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5H1L
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BU of 5h1l by Molmil
Crystal structure of WD40 repeat domains of Gemin5 in complex with 7-nt U4 snRNA fragment
Descriptor: GLYCEROL, Gem-associated protein 5, U4 snRNA (5'-R(*AP*UP*UP*UP*UP*UP*G)-3')
Authors:Jin, W, Wang, Y, Liu, C.P, Yang, N, Jin, M, Cong, Y, Wang, M, Xu, R.M.
Deposit date:2016-10-10
Release date:2016-11-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
5H1M
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BU of 5h1m by Molmil
Crystal structure of WD40 repeat domains of Gemin5 in complex with M7G
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Gem-associated protein 5
Authors:Jin, W, Wang, Y, Liu, C.P, Yang, N, Jin, M, Cong, Y, Wang, M, Xu, R.M.
Deposit date:2016-10-10
Release date:2016-11-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.492 Å)
Cite:Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
5H1J
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BU of 5h1j by Molmil
Crystal structure of WD40 repeat domains of Gemin5
Descriptor: Gem-associated protein 5
Authors:Jin, W, Wang, Y, Liu, C.P, Yang, N, Jin, M, Cong, Y, Wang, M, Xu, R.M.
Deposit date:2016-10-10
Release date:2016-11-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
6LXD
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BU of 6lxd by Molmil
Pri-miRNA bound DROSHA-DGCR8 complex
Descriptor: Microprocessor complex subunit DGCR8, RNA (102-mer), Ribonuclease 3, ...
Authors:Jin, W, Wang, J, Liu, C.P, Wang, H.W, Xu, R.M.
Deposit date:2020-02-10
Release date:2020-04-15
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural Basis for pri-miRNA Recognition by Drosha.
Mol.Cell, 78, 2020
6LXE
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BU of 6lxe by Molmil
DROSHA-DGCR8 complex
Descriptor: Microprocessor complex subunit DGCR8, Ribonuclease 3, ZINC ION
Authors:Jin, W, Wang, J, Liu, C.P, Wang, H.W, Xu, R.M.
Deposit date:2020-02-10
Release date:2020-04-15
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural Basis for pri-miRNA Recognition by Drosha.
Mol.Cell, 78, 2020
5H1K
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BU of 5h1k by Molmil
Crystal structure of WD40 repeat domains of Gemin5 in complex with 13-nt U4 snRNA fragment
Descriptor: Gem-associated protein 5, U4 snRNA (5'-R(*GP*CP*AP*AP*UP*UP*UP*UP*UP*GP*AP*CP*A)-3')
Authors:Wang, Y, Jin, W, Liu, C.P, Yang, N, Jin, M, Cong, Y, Wang, M, Xu, R.M.
Deposit date:2016-10-10
Release date:2016-11-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
5GS8
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BU of 5gs8 by Molmil
Crystal structure of TLA-3 extended-spectrum beta-lactamase
Descriptor: Beta-lactamase, CHLORIDE ION, SODIUM ION, ...
Authors:Wachino, J, Jin, W, Arakawa, Y.
Deposit date:2016-08-14
Release date:2017-07-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural Insights into the TLA-3 Extended-Spectrum beta-Lactamase and Its Inhibition by Avibactam and OP0595.
Antimicrob. Agents Chemother., 61, 2017
5GWA
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BU of 5gwa by Molmil
Crystal structure of TLA-3 extended-spectrum beta-lactamase in a complex with avibactam
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, CHLORIDE ION, ...
Authors:Wachino, J, Jin, W, Arakawa, Y.
Deposit date:2016-09-09
Release date:2017-07-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structural Insights into the TLA-3 Extended-Spectrum beta-Lactamase and Its Inhibition by Avibactam and OP0595.
Antimicrob. Agents Chemother., 61, 2017
5X5G
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BU of 5x5g by Molmil
Crystal structure of TLA-3 extended-spectrum beta-lactamase in a complex with OP0595
Descriptor: (2S,5R)-N-(2-aminoethoxy)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase, SODIUM ION, ...
Authors:Wachino, J, Jin, W, Arakawa, Y.
Deposit date:2017-02-15
Release date:2017-07-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights into the TLA-3 Extended-Spectrum beta-Lactamase and Its Inhibition by Avibactam and OP0595.
Antimicrob. Agents Chemother., 61, 2017
4QYY
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BU of 4qyy by Molmil
Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State
Descriptor: (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Deng, Y, Shipps, G.W, Cooper, A, English, J.M, Annis, D.A, Carr, D, Nan, Y, Wang, T, Zhu, Y.H, Chuang, C, Dayananth, P, Hruza, A.W, Xiao, L, Jin, W, Kirschmeier, P, Windsor, W.T, Samatar, A.A.
Deposit date:2014-07-26
Release date:2014-11-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase.
J.Med.Chem., 57, 2014
1LIR
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BU of 1lir by Molmil
LQ2 FROM LEIURUS QUINQUESTRIATUS, NMR, 22 STRUCTURES
Descriptor: LQ2
Authors:Renisio, J.G, Lu, Z, Blanc, E, Jin, W, Lewis, J.H, Bornet, O, Darbon, H.
Deposit date:1998-04-02
Release date:1998-06-17
Last modified:2019-12-25
Method:SOLUTION NMR
Cite:Solution structure of potassium channel-inhibiting scorpion toxin Lq2.
Proteins, 34, 1999
6DCG
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BU of 6dcg by Molmil
Discovery of MK-8353: An Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology
Descriptor: (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Boga, S.B, Deng, Y, Zhu, L, Nan, Y, Cooper, A, Shipps Jr, G.W, Doll, R, Shih, N, Zhu, H, Sun, R, Wang, T, Paliwal, S, Tsui, H, Gao, X, Yao, X, Desai, J, Wang, J, Alhassan, A.B, Kelly, J, Patel, M, Muppalla, K, Gudipati, S, Zhang, L, Buevich, A, Hesk, D, Carr, D, Dayananth, P, Mei, H, Cox, K, Sherborne, B, Hruza, A.W, Xiao, L, Jin, W, Long, B, Liu, G, Taylor, S.A, Kirschmeier, P, Windsor, W.T, Bishop, R, Samatar, A.A.
Deposit date:2018-05-06
Release date:2018-08-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
ACS Med Chem Lett, 9, 2018
2DOO
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BU of 2doo by Molmil
The structure of IMP-1 complexed with the detecting reagent (DansylC4SH) by a fluorescent probe
Descriptor: BETA-LACTAMASE IMP-1, N-[4-({[5-(DIMETHYLAMINO)-1-NAPHTHYL]SULFONYL}AMINO)BUTYL]-3-SULFANYLPROPANAMIDE, ZINC ION
Authors:Kurosaki, H, Yamaguchi, Y, Yasuzawa, H, Jin, W, Yamagata, Y, Arakawa, Y.
Deposit date:2006-05-01
Release date:2006-11-28
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Probing, inhibition, and crystallographic characterization of metallo-beta-lactamase (IMP-1) with fluorescent agents containing dansyl and thiol groups
Chemmedchem, 1, 2006
2YZ3
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BU of 2yz3 by Molmil
Crystallographic Investigation of Inhibition Mode of the VIM-2 Metallo-beta-lactamase from Pseudomonas aeruginosa with Mercaptocarboxylate Inhibitor
Descriptor: (S)-2-(MERCAPTOMETHYL)-5-PHENYLPENTANOIC ACID, Metallo-beta-lactamase, SULFATE ION, ...
Authors:Yamaguchi, Y, Yamagata, Y, Arakawa, Y, Kurosaki, H.
Deposit date:2007-05-02
Release date:2008-03-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystallographic investigation of the inhibition mode of a VIM-2 metallo-beta-lactamase from Pseudomonas aeruginosa by a mercaptocarboxylate inhibitor.
J.Med.Chem., 50, 2007
7KHF
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BU of 7khf by Molmil
CryoEM structure of LILRB1 D3D4 domain-inserted antibody MDB1 Fab in complex with Plasmodium RIFIN (PF3D7_1373400) V2 domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MDB1 Fab heavy chain, ...
Authors:Xu, K, Kwong, P.D.
Deposit date:2020-10-21
Release date:2021-03-31
Last modified:2021-05-05
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.
Nature, 592, 2021
7KFK
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BU of 7kfk by Molmil
Crystal structure of LILRB1 D3D4 domain in complex with Plasmodium RIFIN (PF3D7_1373400) V2 domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Leukocyte immunoglobulin-like receptor subfamily B member 1, Rifin, ...
Authors:Xu, K, Kwong, P.D.
Deposit date:2020-10-14
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.
Nature, 592, 2021
1WUP
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BU of 1wup by Molmil
Crystal structure of metallo-beta-lactamase IMP-1 mutant (D81E)
Descriptor: ACETIC ACID, Beta-lactamase IMP-1, ZINC ION
Authors:Yamaguchi, Y, Yamagata, Y, Goto, M.
Deposit date:2004-12-08
Release date:2005-03-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Probing the role of Asp-120(81) of metallo-beta-lactamase (IMP-1) by site-directed mutagenesis, kinetic studies, and X-ray crystallography.
J.Biol.Chem., 280, 2005
1WUO
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BU of 1wuo by Molmil
Crystal structure of metallo-beta-lactamase IMP-1 mutant (D81A)
Descriptor: ACETIC ACID, Beta-lactamase IMP-1, ZINC ION
Authors:Yamaguchi, Y, Yamagata, Y, Goto, M.
Deposit date:2004-12-08
Release date:2005-03-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Probing the role of Asp-120(81) of metallo-beta-lactamase (IMP-1) by site-directed mutagenesis, kinetic studies, and X-ray crystallography.
J.Biol.Chem., 280, 2005
6JED
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BU of 6jed by Molmil
Crystal structure of IMP-1 metallo-beta-lactamase in a complex with MCR
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Metallo-beta-lactamase type 2, SULFANYLACETIC ACID, ...
Authors:Wachino, J.
Deposit date:2019-02-05
Release date:2019-08-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:4-Amino-2-Sulfanylbenzoic Acid as a Potent Subclass B3 Metallo-beta-Lactamase-Specific Inhibitor Applicable for Distinguishing Metallo-beta-Lactamase Subclasses.
Antimicrob.Agents Chemother., 63, 2019
3HYF
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BU of 3hyf by Molmil
Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor
Descriptor: 2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid, ACETATE ION, GLYCEROL, ...
Authors:Lansdon, E.B, Kirschberg, T.A.
Deposit date:2009-06-22
Release date:2009-10-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
J.Med.Chem., 52, 2009
3QYB
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BU of 3qyb by Molmil
X-ray Crystal Structure of Human TBC1D4 (AS160) RabGAP domain
Descriptor: TBC1 domain family member 4
Authors:Park, S.Y, Shoelson, S.E.
Deposit date:2011-03-03
Release date:2011-03-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
J.Biol.Chem., 286, 2011
3QYE
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BU of 3qye by Molmil
Crystal Structure of Human TBC1D1 RabGAP domain
Descriptor: TBC1 domain family member 1
Authors:Park, S.Y, Shoelson, S.E.
Deposit date:2011-03-03
Release date:2011-03-23
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
J.Biol.Chem., 286, 2011
2PKU
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BU of 2pku by Molmil
Solution structure of PICK1 PDZ in complex with the carboxyl tail peptide of GluR2
Descriptor: PRKCA-binding protein, peptide (GLU)(SER)(VAL)(LYS)(ILE)
Authors:Pan, L, Wu, H, Shen, C, Shi, Y, Xia, J, Zhang, M.
Deposit date:2007-04-18
Release date:2007-11-20
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes
Embo J., 26, 2007
7CU5
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BU of 7cu5 by Molmil
N-Glycosylation of PD-1 and glycosylation dependent binding of PD-1 specific monoclonal antibody camrelizumab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Programmed cell death protein 1, ...
Authors:Liu, K.F, Tan, S.G, Jin, W.J, Guan, J.W, Wang, W.L, Sun, H, Qi, J.X, Yan, J.H, Chai, Y, Wang, Z.F, Chu, X.D, Gao, G.F.
Deposit date:2020-08-21
Release date:2020-10-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:N-glycosylation of PD-1 promotes binding of camrelizumab.
Embo Rep., 21, 2020
5Y5B
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BU of 5y5b by Molmil
Crystal Structure Of IMP-1 Metallo-beta-lactamase
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Metallo-beta-lactamase type 2, SULFATE ION, ...
Authors:Wachino, J.
Deposit date:2017-08-08
Release date:2018-08-08
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:4-Amino-2-Sulfanylbenzoic Acid as a Potent Subclass B3 Metallo-beta-Lactamase-Specific Inhibitor Applicable for Distinguishing Metallo-beta-Lactamase Subclasses.
Antimicrob.Agents Chemother., 63, 2019

 

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