Author results

4TWA
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CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE (PRS) FROM PLASMODIUM FALCIPARUM
分子名称:Proline--tRNA ligase, CHLORIDE ION, SULFATE ION
著者Jain, V., Yogavel, M., Sharma, A.
登録日2014-06-30
公開日2014-08-13
最終更新日2014-12-03
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase.
J. Struct. Funct. Genomics, 15, 2014
4YDQ
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CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE (PRS) FROM PLASMODIUM FALCIPARUM IN COMPLEX WITH HALOFUGINONE AND AMPPNP
分子名称:Proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ...
著者Jain, V., Yogavel, M., Sharma, A.
登録日2015-02-23
公開日2015-05-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis
Structure, 23, 2015
5JLD
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CRYSTAL STRUCTURE OF ARGINYL-TRNA SYNTHETASE FROM PLASMODIUM FALCIPARUM (PFRRS)
分子名称:Arginyl-tRNA synthetase, putative
著者Jain, V., Manickam, Y., Sharma, A.
登録日2016-04-27
公開日2016-08-24
最終更新日2016-09-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Dimerization of Arginyl-tRNA Synthetase by Free Heme Drives Its Inactivation in Plasmodium falciparum
Structure, 24, 2016
5XIF
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CRYSTAL STRUCTURE OF PROLYL-TRNA SYNTHETASE (PRS) FROM TOXOPLASMA GONDII
分子名称:Prolyl-tRNA synthetase (ProRS), CHLORIDE ION
著者Jain, V., Manickam, Y., Sharma, A.
登録日2017-04-26
公開日2018-03-07
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIG
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII PROLYL-TRNA SYNTHETASE (TGPRS) IN COMPLEX WITH INHIBITOR 1
分子名称:Prolyl-tRNA synthetase (ProRS), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
著者Jain, V., Manickam, Y., Sharma, A.
登録日2017-04-26
公開日2018-03-07
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIH
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII PROLYL-TRNA SYNTHETASE (TGPRS) IN COMPLEX WITH INHIBITOR 5
分子名称:Prolyl-tRNA synthetase (ProRS), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
著者Jain, V., Manickam, Y., Sharma, A.
登録日2017-04-26
公開日2018-03-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XII
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII PROLYL-TRNA SYNTHETASE (TGPRS) IN COMPLEX WITH INHIBITOR 6
分子名称:Prolyl-tRNA synthetase (ProRS), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
著者Jain, V., Manickam, Y., Sharma, A.
登録日2017-04-26
公開日2018-03-07
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIJ
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII PROLYL-TRNA SYNTHETASE (TGPRS) IN COMPLEX WITH INHIBITOR 9
分子名称:Prolyl-tRNA synthetase (ProRS), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
著者Jain, V., Manickam, Y., Sharma, A.
登録日2017-04-26
公開日2018-03-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIK
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII PROLYL-TRNA SYNTHETASE (TGPRS) IN COMPLEX WITH TETRAHYDRO QUINAZOLINONE FEBRIFUGINE
分子名称:Prolyl-tRNA synthetase (ProRS), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
著者Jain, V., Manickam, Y., Sharma, A.
登録日2017-04-26
公開日2018-03-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIL
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR PROLYL-TRNA SYNTHETASE (LMPRS)
分子名称:Putative prolyl-tRNA synthetase, ZINC ION, ACETATE ION, ...
著者Jain, V., Manickam, Y., Sharma, A.
登録日2017-04-26
公開日2018-03-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIO
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CRYSTAL STRUCTURE OF CRYPTOSPORIDIUM PARVUM PROLYL-TRNA SYNTHETASE (CPPRS) IN COMPLEX WITH HALOFUGINONE
分子名称:Proline-tRNA synthetase class II aaRS (Ybak RNA binding domain plus tRNA synthetase), 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ZINC ION, ...
著者Jain, V., Manickam, Y., Sharma, A.
登録日2017-04-26
公開日2018-03-07
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIP
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CRYSTAL STRUCTURE OF EIMERIA TENELLA PROLYL-TRNA SYNTHETASE (ETPRS) IN COMPLEX WITH HALOFUGINONE
分子名称:Prolyl-tRNA synthetase, putative, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者Jain, V., Manickam, Y., Sharma, A.
登録日2017-04-26
公開日2018-03-07
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIQ
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CRYSTAL STRUCTURE OF TOXOPLASMA GONDII PROLYL-TRNA SYNTHETASE (TGPRS) IN COMPLEX WITH HALOFUGINONE
分子名称:Prolyl-tRNA synthetase (ProRS), PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ...
著者Jain, V., Manickam, Y., Sharma, A.
登録日2017-04-26
公開日2018-03-07
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5ZDK
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CRYSTAL STRUCTURE ANALYSIS OF TTQRS IN COMPLEX WITH ATP
分子名称:Glutamine--tRNA ligase, ADENOSINE-5'-TRIPHOSPHATE, CESIUM ION, ...
著者Mutharasappan, N., Jain, V., Sharma, A., Manickam, Y., Jeyaraman, J.
登録日2018-02-23
公開日2018-12-05
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes
Int. J. Biol. Macromol., 120, 2018
5ZDL
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CRYSTAL STRUCTURE ANALYSIS OF TTQRS IN CO-CRYSTALLISED WITH ATP
分子名称:Glutamine--tRNA ligase, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION
著者Mutharasappan, N., Jain, V., Sharma, A., Manickam, Y., Jeyaraman, J.
登録日2018-02-23
公開日2018-12-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes
Int. J. Biol. Macromol., 120, 2018
5ZDO
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CRYSTAL STRUCTURE ANALYSIS OF TTQRS IN CO-CRYSTALLISED WITH ATP
分子名称:Glutamine-tRNA ligase, CHLORIDE ION
著者Mutharasappan, N., Jain, V., Sharma, A., Manickam, Y., Jeyaraman, J.
登録日2018-02-23
公開日2018-12-05
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes
Int. J. Biol. Macromol., 120, 2018
5ZG8
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CRYSTAL STRUCTURE OF TTNRS
分子名称:Asparagine--tRNA ligase
著者Mutharasappan, N., Jain, V., Sharma, A., Manickam, Y., Jeyaraman, J.
登録日2018-03-08
公開日2019-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of TtNRS
To be published
5Z79
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CRYSTAL STRUCTURE ANALYSIS OF THE HPPK-DHPS IN COMPLEX WITH SUBSTRATES
分子名称:Hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase, putative, 6-HYDROXYMETHYLPTERIN-DIPHOSPHATE, ...
著者Manickam, Y., Karl, H., Sharma, A.
登録日2018-01-27
公開日2018-08-29
最終更新日2018-10-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase fromPlasmodium vivaxsheds light on drug resistance
J. Biol. Chem., 293, 2018
6GGM
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HLA-E*01:03 IN COMPLEX WITH THE MTB44 PEPTIDE VARIANT: MTB44*P2-PHE.
分子名称:MHC class I antigen, Beta-2-microglobulin, Mtb44*P2-Phe peptide variant (ARG-PHE-PRO-ALA-LYS-ALA-PRO-LEU-LEU), ...
著者Walters, L.C., Gillespie, G.M., McMichael, A.J., Rozbesky, D., Jones, E.Y., Harlos, K.
登録日2018-05-03
公開日2018-08-08
最終更新日2018-08-22
実験手法X-RAY DIFFRACTION (2.734 Å)
主引用文献Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018
6GH1
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HLA-E*01:03 IN COMPLEX WITH MTB44
分子名称:MHC class I antigen, Beta-2-microglobulin, Enoyl-[acyl-carrier-protein] reductase [NADH], ...
著者Walters, L.C., Gillespie, G.M., McMichael, A.J., Rozbesky, D., Jones, E.Y., Harlos, K.
登録日2018-05-04
公開日2018-08-08
最終更新日2018-08-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018
6GH4
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HLA-E*01:03 IN COMPLEX WITH THE MTB44 PEPTIDE VARIANT: MTB44*P2-GLN.
分子名称:MHC class I antigen, Beta-2-microglobulin, ARG-GLN-PRO-ALA-LYS-ALA-PRO-LEU-LEU, ...
著者Walters, L.C., Gillespie, G.M., McMichael, A.J., Rozbesky, D., Jones, E.Y., Harlos, K.
登録日2018-05-04
公開日2018-08-08
最終更新日2018-08-22
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018
6GHN
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HLA-E*01:03 IN COMPLEX WITH THE MTB44 PEPTIDE VARIANT: MTB44*P9-PHE.
分子名称:HLA class I histocompatibility antigen, E alpha chain variant, Beta-2-microglobulin, ...
著者Walters, L.C., Gillespie, G.M., McMichael, A.J., Rozbesky, D., Jones, E.Y., Harlos, K.
登録日2018-05-08
公開日2018-08-08
最終更新日2018-08-22
実験手法X-RAY DIFFRACTION (2.542 Å)
主引用文献Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018
6GL1
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HLA-E*01:03 IN COMPLEX WITH THE HIV EPITOPE, RL9HIV
分子名称:MHC class I antigen, Beta-2-microglobulin, ARG-MET-TYR-SER-PRO-THR-SER-ILE-LEU, ...
著者Walters, L.C., Gillespie, G.M., McMichael, A.J., Rozbesky, D., Jones, E.Y., Harlos, K.
登録日2018-05-22
公開日2018-08-08
最終更新日2018-08-22
実験手法X-RAY DIFFRACTION (2.623 Å)
主引用文献Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
Nat Commun, 9, 2018