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4L9U
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BU of 4l9u by Molmil
Structure of C-terminal coiled coil of RasGRP1
Descriptor: GLYCEROL, RAS guanyl-releasing protein 1, SULFATE ION
Authors:Iwig, J.S, Vercoulen, Y, Das, R, Barros, T, Limnander, A, Che, Y, Pelton, J.G, Wemmer, D.E, Roose, J.P, Kuriyan, J.
Deposit date:2013-06-18
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6014 Å)
Cite:Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.
Elife, 2, 2013
4L9M
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BU of 4l9m by Molmil
Autoinhibited state of the Ras-specific exchange factor RasGRP1
Descriptor: CITRIC ACID, GLYCEROL, RAS guanyl-releasing protein 1, ...
Authors:Iwig, J.S, Vercoulen, Y, Das, R, Barros, T, Limnander, A, Che, Y, Pelton, J.G, Wemmer, D.E, Roose, J.P, Kuriyan, J.
Deposit date:2013-06-18
Release date:2013-08-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.
Elife, 2, 2013
6AXF
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BU of 6axf by Molmil
Structure of RasGRP2 in complex with Rap1B
Descriptor: RAS guanyl-releasing protein 2, Ras-related protein Rap-1b
Authors:Kondo, Y, Iwig, J.S, Kuriyan, J.
Deposit date:2017-09-06
Release date:2017-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.
Elife, 6, 2017
6AXG
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BU of 6axg by Molmil
Structure of RasGRP4 in complex with HRas
Descriptor: GTPase HRas, RAS guanyl-releasing protein 4
Authors:Kondo, Y, Iwig, J.S, Kuriyan, J.
Deposit date:2017-09-06
Release date:2017-10-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.302 Å)
Cite:A histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.
Elife, 6, 2017
2MA2
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BU of 2ma2 by Molmil
Solution structure of RasGRP2 EF hands bound to calcium
Descriptor: RAS guanyl-releasing protein 2
Authors:Kuriyan, J, Iwig, J, Vercoulen, Y, Das, R, Barros, T, Limnander, A, Che, Y, Pelton, J, Wemmer, D, Roose, J.
Deposit date:2013-06-24
Release date:2013-08-21
Method:SOLUTION NMR
Cite:Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.
Elife, 2, 2013
6P8Z
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BU of 6p8z by Molmil
Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor
Descriptor: 2-[5-chloro-2-cyclopropyl-3-(5-methoxy-3,4-dihydroisoquinoline-2(1H)-carbonyl)-7-methyl-1H-indol-1-yl]-N-(1-propanoylazetidin-3-yl)acetamide, CALCIUM ION, GTPase KRas, ...
Authors:Mohr, C.
Deposit date:2019-06-08
Release date:2019-08-28
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.
Acs Med.Chem.Lett., 10, 2019
6P8W
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BU of 6p8w by Molmil
Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.
Descriptor: CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Mohr, C.
Deposit date:2019-06-08
Release date:2019-08-28
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.
Acs Med.Chem.Lett., 10, 2019
6P8Y
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BU of 6p8y by Molmil
Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.
Descriptor: 2-[5-bromo-3-(5-methoxy-3,4-dihydroisoquinoline-2(1H)-carbonyl)-1H-indol-1-yl]-N-(1-propanoylazetidin-3-yl)acetamide, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Mohr, C.
Deposit date:2019-06-08
Release date:2019-08-28
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.
Acs Med.Chem.Lett., 10, 2019
6P8X
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BU of 6p8x by Molmil
Crystal structure of human KRAS G12C covalently bound to an acryloylazetidine acetamide inhibitor.
Descriptor: 2-[4-bromo-2-(3-phenyl-2,5-dihydro-1H-pyrrole-1-carbonyl)phenoxy]-N-(1-propanoylazetidin-3-yl)acetamide, CALCIUM ION, GTPase KRas, ...
Authors:Mohr, C.
Deposit date:2019-06-08
Release date:2019-08-28
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Discovery ofN-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C.
Acs Med.Chem.Lett., 10, 2019

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PDB entries from 2024-03-27

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