Author results

1MHE
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THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E
Descriptor:HLA CLASS I HISTOCOMPATIBILITY ANTIGEN HLA-E, BETA-2-MICROGLOBULIN, PEPTIDE (VMAPRTVLL), ...
Authors:O'Callaghan, C.A., Tormo, J., Willcox, B.E., Braud, V.B., Jakobsen, B.K., Stuart, D.I., Mcmichael, A.J., Bell, J.I., Jones, E.Y.
Deposit date:1998-08-24
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.
Mol.Cell, 1, 1998
1AGB
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ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGRKKYKL-3R MUTATION)
Descriptor:B*0801, BETA-2 MICROGLOBULIN, HIV-1 GAG PEPTIDE (GGRKKYKL - 3R MUTATION)
Authors:Reid, S.W., Mcadam, S., Smith, K.J., Klenerman, P., O'Callaghan, C.A., Harlos, K., Jakobsen, B.K., Mcmichael, A.J., Bell, J., Stuart, D.I., Jones, E.Y.
Deposit date:1997-03-24
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.
J.Exp.Med., 184, 1996
1AGC
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ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGKKKYQL-7Q MUTATION)
Descriptor:B*0801, BETA-2 MICROGLOBULIN, HIV-1 GAG PEPTIDE (GGKKKYQL - 7Q MUTATION)
Authors:Reid, S.W., Mcadam, S., Smith, K.J., Klenerman, P., O'Callaghan, C.A., Harlos, K., Jakobsen, B.K., Mcmichael, A.J., Bell, J., Stuart, D.I., Jones, E.Y.
Deposit date:1997-03-24
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.
J.Exp.Med., 184, 1996
1AGD
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ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGKKKYKL-INDEX PEPTIDE)
Descriptor:B*0801, BETA-2 MICROGLOBULIN, HIV-1 GAG PEPTIDE (GGKKKYKL - INDEX PEPTIDE)
Authors:Reid, S.W., Mcadam, S., Smith, K.J., Klenerman, P., O'Callaghan, C.A., Harlos, K., Jakobsen, B.K., Mcmichael, A.J., Bell, J., Stuart, D.I., Jones, E.Y.
Deposit date:1997-03-24
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.
J.Exp.Med., 184, 1996
1AGE
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ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGKKKYRL-7R MUTATION)
Descriptor:B*0801, BETA-2 MICROGLOBULIN, HIV-1 GAG PEPTIDE (GGKKKYRL - 7R MUTATION)
Authors:Reid, S.W., Mcadam, S., Smith, K.J., Klenerman, P., O'Callaghan, C.A., Harlos, K., Jakobsen, B.K., Mcmichael, A.J., Bell, J., Stuart, D.I., Jones, E.Y.
Deposit date:1997-03-24
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.
J.Exp.Med., 184, 1996
1AGF
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ANTAGONIST HIV-1 GAG PEPTIDES INDUCE STRUCTURAL CHANGES IN HLA B8-HIV-1 GAG PEPTIDE (GGKKRYKL-5R MUTATION)
Descriptor:B*0801, BETA-2 MICROGLOBULIN, HIV-1 GAG PEPTIDE (GGKKRYKL - 5R MUTATION)
Authors:Reid, S.W., Mcadam, S., Smith, K.J., Klenerman, P., O'Callaghan, C.A., Harlos, K., Jakobsen, B.K., Mcmichael, A.J., Bell, J., Stuart, D.I., Jones, E.Y.
Deposit date:1997-03-24
Release date:1997-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Antagonist HIV-1 Gag peptides induce structural changes in HLA B8.
J.Exp.Med., 184, 1996
2BCK
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CRYSTAL STRUCTURE OF HLA-A*2402 COMPLEXED WITH A TELOMERASE PEPTIDE
Descriptor:HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Jakobsen, B.K., Cole, D.K., Gao, G.F.
Deposit date:2005-10-19
Release date:2006-01-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of HLA-A*2402 complexed with a telomerase peptide.
Eur.J.Immunol., 36, 2006
2CDE
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STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA- GALACTOSYLCERAMIDE SPECIFIC T CELL RECEPTORS - INKT-TCR
Descriptor:INKT-TCR
Authors:Gadola, S.D., Koch, M., Marles-Wright, J., Lissin, N.M., Sheperd, D., Matulis, G., Harlos, K., Villiger, P.M., Stuart, D.I., Jakobsen, B.K., Cerundolo, V., Jones, E.Y.
Deposit date:2006-01-23
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structrue and Binding Kinetics of Three Different Human Cd1D-Alpha-Galactosylceramide-Specific T Cell Receptors
J.Exp.Med., 203, 2006
2CDF
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STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA- GALACTOSYLCERAMIDE-SPECIFIC T CELL RECEPTORS (TCR 5E)
Descriptor:TCR 5E
Authors:Gadola, S.D., Koch, M., Marles-Wright, J., Lissin, N.M., Sheperd, D., Matulis, G., Harlos, K., Villiger, P.M., Stuart, D.I., Jakobsen, B.K., Cerundolo, V., Jones, E.Y.
Deposit date:2006-01-23
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structrue and Binding Kinetics of Three Different Human Cd1D-Alpha-Galactosylceramide-Specific T Cell Receptors
J.Exp.Med., 203, 2006
2CDG
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STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA- GALACTOSYLCERAMIDE-SPECIFIC T CELL RECEPTORS (TCR 5B)
Descriptor:TCR 5E
Authors:Gadola, S.D., Koch, M., Marles-Wright, J., Lissin, N.M., Sheperd, D., Matulis, G., Harlos, K., Villiger, P.M., Stuart, D.I., Jakobsen, B.K., Cerundolo, V., Jones, E.Y.
Deposit date:2006-01-23
Release date:2006-03-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structrue and Binding Kinetics of Three Different Human Cd1D-Alpha-Galactosylceramide-Specific T Cell Receptors
J.Exp.Med., 203, 2006
2F53
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DIRECTED EVOLUTION OF HUMAN T-CELL RECEPTOR CDR2 RESIDUES BY PHAGE DISPLAY DRAMATICALLY ENHANCES AFFINITY FOR COGNATE PEPTIDE-MHC WITHOUT APPARENT CROSS-REACTIVITY
Descriptor:HLA class I histocompatibility antigen, Beta-2-microglobulin, Cancer/testis antigen 1B, ...
Authors:Rizkallah, P.J., Jakobsen, B.K., Dunn, S.M., Sami, M.
Deposit date:2005-11-25
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
2F54
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DIRECTED EVOLUTION OF HUMAN T CELL RECEPTOR CDR2 RESIDUES BY PHAGE DISPLAY DRAMATICALLY ENHANCES AFFINITY FOR COGNATE PEPTIDE-MHC WITHOUT INCREASING APPARENT CROSS-REACTIVITY
Descriptor:HLA class I histocompatibility antigen, Beta-2-microglobulin, Cancer/testis antigen 1B, ...
Authors:Rizkallah, P.J., Jakobsen, B.K., Dunn, S.M., Sami, M.
Deposit date:2005-11-25
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
2HP4
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COMPUTATIONAL DESIGN AND CRYSTAL STRUCTURE OF AN ENHANCED AFFINITY MUTANT HUMAN CD8-ALPHA-ALPHA CO-RECEPTOR
Descriptor:T-cell surface glycoprotein CD8 alpha chain, SULFATE ION, GLYCEROL
Authors:Rizkallah, P.J., Cole, D.K., Jakobsen, B.K., Boulter, J.M., Glick, M., Gao, G.F.
Deposit date:2006-07-17
Release date:2007-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor
Proteins, 67, 2007
2P5E
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CRYSTAL STRUCTURES OF HIGH AFFINITY HUMAN T-CELL RECEPTORS BOUND TO PMHC REVEAL NATIVE DIAGONAL BINDING GEOMETRY
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Sami, M., Rizkallah, P.J., Dunn, S., Li, Y., Moysey, R., Vuidepot, A., Baston, E., Todorov, P., Molloy, P., Gao, F., Boulter, J.M., Jakobsen, B.K.
Deposit date:2007-03-15
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
2P5W
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CRYSTAL STRUCTURES OF HIGH AFFINITY HUMAN T-CELL RECEPTORS BOUND TO PMHC REVEAL NATIVE DIAGONAL BINDING GEOMETRY
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Sami, M., Rizkallah, P.J., Dunn, S., Li, Y., Moysey, R., Vuidepot, A., Baston, E., Todorov, P., Molloy, P., Gao, F., Boulter, J.M., Jakobsen, B.K.
Deposit date:2007-03-16
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
2PYE
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CRYSTAL STRUCTURES OF HIGH AFFINITY HUMAN T-CELL RECEPTORS BOUND TO PMHC REVEALNATIVE DIAGONAL BINDING GEOMETRY TCR CLONE C5C1 COMPLEXED WITH MHC
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Sami, M., Rizkallah, P.J., Dunn, S., Li, Y., Moysey, R., Vuidepot, A., Baston, E., Todorov, P., Molloy, P., Gao, F., Boulter, J.M., Jakobsen, B.K.
Deposit date:2007-05-16
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
2PYF
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CRYSTAL STRUCTURES OF HIGH AFFINITY HUMAN T-CELL RECEPTORS BOUND TO PMHC REVEALNATIVE DIAGONAL BINDING GEOMETRY UNBOUND TCR CLONE 5-1
Descriptor:T-Cell Receptor, Alpha Chain, Beta Chain, ...
Authors:Sami, M., Rizkallah, P.J., Dunn, S., Li, Y., Moysey, R., Vuidepot, A., Baston, E., Todorov, P., Molloy, P., Gao, F., Boulter, J.M., Jakobsen, B.K.
Deposit date:2007-05-16
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
3HG1
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GERMLINE-GOVERNED RECOGNITION OF A CANCER EPITOPE BY AN IMMUNODOMINANT HUMAN T CELL RECEPTOR
Descriptor:MHC class I antigen, Beta-2-microglobulin, CANCER/MART-1, ...
Authors:Cole, D.K., Yuan, F., Rizkallah, P.J., Miles, J.J., Gostick, E., Price, D.A., Gao, G.F., Jakobsen, B.K., Sewell, A.K.
Deposit date:2009-05-13
Release date:2009-07-28
Last modified:2014-04-09
Method:X-RAY DIFFRACTION (3 Å)
Cite:Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
J.Biol.Chem., 284, 2009
4MNQ
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TCR-PEPTIDE SPECIFICITY OVERRIDES AFFINITY ENHANCING TCR-MHC INTERACTIONS
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Sewell, A.K., Jakobsen, B.K.
Deposit date:2013-09-11
Release date:2013-11-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.742 Å)
Cite:T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
J.Biol.Chem., 289, 2014
5BRZ
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MAGE-A3 REACTIVE TCR IN COMPLEX WITH MAGE-A3 IN HLA-A1
Descriptor:HLA class I histocompatibility antigen, A-1 alpha chain, Beta-2-microglobulin, ...
Authors:Raman, M.C.C., Rizkallah, P.J., Simmons, R., Donnellan, Z., Dukes, J., Bossi, G., LeProvost, G., Mahon, T., Hickman, E., LomaX, M., Oates, J., Hassan, N., Vuidepot, A., Sami, M., Cole, D.K., Jakobsen, B.K.
Deposit date:2015-06-01
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Sci Rep, 6, 2016
5BS0
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MAGE-A3 REACTIVE TCR IN COMPLEX WITH TITIN EPITOPE IN HLA-A1
Descriptor:HLA class I histocompatibility antigen, A-1 alpha chain, Beta-2-microglobulin, ...
Authors:Raman, M.C.C., Rizkallah, P.J., Simmons, R., Donellan, Z., Dukes, J., Bossi, G., LeProvost, G., Mahon, T., Hickman, E., Lomax, M., Oates, J., Hassan, N., Vuidepot, A., Sami, M., Cole, D.K., Jakobsen, B.K.
Deposit date:2015-06-01
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Sci Rep, 6, 2016
2BNU
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STRUCTURAL AND KINETIC BASIS FOR HEIGHTENED IMMUNOGENICITY OF T CELL VACCINES
Descriptor:T-CELL RECEPTOR ALPHA CHAIN C REGION, T-CELL RECEPTOR BETA CHAIN C REGION
Authors:Chen, J.-L., Stewart-Jones, G., Bossi, G., Lissin, N.M., Wooldridge, L., Choi, E.M.L., Held, G., Dunbar, P.R., Esnouf, R.M., Sami, M., Boultier, J.M., Rizkallah, P.J., Renner, C., Sewell, A., Van Der Merwe, P.A., Jackobsen, B.K., Griffiths, G., Jones, E.Y., Cerundolo, V.
Deposit date:2005-04-04
Release date:2005-05-24
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines.
J.Exp.Med., 201, 2005
1AKJ
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COMPLEX OF THE HUMAN MHC CLASS I GLYCOPROTEIN HLA-A2 AND THE T CELL CORECEPTOR CD8
Descriptor:MHC CLASS I HISTOCOMPATIBILITY ANTIGEN (HLA-A*0201) (ALPHA CHAIN), BETA 2-MICROGLOBULIN, HIV REVERSE TRANSCRIPTASE EPITOPE, ...
Authors:Tormo, J., Stuart, D.I., Jones, E.Y.
Deposit date:1997-05-21
Release date:1997-09-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2.
Nature, 387, 1997
3UTP
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1E6 TCR SPECIFIC FOR HLA-A*0201-ALWGPDPAAA
Descriptor:1E6 TCR alpha chain, 1E6 TCR beta chain, GLYCEROL, ...
Authors:Rizkallah, P.J., Cole, D.K., Sewell, A.K., Bulek, A.M.
Deposit date:2011-11-26
Release date:2012-01-25
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (2.574 Å)
Cite:Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
3UTQ
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HUMAN HLA-A*0201-ALWGPDPAAA
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J., Cole, D.K., Sewell, A.K., Bulek, A.M.
Deposit date:2011-11-26
Release date:2012-01-25
Last modified:2012-03-07
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
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