Author results

1KVH
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NCSI-GB-BULGE-DNA COMPLEX INDUCED FORMATION OF A DNA BULGE STRUCTURE BY A MOLECULAR WEDGE LIGAND-POST-ACTIVATED NEOCARZINOSTATIN CHROMOPHORE
分子名称:5'-D(*CP*CP*CP*GP*AP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*TP*TP*CP*GP*GP*G)-3', SPIRO[[7-METHOXY-5-METHYL-1,2-DIHYDRO-NAPHTHALENE]-3,1'-[5-HYDROXY-9-[2-METHYLAMINO-2,6-DIDEOXYGALACTOPYRANOSYL-OXY]-5-(2-OXO-[1,3]DIOXOLAN-4-YL)-3A,5,9,9A-TETRAHYDRO-3H-1-OXA-CYCLOPENTA[A]-S-INDACEN-2-ONE]]
著者Gao, X., Stassinopoulos, A., Ji, J., Kwon, Y., Bare, S., Goldberg, I.H.
登録日2002-01-26
公開日2002-06-19
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Induced formation of a DNA bulge structure by a molecular wedge ligand-postactivated neocarzinostatin chromophore.
Biochemistry, 41, 2002
2NEO
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SOLUTION NMR STRUCTURE OF A TWO-BASE DNA BULGE COMPLEXED WITH AN ENEDIYNE CLEAVING ANALOG, 11 STRUCTURES
分子名称:DNA (5'-D(*CP*CP*CP*GP*AP*TP*GP*CP*PGE*GP*CP*AP*AP*TP*TP*CP*GP*GP*G)-3'), SPIRO[[7-METHOXY-5-METHYL-1,2-DIHYDRO-NAPHTHALENE]-3,1'-[5-HYDROXY-9-[2-METHYLAMINO-2,6-DIDEOXYGALACTOPYRANOSYL-OXY]-5-(2-OXO-[1,3]DIOXOLAN-4-YL)-3A,5,9,9A-TETRAHYDRO-3H-1-OXA-CYCLOPENTA[A]-S-INDACEN-2-ONE]]
著者Stassinopoulos, A., Ji, J., Gao, X., Goldberg, I.H.
登録日1997-06-19
公開日1998-01-28
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of a two-base DNA bulge complexed with an enediyne cleaving analog.
Science, 272, 1996
4WJA
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CRYSTAL STRUCTURE OF PAXX
分子名称:Uncharacterized protein C9orf142
著者Xing, M., Yang, M., Huo, W., Feng, F., Wei, L., Ning, S., Yan, Z., Li, W., Wang, Q., Hou, M., Dong, C., Guo, R., Gao, G., Ji, J., Lan, L., Liang, H., Xu, D.
登録日2014-09-29
公開日2015-03-11
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
Nat Commun, 6, 2015
4GMB
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CRYSTAL STRUCTURE OF HUMAN WD REPEAT DOMAIN 5 WITH COMPOUND MM-402
分子名称:WD repeat-containing protein 5, MM-402
著者Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
登録日2012-08-15
公開日2014-02-19
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (2.781 Å)
主引用文献Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J. Med. Chem., 2017
4RL1
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF A LOADING ACYLTRANSFERASE FROM THE AVERMECTIN MODULAR POLYKETIDE SYNTHASE
分子名称:Type I polyketide synthase AVES 1
著者Wang, F., Wang, Y., Zheng, J.
登録日2014-10-15
公開日2015-01-28
最終更新日2015-08-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase.
Acs Chem.Biol., 10, 2015
5VFC
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WDR5 BOUND TO INHIBITOR MM-589
分子名称:WD repeat-containing protein 5, N-{(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide, SULFATE ION, ...
著者Stuckey, J.A.
登録日2017-04-07
公開日2017-06-28
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J. Med. Chem., 60, 2017
4R5Y
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THE COMPLEX STRUCTURE OF BRAF V600E KINASE DOMAIN WITH A NOVEL BRAF INHIBITOR
分子名称:Serine/threonine-protein kinase B-raf, 5-({(1R,1aS,6bR)-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
著者Feng, Y., Peng, H., Zhang, Y., Liu, Y., Wei, M.
登録日2014-08-22
公開日2016-02-24
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Mol.Cancer Ther., 14, 2015
5JZV
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THE STRUCTURE OF D77G HCINAP-ADP
分子名称:Adenylate kinase isoenzyme 6, ADENOSINE-5'-DIPHOSPHATE
著者Liu, Y., Yang, Z., Yang, Y., Cai, X., Zheng, X.
登録日2016-05-17
公開日2016-08-10
最終更新日2017-12-06
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
Nat Commun, 7, 2016
5TUQ
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CRYSTAL STRUCTURE OF A 6-CYCLOHEXYLMETHYL-3-HYDROXYPYRIMIDINE-2,4-DIONE INHIBITOR IN COMPLEX WITH HIV REVERSE TRANSCRIPTASE
分子名称:HIV-1 REVERSE TRANSCRIPTASE, 1-[(benzyloxy)methyl]-6-(cyclohexylmethyl)-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione, MAGNESIUM ION
著者Kirby, K.A., Sarafianos, S.G.
登録日2016-11-07
公開日2017-06-28
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (2.705 Å)
主引用文献6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.
Eur J Med Chem, 128, 2017
2OEY
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SOLUTION STRUCTURE OF A DESIGNED SPIROCYCLIC HELICAL LIGAND BINDING AT A TWO-BASE BULGE SITE IN DNA
分子名称:DNA (25-MER), (1R,3A'S,10'S,10A'R)-7-METHOXY-2-OXO-10',10A'-DIHYDRO-2H,3A'H-SPIRO[NAPHTHALENE-1,3'-PENTALENO[1,2-B]NAPHTHALEN]-10'-YL 2,6-DIDEOXY-2-(METHYLAMINO)-ALPHA-D-GALACTOPYRANOSIDE
著者Zhang, N., Lin, Y., Xiao, Z., Jones, G.B., Goldberg, I.H.
登録日2007-01-01
公開日2007-04-10
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution Structure of a Designed Spirocyclic Helical Ligand Binding at a Two-Base Bulge Site in DNA.
Biochemistry, 46, 2007