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4DDI
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BU of 4ddi by Molmil
Crystal structure of human OTUB1/UbcH5b~Ub/Ub
Descriptor: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1
Authors:Juang, Y.C, Sanches, M, Sicheri, F.
Deposit date:2012-01-18
Release date:2012-02-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.802 Å)
Cite:OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function.
Mol.Cell, 45, 2012
4DDG
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BU of 4ddg by Molmil
Crystal structure of human OTUB1/UbcH5b~Ub/Ub
Descriptor: Polyubiquitin-C, Ubiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1
Authors:Juang, Y.C, Sanches, M, Sicheri, F.
Deposit date:2012-01-18
Release date:2012-02-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.2987 Å)
Cite:OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function.
Mol.Cell, 45, 2012
4I6L
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BU of 4i6l by Molmil
Crystal structure of OTUB1 in complex with ubiquitin variant
Descriptor: Ubiquitin, Ubiquitin thioesterase OTUB1
Authors:Juang, Y.C, Sicheri, F.
Deposit date:2012-11-29
Release date:2013-01-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.488 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
5J26
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BU of 5j26 by Molmil
Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant
Descriptor: Tumor suppressor p53-binding protein 1, Ubiquitin Variant i53
Authors:Wan, L, Canny, M, Juang, Y.C, Durocher, D, Sicheri, F.
Deposit date:2016-03-29
Release date:2016-12-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.5047 Å)
Cite:A genetically encoded inhibitor of 53BP1 to stimulate homology-based gene editing
To Be Published
5D9H
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BU of 5d9h by Molmil
Crystal structure of SPAK (STK39) dimer in the basal activity state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, STE20/SPS1-related proline-alanine-rich protein kinase, ...
Authors:Taylor, C.A, Juang, Y.C, Goldsmith, E.J, Cobb, M.H.
Deposit date:2015-08-18
Release date:2015-09-02
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK.
Biochemistry, 54, 2015
7ROV
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BU of 7rov by Molmil
KRAS G12D Mutant in complex with GMPPCP and cyclic peptide MP-9903
Descriptor: Cyclic peptide MP-9903, GLYCEROL, Isoform 2B of GTPase KRas, ...
Authors:Orth, P.
Deposit date:2021-08-02
Release date:2021-09-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.
Chem Sci, 12, 2021
6OTS
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BU of 6ots by Molmil
Rat ERK2 E320K
Descriptor: Mitogen-activated protein kinase 1
Authors:Taylor, C.A, Cormier, K.W, Juang, Y.-C, Goldsmith, E.J, Cobb, M.H.
Deposit date:2019-05-03
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Functional divergence caused by mutations in an energetic hotspot in ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
5DBX
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BU of 5dbx by Molmil
Crystal structure of murine SPAK(T243D) in complex with AMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, STE20/SPS1-related proline-alanine-rich protein kinase
Authors:Juang, Y.-C.
Deposit date:2015-08-22
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK.
Biochemistry, 54, 2015
4KSJ
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BU of 4ksj by Molmil
Crystal structure of the OTU domain of Gumby/Fam105B at 1.6 angstrom
Descriptor: BETA-MERCAPTOETHANOL, GLYCEROL, Protein FAM105B
Authors:Ceccarelli, D.F, Juang, Y.-C, Sicheri, F.
Deposit date:2013-05-17
Release date:2013-06-05
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Nature, 498, 2013
6BXI
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BU of 6bxi by Molmil
X-ray crystal structure of NDR1 kinase domain
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase 38
Authors:Xiong, S, Sicheri, F.
Deposit date:2017-12-18
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
Structure, 26, 2018
3I3T
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BU of 3i3t by Molmil
Crystal structure of covalent ubiquitin-USP21 complex
Descriptor: ETHANAMINE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 21, ...
Authors:Neculai, D, Avvakumov, G.V, Walker, J.R, Xue, S, Butler-Cole, C, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2009-06-30
Release date:2009-07-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3V6E
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BU of 3v6e by Molmil
Crystal Structure of USP2 and a mutant form of Ubiquitin
Descriptor: CHLORIDE ION, GLYCEROL, Ubiquitin, ...
Authors:Neculai, M, Ernst, A, Sidhu, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2011-12-19
Release date:2012-12-19
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3MTN
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BU of 3mtn by Molmil
Usp21 in complex with a ubiquitin-based, USP21-specific inhibitor
Descriptor: CHLORIDE ION, GLYCEROL, UBIQUITIN VARIANT UBV.21.4, ...
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2010-04-30
Release date:2010-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
3N3K
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BU of 3n3k by Molmil
The catalytic domain of USP8 in complex with a USP8 specific inhibitor
Descriptor: Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 8, ZINC ION
Authors:Walker, J.R, Avvakumov, G.V, Xue, S, Li, Y, Allali-Hassani, A, Lam, R, Ernst, A, Sidhu, S, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2010-05-20
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
6OT6
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BU of 6ot6 by Molmil
Rat ERK2 D319N
Descriptor: Mitogen-activated protein kinase 1, SULFATE ION
Authors:Taylor, C.A, Goldsmith, E.J, Cobb, M.H.
Deposit date:2019-05-02
Release date:2019-07-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Functional divergence caused by mutations in an energetic hotspot in ERK2.
Proc.Natl.Acad.Sci.USA, 116, 2019
4KSK
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BU of 4ksk by Molmil
Gumby/Fam105B in complex with ubiquitin
Descriptor: Polyubiquitin-C, Protein FAM105B, SULFATE ION
Authors:Ceccarelli, D.F, Juang, Y.-C, Sicheri, F.
Deposit date:2013-05-17
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Nature, 498, 2013
4KSL
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BU of 4ksl by Molmil
Gumby/Fam105B in complex with linear di-ubiquitin
Descriptor: Polyubiquitin-C, Protein FAM105B
Authors:Juang, Y.-C, Ceccarelli, D.F, Sicheri, F.
Deposit date:2013-05-17
Release date:2013-06-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Nature, 498, 2013
4O1O
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BU of 4o1o by Molmil
Crystal Structure of RNase L in complex with 2-5A
Descriptor: Ribonuclease L, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate
Authors:Huang, H, Zeqiraj, E, Ceccarelli, D.F, Sicheri, F.
Deposit date:2013-12-16
Release date:2014-02-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol.Cell, 53, 2014
4O1P
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BU of 4o1p by Molmil
Crystal Structure of RNase L in complex with 2-5A and AMP-PNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribonuclease L, ...
Authors:Huang, H, Zeqiraj, E, Ceccarelli, D.F, Sicheri, F.
Deposit date:2013-12-16
Release date:2014-02-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol.Cell, 53, 2014

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PDB entries from 2024-03-27

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