Author results

6FJM
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TUBULIN-DISORAZOLE Z COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Menchon, G., Prota, A.E., Lucena Agell, D., Bucher, P., Jansen, R., Irschik, H., Mueller, R., Paterson, I., Diaz, J.F., Altmann, K.-H., Steinmetz, M.O.
Deposit date:2018-01-22
Release date:2018-05-30
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
1YNJ
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TAQ RNA POLYMERASE-SORANGICIN COMPLEX
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A., Pavlova, O., Zenkin, N., Leon, F., Irschik, H., Jansen, R., Severinov, K., Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
1YNN
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TAQ RNA POLYMERASE-RIFAMPICIN COMPLEX
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A., Pavlova, O., Zenkin, N., Leon, F., Irschik, H., Jansen, R., Severinov, K., Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
2VYP
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RABBIT-MUSCLE G-ACTIN IN COMPLEX WITH MYXOBACTERIAL RHIZOPODIN
Descriptor:ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Hagelueken, G., Albrecht, S.C., Steinmetz, H., Jansen, R., Heinz, D.W., Kalesse, M., Schubert, W.-D.
Deposit date:2008-07-25
Release date:2009-02-24
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:The Absolute Configuration of Rhizopodin and its Inhibition of Actin Polymerization by Dimerization.
Angew.Chem.Int.Ed.Engl., 48, 2009
6FII
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TUBULIN-SPONGISTATIN COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Menchon, G., Prota, A.E., Lucena Angell, D., Bucher, P., Mueller, R., Paterson, I., Diaz, J.F., Altmann, K.-H., Steinmetz, M.O.
Deposit date:2018-01-18
Release date:2018-05-30
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
6FJF
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TUBULIN-FCMAYTANSINE COMPLEX
Descriptor:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
Authors:Menchon, G., Prota, A.E., Lucena Angell, D., Bucher, P., Mueller, R., Paterson, I., Diaz, J.F., Altmann, K.-H., Steinmetz, M.O.
Deposit date:2018-01-22
Release date:2018-05-30
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin.
Nat Commun, 9, 2018
4MQ9
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH GE23077
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Ho, M.X., Arnold, E., Ebright, R.H., Zhang, Y., Tuske, S.
Deposit date:2013-09-16
Release date:2014-05-07
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIN
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX SOAKED WITH GE23077
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhang, Y., Ebright, R.H., Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIO
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS PRE-INSERTION SUBSTRATE COMPLEX FOR DE NOVO TRANSCRIPTION INITIATION
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhang, Y., Ebright, R.H., Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIP
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX SOAKED WITH GE23077, ATP, AND CMPCPP
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhang, Y., Ebright, R.H., Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIQ
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS TRANSCRIPTION INITIATION COMPLEX SOAKED WITH GE23077 AND RIFAMPICIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhang, Y., Ebright, R.H., Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (3.624 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
4OIR
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE TRANSCRIPTION INITIATION COMPLEX SOAKED WITH GE23077 AND RIFAMYCIN SV
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Zhang, Y., Ebright, R.H., Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2014-05-14
Method:X-RAY DIFFRACTION (3.105 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
3DXJ
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CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH THE ANTIBIOTIC MYXOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha; CHAIN A, B, K, ...
Authors:Das, K., Arnold, E.
Deposit date:2008-07-24
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The RNA polymerase "switch region" is a target for inhibitors.
Cell(Cambridge,Mass.), 135, 2008
6EDT
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MYCOBACTERIUM TUBERCULOSIS RNAP OPEN PROMOTER COMPLEX WITH RBPA/CARD AND AP3 PROMOTER
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-10
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6EE8
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MYCOBACTERIUM TUBERCULOSIS RNAP PROMOTER UNWINDING INTERMEDIATE COMPLEX WITH RBPA/CARD AND AP3 PROMOTER
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-13
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6EEC
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MYCOBACTERIUM TUBERCULOSIS RNAP PROMOTER UNWINDING INTERMEDIATE COMPLEX WITH RBPA/CARD AND AP3 PROMOTER CAPTURED BY CORALLOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-13
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
6M7J
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MYCOBACTERIUM TUBERCULOSIS RNAP WITH RBPA/US FORK AND CORALLOPYRONIN
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Darst, S.A., Campbell, E.A., Boyaci Selcuk, H., Chen, J.
Deposit date:2018-08-20
Release date:2018-11-21
Last modified:2019-01-30
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding.
Nature, 565, 2019
5TMF
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RE-REFINEMENT OF THERMUS THERMOPHILUS RNA POLYMERASE
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Wang, J.
Deposit date:2016-10-12
Release date:2016-11-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:On the validation of crystallographic symmetry and the quality of structures.
Protein Sci., 24, 2015