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6PBJ
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BU of 6pbj by Molmil
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase with Gly190Pro mutation
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ...
Authors:Jiao, W, Fan, Y, Blackmore, N.J, Parker, E.J.
Deposit date:2019-06-13
Release date:2020-04-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A single amino acid substitution uncouples catalysis and allostery in an essential biosynthetic enzyme in Mycobacterium tuberculosis .
J.Biol.Chem., 295, 2020
3RZI
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BU of 3rzi by Molmil
The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis cocrystallized and complexed with phenylalanine and tryptophan
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Jiao, W, Jameson, G.B, Hutton, R.D, Parker, E.J.
Deposit date:2011-05-11
Release date:2012-01-25
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Dynamic cross-talk among remote binding sites: the molecular basis for unusual synergistic allostery.
J.Mol.Biol., 415, 2012
2YPP
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BU of 2ypp by Molmil
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase in complex with 3 tyrosine molecules
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Blackmore, N.J, Reichau, S, Jiao, W, Hutton, R.D, Baker, E.N, Jameson, G.B, Parker, E.J.
Deposit date:2012-10-31
Release date:2013-01-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three Sites and You are Out: Ternary Synergistic Allostery Controls Aromatic Aminoacid Biosynthesis in Mycobacterium Tuberculosis.
J.Mol.Biol., 425, 2013
2YPO
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BU of 2ypo by Molmil
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with phenylalanine bound in only one site
Descriptor: GLYCEROL, MANGANESE (II) ION, PHENYLALANINE, ...
Authors:Blackmore, N.J, Reichau, S, Jiao, W, Hutton, R.D, Baker, E.N, Jameson, G.B, Parker, E.J.
Deposit date:2012-10-31
Release date:2013-01-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three Sites and You are Out: Ternary Synergistic Allostery Controls Aromatic Aminoacid Biosynthesis in Mycobacterium Tuberculosis.
J.Mol.Biol., 425, 2013
2YPQ
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BU of 2ypq by Molmil
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with tryptophan and tyrosine bound
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Blackmore, N.J, Reichau, S, Jiao, W, Hutton, R.D, Baker, E.N, Jameson, G.B, Parker, E.J.
Deposit date:2012-10-31
Release date:2013-01-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Three Sites and You are Out: Ternary Synergistic Allostery Controls Aromatic Aminoacid Biosynthesis in Mycobacterium Tuberculosis.
J.Mol.Biol., 425, 2013
3KGF
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BU of 3kgf by Molmil
The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis complexed with phenylalanine and tryptophan
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Parker, E.J, Jameson, G.B, Jiao, W, Webby, C.J, Baker, E.N, Baker, H.M, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2009-10-29
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis
J.Biol.Chem., 285, 2010
7TIN
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BU of 7tin by Molmil
The Structure of S. aureus MenD
Descriptor: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, CALCIUM ION, CHLORIDE ION, ...
Authors:Johnston, J.M, Stanborough, T, Ho, N.A.T, Akazong, E.W, Jiao, W.
Deposit date:2022-01-14
Release date:2022-09-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: a feedback inhibition mechanism of the menaquinone biosynthesis pathway.
Philos.Trans.R.Soc.Lond.B Biol.Sci., 378, 2023
5UBH
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BU of 5ubh by Molmil
Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni with bound ATP
Descriptor: ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ATP phosphoribosyltransferase, ...
Authors:Mittelstaedt, G, Jiao, W, Livingstone, E.K, Parker, E.J.
Deposit date:2016-12-20
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase.
Biochem. J., 475, 2018
5UBI
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BU of 5ubi by Molmil
Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni with bound PRPP
Descriptor: 1,2-ETHANEDIOL, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, ACETATE ION, ...
Authors:Mittelstaedt, G, Jiao, W, Livingstone, E.K, Parker, E.J.
Deposit date:2016-12-20
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase.
Biochem. J., 475, 2018
5UBG
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BU of 5ubg by Molmil
Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni with bound Phosphoribosyl-ATP
Descriptor: ATP phosphoribosyltransferase, CHLORIDE ION, PHOSPHORIBOSYL ATP, ...
Authors:Mittelstaedt, G, Jiao, W, Livingstone, E.K, Parker, E.J.
Deposit date:2016-12-20
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase.
Biochem. J., 475, 2018
5UB9
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BU of 5ub9 by Molmil
Catalytic core domain of Adenosine triphosphate phosphoribosyltransferase from Campylobacter jejuni
Descriptor: ACETATE ION, ATP phosphoribosyltransferase, CHLORIDE ION, ...
Authors:Mittelstaedt, G, Jiao, W, Livingstone, E.K, Parker, E.J.
Deposit date:2016-12-20
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A dimeric catalytic core relates the short and long forms of ATP-phosphoribosyltransferase.
Biochem. J., 475, 2018
3NUD
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BU of 3nud by Molmil
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis complexed with phenylalanine
Descriptor: PHENYLALANINE, PHOSPHATE ION, Probable 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG
Authors:Parker, E.J, Jameson, G.B, Jiao, W, Webby, C.J, Baker, E.N, Baker, H.M.
Deposit date:2010-07-06
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis
J.Biol.Chem., 285, 2010
3NV8
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BU of 3nv8 by Molmil
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in complex with phosphoenol pyruvate and manganese (thesit-free)
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Parker, E.J, Jameson, G.B, Jiao, W, Hutton, R.H, Webby, C.J, Baker, E.N, Baker, H.M.
Deposit date:2010-07-08
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis
J.Biol.Chem., 285, 2010
3NUE
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BU of 3nue by Molmil
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from mycobacterium tuberculosis complexed with tryptophan
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Parker, E.J, Jameson, G.B, Jiao, W, Webby, C.J, Baker, E.N, Baker, H.M.
Deposit date:2010-07-06
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis
J.Biol.Chem., 285, 2010
3PFP
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BU of 3pfp by Molmil
Structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with an active site inhibitor
Descriptor: (2R)-2,7-bis(phosphonooxy)heptanoic acid, (2S)-2,7-bis(phosphonooxy)heptanoic acid, CHLORIDE ION, ...
Authors:Reichau, S, Jiao, W, Walker, S.R, Hutton, R.D, Parker, E.J, Baker, E.N.
Deposit date:2010-10-28
Release date:2011-03-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design
J.Biol.Chem., 286, 2011
5E5G
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BU of 5e5g by Molmil
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with D-tryptophan bound in the tryptophan and phenylalanine binding sites
Descriptor: 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase, D-TRYPTOPHAN, MANGANESE (II) ION, ...
Authors:Reichau, S, Jiao, W, Parker, E.J.
Deposit date:2015-10-08
Release date:2016-06-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using -Amino Acids.
Plos One, 11, 2016
5E4N
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BU of 5e4n by Molmil
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis with D-tyrosine bound in the tyrosine and phenylalanine binding sites
Descriptor: 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase, CHLORIDE ION, D-TYROSINE, ...
Authors:Reichau, S, Jiao, W, Parker, E.J.
Deposit date:2015-10-06
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using -Amino Acids.
Plos One, 11, 2016
5E2L
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BU of 5e2l by Molmil
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with D-phenylalanine
Descriptor: 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase, CHLORIDE ION, D-PHENYLALANINE, ...
Authors:Reichau, S, Jiao, W, Parker, E.J.
Deposit date:2015-10-01
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using -Amino Acids.
Plos One, 11, 2016
5E40
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BU of 5e40 by Molmil
3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis with D-tyrosine bound in the phenylalanine binding site
Descriptor: 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase, D-TYROSINE, GLYCEROL, ...
Authors:Reichau, S, Jiao, W, Parker, E.J.
Deposit date:2015-10-05
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using -Amino Acids.
Plos One, 11, 2016
5E7Z
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BU of 5e7z by Molmil
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis in complex with D/L-tryptophan and D-phenylalanine
Descriptor: 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase, D-PHENYLALANINE, D-TRYPTOPHAN, ...
Authors:Reichau, S, Jiao, W, Parker, E.J.
Deposit date:2015-10-13
Release date:2016-06-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using -Amino Acids.
Plos One, 11, 2016
5EX4
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BU of 5ex4 by Molmil
3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis complexed with tryptophan in all three allosteric binding sites
Descriptor: 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase, CHLORIDE ION, GLYCEROL, ...
Authors:Reichau, S, Jiao, W, Blackmore, N.J, Hutton, R.D, Parker, E.J.
Deposit date:2015-11-23
Release date:2015-12-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis complexed with tryptophan in all three allosteric binding sites
to be published
4MB1
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BU of 4mb1 by Molmil
The Structure of MalL mutant enzyme G202P from Bacillus subtilus
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Oligo-1,6-glucosidase 1
Authors:Hobbs, J.K, Jiao, W, Easter, A.D, Parker, E.J, Schipper, L.A, Arcus, V.L.
Deposit date:2013-08-19
Release date:2013-09-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates.
Acs Chem.Biol., 8, 2013
4MAZ
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BU of 4maz by Molmil
The Structure of MalL mutant enzyme V200S from Bacillus subtilus
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, MAGNESIUM ION, ...
Authors:Hobbs, J.K, Jiao, W, Easter, A.D, Parker, E.J, Schipper, L.A, Arcus, V.L.
Deposit date:2013-08-18
Release date:2013-09-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates.
Acs Chem.Biol., 8, 2013
4M8U
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BU of 4m8u by Molmil
The Structure of MalL mutant enzyme V200A from Bacillus subtilus
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GLYCEROL, ...
Authors:Hobbs, J.K, Jiao, W, Easter, A.D, Parker, E.J, Schipper, L.A, Arcus, V.L.
Deposit date:2013-08-13
Release date:2013-09-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates.
Acs Chem.Biol., 8, 2013
4M56
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BU of 4m56 by Molmil
The Structure of Wild-type MalL from Bacillus subtilis
Descriptor: D-glucose, GLYCEROL, Oligo-1,6-glucosidase 1, ...
Authors:Hobbs, J.K, Jiao, W, Easter, A.D, Parker, E.J, Schipper, L.A, Arcus, V.L.
Deposit date:2013-08-08
Release date:2013-10-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates.
Acs Chem.Biol., 8, 2013

 

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