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1W3B
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BU of 1w3b by Molmil
The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Descriptor: CALCIUM ION, UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110
Authors:Jinek, M, Rehwinkel, J, Lazarus, B.D, Izaurralde, E, Hanover, J.A, Conti, E.
Deposit date:2004-07-14
Release date:2004-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Superhelical Tpr-Repeat Domain of O-Linked Glcnac Transferase Exhibits Structural Similarities to Importin Alpha
Nat.Struct.Mol.Biol., 11, 2004
2J0B
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BU of 2j0b by Molmil
Structure of the catalytic domain of mouse Manic Fringe in complex with UDP and manganese
Descriptor: BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, MANGANESE (II) ION, POTASSIUM ION, ...
Authors:Jinek, M, Chen, Y.-W, Clausen, H, Cohen, S.M, Conti, E.
Deposit date:2006-08-01
Release date:2006-09-04
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
2J0A
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BU of 2j0a by Molmil
Structure of the catalytic domain of mouse Manic Fringe
Descriptor: BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, POTASSIUM ION, SULFATE ION
Authors:Jinek, M, Chen, Y.-W, Clausen, H, Cohen, S.M, Conti, E.
Deposit date:2006-08-01
Release date:2006-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
4CMP
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BU of 4cmp by Molmil
Crystal structure of S. pyogenes Cas9
Descriptor: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, SULFATE ION
Authors:Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A.
Deposit date:2014-01-16
Release date:2014-02-12
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.
Science, 343, 2014
4CMQ
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BU of 4cmq by Molmil
Crystal structure of Mn-bound S.pyogenes Cas9
Descriptor: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MANGANESE (II) ION, SULFATE ION
Authors:Jinek, M, Jiang, F, Taylor, D.W, Sternberg, S.H, Kaya, E, Ma, E, Anders, C, Hauer, M, Zhou, K, Lin, S, Kaplan, M, Iavarone, A.T, Charpentier, E, Nogales, E, Doudna, J.A.
Deposit date:2014-01-17
Release date:2014-02-12
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structures of Cas9 Endonucleases Reveal RNA- Mediated Conformational Activation
Science, 343, 2014
2VXG
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BU of 2vxg by Molmil
Crystal structure of the conserved C-terminal region of Ge-1
Descriptor: CG6181-PA, ISOFORM A
Authors:Jinek, M, Eulalio, A, Lingel, A, Helms, S, Conti, E, Izaurralde, E.
Deposit date:2008-07-04
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The C-Terminal Region of Ge-1 Presents Conserved Structural Features Required for P-Body Localization.
RNA, 14, 2008
2X04
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BU of 2x04 by Molmil
Crystal structure of the PABC-TNRC6C complex
Descriptor: POLYADENYLATE-BINDING PROTEIN 1, SULFATE ION, TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN
Authors:Jinek, M, Fabian, M.R, Coyle, S.M, Sonenberg, N, Doudna, J.A.
Deposit date:2009-12-04
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated Deadenylation
Nat.Struct.Mol.Biol., 17, 2010
2Y35
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BU of 2y35 by Molmil
Crystal structure of Xrn1-substrate complex
Descriptor: DT11 (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP)-3', LD22664P, MAGNESIUM ION
Authors:Jinek, M, Coyle, S.M, Doudna, J.A.
Deposit date:2010-12-18
Release date:2011-03-16
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Coupled 5' Nucleotide Recognition and Processivity in Xrn1-Mediated Mrna Decay.
Mol.Cell, 41, 2011
6F9S
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BU of 6f9s by Molmil
Crystal structure of the C-terminal RecA domain of DDX6 in complex with a conserved peptide from LSM14
Descriptor: Cytokinesis, Apoptosis, RNA-associated, ...
Authors:Jinek, M, Brandmann, T.
Deposit date:2017-12-15
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
EMBO J., 37, 2018
6FDL
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BU of 6fdl by Molmil
Crystal structure of the NYN domain of human MARF1
Descriptor: Meiosis regulator and mRNA stability factor 1
Authors:Jinek, M, Brandmann, T.
Deposit date:2017-12-26
Release date:2018-11-07
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
Nucleic Acids Res., 46, 2018
6I1L
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BU of 6i1l by Molmil
Crystal structure of FnCas12a in complex with a crRNA guide and ssDNA target
Descriptor: CITRIC ACID, CRISPR-associated endonuclease Cas12a, MAGNESIUM ION, ...
Authors:Jinek, M, Swarts, D.C.
Deposit date:2018-10-29
Release date:2019-01-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.
Mol. Cell, 73, 2019
6I1K
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BU of 6i1k by Molmil
Crystal structure of catalytically inactive FnCas12a in complex with a crRNA guide and a dsDNA target
Descriptor: 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas12a, DNA non-target strand (33-MER), ...
Authors:Jinek, M, Swarts, D.C.
Deposit date:2018-10-29
Release date:2019-01-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.
Mol. Cell, 73, 2019
4C8Y
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BU of 4c8y by Molmil
Cas6 (TTHA0078) substrate mimic complex
Descriptor: CAS6A, R1 REPEAT RNA SUBSTRATE MIMIC, SULFATE ION
Authors:Jinek, M, Niewoehner, O, Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C97
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BU of 4c97 by Molmil
Cas6 (TTHA0078) H37A mutant
Descriptor: CAS6A, SULFATE ION
Authors:Jinek, M, Niewoehner, O, Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C98
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BU of 4c98 by Molmil
Thermus thermophilus Cas6 (TTHB231)
Descriptor: CAS6B, ZINC ION
Authors:Jinek, M, Niewoehner, O, Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C8Z
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BU of 4c8z by Molmil
Cas6 (TTHA0078) product complex
Descriptor: CAS6A, POTASSIUM ION, R1 REPEAT RNA CLEAVAGE PRODUCT, ...
Authors:Jinek, M, Niewoehner, O, Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C9D
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BU of 4c9d by Molmil
Cas6 (TTHB231) product complex
Descriptor: CAS6B, R3 REPEAT RNA CLEAVAGE PRODUCT
Authors:Jinek, M, Niewoehner, O, Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases.
Nucleic Acids Res., 42, 2014
8QLP
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BU of 8qlp by Molmil
CryoEM structure of the RNA/DNA bound SPARTA (BabAgo/TIR-APAZ) tetrameric complex
Descriptor: DNA (5'-D(*AP*CP*TP*AP*AP*TP*AP*GP*AP*TP*TP*AP*GP*AP*GP*CP*CP*GP*TP*C)-3'), MAGNESIUM ION, RNA (5'-R(*AP*UP*GP*AP*CP*GP*GP*CP*UP*CP*UP*AP*AP*UP*CP*UP*AP*UP*UP*AP*GP*U)-3'), ...
Authors:Finocchio, G, Koopal, B, Potocnik, A, Heijstek, C, Jinek, M, Swarts, D.
Deposit date:2023-09-20
Release date:2024-01-31
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA.
Nucleic Acids Res., 52, 2024
7Z4J
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BU of 7z4j by Molmil
SpCas9 bound to 18-nucleotide complementary DNA substrate in the catalytic state
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, Non-target strand of 18-nucleotide complementary DNA substrate, ...
Authors:Pacesa, M, Jinek, M.
Deposit date:2022-03-03
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4C
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BU of 7z4c by Molmil
SpCas9 bound to 6 nucleotide complementary DNA substrate
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 6 nucleotide complementary DNA substrate, Target strand of 6 nucleotide complementary DNA substrate, ...
Authors:Pacesa, M, Jinek, M.
Deposit date:2022-03-03
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4K
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BU of 7z4k by Molmil
SpCas9 bound to 10-nucleotide complementary DNA substrate
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 10-nucleotide complementary DNA substrate, Target strand of 10-nucleotide complementary DNA substrate, ...
Authors:Pacesa, M, Jinek, M.
Deposit date:2022-03-04
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.81 Å)
Cite:R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4I
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BU of 7z4i by Molmil
SpCas9 bound to 16-nucleotide complementary DNA substrate
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 16-nucleotide complementary DNA substrate, POTASSIUM ION, ...
Authors:Pacesa, M, Jinek, M.
Deposit date:2022-03-03
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4H
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BU of 7z4h by Molmil
SpCas9 bound to 14-nucleotide complementary DNA substrate
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 14-nucleotide complementary DNA substrate, Target strand of 14-nucleotide complementary DNA substrate, ...
Authors:Pacesa, M, Jinek, M.
Deposit date:2022-03-03
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4L
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BU of 7z4l by Molmil
SpCas9 bound to 18-nucleotide complementary DNA substrate in the checkpoint state
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, Non-target strand of 18-nucleotide complementary DNA substrate, ...
Authors:Pacesa, M, Jinek, M.
Deposit date:2022-03-04
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4G
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BU of 7z4g by Molmil
SpCas9 bound to 12-nucleotide complementary DNA substrate
Descriptor: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 12-nucleotide complementary DNA substrate, Target strand of 12-nucleotide complementary DNA substrate, ...
Authors:Pacesa, M, Jinek, M.
Deposit date:2022-03-03
Release date:2022-08-31
Last modified:2022-09-14
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022

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