Author results

4CMP
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CRYSTAL STRUCTURE OF S. PYOGENES CAS9
分子名称:CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, SULFATE ION, MAGNESIUM ION
著者Jinek, M., Jiang, F., Taylor, D.W., Sternberg, S.H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M., Iavarone, A.T., Charpentier, E., Nogales, E., Doudna, J.A.
登録日2014-01-16
公開日2014-02-12
最終更新日2014-03-26
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.
Science, 343, 2014
4CMQ
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CRYSTAL STRUCTURE OF MN-BOUND S.PYOGENES CAS9
分子名称:CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MANGANESE (II) ION, SULFATE ION
著者Jinek, M., Jiang, F., Taylor, D.W., Sternberg, S.H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M., Iavarone, A.T., Charpentier, E., Nogales, E., Doudna, J.A.
登録日2014-01-17
公開日2014-02-12
最終更新日2014-03-26
実験手法X-RAY DIFFRACTION (3.09 Å)
主引用文献Structures of Cas9 Endonucleases Reveal RNA- Mediated Conformational Activation
Science, 343, 2014
1W3B
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THE SUPERHELICAL TPR DOMAIN OF O-LINKED GLCNAC TRANSFERASE REVEALS STRUCTURAL SIMILARITIES TO IMPORTIN ALPHA.
分子名称:UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110, CALCIUM ION
著者Jinek, M., Rehwinkel, J., Lazarus, B.D., Izaurralde, E., Hanover, J.A., Conti, E.
登録日2004-07-14
公開日2004-09-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献The Superhelical Tpr-Repeat Domain of O-Linked Glcnac Transferase Exhibits Structural Similarities to Importin Alpha
Nat.Struct.Mol.Biol., 11, 2004
2J0A
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STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE
分子名称:BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, SULFATE ION, POTASSIUM ION
著者Jinek, M., Chen, Y.-W., Clausen, H., Cohen, S.M., Conti, E.
登録日2006-08-01
公開日2006-09-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
2J0B
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STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE IN COMPLEX WITH UDP AND MANGANESE
分子名称:BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, SULFATE ION, POTASSIUM ION, ...
著者Jinek, M., Chen, Y.-W., Clausen, H., Cohen, S.M., Conti, E.
登録日2006-08-01
公開日2006-09-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
2VXG
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CRYSTAL STRUCTURE OF THE CONSERVED C-TERMINAL REGION OF GE-1
分子名称:CG6181-PA, ISOFORM A
著者Jinek, M., Eulalio, A., Lingel, A., Helms, S., Conti, E., Izaurralde, E.
登録日2008-07-04
公開日2008-09-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The C-Terminal Region of Ge-1 Presents Conserved Structural Features Required for P-Body Localization.
RNA, 14, 2008
2X04
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CRYSTAL STRUCTURE OF THE PABC-TNRC6C COMPLEX
分子名称:POLYADENYLATE-BINDING PROTEIN 1, TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN, SULFATE ION
著者Jinek, M., Fabian, M.R., Coyle, S.M., Sonenberg, N., Doudna, J.A.
登録日2009-12-04
公開日2010-01-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated Deadenylation
Nat.Struct.Mol.Biol., 17, 2010
2Y35
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CRYSTAL STRUCTURE OF XRN1-SUBSTRATE COMPLEX
分子名称:LD22664P, DT11 (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP)-3', MAGNESIUM ION
著者Jinek, M., Coyle, S.M., Doudna, J.A.
登録日2010-12-18
公開日2011-03-16
最終更新日2011-08-03
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Coupled 5' Nucleotide Recognition and Processivity in Xrn1-Mediated Mrna Decay.
Mol.Cell, 41, 2011
4C8Y
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CAS6 (TTHA0078) SUBSTRATE MIMIC COMPLEX
分子名称:CAS6A, R1 REPEAT RNA SUBSTRATE MIMIC, SULFATE ION
著者Jinek, M., Niewoehner, O., Doudna, J.A.
登録日2013-10-02
公開日2013-11-06
最終更新日2014-02-12
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C8Z
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CAS6 (TTHA0078) PRODUCT COMPLEX
分子名称:CAS6A, R1 REPEAT RNA CLEAVAGE PRODUCT, SULFATE ION, ...
著者Jinek, M., Niewoehner, O., Doudna, J.A.
登録日2013-10-02
公開日2013-11-06
最終更新日2014-02-12
実験手法X-RAY DIFFRACTION (2.503 Å)
主引用文献Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C97
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CAS6 (TTHA0078) H37A MUTANT
分子名称:CAS6A, SULFATE ION
著者Jinek, M., Niewoehner, O., Doudna, J.A.
登録日2013-10-02
公開日2013-11-06
最終更新日2014-07-23
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C98
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THERMUS THERMOPHILUS CAS6 (TTHB231)
分子名称:CAS6B, ZINC ION
著者Jinek, M., Niewoehner, O., Doudna, J.A.
登録日2013-10-02
公開日2013-11-06
最終更新日2014-02-12
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C9D
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CAS6 (TTHB231) PRODUCT COMPLEX
分子名称:CAS6B, R3 REPEAT RNA CLEAVAGE PRODUCT
著者Jinek, M., Niewoehner, O., Doudna, J.A.
登録日2013-10-02
公開日2013-11-06
最終更新日2017-03-01
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases.
Nucleic Acids Res., 42, 2014
6F9S
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CRYSTAL STRUCTURE OF THE C-TERMINAL RECA DOMAIN OF DDX6 IN COMPLEX WITH A CONSERVED PEPTIDE FROM LSM14
分子名称:Probable ATP-dependent RNA helicase DDX6, Cytokinesis, Apoptosis, ...
著者Jinek, M., Brandmann, T.
登録日2017-12-15
公開日2018-03-21
最終更新日2018-04-11
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
EMBO J., 37, 2018
6FDL
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CRYSTAL STRUCTURE OF THE NYN DOMAIN OF HUMAN MARF1
分子名称:Meiosis regulator and mRNA stability factor 1
著者Jinek, M., Brandmann, T.
登録日2017-12-26
公開日2018-11-07
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
Nucleic Acids Res., 46, 2018
6I1K
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CRYSTAL STRUCTURE OF CATALYTICALLY INACTIVE FNCAS12A IN COMPLEX WITH A CRRNA GUIDE AND A DSDNA TARGET
分子名称:CRISPR-associated endonuclease Cas12a, crRNA (40-MER), DNA target strand (38-MER), ...
著者Jinek, M., Swarts, D.C.
登録日2018-10-29
公開日2019-01-23
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.
Mol. Cell, 73, 2019
6I1L
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CRYSTAL STRUCTURE OF FNCAS12A IN COMPLEX WITH A CRRNA GUIDE AND SSDNA TARGET
分子名称:CRISPR-associated endonuclease Cas12a, crRNA (40-MER), ssDNA target strand, ...
著者Jinek, M., Swarts, D.C.
登録日2018-10-29
公開日2019-01-23
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.98 Å)
主引用文献Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.
Mol. Cell, 73, 2019
5FQ5
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CRYSTAL STRUCTURE OF CAS9-SGRNA-DNA COMPLEX SOLVED BY NATIVE SAD PHASING
分子名称:SGRNA, CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, TARGET DNA STRAND PROXIMAL FRAGMENT, ...
著者Olieric, V., Weinert, T., Finke, A., Anders, C., Jinek, M., Wang, M.
登録日2015-12-07
公開日2016-03-23
実験手法X-RAY DIFFRACTION (2.136 Å)
主引用文献Data-Collection Strategy for Challenging Native Sad Phasing.
Acta Crystallogr.,Sect.D, 72, 2016
6F9N
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CRYSTAL STRUCTURE OF THE HUMAN CPSF160-WDR33 COMPLEX
分子名称:Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33
著者Clerici, M., Jinek, M.
登録日2017-12-14
公開日2018-01-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.
Elife, 6, 2017
6FBS
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CRYO-EM STRUCTURE OF THE HUMAN CPSF160-WDR33-CPSF30 COMPLEX BOUND TO THE PAS AAUAAA MOTIF AT 3.1 ANGSTROM RESOLUTION
分子名称:Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33, Cleavage and polyadenylation specificity factor subunit 4, ...
著者Clerici, M., Faini, M., Jinek, M.
登録日2017-12-19
公開日2018-01-31
最終更新日2018-02-21
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.
Nat. Struct. Mol. Biol., 25, 2018
6FUW
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CRYO-EM STRUCTURE OF THE HUMAN CPSF160-WDR33-CPSF30 COMPLEX BOUND TO THE PAS AAUAAA MOTIF AT 3.1 ANGSTROM RESOLUTION
分子名称:Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33, Cleavage and polyadenylation specificity factor subunit 4, ...
著者Clerici, M., Faini, M., Jinek, M.
登録日2018-02-28
公開日2018-03-21
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.
Nat. Struct. Mol. Biol., 25, 2018
2XLI
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CRYSTAL STRUCTURE OF THE CSY4-CRRNA COMPLEX, MONOCLINIC FORM
分子名称:CSY4 ENDORIBONUCLEASE, 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3'
著者Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.
登録日2010-07-20
公開日2010-09-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
2XLJ
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CRYSTAL STRUCTURE OF THE CSY4-CRRNA COMPLEX, HEXAGONAL FORM
分子名称:CSY4 ENDORIBONUCLEASE, 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3'
著者Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.
登録日2010-07-20
公開日2010-09-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
2XLK
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CRYSTAL STRUCTURE OF THE CSY4-CRRNA COMPLEX, ORTHORHOMBIC FORM
分子名称:CSY4 ENDORIBONUCLEASE, 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3'
著者Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.
登録日2010-07-21
公開日2010-09-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.805 Å)
主引用文献Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
2Y8W
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STRUCTURE OF CRISPR ENDORIBONUCLEASE CSE3 BOUND TO 20 NT RNA
分子名称:CSE3, 5'-R(*UP*CP*CP*CP*CP*AP*CP*GP*CP*GP*UP*GP*UP*GP *GP*GP*DGP*AP*UP*G)-3'
著者Sashital, D.G., Jinek, M., Doudna, J.A.
登録日2011-02-11
公開日2011-05-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献An RNA-Induced Conformational Change Required for Crispr RNA Cleavage by the Endoribonuclease Cse3.
Nat.Struct.Mol.Biol., 18, 2011
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