin receptor, GLYCEROL
Authors:Jude, K.M., Mohan, K., Garcia, K.C., Guo, Y.
Deposit date:2018-10-04
Release date:2019-06-05
Last modified:2019-06-12
Method:X-RAY DIFFRACTION (3.163 Å)
Cite:Topological control of cytokine receptor signaling induces differential effects in hematopoiesis.
Science, 364, 2019
2NMX
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STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE I
Descriptor:Carbonic anhydrase 1, ZINC ION, N-{2-[4-(AMINOSULFONYL)PHENYL]ETHYL}ACETAMIDE, ...
Authors:Christianson, D.W., Jude, K.M.
Deposit date:2006-10-23
Release date:2007-04-24
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II
J.Am.Chem.Soc., 129, 2007
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