Author results

4XS7
  • Download 4xs7
  • View 4xs7
Molmil generated image of 4xs7
DETERMINING THE MOLECULAR BASIS FOR STARTER UNIT SELECTION DURING DAUNORUBICIN BIOSYNTHESIS
Descriptor:Daunorubicin-doxorubicin polyketide synthase
Authors:Jackson, D.R., Valentic, T.R., Tsai, S.C., Patel, A., Mohammed, L., Vasilakis, K., Wattana-amorn, P., Long, P.F., Crump, M.P., Crosby, J.
Deposit date:2015-01-22
Release date:2016-01-27
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis
To Be Published
4XS9
  • Download 4xs9
  • View 4xs9
Molmil generated image of 4xs9
DETERMINING THE MOLECULAR BASIS FOR STARTER UNIT SELECTION DURING DAUNORUBICIN BIOSYNTHESIS
Descriptor:Daunorubicin-doxorubicin polyketide synthase, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-[2-(propanoylamino)ethyl]-beta-alaninamide
Authors:Jackson, D.R., Valentic, T.R., Tsai, S.C., Patel, A., Mohammed, L., Vasilakis, K., Wattana-amorn, P., Long, P.F., Crump, M.P., Crosby, J.
Deposit date:2015-01-22
Release date:2016-01-27
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.002 Å)
Cite:Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis
To Be Published
4XSA
  • Download 4xsa
  • View 4xsa
Molmil generated image of 4xsa
DETERMINING THE MOLECULAR BASIS FOR STARTER UNIT SELECTION DURING DAUNORUBICIN BIOSYNTHESIS
Descriptor:Daunorubicin-doxorubicin polyketide synthase
Authors:Jackson, D.R., Valentic, T.R., Tsai, S.C., Patel, A., Mohammed, L., Vasilakis, K., Wattana-amorn, P., Long, P.F., Crump, M.P., Crosby, J.
Deposit date:2015-01-22
Release date:2016-01-27
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.204 Å)
Cite:Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis
To Be Published
4XSB
  • Download 4xsb
  • View 4xsb
Molmil generated image of 4xsb
DETERMINING THE MOLECULAR BASIS FOR STARTER UNIT SELECTION DURING DAUNORUBICIN BIOSYNTHESIS
Descriptor:Daunorubicin-doxorubicin polyketide synthase
Authors:Jackson, D.R., Valentic, T.R., Tsai, S.C., Patel, A., Mohammed, L., Vasilakis, K., Wattana-amorn, P., Long, P.F., Crump, M.P., Crosby, J.
Deposit date:2015-01-22
Release date:2016-01-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:Determining the Molecular Basis for Starter Unit Selection During Daunorubicin Biosynthesis
To Be Published
5TT4
  • Download 5tt4
  • View 5tt4
Molmil generated image of 5tt4
DETERMINING THE MOLECULAR BASIS FOR STARTER UNIT SELECTION DURING DAUNORUBICIN BIOSYNTHESIS
Descriptor:Daunorubicin-doxorubicin polyketide synthase
Authors:Jackson, D.R., Valentic, T.R., Patel, A., Tsai, S.C., Mohammed, L., Vasilakis, K., Wattana-amorn, P., Long, P.F., Crump, M.P., Crosby, J.
Deposit date:2016-11-01
Release date:2016-11-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Determining the Molecular Basis For Starter Unit Selection During Daunorubicin Biosynthesis
To Be Published
4WV3
  • Download 4wv3
  • View 4wv3
Molmil generated image of 4wv3
CRYSTAL STRUCTURE OF THE ANTHRANILATE COA LIGASE AUAEII IN COMPLEX WITH ANTHRANOYL-AMP
Descriptor:Anthranilate-CoA ligase, 5'-O-[(S)-[(2-aminobenzoyl)oxy](hydroxy)phosphoryl]adenosine
Authors:Tsai, S.C., Muller, R., Jackson, D.R., Tu, S.S., Nguyen, M., Barajas, J.F., Pistorious, D., Krug, D.
Deposit date:2014-11-04
Release date:2015-11-11
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.599 Å)
Cite:Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis.
Acs Chem.Biol., 11, 2016
4X4J
  • Download 4x4j
  • View 4x4j
Molmil generated image of 4x4j
STRUCTURAL AND FUNCTIONAL STUDIES OF BEXE: INSIGHTS INTO OXIDATION DURING BE-7585A BIOSYNTHESIS
Descriptor:Putative oxygenase, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Tsai, S.-C., Jackson, D.R., Patel, A., Barajas, J.F., Rohr, J., Yu, X., Liu, H.-W., Sasaki, E., Calveras, J., Metsa-Ketela, M.
Deposit date:2014-12-02
Release date:2015-12-02
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis
To Be Published
4XRT
  • Download 4xrt
  • View 4xrt
Molmil generated image of 4xrt
CRYSTAL STRUCTURE OF THE DI-DOMAIN ARO/CYC STFQ FROM THE STEFFIMYCIN BIOSYNTHETIC PATHWAY
Descriptor:StfQ Aromatase/Cyclase, FORMIC ACID
Authors:Tsai, S.C., Caldara-Festin, G.M., Jackson, D.R., Aguilar, S., Patel, A., Nguyen, M., Sasaki, E., Valentic, T.R., Barajas, J.F., Vo, M., Khanna, A., Liu, H.-W.
Deposit date:2015-01-21
Release date:2015-12-02
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4XRW
  • Download 4xrw
  • View 4xrw
Molmil generated image of 4xrw
CRYSTAL STRUCTURE OF THE DI-DOMAIN ARO/CYC BEXL FROM THE BE-7585A BIOSYNTHETIC PATHWAY
Descriptor:BexL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Tsai, S.C., Caldara-Festin, G.M., Jackson, D.R., Aguilar, S., Patel, A., Nguyen, M., Sasaki, E., Valentic, T.R., Barajas, J.F., Vo, M., Khanna, A., Liu, H.-W.
Deposit date:2015-01-21
Release date:2015-12-02
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
5KBZ
  • Download 5kbz
  • View 5kbz
Molmil generated image of 5kbz
STRUCTURE OF THE PKSA PRODUCT TEMPLATE DOMAIN IN COMPLEX WITH A PHOSPHOPANTETHEINE MIMETIC
Descriptor:Noranthrone synthase, (14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate
Authors:Tsai, S.C., Burkart, M.D., Townsend, C.A., Barajas, J.F., Shakya, G., Topper, C.L., Moreno, G., Jackson, D.R., Rivera, H., La Clair, J.J., Vagstad, A.
Deposit date:2016-06-03
Release date:2017-05-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5KOF
  • Download 5kof
  • View 5kof
Molmil generated image of 5kof
CROSSLINKED CRYSTAL STRUCTURE OF TYPE II FATTY ACID SYNTHASE KETOSYNTHASE, FABB, AND ACYL CARRIER PROTEIN, ACPP
Descriptor:3-oxoacyl-[acyl-carrier-protein] synthase 1, Acyl carrier protein, [(3~{S})-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-(prop-2-enoylamino)ethylamino]propyl]amino]butyl] dihydrogen phosphate
Authors:Milligan, J.C., Jackson, D.R., Barajas, J.F., Tsai, S.C.
Deposit date:2016-06-30
Release date:2018-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crosslinked Crystal Structure of Type II Fatty Acid Synthase Ketosynthase, FabB, and Acyl Carrier Protein, AcpP
To Be Published
4KEH
  • Download 4keh
  • View 4keh
Molmil generated image of 4keh
CROSSLINKED CRYSTAL STRUCTURE OF TYPE II FATTY SYNTHASE DEHYDRATASE, FABA, AND ACYL CARRIER PROTEIN, ACPP
Descriptor:N-{3-[DIHYDROXY(NONYL)-LAMBDA~4~-SULFANYL]PROPYL}-N~3~-[(2R)-2-HYDROXY-3,3-DIMETHYL-4-(PHOSPHONOOXY)BUTANOYL]-BETA-ALANINAMIDE, Acyl carrier protein, N-{3-[dihydroxy(nonyl)-lambda~4~-sulfanyl]propyl}-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide
Authors:Nguyen, C., Haushalter, R., Finzel, K., Leong, J., Le, B.C., Burkart, M., Tsai, S.C.
Deposit date:2013-04-25
Release date:2013-12-25
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Trapping the dynamic acyl carrier protein in fatty acid biosynthesis.
Nature, 505, 2014
4U7W
  • Download 4u7w
  • View 4u7w
Molmil generated image of 4u7w
THE CRYSTAL STRUCTURE OF THE TERMINAL R DOMAIN FROM THE MYXALAMID PKS-NRPS BIOSYNTHETIC PATHWAY
Descriptor:MxaA, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ACETATE ION
Authors:Tsai, S.C., Keasling, J.D., Luo, R., Barajas, J.F., Phelan, R.M., Schaub, A.J., Kliewer, J.
Deposit date:2014-07-31
Release date:2015-08-12
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols.
Chem.Biol., 22, 2015
4W4T
  • Download 4w4t
  • View 4w4t
Molmil generated image of 4w4t
THE CRYSTAL STRUCTURE OF THE TERMINAL R DOMAIN FROM THE MYXALAMID PKS-NRPS BIOSYNTHETIC PATHWAY
Descriptor:MxaA, ACETATE ION
Authors:Tsai, S.C., Keasling, J.D., Luo, R., Barajas, J.F., Phelan, R.M., Schaub, A.J., Kliewer, J.
Deposit date:2014-08-15
Release date:2015-08-12
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.845 Å)
Cite:Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols.
Chem.Biol., 22, 2015
5THQ
  • Download 5thq
  • View 5thq
Molmil generated image of 5thq
COMPREHENSIVE ANALYSIS OF A NOVEL KETOREDUCTASE FOR PENTANGULAR POLYPHENOL BIOSYNTHESIS
Descriptor:3-oxoacyl-ACP reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Valentic, T.R., Tsai, S.C., Brady, S.F.
Deposit date:2016-09-30
Release date:2016-11-09
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis.
ACS Chem. Biol., 11, 2016
5TII
  • Download 5tii
  • View 5tii
Molmil generated image of 5tii
COMPREHENSIVE ANALYSIS OF A NOVEL KETOREDUCTASE FOR PENTANGULAR POLYPHENOL BIOSYNTHESIS
Descriptor:3-oxoacyl-ACP reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Valentic, T.R., Tsai, S.C., Brady, S.F.
Deposit date:2016-10-03
Release date:2016-11-09
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis.
ACS Chem. Biol., 11, 2016