Author results

4ID7
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ACK1 KINASE IN COMPLEX WITH THE INHIBITOR CIS-3-[8-AMINO-1-(4-PHENOXYPHENYL)IMIDAZO[1,5-A]PYRAZIN-3-YL]CYCLOBUTANOL
Descriptor:Activated CDC42 kinase 1, cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol, SULFATE ION
Authors:Jin, M., Wang, J., Kleinberg, A., Kadalbajoo, M., Siu, K., Cooke, A., Bittner, M., Yao, Y., Thelemann, A., Ji, Q., Bhagwat, S., Crew, A.P., Pachter, J., Epstein, D., Mulvihill, M.J.
Deposit date:2012-12-11
Release date:2013-01-30
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
6KRD
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TRIC AT 0.05 MM ADP-ALFX, CONFORMATION 4, 0.05-C4
Descriptor:T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M., Cong, Y.
Deposit date:2019-08-21
Release date:2019-09-18
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.38 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KRE
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TRIC AT 0.05 MM ADP-ALFX, CONFORMATION 2, 0.05-C2
Descriptor:T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M., Cong, Y.
Deposit date:2019-08-21
Release date:2019-09-18
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.45 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KS6
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TRIC AT 0.2 MM ADP-ALFX, CONFORMATION 1, 0.2-C1
Descriptor:T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M., Cong, Y.
Deposit date:2019-08-23
Release date:2019-09-18
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (2.99 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KS7
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TRIC AT 0.1 MM ADP-ALFX, CONFORMATION 1, 0.1-C1
Descriptor:T-complex protein 1 subunit eta, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ...
Authors:Jin, M., Cong, Y.
Deposit date:2019-08-23
Release date:2019-09-18
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.62 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
6KS8
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TRIC AT 0.1 MM ADP-ALFX, CONFORMATION 4, 0.1-C4
Descriptor:T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Jin, M., Cong, Y.
Deposit date:2019-08-23
Release date:2019-09-18
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.69 Å)
Cite:An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity.
Proc.Natl.Acad.Sci.USA, 116, 2019
5H1J
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CRYSTAL STRUCTURE OF WD40 REPEAT DOMAINS OF GEMIN5
Descriptor:Gem-associated protein 5
Authors:Jin, W., Wang, Y., Liu, C.P., Yang, N., Jin, M., Cong, Y., Wang, M., Xu, R.M.
Deposit date:2016-10-10
Release date:2016-11-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
5H1K
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CRYSTAL STRUCTURE OF WD40 REPEAT DOMAINS OF GEMIN5 IN COMPLEX WITH 13-NT U4 SNRNA FRAGMENT
Descriptor:Gem-associated protein 5, U4 snRNA (5'-R(*GP*CP*AP*AP*UP*UP*UP*UP*UP*GP*AP*CP*A)-3')
Authors:Wang, Y., Jin, W., Liu, C.P., Yang, N., Jin, M., Cong, Y., Wang, M., Xu, R.M.
Deposit date:2016-10-10
Release date:2016-11-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
5H1L
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CRYSTAL STRUCTURE OF WD40 REPEAT DOMAINS OF GEMIN5 IN COMPLEX WITH 7-NT U4 SNRNA FRAGMENT
Descriptor:Gem-associated protein 5, U4 snRNA (5'-R(*AP*UP*UP*UP*UP*UP*G)-3'), GLYCEROL
Authors:Jin, W., Wang, Y., Liu, C.P., Yang, N., Jin, M., Cong, Y., Wang, M., Xu, R.M.
Deposit date:2016-10-10
Release date:2016-11-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
5H1M
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CRYSTAL STRUCTURE OF WD40 REPEAT DOMAINS OF GEMIN5 IN COMPLEX WITH M7G
Descriptor:Gem-associated protein 5, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE
Authors:Jin, W., Wang, Y., Liu, C.P., Yang, N., Jin, M., Cong, Y., Wang, M., Xu, R.M.
Deposit date:2016-10-10
Release date:2016-11-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.492 Å)
Cite:Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
7KKJ
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STRUCTURE OF ANTI-SARS-COV-2 SPIKE NANOBODY MNB6
Descriptor:Synthetic nanobody mNb6, SULFATE ION, CHLORIDE ION
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 2020
7KKK
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SARS-COV-2 SPIKE IN COMPLEX WITH NEUTRALIZING NANOBODY NB6
Descriptor:SARS-CoV-2 spike glycoprotein, Synthetic nanobody Nb6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 2020
7KKL
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SARS-COV-2 SPIKE IN COMPLEX WITH NEUTRALIZING NANOBODY MNB6
Descriptor:SARS-CoV-2 spike glycoprotein, Synthetic nanobody mNb6, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Schoof, M.S., Faust, B.F., Saunders, R.A., Sangwan, S., Rezelj, V., Hoppe, N., Boone, M., Billesboelle, C.B., Puchades, C., Azumaya, C.M., Kratochvil, H.T., Zimanyi, M., Desphande, I., Liang, J., Dickinson, S., Nguyen, H.C., Chio, C.M., Merz, G.E., Thompson, M.C., Diwanji, D., Schaefer, K., Anand, A.A., Dobzinski, N., Zha, B.S., Simoneau, C.R., Leon, K., White, K.M., Chio, U.S., Gupta, M., Jin, M., Li, F., Liu, Y., Zhang, K., Bulkley, D., Sun, M., Smith, A.M., Rizo, A.N., Moss, F., Brilot, A.F., Pourmal, S., Trenker, R., Pospiech, T., Gupta, S., Barsi-Rhyne, B., Belyy, V., Barile-Hill, A.W., Nock, S., Liu, Y., Krogan, N.J., Ralston, C.Y., Swaney, D.L., Garcia-Sastre, A., Ott, M., Vignuzzi, M., Walter, P., Manglik, A., QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 2020
4KNB
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C-MET IN COMPLEX WITH OSI LIGAND
Descriptor:Hepatocyte growth factor receptor, 7-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine, GAMMA-BUTYROLACTONE
Authors:Wang, J., Steinig, A.G., Li, A.H., Chen, X., Dong, H., Ferraro, C., Jin, M., Kadalbajoo, M., Kleinberg, A., Stolz, K.M., Tavares-Greco, P.A., Wang, T., Albertella, M.R., Peng, Y., Crew, L., Kahler, J.
Deposit date:2013-05-09
Release date:2014-04-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.
Bioorg.Med.Chem.Lett., 23, 2013
4IP3
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COMPLEX STRUCTURE OF OSPI AND UBC13
Descriptor:ORF169b, Ubiquitin-conjugating enzyme E2 N
Authors:Fu, P., Jin, M., Zhang, X., Xu, L., Xia, Z., Zhu, Y.
Deposit date:2013-01-09
Release date:2013-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure Analysis of Ubc13 Inactivation
To be Published
5GW4
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STRUCTURE OF YEAST NPP-TRIC
Descriptor:T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Zang, Y., Jin, M., Wang, H., Cong, Y.
Deposit date:2016-09-08
Release date:2016-10-26
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.
Nat. Struct. Mol. Biol., 23, 2016
5GW5
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STRUCTURE OF TRIC-AMP-PNP
Descriptor:T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ...
Authors:Zang, Y., Jin, M., Wang, H., Cong, Y.
Deposit date:2016-09-08
Release date:2016-10-26
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM.
Nat. Struct. Mol. Biol., 23, 2016
5JDB
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BINDING SPECIFICITY OF P[8] VP8* PROTEINS OF ROTAVIRUS VACCINE STRAINS WITH HISTO-BLOOD GROUP ANTIGENS
Descriptor:Outer capsid protein VP4
Authors:Sun, X., Guo, N., Li, D., Zhou, Y., Jin, M., Xie, G., Pang, L., Zhang, Q., Cao, Y., Duan, Z.
Deposit date:2016-04-16
Release date:2016-07-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Binding specificity of P[8] VP8* proteins of rotavirus vaccine strains with histo-blood group antigens.
Virology, 495, 2016
5WCO
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MATRIX PROTEIN (M1) OF INFECTIOUS SALMON ANAEMIA VIRUS
Descriptor:NS2
Authors:Zhang, W., Zheng, W., Toh, Y., Betancourt, M.A., Tu, J., Fan, Y., Vakharia, V., Liu, J., McNew, J.A., Jin, M., Tao, Y.J.
Deposit date:2017-07-01
Release date:2017-08-16
Last modified:2019-12-11
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Crystal structure of an orthomyxovirus matrix protein reveals mechanisms for self-polymerization and membrane association.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6LE5
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CRYSTAL STRUCTURE OF THE MITOCHONDRIAL CALCIUM UPTAKE 1 AND 2 HETERODIMER (MICU1-MICU2 HETERODIMER) IN AN APO STATE
Descriptor:Calcium uptake protein 1, mitochondrial, Calcium uptake protein 2
Authors:Park, J., Lee, Y., Park, T., Kang, J.Y., Jin, M., Yang, J., Eom, S.H.
Deposit date:2019-11-24
Release date:2020-03-04
Last modified:2020-03-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the MICU1-MICU2 heterodimer provides insights into the gatekeeping threshold shift.
Iucrj, 7, 2020
6PWC
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A COMPLEX STRUCTURE OF ARRESTIN-2 BOUND TO NEUROTENSIN RECEPTOR 1
Descriptor:Neurotensin receptor type 1, Neurotensin peptide, Beta-arrestin-1, ...
Authors:Yin, W., Li, Z., Jin, M., Yin, Y.-L., de Waal, P.W., Pal, K., Gao, X., He, Y., Gao, J., Wang, X., Zhang, Y., Zhou, H., Melcher, K., Jiang, Y., Cong, Y., Zhou, X.E., Yu, X., Xu, H.E.
Deposit date:2019-07-22
Release date:2019-12-04
Last modified:2020-01-08
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:A complex structure of arrestin-2 bound to a G protein-coupled receptor.
Cell Res., 29, 2019
6J10
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CICLOPIROX INHIBITS HEPATITIS B VIRUS SECRETION BY BLOCKING CAPSID ASSEMBLY
Descriptor:Capsid protein, 6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one
Authors:Park, S., Jin, M.S., Cho, Y., Kang, J., Kim, S., Park, M., Park, H., Kim, J., Park, S., Hwang, J., Kim, Y., Kim, Y.J.
Deposit date:2018-12-27
Release date:2019-04-17
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ciclopirox inhibits Hepatitis B Virus secretion by blocking capsid assembly.
Nat Commun, 10, 2019
7KDT
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HUMAN TOM70 IN COMPLEX WITH SARS COV2 ORF9B
Descriptor:Mitochondrial import receptor subunit TOM70, ORF9b protein
Authors:QCRG Structural Biology Consortium
Deposit date:2020-10-09
Release date:2020-10-21
Last modified:2020-11-04
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science, 2020
5FCS
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DIABODY
Descriptor:Diabody, SULFATE ION
Authors:Mosyak, L., Root, A.
Deposit date:2015-12-15
Release date:2016-12-14
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Antibodies, 5, 2016
5YSX
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STRUCTURE OF P DOMAIN OF GII.2 NOROVIRUSES
Descriptor:VP1
Authors:Duan, Z., Ao, Y.
Deposit date:2017-11-16
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.202 Å)
Cite:Genetic Analysis of Reemerging GII.P16-GII.2 Noroviruses in 2016-2017 in China.
J. Infect. Dis., 218, 2018
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171588
PDB entries from 2020-11-25