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7PMK
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BU of 7pmk by Molmil
S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
Descriptor: Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA helicase, ...
Authors:Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D.
Deposit date:2021-09-02
Release date:2021-11-10
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
7PMN
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BU of 7pmn by Molmil
S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
Descriptor: Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha-binding protein, ...
Authors:Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D.
Deposit date:2021-09-02
Release date:2021-11-10
Last modified:2022-01-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
8OUW
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BU of 8ouw by Molmil
Cryo-EM structure of CMG helicase bound to TIM-1/TIPN-1 and homodimeric DNSN-1 on fork DNA (Caenorhabditis elegans)
Descriptor: Cell division control protein 45 homolog, DNA Lagging Strand Template, DNA Leading Strand Template, ...
Authors:Jenkyn-Bedford, M, Yeeles, J.T.P, Labib, K.P.M.
Deposit date:2023-04-25
Release date:2023-08-16
Last modified:2023-10-04
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:DNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in Caenorhabditis elegans.
Science, 381, 2023
7PLO
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BU of 7plo by Molmil
H. sapiens replisome-CUL2/LRR1 complex
Descriptor: Cell division control protein 45 homolog, Claspin, Cullin-2, ...
Authors:Jones, M.J, Yeeles, J.T.P, Deegan, T.D, Jenkyn-Bedford, M.
Deposit date:2021-09-01
Release date:2021-11-10
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
6SKL
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BU of 6skl by Molmil
Cryo-EM structure of the CMG Fork Protection Complex at a replication fork - Conformation 1
Descriptor: Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA fork, ...
Authors:Yeeles, J, Baretic, D, Jenkyn-Bedford, M.
Deposit date:2019-08-16
Release date:2020-05-06
Last modified:2020-06-17
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork.
Mol.Cell, 78, 2020
6SKO
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BU of 6sko by Molmil
Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork - conformation 2 MCM CTD:ssDNA
Descriptor: DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ...
Authors:Yeeles, J, Baretic, D, Jenkyn-Bedford, M.
Deposit date:2019-08-16
Release date:2020-05-06
Last modified:2020-06-17
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork.
Mol.Cell, 78, 2020
6R4S
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BU of 6r4s by Molmil
Crystal structure of the Pri1 subunit of human primase bound to ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA primase small subunit, MANGANESE (II) ION, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-03-24
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R4T
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BU of 6r4t by Molmil
Crystal structure of the Pri1 subunit of human primase bound to vidarabine triphosphate
Descriptor: 1,2-ETHANEDIOL, 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-amine, DNA primase small subunit, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-03-24
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R5E
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BU of 6r5e by Molmil
Crystal structure of the Pri1 subunit of human primase bound to 2F-ATP
Descriptor: 1,2-ETHANEDIOL, 2-fluoro-ATP, DNA primase small subunit, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-03-24
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6RB4
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BU of 6rb4 by Molmil
Crystal structure of the Pri1 subunit of human primase
Descriptor: 1,2-ETHANEDIOL, DNA primase small subunit, ZINC ION
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-04-09
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R5D
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BU of 6r5d by Molmil
Crystal structure of the Pri1 subunit of human primase bound to dATP
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA primase small subunit, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-03-24
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
6R4U
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BU of 6r4u by Molmil
Crystal structure of the Pri1 subunit of human primase bound to fludarabine triphosphate
Descriptor: 1,2-ETHANEDIOL, 2-fluoro-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-a mine, DNA primase small subunit, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2019-03-24
Release date:2019-09-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Inhibition of Human Primase by Arabinofuranosyl Nucleoside Analogues Fludarabine and Vidarabine.
Acs Chem.Biol., 14, 2019
7PFO
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BU of 7pfo by Molmil
Core human replisome
Descriptor: Cell division control protein 45 homolog, Claspin, DNA polymerase epsilon catalytic subunit A, ...
Authors:Jones, M.J, Yeeles, J.T.P.
Deposit date:2021-08-11
Release date:2021-11-10
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of a human replisome shows the organisation and interactions of a DNA replication machine.
Embo J., 40, 2021

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PDB entries from 2024-03-27

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