Author results

3JSD
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
分子名称:Insulin A chain, Insulin B chain, ZINC ION, ...
著者Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
登録日2009-09-10
公開日2010-09-15
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3P2X
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
分子名称:Insulin, ZINC ION, CHLORIDE ION, ...
著者Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
登録日2010-10-04
公開日2011-11-23
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
登録日2010-10-04
公開日2011-11-23
最終更新日2014-10-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3ROV
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
分子名称:Insulin, PHENOL, ZINC ION, ...
著者Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
登録日2011-04-26
公開日2012-05-02
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
1J73
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CRYSTAL STRUCTURE OF AN UNSTABLE INSULIN ANALOG WITH NATIVE ACTIVITY.
分子名称:insulin a, insulin b, ZINC ION
著者Wan, Z., Zhao, M., Nakagawa, S., Jia, W., Weiss, M.A.
登録日2001-05-15
公開日2001-05-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1SJT
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MINI-PROINSULIN, TWO CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP, NMR, 20 STRUCTURES
分子名称:PROINSULIN
著者Hua, Q.X., Hu, S.Q., Jia, W.H., Chu, Y.C., Burke, G.T., Wang, S.H., Katsoyannis, P.G., Weiss, M.A.
登録日1997-10-09
公開日1998-03-18
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
1SJU
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MINI-PROINSULIN, SINGLE CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP AND PEPTIDE BOND BETWEEN LYS B 29 AND GLY A 1, NMR, 20 STRUCTURES
分子名称:PROINSULIN
著者Hua, Q.X., Hu, S.Q., Jia, W.H., Chu, Y.C., Burke, G.T., Wang, S.H., Katsoyannis, P.G., Weiss, M.A.
登録日1997-10-09
公開日1998-03-18
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
1VKT
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HUMAN INSULIN TWO DISULFIDE MODEL, NMR, 10 STRUCTURES
分子名称:INSULIN
著者Hua, Q.X., Hu, S.Q., Frank, B.H., Jia, W.H., Chu, Y.C., Wang, S.H., Burke, G.T., Katsoyannis, P.G., Weiss, M.A.
登録日1996-10-14
公開日1997-04-01
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
2JMN
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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
分子名称:Insulin A chain, Insulin B chain
著者Hua, Q.X., Hu, S.Q., Frank, B.H., Jia, W.H., Chu, Y.C., Wang, S.H., Burke, G.T., Katsoyannis, P.G., Weiss, M.A.
登録日2006-11-21
公開日2006-12-05
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
2JZQ
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DESIGN OF AN ACTIVE ULTRA-STABLE SINGLE-CHAIN INSULIN ANALOG 20 STRUCTURES
分子名称:Insulin
著者Hua, Q.X., Nakarawa, S., Jia, W.H., Huang, K., Philips, N.F., Hu, S.Q., Weiss, M.A.
登録日2008-01-11
公開日2008-02-26
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
2K91
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ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
分子名称:Insulin
著者Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
登録日2008-09-29
公開日2008-11-18
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2K9R
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ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
分子名称:Insulin
著者Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
登録日2008-10-23
公開日2008-11-11
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2KJI
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A DIVERGENT INS PROTEIN IN C. ELEGANS STRUCTURALLY RESEMBLE INSULIN AND ACTIVATES THE HUMAN INSULIN RECEPTOR
分子名称:Probable insulin-like peptide beta-type 5
著者Hua, Q.X., Nakarawa, S.H., Wilken, R., Ramos, R.R., Jia, W.H., Bass, J., Weiss, M.A.
登録日2009-05-28
公開日2009-06-16
最終更新日2019-09-18
実験手法SOLUTION NMR
主引用文献A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor.
Genes Dev., 17, 2003
1RWE
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ENHANCING THE ACTIVITY OF INSULIN AT RECEPTOR EDGE: CRYSTAL STRUCTURE AND PHOTO-CROSS-LINKING OF A8 ANALOGUES
分子名称:insulin, Insulin, ZINC ION, ...
著者Wan, Z., Xu, B., Chu, Y.C., Li, B., Nakagawa, S.H., Qu, Y., Hu, S.Q., Katsoyannis, P.G., Weiss, M.A.
登録日2003-12-16
公開日2005-02-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004