Author results

1KVH
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NCSI-GB-BULGE-DNA COMPLEX INDUCED FORMATION OF A DNA BULGE STRUCTURE BY A MOLECULAR WEDGE LIGAND-POST-ACTIVATED NEOCARZINOSTATIN CHROMOPHORE
Descriptor:5'-D(*CP*CP*CP*GP*AP*TP*GP*C)-3', 5'-D(*GP*CP*AP*AP*TP*TP*CP*GP*GP*G)-3', SPIRO[[7-METHOXY-5-METHYL-1,2-DIHYDRO-NAPHTHALENE]-3,1'-[5-HYDROXY-9-[2-METHYLAMINO-2,6-DIDEOXYGALACTOPYRANOSYL-OXY]-5-(2-OXO-[1,3]DIOXOLAN-4-YL)-3A,5,9,9A-TETRAHYDRO-3H-1-OXA-CYCLOPENTA[A]-S-INDACEN-2-ONE]]
Authors:Gao, X., Stassinopoulos, A., Ji, J., Kwon, Y., Bare, S., Goldberg, I.H.
Deposit date:2002-01-26
Release date:2002-06-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Induced formation of a DNA bulge structure by a molecular wedge ligand-postactivated neocarzinostatin chromophore.
Biochemistry, 41, 2002
2NEO
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SOLUTION NMR STRUCTURE OF A TWO-BASE DNA BULGE COMPLEXED WITH AN ENEDIYNE CLEAVING ANALOG, 11 STRUCTURES
Descriptor:DNA (5'-D(*CP*CP*CP*GP*AP*TP*GP*CP*PGE*GP*CP*AP*AP*TP*TP*CP*GP*GP*G)-3'), SPIRO[[7-METHOXY-5-METHYL-1,2-DIHYDRO-NAPHTHALENE]-3,1'-[5-HYDROXY-9-[2-METHYLAMINO-2,6-DIDEOXYGALACTOPYRANOSYL-OXY]-5-(2-OXO-[1,3]DIOXOLAN-4-YL)-3A,5,9,9A-TETRAHYDRO-3H-1-OXA-CYCLOPENTA[A]-S-INDACEN-2-ONE]]
Authors:Stassinopoulos, A., Ji, J., Gao, X., Goldberg, I.H.
Deposit date:1997-06-19
Release date:1998-01-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a two-base DNA bulge complexed with an enediyne cleaving analog.
Science, 272, 1996
4WJA
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CRYSTAL STRUCTURE OF PAXX
Descriptor:Uncharacterized protein C9orf142
Authors:Xing, M., Yang, M., Huo, W., Feng, F., Wei, L., Ning, S., Yan, Z., Li, W., Wang, Q., Hou, M., Dong, C., Guo, R., Gao, G., Ji, J., Lan, L., Liang, H., Xu, D.
Deposit date:2014-09-29
Release date:2015-03-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
Nat Commun, 6, 2015
4GMB
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CRYSTAL STRUCTURE OF HUMAN WD REPEAT DOMAIN 5 WITH COMPOUND MM-402
Descriptor:WD repeat-containing protein 5, MM-402
Authors:Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.781 Å)
Cite:Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J. Med. Chem., 2017
4RL1
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF A LOADING ACYLTRANSFERASE FROM THE AVERMECTIN MODULAR POLYKETIDE SYNTHASE
Descriptor:Type I polyketide synthase AVES 1
Authors:Wang, F., Wang, Y., Zheng, J.
Deposit date:2014-10-15
Release date:2015-01-28
Last modified:2015-08-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase.
Acs Chem.Biol., 10, 2015
5VFC
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WDR5 BOUND TO INHIBITOR MM-589
Descriptor:WD repeat-containing protein 5, N-{(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N'-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl}-2-methylpropanamide, SULFATE ION, ...
Authors:Stuckey, J.A.
Deposit date:2017-04-07
Release date:2017-06-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J. Med. Chem., 60, 2017
4R5Y
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THE COMPLEX STRUCTURE OF BRAF V600E KINASE DOMAIN WITH A NOVEL BRAF INHIBITOR
Descriptor:Serine/threonine-protein kinase B-raf, 5-({(1R,1aS,6bR)-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
Authors:Feng, Y., Peng, H., Zhang, Y., Liu, Y., Wei, M.
Deposit date:2014-08-22
Release date:2016-02-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Mol.Cancer Ther., 14, 2015
5JZV
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THE STRUCTURE OF D77G HCINAP-ADP
Descriptor:Adenylate kinase isoenzyme 6, ADENOSINE-5'-DIPHOSPHATE
Authors:Liu, Y., Yang, Z., Yang, Y., Cai, X., Zheng, X.
Deposit date:2016-05-17
Release date:2016-08-10
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
Nat Commun, 7, 2016
5TUQ
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CRYSTAL STRUCTURE OF A 6-CYCLOHEXYLMETHYL-3-HYDROXYPYRIMIDINE-2,4-DIONE INHIBITOR IN COMPLEX WITH HIV REVERSE TRANSCRIPTASE
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 1-[(benzyloxy)methyl]-6-(cyclohexylmethyl)-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione, MAGNESIUM ION
Authors:Kirby, K.A., Sarafianos, S.G.
Deposit date:2016-11-07
Release date:2017-06-28
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.705 Å)
Cite:6-Cyclohexylmethyl-3-hydroxypyrimidine-2,4-dione as an inhibitor scaffold of HIV reverase transcriptase: Impacts of the 3-OH on inhibiting RNase H and polymerase.
Eur J Med Chem, 128, 2017
2OEY
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SOLUTION STRUCTURE OF A DESIGNED SPIROCYCLIC HELICAL LIGAND BINDING AT A TWO-BASE BULGE SITE IN DNA
Descriptor:DNA (25-MER), (1R,3A'S,10'S,10A'R)-7-METHOXY-2-OXO-10',10A'-DIHYDRO-2H,3A'H-SPIRO[NAPHTHALENE-1,3'-PENTALENO[1,2-B]NAPHTHALEN]-10'-YL 2,6-DIDEOXY-2-(METHYLAMINO)-ALPHA-D-GALACTOPYRANOSIDE
Authors:Zhang, N., Lin, Y., Xiao, Z., Jones, G.B., Goldberg, I.H.
Deposit date:2007-01-01
Release date:2007-04-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of a Designed Spirocyclic Helical Ligand Binding at a Two-Base Bulge Site in DNA.
Biochemistry, 46, 2007