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1OYH
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CRYSTAL STRUCTURE OF P13 ALANINE VARIANT OF ANTITHROMBIN
Descriptor:Antithrombin-III, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Johnson, D.J.D., Huntington, J.A.
Deposit date:2003-04-04
Release date:2004-04-13
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:The influence of hinge region residue Glu-381 on antithrombin allostery and metastability
J.Biol.Chem., 279, 2004
1T1F
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CRYSTAL STRUCTURE OF NATIVE ANTITHROMBIN IN ITS MONOMERIC FORM
Descriptor:Antithrombin-III, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Johnson, D.J.D., Huntington, J.A.
Deposit date:2004-04-16
Release date:2005-10-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation
J.Biol.Chem., 281, 2006
2AFQ
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1.9 ANGSTROM CRYSTAL STRUCTURE OF WILD-TYPE HUMAN THROMBIN IN THE SODIUM FREE STATE
Descriptor:Prothrombin, GLYCEROL
Authors:Johnson, D.J.D., Adams, T.E., Huntington, J.A.
Deposit date:2005-07-26
Release date:2005-11-15
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Crystal structure of wild-type human thrombin in the Na+-free state
Biochem.J., 392, 2005
1NQ9
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CRYSTAL STRUCTURE OF ANTITHROMBIN IN THE PENTASACCHARIDE-BOUND INTERMEDIATE STATE
Descriptor:Antithrombin-III, N-ACETYL-D-GLUCOSAMINE, HEPARIN PENTASACCHARIDE
Authors:Huntington, J.A., Johnson, D.J.D.
Deposit date:2003-01-21
Release date:2003-09-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Antithrombin in a Heparin-Bound Intermediate State
Biochemistry, 42, 2003
5NBU
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CRYSTAL STRUCTURE OF NATIVE ALPHA-1-ANTITRYPSIN WITH SEVEN STABILISING MUTATIONS
Descriptor:Alpha-1-antitrypsin, GLYCEROL, OXAMIC ACID
Authors:Huntington, J.A., Pomowski, A., Johnson, D.J.D.
Deposit date:2017-03-02
Release date:2018-03-21
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
5NBV
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CRYSTAL STRUCTURE OF NATIVE ALPHA-1-ANTITRYPSIN WITH SEVEN STABILISING MUTATIONS
Descriptor:Alpha-1-antitrypsin, GLYCEROL
Authors:Huntington, J.A., Pomowski, A., Johnson, D.J.D.
Deposit date:2017-03-02
Release date:2018-03-21
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
2B4X
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CRYSTAL STRUCTURE OF ANTITHROMBIN-III
Descriptor:Antithrombin-III, N-ACETYL-D-GLUCOSAMINE
Authors:Adams, T.E., Huntington, J.A., Johnson, D.J.D., Bock, S.C.
Deposit date:2005-09-27
Release date:2006-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Antithrombin-III
To be Published
1CVW
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CRYSTAL STRUCTURE OF ACTIVE SITE-INHIBITED HUMAN COAGULATION FACTOR VIIA (DES-GLA)
Descriptor:COAGULATION FACTOR VIIA (LIGHT CHAIN) (DES-GLA), COAGULATION FACTOR VIIA (HEAVY CHAIN) (DES-GLA), N-{[5-(dimethylamino)naphthalen-1-yl]sulfonyl}-L-alpha-glutamyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]glycinamide, ...
Authors:Kemball-Cook, G., Johnson, D.J.D., Tuddenham, E.G.D., Harlos, K.
Deposit date:1999-08-24
Release date:1999-08-31
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla).
J.Struct.Biol., 127, 1999
3KCG
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CRYSTAL STRUCTURE OF THE ANTITHROMBIN-FACTOR IXA-PENTASACCHARIDE COMPLEX
Descriptor:Coagulation factor IXa light chain, Coagulation factor IXa heavy chain, Antithrombin-III, ...
Authors:Huntington, J.A., Johnson, D.J.D.
Deposit date:2009-10-21
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
4BXS
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CRYSTAL STRUCTURE OF THE PROTHROMBINASE COMPLEX FROM THE VENOM OF PSEUDONAJA TEXTILIS
Descriptor:FACTOR X-LIKE PROTEASE, VENOM PROTHROMBIN ACTIVATOR PSEUTARIN-C NON-CATALYTIC SUBUNIT, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Lechtenberg, B.C., Murray-Rust, T.A., Johnson, D.J.D., Adams, T.E., Krishnaswamy, S., Camire, R.M., Huntington, J.A.
Deposit date:2013-07-15
Release date:2013-07-31
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
Blood, 122, 2013
4BXW
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CRYSTAL STRUCTURE OF THE PROTHROMBINASE COMPLEX FROM THE VENOM OF PSEUDONAJA TEXTILIS
Descriptor:FACTOR XA, COAGULATION FACTOR V, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ...
Authors:Lechtenberg, B.C., Murray-Rust, T.A., Johnson, D.J.D., Adams, T.E., Krishnaswamy, S., Camire, R.M., Huntington, J.A.
Deposit date:2013-07-16
Release date:2013-07-31
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
Blood, 122, 2013
4EB1
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HYPERSTABLE IN-FRAME INSERTION VARIANT OF ANTITHROMBIN
Descriptor:Antithrombin-III, N-ACETYL-D-GLUCOSAMINE
Authors:Martinez-Martinez, I., Johnson, D.J.D., Yamasaki, M., Corral, J., Huntington, J.A.
Deposit date:2012-03-23
Release date:2012-07-18
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Type II antithrombin deficiency caused by a large in-frame insertion: structural, functional and pathological relevance.
J.Thromb.Haemost., 10, 2012
6I8S
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DISCOVERY AND CHARACTERISATION OF AN ANTIBODY THAT SELECTIVELY MODULATES THE INHIBITORY ACTIVITY OF PLASMINOGEN ACTIVATOR INHIBITOR-1
Descriptor:Plasminogen activator inhibitor 1, HEAVY CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY, LIGHT CHAIN OF FAB FRAGMENT FROM AN PAI-1 ANTIBODY
Authors:Vousden, K.A., Lundqvist, T., Popovic, B.
Deposit date:2018-11-21
Release date:2019-02-13
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1.
Sci Rep, 9, 2019