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5ONI
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LOW-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P
Descriptor:Casein kinase II subunit alpha, 4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione, SULFATE ION, ...
Authors:Hochscherf, J., Lindenblatt, D., Witulski, B., Birus, R., Aichele, D., Marminon, C., Bouaziz, Z., Le Borgne, M., Jose, J., Niefind, K.
Deposit date:2017-08-03
Release date:2017-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2 alpha and Its Paralog CK2 alpha '.
Pharmaceuticals (Basel), 10, 2017
5OOI
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STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P
Descriptor:Casein kinase II subunit alpha', 4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione, 1,2-ETHANEDIOL, ...
Authors:Hochscherf, J., Lindenblatt, D., Witulski, B., Birus, R., Aichele, D., Marminon, C., Bouaziz, Z., Le Borgne, M., Jose, J., Niefind, K.
Deposit date:2017-08-07
Release date:2017-12-27
Last modified:2018-10-10
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2 alpha and Its Paralog CK2 alpha '.
Pharmaceuticals (Basel), 10, 2017
6HBN
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HIGH-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA/CSKN2A1 GENE PRODUCT) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR THN27
Descriptor:Casein kinase II subunit alpha, CHLORIDE ION, 5-propan-2-yl-4-prop-2-enoxy-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione, ...
Authors:Niefind, K., Hochscherf, J., Dimper, V., Witulski, B., Lindenblatt, D., Jose, J., Le Borgne, M.
Deposit date:2018-08-10
Release date:2019-03-27
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Diacritic Binding of an Indenoindole Inhibitor by CK2alpha Paralogs Explored by a Reliable Path to Atomic Resolution CK2alpha' Structures
Acs Omega, 2019
6HMB
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STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE INHIBITOR CX-4945 (SILMITASERTIB)
Descriptor:Casein kinase II subunit alpha', 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Niefind, K., Lindenblatt, D., Applegate, V.M., Jose, J., Le Borgne, M.
Deposit date:2018-09-12
Release date:2019-03-27
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:Diacritic Binding of an Indenoindole Inhibitor by CK2alpha Paralogs Explored by a Reliable Path to Atomic Resolution CK2alpha' Structures
Acs Omega, 2019
6HMC
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STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR THN27
Descriptor:Casein kinase II subunit alpha', 1,2-ETHANEDIOL, 5-propan-2-yl-4-prop-2-enoxy-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione
Authors:Niefind, K., Lindenblatt, D., Dimper, V., Jose, J., Le Borgne, M.
Deposit date:2018-09-12
Release date:2019-03-27
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:Diacritic Binding of an Indenoindole Inhibitor by CK2alpha Paralogs Explored by a Reliable Path to Atomic Resolution CK2alpha' Structures
Acs Omega, 2019
6HMD
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STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR AR18
Descriptor:Casein kinase II subunit alpha', 1,2-ETHANEDIOL, 5-[2-(diethylamino)ethyl]-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione, ...
Authors:Niefind, K., Lindenblatt, D., Jose, J., Le Borgne, M.
Deposit date:2018-09-12
Release date:2019-03-27
Method:X-RAY DIFFRACTION (1 Å)
Cite:Diacritic Binding of an Indenoindole Inhibitor by CK2alpha Paralogs Explored by a Reliable Path to Atomic Resolution CK2alpha' Structures
Acs Omega, 2019
6HME
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LOW-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA; CSNK2A1 GENE PRODUCT) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR THN27
Descriptor:Casein kinase II subunit alpha, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Niefind, K., Lindenblatt, D., Jose, J., Le Borgne, M.
Deposit date:2018-09-12
Release date:2019-03-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Diacritic Binding of an Indenoindole Inhibitor by CK2alpha Paralogs Explored by a Reliable Path to Atomic Resolution CK2alpha' Structures
Acs Omega, 2019
6HMQ
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STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE BENZOTRIAZOLE-TYPE INHIBITOR MB002
Descriptor:Casein kinase II subunit alpha', 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 1,2-ETHANEDIOL, ...
Authors:Niefind, K., Lindenblatt, D., Applegate, V.M., Jose, J., Le Borgne, M.
Deposit date:2018-09-12
Release date:2019-03-27
Method:X-RAY DIFFRACTION (0.97 Å)
Cite:Diacritic Binding of an Indenoindole Inhibitor by CK2alpha Paralogs Explored by a Reliable Path to Atomic Resolution CK2alpha' Structures
Acs Omega, 2019
5N9K
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CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE, TIGHT-BINDING DIBENZOFURAN INHIBITOR TF107 (5)
Descriptor:Casein kinase II subunit alpha, 1,3-bis(chloranyl)-6-[(~{E})-(4-methoxyphenyl)iminomethyl]dibenzofuran-2,7-diol, ACETATE ION, ...
Authors:Schnitzler, A., Gratz, A., Bollacke, A., Weyrich, M., Kucklaender, U., Wuensch, B., Goetz, C., Niefind, K., Jose, J.
Deposit date:2017-02-25
Release date:2018-02-28
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.643 Å)
Cite:A pi-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors.
Pharmaceuticals, 11, 2018
5N9L
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CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE DIBENZOFURAN INHIBITOR TF (4B)
Descriptor:Casein kinase II subunit alpha, (4~{Z})-6,7-bis(chloranyl)-4-[[(4-methylphenyl)amino]methylidene]-8-oxidanyl-1,2-dihydrodibenzofuran-3-one, ACETATE ION, ...
Authors:Schnitzler, A., Gratz, A., Bollacke, A., Weyrich, M., Kucklaender, U., Wuensch, B., Goetz, C., Niefind, K., Jose, J.
Deposit date:2017-02-25
Release date:2018-02-28
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:A pi-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors.
Pharmaceuticals, 11, 2018
5N9N
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CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE, TIGHT-BINDING DIBENZOFURAN INHIBITOR TF85 (4A)
Descriptor:Casein kinase II subunit alpha, (4~{Z})-7,9-bis(chloranyl)-4-[[(4-methoxyphenyl)amino]methylidene]-8-oxidanyl-1,2-dihydrodibenzofuran-3-one, ACETATE ION, ...
Authors:Schnitzler, A., Gratz, A., Bollacke, A., Weyrich, M., Kucklaender, U., Wuensch, B., Goetz, C., Niefind, K., Jose, J.
Deposit date:2017-02-25
Release date:2018-02-28
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.841 Å)
Cite:A pi-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors.
Pharmaceuticals, 11, 2018
3J0F
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SINDBIS VIRION
Descriptor:Capsid protein, E1 envelope glycoprotein, E2 envelope glycoprotein
Authors:Tang, J., Jose, J., Zhang, W., Chipman, P., Kuhn, R.J., Baker, T.S.
Deposit date:2011-07-08
Release date:2011-10-12
Last modified:2012-05-30
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Molecular Links between the E2 Envelope Glycoprotein and Nucleocapsid Core in Sindbis Virus.
J.Mol.Biol., 414, 2011
4IB5
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STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT IN COMPLEX WITH A CK2BETA-COMPETITIVE CYCLIC PEPTIDE
Descriptor:Casein kinase II subunit alpha, CK2beta-derived cyclic peptide, GLYCEROL, ...
Authors:Raaf, J., Guerra, B., Neundorf, I., Bopp, B., Issinger, O.-G., Jose, J., Pietsch, M., Niefind, K.
Deposit date:2012-12-08
Release date:2013-03-20
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:First structure of protein kinase CK2 catalytic subunit with an effective CK2 beta-competitive ligand
Acs Chem.Biol., 8, 2013
4UOK
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ELECTRON CRYO-MICROSCOPY OF VENEZUELAN EQUINE ENCEPHALITIS VIRUS TC-83 IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB 3B4C-4
Descriptor:FAB FRAGMENT HEAVY CHAIN, FAB FRAGMENT LIGHT CHAIN
Authors:Porta, J., Jose, J., Roehrig, J.T., Blair, C.D., Kuhn, R.J., G Rossmann, M.
Deposit date:2014-06-04
Release date:2014-09-17
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (18 Å)
Cite:Locking and Blocking the Viral Landscape of an Alphavirus with Neutralizing Antibodies.
J.Virol., 88, 2014
4UOM
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ELECTRON CRYO-MICROSCOPY OF VENEZUELAN EQUINE ENCEPHALITIS VIRUS TC- 83 IN COMPLEX WITH NEUTRALIZING ANTIBODY FAB F5
Descriptor:FAB FRAGMENT HEAVY CHAIN, FAB FRAGMENT LIGHT CHAIN
Authors:Porta, J., Jose, J., Roehrig, J.T., Blair, C.D., Kuhn, R.J., Rossmann, M.G.
Deposit date:2014-06-05
Release date:2014-10-15
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (17 Å)
Cite:Locking and Blocking the Viral Landscape of an Alphavirus with Neutralizing Antibodies.
J.Virol., 88, 2014
5OMY
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HIGH-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA) IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P
Descriptor:Casein kinase II subunit alpha, 4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione, CHLORIDE ION
Authors:Hochscherf, J., Lindenblatt, D., Witulski, B., Birus, R., Aichele, D., Marminon, C., Bouaziz, Z., Le Borgne, M., Jose, J., Niefind, K.
Deposit date:2017-08-02
Release date:2017-12-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2 alpha and Its Paralog CK2 alpha '.
Pharmaceuticals (Basel), 10, 2017
3MUU
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CRYSTAL STRUCTURE OF THE SINDBIS VIRUS E2-E1 HETERODIMER AT LOW PH
Descriptor:Structural polyprotein, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Li, L., Jose, J., Xiang, Y., Kuhn, R.J., Rossmann, M.G.
Deposit date:2010-05-03
Release date:2010-11-24
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Structural changes of envelope proteins during alphavirus fusion.
Nature, 468, 2010
3MUW
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PSEUDO-ATOMIC STRUCTURE OF THE E2-E1 PROTEIN SHELL IN SINDBIS VIRUS
Descriptor:Structural polyprotein
Authors:Li, L., Jose, J., Xiang, Y., Kuhn, R.J., Rossmann, M.G.
Deposit date:2010-05-03
Release date:2010-11-24
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Structural changes of envelope proteins during alphavirus fusion.
Nature, 468, 2010
4MEE
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CRYSTAL STRUCTURE OF THE TRANSPORT UNIT OF THE AUTOTRANSPORTER AIDA-I FROM ESCHERICHIA COLI
Descriptor:Diffuse adherence adhesin
Authors:Gawarzewski, I., Tschapek, B., Hoeppner, A., Smits, S.H., Jose, J., Schmitt, L.
Deposit date:2013-08-26
Release date:2014-06-04
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the transport unit of the autotransporter adhesin involved in diffuse adherence from Escherichia coli.
J.Struct.Biol., 187, 2014
4O6B
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DENGUE TYPE2 VIRUS NON-STRUCTURAL PROTEIN 1 (NS1) FORM 1 CRYSTAL
Descriptor:Non-structural protein 1, N-ACETYL-D-GLUCOSAMINE
Authors:Akey, D.L., Smith, J.L.
Deposit date:2013-12-20
Release date:2014-02-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.0005 Å)
Cite:Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.
Science, 343, 2014
4O6C
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WEST NILE VIRUS NON-STRUCTURAL PROTEIN 1 (NS1) FORM 2 CRYSTAL
Descriptor:NS1, N-ACETYL-D-GLUCOSAMINE, SULFATE ION
Authors:Akey, D.L., Smith, J.L.
Deposit date:2013-12-20
Release date:2014-02-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.7508 Å)
Cite:Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.
Science, 343, 2014
4O6D
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WEST NILE VIRUS NON-STRUCTURAL PROTEIN 1 (NS1) FORM 1 CRYSTAL
Descriptor:NS1, N-ACETYL-D-GLUCOSAMINE, OXTOXYNOL-10, ...
Authors:Akey, D.L., Smith, J.L.
Deposit date:2013-12-20
Release date:2014-02-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5936 Å)
Cite:Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.
Science, 343, 2014
3N40
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CRYSTAL STRUCTURE OF THE IMMATURE ENVELOPE GLYCOPROTEIN COMPLEX OF CHIKUNGUNYA VIRUS.
Descriptor:P62 envelope glycoprotein, E1 envelope glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Voss, J., Vaney, M.C., Duquerroy, S., Rey, F.A.
Deposit date:2010-05-21
Release date:2010-12-01
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography.
Nature, 468, 2010
3N41
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CRYSTAL STRUCTURE OF THE MATURE ENVELOPE GLYCOPROTEIN COMPLEX (SPONTANEOUS CLEAVAGE) OF CHIKUNGUNYA VIRUS.
Descriptor:E3 envelope glycoprotein, E2 envelope glycoprotein, E1 envelope glycoprotein, ...
Authors:Voss, J., Vaney, M.C., Duquerroy, S., Rey, F.A.
Deposit date:2010-05-21
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography.
Nature, 468, 2010
3N42
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CRYSTAL STRUCTURES OF THE MATURE ENVELOPE GLYCOPROTEIN COMPLEX (FURIN CLEAVAGE) OF CHIKUNGUNYA VIRUS.
Descriptor:E3 envelope glycoprotein, E2 envelope glycoprotein, E1 envelope glycoprotein, ...
Authors:Voss, J., Vaney, M.C., Duquerroy, S., Rey, F.A.
Deposit date:2010-05-21
Release date:2010-12-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography.
Nature, 468, 2010
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