Author results

2JQ7
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MODEL FOR THIOSTREPTON BINDING TO THE RIBOSOMAL L11-RNA
Descriptor:50S RIBOSOMAL PROTEIN L11, RIBOSOMAL RNA, THIOSTREPTON
Authors:Jonker, H.R.A., Ilin, S., Grimm, S.K., Woehnert, J., Schwalbe, H.
Deposit date:2007-05-30
Release date:2007-07-03
Last modified:2017-11-01
Method:SOLUTION NMR
Cite:L11 Domain Rearrangement Upon Binding to RNA and Thiostrepton Studied by NMR Spectroscopy
Nucleic Acids Res., 35, 2007
2PHE
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MODEL FOR VP16 BINDING TO PC4
Descriptor:TRANSCRIPTIONAL COACTIVATOR PC4, Alpha trans-inducing protein
Authors:Jonker, H.R.A., Wechselberger, R.W., Boelens, R., Folkers, G.E., Kaptein, R.
Deposit date:2007-04-11
Release date:2007-04-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Properties of the Promiscuous VP16 Activation Domain
Biochemistry, 44, 2005
2PHG
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MODEL FOR VP16 BINDING TO TFIIB
Descriptor:Transcription initiation factor IIB, Alpha trans-inducing protein
Authors:Jonker, H.R.A., Wechselberger, R.W., Boelens, R., Folkers, G.E., Kaptein, R.
Deposit date:2007-04-11
Release date:2007-04-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural Properties of the Promiscuous VP16 Activation Domain
Biochemistry, 44, 2005
2K3F
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RIBOSOMAL PROTEIN L11 FROM THERMOTOGA MARITIMA
Descriptor:50S ribosomal protein L11
Authors:Jonker, H.R.A., Ilin, S., Schwalbe, H., Woehnert, J.
Deposit date:2008-05-06
Release date:2008-06-17
Last modified:2013-09-04
Method:SOLUTION NMR
Cite:Domain reorientation and induced fit upon RNA binding: solution structure and dynamics of ribosomal protein L11 from Thermotoga maritima
ChemBioChem, 6, 2005
6F2X
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STRUCTURAL CHARACTERIZATION OF THE MYCOBACTERIUM TUBERCULOSIS PROTEIN TYROSINE KINASE A (PTKA)
Descriptor:Protein Tyrosine Kinase A
Authors:Niesteruk, A., Jonker, H.R.A., Sreeramulu, S., Richter, C., Hutchison, M., Linhard, V., Schwalbe, H.
Deposit date:2017-11-27
Release date:2018-07-04
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:The domain architecture of PtkA, the first tyrosine kinase fromMycobacterium tuberculosis, differs from the conventional kinase architecture.
J. Biol. Chem., 293, 2018
2K5B
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HUMAN CDC37-HSP90 DOCKING MODEL BASED ON NMR
Descriptor:Heat shock protein HSP 90-alpha, Hsp90 co-chaperone Cdc37
Authors:Sreeramulu, S., Jonker, H.R.A., Lancaster, C.R., Richter, C., Langer, T., Schwalbe, H.
Deposit date:2008-06-26
Release date:2008-12-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy
J.Biol.Chem., 284, 2009
2KER
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ALPHA-AMYLASE INHIBITOR PARVULUSTAT (Z-2685) FROM STREPTOMYCES PARVULUS
Descriptor:Alpha-amylase inhibitor Z-2685
Authors:Rehm, S., Han, S., Hassani, I., Sokocevic, A., Jonker, H.R.A., Engels, J.W., Schwalbe, H.
Deposit date:2009-02-02
Release date:2009-02-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158
Chembiochem, 10, 2009
2KMJ
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HIGH RESOLUTION NMR SOLUTION STRUCTURE OF A COMPLEX OF HIV-2 TAR RNA AND A SYNTHETIC TRIPEPTIDE IN A 1:2 STOICHIOMETRY
Descriptor:RNA (28-MER), Pyrimidinylpeptide
Authors:Ferner, J., Suhartono, M., Breitung, S., Jonker, H.R.A., Hennig, M., Woehnert, J., Goebel, M., Schwalbe, H.
Deposit date:2009-07-30
Release date:2009-08-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.
Chembiochem, 10, 2009
2KOC
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NMR SOLUTION STRUCTURE OF A 14-MER HAIRPIN RNA WITH CUUCGG TETRALOOP
Descriptor:RNA (5'-R(P*GP*GP*CP*AP*CP*UP*UP*CP*GP*GP*UP*GP*CP*C)-3')
Authors:Nozinovic, S., Fuertig, B., Jonker, H.R.A., Richter, C., Schwalbe, H.
Deposit date:2009-09-17
Release date:2009-12-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:High-resolution NMR structure of an RNA model system: the 14-mer cUUCGg tetraloop hairpin RNA
Nucleic Acids Res., 2009
2W0G
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HSP90 CO-CHAPERONE CDC37
Descriptor:HSP90 CO-CHAPERONE CDC37
Authors:Sreeramulu, S., Jonker, H.R.A., Schwalbe, H., Lancaster, C.R.D.
Deposit date:2008-08-15
Release date:2008-12-09
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:The Human Cdc37.Hsp90 Complex Studied by Heteronuclear NMR Spectroscopy.
J.Biol.Chem., 284, 2009
5GQS
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NMR BASED SOLUTION STRUCTURE OF PTS SYSTEM, GALACTITOL-SPECIFIC IIB COMPONENT FROM METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS
Descriptor:PTS galactitol transporter subunit IIB
Authors:Wahab, A., Schwalbe, H., Shahid, M.F., Richter, C., Jonker, H.R.A.
Deposit date:2016-08-08
Release date:2016-09-14
Method:SOLUTION NMR
Cite:NMR based solution structure of PTS system, galactitol-specific IIB component from methicillin resistant Staphylococcus aureus
To Be Published
5MVB
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SOLUTION STRUCTURE OF A HUMAN G-QUADRUPLEX HYBRID-2 FORM IN COMPLEX WITH A GOLD-LIGAND.
Descriptor:DNA (26-MER), POTASSIUM ION, bis(m2-Oxo)-bis(2-methyl-2,2'-bipyridine)-di-gold(iii)
Authors:Wirmer-Bartoschek, J., Jonker, H.R.A., Bendel, L.E., Gruen, T., Bazzicalupi, C., Messori, L., Gratteri, P., Schwalbe, H.
Deposit date:2017-01-16
Release date:2017-05-31
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding.
Angew. Chem. Int. Ed. Engl., 56, 2017
5N5C
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NMR SOLUTION STRUCTURE OF THE TSL2 RNA HAIRPIN
Descriptor:RNA (19-MER)
Authors:Garcia-Lopez, A., Wacker, A., Tessaro, F., Jonker, H.R.A., Richter, C., Comte, A., Berntenis, N., Schmucki, R., Hatje, K., Sciarra, D., Konieczny, P., Fournet, G., Faustino, I., Orozco, M., Artero, R., Goekjian, P., Metzger, F., Ebeling, M., Joseph, B., Schwalbe, H., Scapozza, L.
Deposit date:2017-02-13
Release date:2018-03-14
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.
Nat Commun, 9, 2018
6F27
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NMR SOLUTION STRUCTURE OF NON-BOUND [DES-ARG10]-KALLIDIN (DAKD)
Descriptor:DAKD
Authors:Richter, C., Jonker, H.R.A., Schwalbe, H., Joedicke, L., Mao, J., Kuenze, G., Reinhart, C., Kalavacherla, T., Meiler, J., Preu, J., Michel, H., Glaubitz, C.
Deposit date:2017-11-23
Release date:2018-01-10
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6Q2Z
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NMR SOLUTION STRUCTURE OF THE HVO_2922 PROTEIN FROM HALOFERAX VOLCANII
Descriptor:UPF0339 family protein
Authors:Kubatova, N., Jonker, H.R.A., Saxena, K., Richter, C., Marchfelder, A., Schwalbe, H.
Deposit date:2018-12-03
Release date:2019-06-12
Method:SOLUTION NMR
Cite:Solution structure and dynamics of the small protein HVO_2922 from Haloferax volcanii.
Chembiochem, 2019
2L2W
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THIOSTREPTON
Descriptor:Thiostrepton
Authors:Jonker, H.R.A., Baumann, S., Wolf, A., Schoof, S., Hiller, F., Schulte, K.W., Kirschner, K.N., Schwalbe, H., Arndt, H.-D.
Deposit date:2010-08-27
Release date:2011-02-02
Last modified:2013-05-08
Method:SOLUTION NMR
Cite:NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site.
Angew.Chem.Int.Ed.Engl., 50, 2011
2L2X
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THIOSTREPTON, OXIDIZED AT CA-CB BOND OF RESIDUE 9
Descriptor:Thiostrepton
Authors:Jonker, H.R.A., Baumann, S., Wolf, A., Schoof, S., Hiller, F., Schulte, K.W., Kirschner, K.N., Schwalbe, H., Arndt, H.-D.
Deposit date:2010-08-27
Release date:2011-02-02
Last modified:2013-06-26
Method:SOLUTION NMR
Cite:NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site.
Angew.Chem.Int.Ed.Engl., 50, 2011
2L2Y
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THIOSTREPTON, EPIMER FORM OF RESIDUE 9
Descriptor:Thiostrepton
Authors:Jonker, H.R.A., Baumann, S., Wolf, A., Schoof, S., Hiller, F., Schulte, K.W., Kirschner, K.N., Schwalbe, H., Arndt, H.-D.
Deposit date:2010-08-27
Release date:2011-02-02
Last modified:2013-06-26
Method:SOLUTION NMR
Cite:NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site.
Angew.Chem.Int.Ed.Engl., 50, 2011
2L2Z
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THIOSTREPTON, REDUCED AT N-CA BOND OF RESIDUE 14
Descriptor:Thiostrepton
Authors:Jonker, H.R.A., Baumann, S., Wolf, A., Schoof, S., Hiller, F., Schulte, K.W., Kirschner, K.N., Schwalbe, H., Arndt, H.-D.
Deposit date:2010-08-27
Release date:2011-02-02
Last modified:2013-06-26
Method:SOLUTION NMR
Cite:NMR structures of thiostrepton derivatives for characterization of the ribosomal binding site.
Angew.Chem.Int.Ed.Engl., 50, 2011
2LUO
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NMR SOLUTION STRUCTURE OF APO-MPTPA
Descriptor:LOW MOLECULAR WEIGHT PROTEIN-TYROSINE-PHOSPHATASE A
Authors:Stehle, T., Sreeramulu, S., Loehr, F., Richter, C., Saxena, K., Jonker, H.R.A., Schwalbe, H.
Deposit date:2012-06-19
Release date:2012-08-15
Last modified:2012-10-24
Method:SOLUTION NMR
Cite:The Apo-structure of the Low Molecular Weight Protein-tyrosine Phosphatase A (MptpA) from Mycobacterium tuberculosis Allows for Better Target-specific Drug Development.
J.Biol.Chem., 287, 2012
2MW4
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TETRAMERIZATION DOMAIN OF THE CIONA INTESTINALIS P53/P73-B TRANSCRIPTION FACTOR PROTEIN
Descriptor:Transcription factor protein
Authors:Heering, J.P., Jonker, H.R.A., Loehr, F., Schwalbe, H., Doetsch, V.
Deposit date:2014-10-27
Release date:2015-10-28
Last modified:2016-02-10
Method:SOLUTION NMR
Cite:Structural investigations of the p53/p73 homologs from the tunicate species Ciona intestinalis reveal the sequence requirements for the formation of a tetramerization domain.
Protein Sci., 25, 2016
2N9Q
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PHOTOSWITCHABLE G-QUADRUPLEX
Descriptor:DNA (5'-D(*GP*GP*(AZW)P*GP*G)-3'), POTASSIUM ION
Authors:Thevarpadam, J., Bessi, I., Binas, O., Goncalves, D.P.N., Slavov, C., Jonker, H.R.A., Richter, C., Wachtveitl, J., Schwalbe, H., Heckel, A.
Deposit date:2015-12-02
Release date:2016-02-17
Last modified:2016-03-02
Method:SOLUTION NMR
Cite:Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.
Angew.Chem.Int.Ed.Engl., 55, 2016
3POK
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INTERLEUKIN-1-BETA LBT L3 MUTANT
Descriptor:Interleukin-1 beta
Authors:Barthelmes, K., Reynolds, A.M., Peisach, E., Jonker, H.R.A., DeNunzio, N.J., Allen, K.N., Imperiali, B., Schwalbe, H.
Deposit date:2010-11-22
Release date:2011-01-19
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Engineering encodable lanthanide-binding tags into loop regions of proteins.
J.Am.Chem.Soc., 133, 2011
5LCP
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COCRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE (PKA) IN COMPLEX WITH FASUDIL (M77)
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, ...
Authors:Wienen-Schmidt, B., Heine, A., Klebe, G.
Deposit date:2016-06-22
Release date:2018-01-17
Method:X-RAY DIFFRACTION (1.433 Å)
Cite:Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with Fasudil (M77)
To Be Published
5LCQ
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COCRYSTAL STRUCTURE OF CAMP-DEPENDENT PROTEIN KINASE (PKA) IN COMPLEX WITH LONG-CHAIN FASUDIL-DERIVATIVE (LIGAND 05)
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}-[2-(propylamino)ethyl]isoquinoline-5-sulfonamide, ...
Authors:Wienen-Schmidt, B., Heine, A., Klebe, G.
Deposit date:2016-06-22
Release date:2018-01-17
Method:X-RAY DIFFRACTION (1.423 Å)
Cite:Cocrystal structure of cAMP-dependent Protein Kinase (PKA) in complex with different Fasudil-derivatives
To Be Published
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