Author results

2VKZ
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STRUCTURE OF THE CERULENIN-INHIBITED FUNGAL FATTY ACID SYNTHASE TYPE I MULTIENZYME COMPLEX
Descriptor:FATTY ACID SYNTHASE SUBUNIT ALPHA, FATTY ACID SYNTHASE SUBUNIT BETA, (2S, ...
Authors:Johansson, P., Wiltschi, B., Kumari, P., Kessler, B., Vonrhein, C., Vonck, J., Oesterhelt, D., Grininger, M.
Deposit date:2008-01-07
Release date:2008-08-12
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (4 Å)
Cite:Inhibition of the Fungal Fatty Acid Synthase Type I Multienzyme Complex.
Proc.Natl.Acad.Sci.USA, 105, 2008
4AJD
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IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF PDE10 FRAGMENT INHIBITORS
Descriptor:CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, PDE10, ...
Authors:Johansson, P., Albert, J.S., Spadola, L., Akerud, T., Back, E., Hillertz, P., Horsefeld, R., Scott, C., Spear, N., Tian, G., Tigerstrom, A., Aharony, D., Geschwindner, S.
Deposit date:2012-02-16
Release date:2013-03-06
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification and Structural Characterization of Pde10 Fragment Inhibitors
To be Published
4AJF
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IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF PDE10 FRAGMENT INHIBITORS
Descriptor:CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, ZINC ION, ...
Authors:Johansson, P., Albert, J.S., Spadola, L., Akerud, T., Back, E., Hillertz, P., Horsefeld, R., Scott, C., Spear, N., Tian, G., Tigerstrom, A., Aharony, D., Geschwindner, S.
Deposit date:2012-02-16
Release date:2013-03-06
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification and Structural Characterization of Pde10 Fragment Inhibitors
To be Published
4AJG
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IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF PDE10 FRAGMENT INHIBITORS
Descriptor:CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, ZINC ION, ...
Authors:Johansson, P., Albert, J.S., Spadola, L., Akerud, T., Back, E., Hillertz, P., Horsefeld, R., Scott, C., Spear, N., Tian, G., Tigerstrom, A., Aharony, D., Geschwindner, S.
Deposit date:2012-02-16
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification and Structural Characterization of Pde10 Fragment Inhibitors
To be Published
6EJ2
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BACE1 COMPOUND 28
Descriptor:Beta-secretase 1, compound 28
Authors:Johansson, P.
Deposit date:2017-09-20
Release date:2018-04-18
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Toward beta-Secretase-1 Inhibitors with Improved Isoform Selectivity.
J. Med. Chem., 61, 2018
6EJ3
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BACE1 COMPOUND 23
Descriptor:Beta-secretase 1, (1r,4r)-4-methoxy-6'-(5-methyl-3-pyridinyl)-3'H-dispiro[cyclohexane-1,2'-indene-1',4''-[1,3]oxazol]-2''-amine
Authors:Johansson, P.
Deposit date:2017-09-20
Release date:2018-04-18
Last modified:2018-05-09
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Toward beta-Secretase-1 Inhibitors with Improved Isoform Selectivity.
J. Med. Chem., 61, 2018
1UMZ
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XYLOGLUCAN ENDOTRANSGLYCOSYLASE IN COMPLEX WITH THE XYLOGLUCAN NONASACCHARIDE XLLG.
Descriptor:XYLOGLUCAN ENDOTRANSGLYCOSYLASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Johansson, P., Brumer, H., Kallas, A.M., Henriksson, H., Denman, S.E., Teeri, T.T., Jones, T.A.
Deposit date:2003-09-03
Release date:2004-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of a Poplar Xyloglucan Endotransglycosylase Reveal Details of Transglycosylation Acceptor Binding
Plant Cell, 16, 2004
1UN1
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XYLOGLUCAN ENDOTRANSGLYCOSYLASE NATIVE STRUCTURE.
Descriptor:XYLOGLUCAN ENDOTRANSGLYCOSYLASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Johansson, P., Brumer, H., Kallas, A., Henriksson, H., Denman, S., Teeri, T.T., Jones, T.A.
Deposit date:2003-09-03
Release date:2004-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of a Poplar Xyloglucan Endotransglycosylase Reveal Details of Transglycosylation Acceptor Binding
Plant Cell, 16, 2004
2BNG
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STRUCTURE OF AN M.TUBERCULOSIS LEH-LIKE EPOXIDE HYDROLASE
Descriptor:MB2760, CALCIUM ION
Authors:Johansson, P., Arand, M., Unge, T., Bergfors, T., Jones, T.A., Mowbray, S.L.
Deposit date:2005-03-24
Release date:2005-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of an Atypical Epoxide Hydrolase from Mycobacterium Tuberculosis Gives Insights Into its Function.
J.Mol.Biol., 351, 2005
2C2I
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STRUCTURE AND FUNCTION OF RV0130, A CONSERVED HYPOTHETICAL PROTEIN FROM M.TUBERCULOSIS
Descriptor:RV0130
Authors:Johansson, P., Castell, A., Jones, T.A., Backbro, K.
Deposit date:2005-09-29
Release date:2006-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and Function of Rv0130, a Conserved Hypothetical Protein from Mycobacterium Tuberculosis.
Protein Sci., 15, 2006
2WAS
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STRUCTURE OF THE FUNGAL TYPE I FAS PPT DOMAIN
Descriptor:3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE
Authors:Johansson, P., Mulincacci, B., Koestler, C., Grininger, M.
Deposit date:2009-02-15
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Multimeric Options for the Auto-Activation of the Saccharomyces Cerevisiae Fas Type I Megasynthase.
Structure, 17, 2009
2WAT
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STRUCTURE OF THE FUNGAL TYPE I FAS PPT DOMAIN IN COMPLEX WITH COA
Descriptor:3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, CHLORIDE ION, COENZYME A, ...
Authors:Johansson, P., Mulincacci, B., Koestler, C., Grininger, M.
Deposit date:2009-02-15
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Multimeric Options for the Auto-Activation of the Saccharomyces Cerevisiae Fas Type I Megasynthase.
Structure, 17, 2009
2YOP
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LONG WAVELENGTH S-SAD STRUCTURE OF FAM3B PANDER
Descriptor:PROTEIN FAM3B, GLYCEROL
Authors:Johansson, P., Bernstrom, J., Gorman, T., Oster, L., Backstrom, S., Schweikart, F., Xu, B., Xue, Y., Holmberg Schiavone, L.
Deposit date:2012-10-26
Release date:2013-01-30
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Fam3B Pander and Fam3C Ilei Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-Like Fold.
Structure, 21, 2013
2YOQ
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STRUCTURE OF FAM3B PANDER E30 CONSTRUCT
Descriptor:PROTEIN FAM3B, GLYCEROL
Authors:Johansson, P., Bernstrom, J., Gorman, T., Oster, L., Backstrom, S., Schweikart, F., Xu, B., Xue, Y., Holmberg Schiavone, L.
Deposit date:2012-10-26
Release date:2013-01-30
Last modified:2013-02-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Fam3B Pander and Fam3C Ilei Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-Like Fold.
Structure, 21, 2013
3HMJ
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SACCHAROMYCES CEREVISIAE FAS TYPE I
Descriptor:Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, (2S, ...
Authors:Johansson, P., Mulinacci, B., Koestler, C., Vollrath, R., Oesterhelt, D., Grininger, M.
Deposit date:2009-05-29
Release date:2009-09-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase
Structure, 17, 2009
5JNQ
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MRAY TUNICAMYCIN COMPLEX
Descriptor:Phospho-N-acetylmuramoyl-pentapeptide-transferase, Tunicamycin, PALMITIC ACID, ...
Authors:Johansson, P.
Deposit date:2016-04-30
Release date:2017-01-11
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:MraY-antibiotic complex reveals details of tunicamycin mode of action.
Nat. Chem. Biol., 13, 2017
5LC2
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XRAY STRUCTURE OF HUMAN FAM3C ILEI MONOMER
Descriptor:Protein FAM3C
Authors:Johansson, P., Jansson, A.
Deposit date:2016-06-19
Release date:2017-08-02
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The interleukin-like epithelial-mesenchymal transition inducer ILEI exhibits a non-interleukin-like fold and is active as a domain-swapped dimer.
J. Biol. Chem., 292, 2017
5LC3
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XRAY STRUCTURE OF MOUSE FAM3C ILEI MONOMER
Descriptor:Protein FAM3C
Authors:Johansson, P., Jansson, A.
Deposit date:2016-06-19
Release date:2017-08-02
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The interleukin-like epithelial-mesenchymal transition inducer ILEI exhibits a non-interleukin-like fold and is active as a domain-swapped dimer.
J. Biol. Chem., 292, 2017
5LC4
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XRAY STRUCTURE OF MOUSE FAM3C ILEI DIMER
Descriptor:Protein FAM3C
Authors:Johansson, P., Jansson, A.
Deposit date:2016-06-19
Release date:2017-08-02
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:The interleukin-like epithelial-mesenchymal transition inducer ILEI exhibits a non-interleukin-like fold and is active as a domain-swapped dimer.
J. Biol. Chem., 292, 2017
4B70
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AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB- LOWERING IN BRAIN
Descriptor:BETA-SECRETASE 1, (2S)-2-[3-(3-chlorophenyl)phenyl]-2-methyl-5,6-dihydro-1,3-oxazin-4-amine
Authors:Gravenfors, Y., Blid, J., Ginman, T., Karlstrom, S., Kihlstrom, J., Kolmodin, K., Lindstrom, J., Berg, S., Kieseritzky, F., Slivo, C., Swahn, B., Viklund, J., Olsson, L., Johansson, P., Eketjall, S., Falting, J., Jeppsson, F., Stromberg, K., Janson, J., Rahm, F.
Deposit date:2012-08-16
Release date:2013-06-26
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Core Refinement Toward Permeable Beta-Secretase (Bace-1) Inhibitors with Low Herg Activity.
J.Med.Chem., 56, 2013
4B72
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AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB- LOWERING IN BRAIN
Descriptor:BETA-SECRETASE 1, (6R)-6-(4-methoxyphenyl)-2-methyl-6-(3-pyrimidin-5-ylphenyl)pyrrolo[3,4-d][1,3]thiazol-4-amine
Authors:Gravenfors, Y., Blid, J., Ginman, T., Karlstrom, S., Kihlstrom, J., Kolmodin, K., Lindstrom, J., Berg, S., Kieseritzky, F., Slivo, C., Swahn, B., Viklund, J., Olsson, L., Johansson, P., Eketjall, S., Falting, J., Jeppsson, F., Stromberg, K., Janson, J., Rahm, F.
Deposit date:2012-08-16
Release date:2013-06-26
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Core Refinement Toward Permeable Beta-Secretase (Bace-1) Inhibitors with Low Herg Activity.
J.Med.Chem., 56, 2013
4B77
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AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB- LOWERING IN BRAIN
Descriptor:BETA-SECRETASE 1, DIMETHYL SULFOXIDE, (5R)-5-(4-methoxyphenyl)-5-(3-pyrimidin-5-ylphenyl)-3,4-dihydropyrrol-2-amine
Authors:Gravenfors, Y., Blid, J., Ginman, T., Karlstrom, S., Kihlstrom, J., Kolmodin, K., Lindstrom, J., Berg, S., Kieseritzky, F., Slivo, C., Swahn, B., Viklund, J., Olsson, L., Johansson, P., Eketjall, S., Falting, J., Jeppsson, F., Stromberg, K., Janson, J., Rahm, F.
Deposit date:2012-08-16
Release date:2013-06-26
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Core Refinement Toward Permeable Beta-Secretase (Bace-1) Inhibitors with Low Herg Activity.
J.Med.Chem., 56, 2013
4B78
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AMINOIMIDAZOLES AS BACE-1 INHIBITORS: FROM DE NOVO DESIGN TO AB- LOWERING IN BRAIN
Descriptor:BETA-SECRETASE 1, (3R,5R)-3-methoxy-5-(4-methoxyphenyl)-5-(3-pyridin-3-ylphenyl)-3,4-dihydropyrrol-2-amine
Authors:Gravenfors, Y., Blid, J., Ginman, T., Karlstrom, S., Kihlstrom, J., Kolmodin, K., Lindstrom, J., Berg, S., Kieseritzky, F., Slivo, C., Swahn, B., Viklund, J., Olsson, L., Johansson, P., Eketjall, S., Falting, J., Jeppsson, F., Stromberg, K., Janson, J., Rahm, F.
Deposit date:2012-08-16
Release date:2013-06-26
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Core Refinement Toward Permeable Beta-Secretase (Bace-1) Inhibitors with Low Herg Activity.
J.Med.Chem., 56, 2013
4AJM
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DEVELOPMENT OF A PLATE-BASED OPTICAL BIOSENSOR METHODOLOGY TO IDENTIFY PDE10 FRAGMENT INHIBITORS
Descriptor:CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, ZINC ION, ...
Authors:Geschwindner, S., Johansson, P., Spadola, L., Akerud, T., Back, E., Hillertz, P., Horsefeld, R., Scott, C., Spear, N., Tian, G., Tigerstrom, A., Aharony, D., Albert, J.S.
Deposit date:2012-02-16
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Development of a Plate-Based Optical Biosensor Methodology to Identify Pde10 Fragment Inhibitors
To be Published
5NDD
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CRYSTAL STRUCTURE OF A THERMOSTABILISED HUMAN PROTEASE-ACTIVATED RECEPTOR-2 (PAR2) IN COMPLEX WITH AZ8838 AT 2.8 ANGSTROM RESOLUTION
Descriptor:Lysozyme,Proteinase-activated receptor 2,Soluble cytochrome b562,Proteinase-activated receptor 2, (~{S})-(4-fluoranyl-2-propyl-phenyl)-(1~{H}-imidazol-2-yl)methanol, SODIUM ION, ...
Authors:Cheng, R.K.Y., Fiez-Vandal, C., Schlenker, O., Edman, K., Aggeler, B., Brown, D.G., Brown, G., Cooke, R.M., Dumelin, C.E., Dore, A.S., Geschwindner, S., Grebner, C., Hermansson, N.-O., Jazayeri, A., Johansson, P., Leong, L., Prihandoko, R., Rappas, M., Soutter, H., Snijder, A., Sundstrom, L., Tehan, B., Thornton, P., Troast, D., Wiggin, G., Zhukov, A., Marshall, F.H., Dekker, N.
Deposit date:2017-03-08
Release date:2017-05-03
Last modified:2017-05-17
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural insight into allosteric modulation of protease-activated receptor 2.
Nature, 545, 2017
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